The immunochemical basis of hypersensivity and immunity

  • Edward E. Fischel
Part of the Handbuch der Allgemeinen Pathologie book series (PATHOLOGIE, volume 7 / 2)


This review is intended as a general survey of some basic contributions to the field of allergy and immunology particularly from the point of view of immunochemical principles, with certain aspects treated in detail for illustration. The literature cited is chiefly from English and American sources, in part because it is difficult enough to be conversant with articles in a rapidly expanding area limited by a single language. Many highly significant contributions have been omitted because of this as well as limitations of space and time.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Abell, R. G., and H. P. Schenck: Microscopic observations on the behavior of living blood vessels of the rabbit during the reaction of anaphylaxis. J. Immunol. 34, 195 (1938).Google Scholar
  2. Adler, F. L.: On hemolysis mediated by non-erythrocytic antigens, their homologous antibodies and complement. Proc. Soc. exp. Biol. (N.Y.) 74, 651 (1950).Google Scholar
  3. Algire, G. H.: Diffusion chamber techniques for studies of cellular immunity. Ann. N.Y. Acad. Sci. 69, 663 (1957).PubMedGoogle Scholar
  4. Allen, P. Z., and E. A. Kabat: Studies on the capacity of some polysaccharides to elicit antibody formation in man. J. exp. Med. 105, 383 (1957).PubMedGoogle Scholar
  5. Allison, A. C, and J. H. Humphrey: A theoretical and experimental analysis of double diffusion precipitin reactions in gels, and its application to characterization of antigens. Immunology 3, 95–106 (1960).PubMedGoogle Scholar
  6. Anderson, J. F., and M. J. Rosenau: Anaphylaxis. Harvey Lect. 117 (1908).Google Scholar
  7. Anderson, J. R., R. B. Goudie, K. G. Gray, and G. C. Timbury: Autoantibodies in Addison’s disease. Lancet 19571, 1123.Google Scholar
  8. Andres, G. A., C. Morgan, K. C. Hsu, R. A. Rifkind, and B. C. Seegal: Electron microscopic studies of experimental nephritis with ferritin-conjugated antibody. J. exp. Med. 115, 929 (1962).PubMedGoogle Scholar
  9. Aronson, J. D.: The specific cytotoxic action of tuberculin in tissue culture. J. exp. Med. 54, 387 (1931).PubMedGoogle Scholar
  10. Arthus, M.: Injections repetees de serum du cheval chez le lapin. C.R. Soc. Biol. (Paris) 55, 817 (1903).Google Scholar
  11. Arthus, M., and M. Breton: Lesions cutanees produites par les injections de serum de cheval chez le lapin anaphylactise par et pour ce serum. C.R. Soc. Biol. (Paris) 55, 1478 (1903).Google Scholar
  12. Asherson, G. L.: Antibodies against nuclear and cytoplasmic cell constituents in systemic lupus erythematosus and other diseases. Brit. J. exp. Path. 40, 209 (1959).PubMedGoogle Scholar
  13. Askonas, B. A., and J. H. Humphrey: Antibody formation in slices of granulomata produced by adjuvant. Biochem. J. 60 (1955).Google Scholar
  14. Askonas, B. A., and J. H. Humphrey: Formation of specific antibodies and gamma globulin in vitro. A study of synthetic ability of various tissues from rabbits immunized by different methods. Biochem. J. 68, 252 (1958).PubMedGoogle Scholar
  15. Audia, M., and J. Noah: Supravital staining of leucocytes from ragweed sensitive individuals. J. Allergy 32, 223 (1961).Google Scholar
  16. Auer, J.: Local autoinoculation of the sensitized organism with foreign protein as a cause of abnormal reactions. J. exp. Med. 32, 427 (1920).PubMedGoogle Scholar
  17. Austen, K. F., and W. E. Brocklehurst: Anaphylaxis in chopped guinea pig lung. II. Enhancement of the anaphylactic release of histamine and slow reacting substance by certain dibasic aliphatic acids and inhibition by monobasic fatty acids. J. exp. Med. 113, 54 (1961).Google Scholar
  18. Austen, K. F., and W. E. Brocklehurst: Anaphylaxis in chopped guinea pig lung. I. Effect of peptidase substrates and inhibitors. J. exp. Med. 113, 521 (1962).Google Scholar
  19. Bail, O.: Übertragung der Tuberkulinempfindlichkeit. Z. Immun.-Forsch. 4, 470 (1910).Google Scholar
