Kinetics of 11C-Labeled Opiates Studied with Positron Emission Tomography in the Brain of the Rhesus Monkey
Our knowledge of the pharmacokinetics of analgesics and antimigraine drugs in cranial structures is incomplete. This is mainly due to the difficulties of sampling blood or tissue from the region in question. However, the development of positron emission tomography (PET) has made it possible to obtain cross-sectional images of the distribution of 11C-labeled drugs and metabolites in the living animal. PET studies with 11C-labeled drugs make dynamic quantitative in vivo autoradiography of the head possible.
KeywordsPositron Emission Tomography Rhesus Monkey Positron Emission Tomography Study Gamma Photon Positron Emission Tomography Examination
Unable to display preview. Download preview PDF.
- 2.Hartvig P, Bergström K, Lindberg B, Lundberg PO, Lundqvist H, Långström B, Svärd H, Rane A (to be published) Kinetics of l1C-labeled opiates in the brain of rhesus monkey. J Pharmacol Exp TherGoogle Scholar
- 3.Långström B, Antoni G, Halldin C, Svärd H, Bergson G (1982) Synthesis of some 11C-labeled alkaloids. Chem Scripta 20: 46–48Google Scholar