Kinetics of 11C-Labeled Opiates Studied with Positron Emission Tomography in the Brain of the Rhesus Monkey

  • P. O. Lundberg
  • P. Hartvig
  • K. Bergström
  • B. Lindberg
  • H. Lundqvist
  • B. Långström
  • H. Svärd
  • A. Rane
Conference paper

Abstract

Our knowledge of the pharmacokinetics of analgesics and antimigraine drugs in cranial structures is incomplete. This is mainly due to the difficulties of sampling blood or tissue from the region in question. However, the development of positron emission tomography (PET) has made it possible to obtain cross-sectional images of the distribution of 11C-labeled drugs and metabolites in the living animal. PET studies with 11C-labeled drugs make dynamic quantitative in vivo autoradiography of the head possible.

Keywords

Catheter Dioxide Morphine Radionuclide Iodide 

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References

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    Eriksson L, Bohm C, Kesselberg G, Blomqvist G, Litton J, Widen L, Bergström M, Ericsson K, Greitz T (1982) A four ring positron camera system for emission tomography of the brain. IEE Transact Nucl Sci 29: 539–543CrossRefGoogle Scholar
  2. 2.
    Hartvig P, Bergström K, Lindberg B, Lundberg PO, Lundqvist H, Långström B, Svärd H, Rane A (to be published) Kinetics of l1C-labeled opiates in the brain of rhesus monkey. J Pharmacol Exp TherGoogle Scholar
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    Långström B, Antoni G, Halldin C, Svärd H, Bergson G (1982) Synthesis of some 11C-labeled alkaloids. Chem Scripta 20: 46–48Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • P. O. Lundberg
  • P. Hartvig
  • K. Bergström
  • B. Lindberg
  • H. Lundqvist
  • B. Långström
  • H. Svärd
  • A. Rane

There are no affiliations available

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