  20. Bail, O.: Weitere Versuche, betreffend die Übertragung der Tuberkulinempfindlichkeit. Z. Immun.-Forsch. 12, 451 (1912).Google Scholar
  21. Bailly, D.: Acquired immunity in rabbits to infection with group A type 30 hemolytic streptococcus: its relation to antibodies to the M protein. J. Immunol. 64, 245 (1950).PubMedGoogle Scholar
  22. Barrett, M. K.: The nature of tumor immunity. In: Symposium on the origin of drug resistance. New York: Academic Press 1954.Google Scholar
  23. Bassett, C. A., D. H. Campbell, W. J. Evans, and W. R. Earle: The cytotoxic activity of rabbit immune globulin prepared from tissue cultures of human skin and whole placenta. J. Immunol. 78, 79 (1957).PubMedGoogle Scholar
  24. Becker, E. L.: Concerning the mechanism of complement action. II. The nature of the first component of guinea pig complement. J. Immunol. 77, 469 (1956).PubMedGoogle Scholar
  25. Becker, E. L., J. Munoz, C. Lapresle and L. J. Le Beau: Antigen-antibody reactions in agar. II. Elementary theory and determination of diffusion coefficients of antigen. J. Immunol. 67, 501 (1951).PubMedGoogle Scholar
  26. Beiser, S. M., B. F. Erlanger, F. J. Agate, and S. Lieberman: Antigenicity of steroid-protein conjugates. Science 129, 564 (1959).PubMedGoogle Scholar
  27. Benacerraf, B.: Aspects quantitatifs des reactions anaphylatiques et du phenomene d’Arthus. Atti VI. Congr. int. Microbiol. Roma 2, 85 (1953).Google Scholar
  28. Benacerraf, B., G. Biozzi and B.N. Halpern: The effect of histamine upon the local fixation of antibodies in the skin of the guinea pig. J. Immunol. 73, 318 (1954).PubMedGoogle Scholar
  29. Benacerraf, B., and E. E. Fischel: Effect of phenergan (N-dimethylamine-2-propyl-l-thiodiphenylamine, 3277 RP) on the Arthus reaction in rabbits. Proc. Soc. exp. Biol. (N.Y.) 71, 349 (1949).Google Scholar
  30. Benacerraf, B., and P. G. H. Gell: Studies on hypersensitivity. I. Delayed and Arthus-type skin reactivity to protein conjugates in guinea pigs. Immunology 2, 53 (1959).PubMedGoogle Scholar
  31. Benacerraf, B., and B. N. Halpern: Variations chronologiques de l’apparition de la sensibilisation des organes lisses lors de la transmission passive de l’anaphylaxie en fonction de la dose d’anticorps injectee chez le cobaye. C.R. Soc. Biol. (Paris) 143, 1565 (1949).Google Scholar
  32. Benacerraf, B., and E. A. Kabat: A quantitative study of the Arthus phenomenon induced passively in the guinea pig. J. Immunol. 64, 1 (1950).PubMedGoogle Scholar
  33. Benacerraf, B., and B. B. Levine: Immunological specificity of delayed and immediate hypersensitivity reactions. J. exp. Med. 115, 1023 (1962).PubMedGoogle Scholar
  34. Benacerraf, B., A. Norden and E. E. Fischel: Unpublished studies.Google Scholar
  35. Berenbaum, M. C: The effect of cytotoxic agents on antibody production. Nature (Lond.) 185, 167 (1960).Google Scholar
  36. Berger, W., u. K. Hansen: Allergie. Leipzig: Georg Thieme 1940.Google Scholar
  37. Berson, S.A., R. S. Yalow, A. Bauman, M. A. Rothschild and K. Newerly: Insulin-I131 metabolism in human subjects: Demonstration of insulin binding globulin in the circulation of insulin treated subjects. J. clin. Invest. 35, 170 (1956).PubMedGoogle Scholar
  38. Berson, S.A., R. S. Yalow, A. Bauman, M. A. Rothschild and K. Newerly: Quantitative aspects of the reaction between insulin and insulin-binding antibodies. J. clin. Invest. 38, 1996 (1959).Google Scholar
  39. Besredka, A.: Anaphylaxis and Antianaphylaxis. St. Louis: C. V. Mosby Comp. 1919.Google Scholar
  40. Bier, O., and R. S. Furla-netto: Unpublished, personal communication.Google Scholar
  41. Bier, O., and M. Siqueira: Passive reversed cutaneous anaphylaxis to protein antigens. Prelim, report. Int. Arch. Allergy 6, 391 (1955).PubMedGoogle Scholar
  42. Bier, O., M. Siquiera and A. G. Osler: Studies on mechanism of hypersensitivity phenomena; effect of in vivo antigen-antibody reaction on passive cutaneous anaphylaxis in the rat. Int. Arch. Allergy 7, 1 (1955).PubMedGoogle Scholar
  43. Billingham, R. E., L. Brent and P. B. Medawar: „Actively acquired tolerance“ of foreign cells. Nature (Lond.) 172, 603 (1953).Google Scholar
  44. Billingham, R. E., L. Brent and P. B. Medawar: The antigenic stimulus in transplantation immunity. Nature (Lond.) 178, 514 (1956).Google Scholar
  45. Billingham, R. E., and W.K. Silvers: Transplantation of tissues and cells. Philadelphia: Wistar Inst.Press 1961.Google Scholar
  46. Biozzi, G., B. Benacerraf and B.N. Halpern: Cf. Benacerraf 1953.Google Scholar
  47. Biozzi, G., B.N. Halpern and B. Benacerraf: Conditions influencing the local fixation of antibodies in passive cutaneous anaphylaxis of the guinea pig. Acta allerg. (Kbh.) Suppl. 3, 184 (1953).Google Scholar
  48. Bjorneboe, M.: The standardization of rabbit antipneumococcal serum. Third Int. Congr. Microbiology, New York, 1939. Proc. p. 812.Google Scholar
  49. Bjornboe, M., E. E. Fischel and H. C. Stoerk: The effect of cortisone and adrenocorticotrophic hormone on the concentration of circulating antibody. J. exp. Med. 93, 37 (1951).Google Scholar
  50. Böhmig, R., and H. F. Swift: Comparative histologic reactions in cut-aneous lesions induced by streptococci in rabbits previously inoculated intracutaneously or intravenously. Arch. Path. (Chicago) 15, 611 (1933).Google Scholar
  51. Bordet, J., et O. Gengou: Sur l’existence de substances sensibilisatrices dans la plupart des serums antimicro-biens. Ann. Inst. Pasteur 15, 289 (1901).Google Scholar
  52. Borek, F., and A.M. Silverstein: Characterization and purification of ferritin-antibody globulin conjugates. J. Immunol. 87, 555 (1961).PubMedGoogle Scholar
  53. Boughton, T. H.: Vascular lesions in chronic protein intoxication. J. Immunol. 2, 501 (1917).Google Scholar
  54. Boyd, W. C: Fundamentals of immunology, 2. edit. New York: Interscience Publ. 1956.Google Scholar
  55. Boyden, S.V.: The absorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. J. exp. Med. 93, 107 (1951).PubMedGoogle Scholar
  56. Boyden, S.V.: Approaches to the problem of detecting antibodies. In: Shaffer, Lo Grippo and Chase. Editor: This reference is cited fully in this bibliography under “Shaffer, etc.”: 1959.Google Scholar
  57. Brahn, B., and F. Schiff: Inhibition of hemolysis by specific antibody and by the combination of the AB with inhibitory or competitive antigenic frac-tions. Klin. Wschr. 1929, 1523.Google Scholar
  58. Broberger, O., and P. Perlmann: Demonstration of an epithelial antigen in colon by means of fluorescent antibodies from children with ulcerative colitis. J. exp. Med. 115, 13 (1962).PubMedGoogle Scholar
  59. Brocklehurst, W.E., J.H. Humphrey and W. L. M. Perry: The in vitro uptake of rabbit antibody by chopped guinea pig lung and its relationship to anaphylactic sensitization. Immunology 4, 67 (1961).Google Scholar
  60. Brunn, E.: Experimental investigations in serum allergy with reference to the etiology of rheumatic joint diseases. Copenhagen: Munksgaard 1940.Google Scholar
  61. Brunins, F. E.: Chemical studies on the true Forssman hapten, the corresponding antibody, and their interaction. Stockholm: Aktiebolaget Fahlcrantz 1936.Google Scholar
  62. Buchbinder, L.: Heterophile phenomena in immunology. Arch. Path. (Chicago) 19, 841 (1935).Google Scholar
  63. Buckley, J. J., S. M. Buckley and M. L. Keeve: Tissue culture studies on liver cells of tuberculin sensitized animals in the presence of tuberculin (PPD). Bull. Johns Hopk. Hosp. 89, 303 (1951).Google Scholar
  64. Bukantz, S.C, C.R. Rein and J.F. Kent: Studies in complement fixation. II. Preservation of sheep’s blood in citrose dextrose mixtures (modified Alsever’s solution) for use in the complement fixation reaction. J. Lab. clin. Med. 31, 394 (1946).PubMedGoogle Scholar
  65. Burdon, K. L., J. P. Mc Govern, G. D. Barkin and W.M. Meyers: Fibrinolysis and anaphylaxis. I. J. Allergy 32, 55 (1961).Google Scholar
  66. Burky, E. L.: Relation of ocular sensitivity to the Arthus phenomenon in the rabbit. Arch. Ophthal. (Chicago) 10, 368 (1933a).Google Scholar
  67. Burky, E. L.: The production in the rabbit of hypersensitive reactions to lens, rabbit muscle and low ragweed extracts by the action of staphylococcus toxin. J. Allergy 5, 466 (1933b).Google Scholar
  68. Burnet, F. M., and F. Fenner: The production of antibodies. Melbourne: Macmillan 1953.Google Scholar
  69. Butler, V. P., S. M. Beiser, B. F. Erlanger, S. W. Tannenbaum, S. Cohen, and A. Bendich: Purine-specific antibodies which react with desoxyribonucleic acid (DNA). Proc. nat. Acad. Sci. (Wash.) 48, 1597 (1962).Google Scholar
  70. Campbell, D. H., and N. Bulman: Progress in the chemistry of organic natural products. L. Zechmeister, edit. 9, p. 443. Vienna 1952.Google Scholar
  71. Campbell, D. H., and J. S. Garvey: The fate of foreign antigen and speculations as to its role in immune mechanisms. Lab. Invest. 10, 1126 (1961).PubMedGoogle Scholar
  72. Campbell, D. H., and G. E. Mc Casland: In vitro anaphylactic response to polyhaptenic and monohaptenic simple antigens. J. Immunol. 49, 315 (1944).Google Scholar
  73. Campbell, D. H., and D. H. Sussdorf: The use of pollen grains for the detection of specific antibody. J. Allergy 32, 357 (1961).PubMedGoogle Scholar
  74. Campbell, D. H., and D. H. Sussdorf: Cancer Chemotherapy. A bibliography of agents. 1946–1954. Cancer Res. 16, Suppl. 4 (1956).Google Scholar
  75. Cannon, P. R., and C. E. Marshall: Studies on the mechanism of the Arthus phenomenon. J. Immunol. 40, 127 (1941).Google Scholar
  76. Caroli, J., et M. Bessis: Immunisation de la mere par le foetus chez la jument mulassiere. C. R. Soc. Biol. (Paris) 141, 386 (1947).Google Scholar
  77. Caroli, J., et M. Bessis: Rev. Hemat. 2, 207 (1947).Google Scholar
  78. Cavelti, P. A.: Studies on the pathogenesis of rheumatic fever. I. Experimental production of autoantibodies to heart, skeletal muscle and connective tissue. Arch. Path. (Chicago) 44, 1 (1947a).Google Scholar
  79. Cavelti, P. A.: II. Cardiac lesions produced in rats by means of autoantibodies to heart and connective tissue. Arch. Path. (Chicago) 44, 13 (1947b).Google Scholar
  80. Cavelti, P. A.: Pathogenesis of glomerulonephritis and rheumatic fever. In vivo activation of tissue antigens as a result of streptococcic infection and consecutive formation of autoantibodies. Arch. Path. (Chicago) 44, 119 (1947c).Google Scholar
  81. Chandler, M. H., L. Rosenberg and E. E. Fischel: Persistence of passively administered guinea pig and rabbit antibody in the guinea pig. J. Immunol. 82, 103 (1959).PubMedGoogle Scholar
  82. Chase, M. W.: Production of local skin reactivity by passive transfer of anti-protein sera. Proc. Soc. exp. Biol. (N. Y.) 52, 238 (1943).Google Scholar
  83. Chase, M. W.: The cellular transfer of cutaneous hypersensitivity to tuberculin. Proc. Soc. exp. Biol. (N. Y.) 59, 134 (1945).Google Scholar
  84. Chase, M. W.: The cellular transfer of cutaneous hypersensitivity. J. Bact. 51, 643 (1946 a).PubMedGoogle Scholar
  85. Chase, M. W.: Inhibition of experimental drug allergy by prior feeding of sensitizing agent. Proc. Soc. exp. Biol. 61, 257 (1946b).PubMedGoogle Scholar
  86. Chase, M. W.: Studies on the sensitization of animals with simple chemical compounds. X. Antibodies inducing immediate type skin reactions. J. exp. Med. 86, 489–514 (1947).Google Scholar
  87. Chase, M. W.: In: Dubos, Bacterial and mycotic infections of man. Philadelphia: J. B. Lippincott Company 1952.Google Scholar
  88. Chase, M. W.: Experimental sensitization with particular reference to picryl chloride. Int. Arch. Allergy 5, 163 (1954).PubMedGoogle Scholar
  89. Chase, M. W.: Immunologic tolerance. Ann. Rev. Microbiol. 13, 349 (1959a).Google Scholar
  90. Chase, M. W.: Models for hypersensitivity studies. In: H. S. Lawrence ed., Cellular and humoral aspects of the hypersensitive state. New York: Hoeber 1959b.Google Scholar
  91. Chase, M. W., and J. R. Battisto: The duration of dermal sensitization following cellular transfer in guinea pigs. J. Allergy 26, 83 (1955).Google Scholar
  92. Chew, W. B., D. J. Stephens and J. S. Lawrence: Antileucocytic serum. J. Immunol. 30, 301 (1936).Google Scholar
  93. Christian, C. L., and R. J. Thurer: Studies of anaphylaxis: effect of decomplementation with aggregated gamma globulin. J. Immunol. 88, 93 (1962).Google Scholar
  94. Christian, R. M., D. M. Ervin and L. E. Young: Observations on the in-vitro behavior of dog isoantibodies. J. Immunol. 66, 37 (1951).PubMedGoogle Scholar
  95. Coburn, A. F.: Observations on the mechanism of rheumatic fever. Lancet 1936, 1025.Google Scholar
  96. Cochrane, C. G., and W. O. Weigle: The cutaneous reaction to soluble antigen-antibody complexes. A comparison with the Arthus phenomenon. J. exp. Med. 108, 591 (1958).PubMedGoogle Scholar
  97. Cochrane, C. G., and W. O. Weigle, and F. M. Dixon: The role of polymorphonuclear leucocytes in the initiation and cessation of the Arthus vasculitis. J. exp. Med. 110, 481 (1959).PubMedGoogle Scholar
  98. Cohn, M., L. Wetter and H. Deutsch: Immunological studies on egg white proteins. I. Precipitation of chickenovalbumin and conalbumin by rabbit and horse-antisera. J. Immunol. 61, 283 (1949).PubMedGoogle Scholar
  99. Cole, L. R., and C. B. Favour: Correlations between plasma protein fractions, antibody titers and the passive transfer of delayed and immediate cutaneous reactivity to tuberculin PPD and tuberculopolysaccharides. J. exp. Med. 101, 391 (1955).PubMedGoogle Scholar
  100. Collins, R. C.: Further experimental studies on sympathetic ophthalmia. Amer. J. Ophthal. 36, 150 (1953).PubMedGoogle Scholar
  101. Colover, J., and L. E. Glynn: Experimental Iso-immune adrenalitis. Immunology 1, 172 (1958).PubMedGoogle Scholar
  102. Cooke, R. A.: Allergy in theory and practice. Philadelphia: W. B. Saunders Company 1947.Google Scholar
  103. Cooke, R. A., A. E. O. Menzel, W. R. Kessler and P. A. Myers: The antibody mechanisms of ragweed allergy. Electrophoretic and chemical studies. I. The blocking antibody. J. exp. Med. 101, 177 (1955).Google Scholar
  104. Coombs, R. A., A. E. Mourant and R. R. Race: A new test for the detection of weak and “incomplete” Rh agglutinins. Brit. J. exp. Path. 26, 255 (1945).PubMedGoogle Scholar
  105. Coons, A. H.: The penetration of antigens into connective tissue in rheumatic fever, A symposium. L. Thomas, edit. Minneapolis: University Minn. Press 1952.Google Scholar
  106. Coons, A. H.: The localization of antigen in tissue cells by means of fluoresceinGoogle Scholar
  107. Coons, A. H.: labeled antibody. In: The nature and significance of the antibody response. A. M. Pappenheimer Jr., edit. New York: Columbia University Press 1953.Google Scholar
  108. Coons, A. H.: Labelled antigens and antibodies. Ann. Rev. Microbiol. 8, 333 (1954).Google Scholar
  109. Coons, A. H., E. H. Leduc and J. M. Connolly: Studies on antibody production. J. exp. Med. 102, 49 (1955).PubMedGoogle Scholar
  110. Coulson, E. J., and H. Stevens: Quantitative studies in anaphylaxis. J. Immunol. 61, 1, 11, 119 (1949).Google Scholar
  111. Crampton, C. F., and F. Haurowitz: Deposition of small doses of injected antigen in rabbits. J. Immunol. 69, 457 (1952).PubMedGoogle Scholar
  112. Cromartie, W. J., W. L. Bloom and D. W. Watson: Studies on infection with Bacillus anthracis. I. A histopathological study of skin lesions by B. anthracis in susceptible and resistant animal species. J. infect. Dis. 80, 1 (1947).Google Scholar
  113. Culbertson, J. T.: The relationship of circulating antibody to the local inflammatory reaction to antigen (the Arthus phenomenon). J. Immunol. 29, 29 (1935).Google Scholar
  114. Cushing, J. E., and D. H. Campbell: Principles of immunology. New York: McGraw-Hill Book Co. 1957.Google Scholar
  115. Dacie, J. F.: The hemolytic anemias, congenital and acquired. London: Blackwell 1954.Google Scholar
  116. Dakin, H. D., and H. H. Dale: Chemical structure and antigenic specificity. A comparison of the crystalline egg-albumins of the hen and the duck. Biochem. J. 13, 248 (1919).PubMedGoogle Scholar
  117. Dale, H. H.: The anaphylactic reaction of plain muscle in the guinea pig. J. Pharmacol, exp. Ther. 4, 167 (1913).Google Scholar
  118. Dameshek, W., and S. O. Scwhartz: Acute hemolytic anemia. Medicine (Baltimore) 19, 231 (1940).Google Scholar
  119. Dammin, G. J., and S. C. Bukantz: Modification of biologic response in experimental hypersensitivity. J. Amer. Med. Ass. 139, 358 (1949).Google Scholar
  120. Davenport, F. M.: Applied immunology of mineral oil adjuvants. J. Allergy 32, 177 (1961).Google Scholar
  121. Davidson, W. T. G.: An investigation into the phenomenon of serum disease. The relation between its various forms and the proteins of horse serum. Glasg. med. J. 91, 321; 92, 20, 75, 129, 182 (1919).Google Scholar
  122. Davis, B.: Biologic false positive serologic tests for syphilis. Medicine (Baltimore) 23, 359 (1944).Google Scholar
  123. Davis, B. D., E. A. Kabat, A. Harris and D. H. Moore: The anticomplementary activity of serum gamma globulin. J. Immunol. 49, 223 (1944).Google Scholar
  124. Dawson, C. R.: The chemistry of poison ivy. Trans. N.Y. Acad. Sci. II, 18, 427 (1956)Google Scholar
  125. Deicher, H. R. G., H. R. Holman, and H. G. Kunkel: The precipitin reaction between DNA and a serum factor in systemic lupus erythematosus. J. exp. Med. 109, 97 (1959).PubMedGoogle Scholar
  126. Derick, C. L., C. H. Hitchcock and H. F. Swift: Reactions of rabbits to non-hemolytic streptococci. III. A study of modes of sensitization. J. exp. Med. 5, 1 (1930).Google Scholar
  127. De Vries, J. A.: The effect of adrenocorticotrophic hormone on circulating antibody levels. J. Immunol. 65, 1 (1950).Google Scholar
  128. Dienes, L., and E. W. Schoenheit: The reproduction of tuberculin hyper-sensitiveness in guinea pigs with various protein substances. Amer. Rev. Tuberc. 20, 92 (1929).Google Scholar
  129. Dixon, F. J.: The use of I131 in immunologic investigation. J. Allergy 24, 547 (1953).PubMedGoogle Scholar
  130. Dixon, F. J.: The metabolism of antigen and antibody. J. Allergy 25, 487 (1954).PubMedGoogle Scholar
  131. Dixon, F. J.: Autoimmunity in Disease. Ann. Rev. Med. 9, 257 (1958).PubMedGoogle Scholar
  132. Dixon, F. J., J. D. Feldman and J. J. Vazquez: Experimental glomerulonephritis. The pathogenesis of a laboratory model resembling the spectrum of human glomerulonephritis. J. exp. Med. 113, 899 (1961).PubMedGoogle Scholar
  133. Dixon, F. J., and P. H. Maurer: Effects of large infusions of heterologous serum proteins on the serum protein metabolism of rabbits. J. exp. Med. 101, 233 (1955a).PubMedGoogle Scholar
  134. Dixon, F. J., and P. H. Maurer: Immunologic unresponsiveness induced by protein antigens. J. exp. Med. 101, 245 (1955b).PubMedGoogle Scholar
  135. Dixon, F. J., and P. H. Maurer: Specificity of the secondary response to protein antigens. J. Immunol. 74, 418 (1955c).PubMedGoogle Scholar
  136. Dixon, F. J., J. J. Vazquez, W. O. Weigle and C. G. Cochrane: Pathogenesis of serum sickness. Arch. Path. 65, 18 (1958).Google Scholar
  137. Dixon, F. J., and S. Warren: Antigen tracer studies and histologic observations in anaphylactic shock in the guinea pig. Amer. Sci. 219, 414 (1950).Google Scholar
  138. Doerr, R.: Allergische Phänomene. In A. Bethe, G. v. Bergmann, G.Embden u. A. Elligers Handbuch der normalen und pathologischen Physiologie, Bd. 13, 650. Berlin: Springer 1929.Google Scholar
  139. Doerr, R.: Die Immunitätsforschung, Bd. 1–7. Wien: Springer 1947–1951.Google Scholar
  140. Doerr, R., u. W. Berger: Immunologische Analyse der komplexen Struktur des Serumeiweißes. Z. Hyg. Infekt.-Kr. 96, 191 (1922).Google Scholar
  141. Doerr, R., u. V. K. Russ: Studien über Anaphylaxie. III. Der anaphylaktische Immunkörper und seine Beziehungen zum Eiweißantigen. Z. Immun.-Forsch. 3, 181 (1909).Google Scholar
  142. Donath, J., u. K. Landsteiner: Über paroxysmale Haemoglobin-urie. Münch, med. Wschr. 1904, 1590.Google Scholar
  143. Doniach, D., and I. M. Roitt: Autoantibodies in Disease. Ann. Rev. Med. 13, 213 (1962).PubMedGoogle Scholar
  144. Dougherty, T. F., J. H. Chase and A. White: Pituitary-adrenal cortical control of antibody release from lymphocytes. An explanation of the anamnestic response. Proc. Soc. exp. Biol. (N.Y.) 58, 135 (1945).Google Scholar
  145. Dresser, D. W.: Acquired immunological tolerance to a fraction of bovine gamma globulin. Immunology 4, 13 (1961).PubMedGoogle Scholar
  146. Dutton, R. W., A. H. Dutton and J. H. Vaughan: The effect of 5-bromouracil deoxyriboside on the synthesis of antibody in vitro. Biochem. J. 75, 230 (1960).PubMedGoogle Scholar
  147. Earle, D.P.: Symposium on glomerulonephritis. J.chron.Dis. 5, 1 (1957).Google Scholar
  148. Easton, J.M., B.Goldberg and H.Green: Immune cytolysis: electron microscopic localization of cellular antigens with ferritin-antibody conjugates. J.exp.Med. 115, 275 (1962).PubMedGoogle Scholar
  149. Eaton, M. D., W. D. Murphy and V. L. Hanford: Heterogenetic antibodies in acute hepatitis. J. exp. Med. 79, 539 (1944).PubMedGoogle Scholar
  150. Ehrenkrantz, J. N., and B. H. Waksman: Failure to transfer tuberculin sensitivity passively with plasma fractions containing alpha-globulin. J. exp. Med. 104, 935 (1956).Google Scholar
  151. Ehrich, W. E.: Die Entzündung. Dieses Handbuch, Bd. VII/1.Google Scholar
  152. Ehrich, W. E., J. Seifter and C. Forman: Experimental serum disease. J. exp. Med. 89, 23 (1949).PubMedGoogle Scholar
  153. Eisen, H. N., and S. Belman: Studies of hypersensitivity to low molecular weight substances. II. Reactions of some allergenic substituted dinitrobenzenes with cysteine or cystine of skin proteins. J. exp. Med. 98, 533 (1953).PubMedGoogle Scholar
  154. Eisen, H. N., and F. Karush: The interaction between purified antibody and homologous hapten, valence and association constant. J. Amer. Chem. Soc. 71, 363 (1949a).Google Scholar
  155. Eisen, H. N., and F. Karush: The significance of “Valence” in antibody interactions. J. Allergy 20, 393 (1949b).Google Scholar
  156. Eisen, H. N., M. M. Mayer, D. H. Moore, R. Tarr and H. C. Stoerk: Failure of adrenal cortical activity to influence circulating antibodies and gamma globulin. Proc. Soc. exp. Biol. (N. Y.) 65, 301 (1947).Google Scholar
  157. Eisen, H. N., L. Orris and S. Belman: Elicitation of delayed allergic skin reactions with haptens: the dependence of elicitation on hapten combination with protein. J. exp. Med. 95, 473 (1952).PubMedGoogle Scholar
  158. Evans, R. S., K. Takahashi, R. T. Duane, R. Payne and C. K. Liu: Primary thrombocytopenic purpura and acquired hemolytic anemia. Arch, intern. Med. 87, 48 (1951).Google Scholar
  159. Fagraeus, A.: Antibody production in relation to the development of plasma cells. Acta med. scand. Suppl. 204 (1948).Google Scholar
  160. Farr, R. S.: A quantitative immunochemical measure of the primary interaction between I131 BSA and antibody. J. infect. Dis. 103, 239 (1958).PubMedGoogle Scholar
  161. Favour, C. B.: Lytic effect of bacterial products on lymphocytes in tuberculous animals. Proc. Soc. exp. Biol. (N.Y.) 65, 269 (1947).Google Scholar
  162. Feinberg, S.M.: The antihistaminic drugs. Amer. J. Med. 3, 560 (1947).PubMedGoogle Scholar
  163. Felton, L. D.: The significance of antigen in animal tissues. J. Immunol. 61, 107 (1949).PubMedGoogle Scholar
  164. Felton, L. D., G. Kauffmann, B. Prescott and B. Ottinger: Studies on the mechanism of the immunological paralysis induced in mice by pneumococcal polysaccharides. J. Immunol. 47, 14 (1955).Google Scholar
  165. Fierz, H. E., W. Jadassohn and W. Stoll: Anaphylactic sensitization with chemically definite compounds. J. exp. Med. 65, 339 (1937).PubMedGoogle Scholar
  166. Finch, S. C, J. F. Ross and F. G. Ebaugh Jr.: Immunologic mechanisms of leukocyte abnormalities. J. Lab. clin. Med. 42, 555 (1953).PubMedGoogle Scholar
  167. Finger, I., and E. A. Kabat: A comparison of human antisera to purified diphtheria toxin with antisera to other purified antigens by quantitative precipitin and gel diffusion techniques. J. exp. Med. 105, 453 (1958).Google Scholar
  168. Fischel, E. E.: Effect of salicylate and tripelennamine hydrochloride (pyribenzamine) on the Arthus reaction and on bacterial allergic reactions. Proc. Soc. exp. Biol. (N. Y.) 66, 537 (1947).Google Scholar
  169. Fischel, E. E.: The role of allergy in the pathogenesis of rheumatic fever. Amer. J. Med. 7, 772 (1949).PubMedGoogle Scholar
  170. Fischel, E. E.: The relationship of adrenal cortical activity to immune responses. Bull. N. Y. Acad. Med. 26, 255 (1950).PubMedGoogle Scholar
  171. Fischel, E. E.: Adrenal hormones and the development of antibody and hypersensitivity. In G. Shwartzman, The effect of ACTH and cortisone upon infection and resistance. New York: Columbia University Press 1953a.Google Scholar
  172. Fischel, E. E.: Serum complement as an indication of the presence and degree of inflammatory reaction in various diseases. J. clin. Invest. 32, 568 (1953b).Google Scholar
  173. Fischel, E. E.: Immune response in glomerulonephritis. J. chron. Dis. 5, 34 (1957).PubMedGoogle Scholar
  174. Fischel, E. E., C.W. Frank, A.J. Boltax, and M. Arcasoy: Observations on the treatment of rheumatic fever with salicylate, ACTH and cortisone. II. Combined salicylate and corticoid therapy and attempts at rebound suppression. Arthr. and Rheum. 1, 351 (1958).Google Scholar
  175. Fischel, E.E., and D.C. Gajdusek: Serum complement in acute glomerulonephritis and other renal diseases. Amer. J. Med. 12, 190 (1952).PubMedGoogle Scholar
  176. Fischel, E. E., and E. A. Kabat: A quantitative study of the Arthus phenomenon induced passively in the rabbit. J. Immunol. 55, 337 (1947).PubMedGoogle Scholar
  177. Fischel, E. E., E. A. Kabat, H. C. Stoerck and A. Bezer: The role of tubercle bacilli in adjuvant emulsions on antibody production to egg albumin. J. Immunol. 69, 611 (1952).PubMedGoogle Scholar
  178. Fischel, E. E., E. A. Kabat, H. C. Stoerck, M. Skolnick and A. E. Bezer: Suppression by cortisone of granuloma formation and antibody production to egg albumin with Freund adjuvants. J. Allergy 25, 195 (1954).PubMedGoogle Scholar
  179. Fischel, E. E., M. Le May and E. A. Kabat: The effect of adrenocorticotrophic hormone and x-ray on the amount of circulating antibody. J. Immunol. 61, 89 (1949).PubMedGoogle Scholar
  180. Fischel, E. E., and R. H. Pauli: Serological studies in rheumatic fever. I. The “phase” reaction and the detection of autoantibodies in the rheumatic state. J. exp. Med. 89, 669 (1949).PubMedGoogle Scholar
  181. Fischel, E. E., R. H. Pauli and J. Lesh: Serological studies in rheumatic fever. II. Serum complement in the rheumatic state. J. clin. Invest. 28, 1172 (1949).Google Scholar
  182. Fischel, E. E., J. H. Vaughan and C. Photopoulos: Inhibition of rapid production of antibody by cortisone. Study of the secondary response. Proc. Soc. exp. Biol. (N.Y.) 51, 344 (1952).Google Scholar
  183. Fisher, J. P., and J. T. Connell: Passive cutaneous anaphylaxis in the guinea pig with serum of allergic patients treated with ragweed extract emulsions. J. Allergy 33, 59 (1962).Google Scholar
  184. Fisher, S., and E. V. Keogh: Lysis by complement of erythrocytes which have absorbed a bacterial component and its antibody. Nature (Lond.) 165, 248 (1950).Google Scholar
  185. Forssman, J.: Die Her-stellung hochwertiger spezifischer Schafhämolysine ohne Verwendung von Schafblut. Biochem. Z. 30, 78 (1911).Google Scholar
  186. Freedman, S. O., A. I. Siddiqui, J. Krupey, and A. H. Sehon: Identification of a simple chemical compound (chlorogenic acid) as an allergen in plant materials causing human atopic disease. Trans. Assoc. Amer. Physicians, 75th Annual Meeting, May 1, 1962.Google Scholar
  187. Freund, J.: Some aspects of acitve immunization. Ann. Rev. Microbiol. 1, 291 (1947).Google Scholar
  188. Freund, J.: The effect of paraffin oil and mycobacteria on antibody formation and sensitization. A review. Amer. J. clin. Path. 21, 645 (1951).Google Scholar
  189. Freund, J.: The mode of action of immunologic adjuvants. In: Advances in Tuberculosis Research, vol. 7. Basel u. New York: S. Karger 1955.Google Scholar
  190. Freund, J., E. R. Stern and T. M. Pisani: Isoallergic encephalomyelitis and radiculitis in guinea pigs after one injection of brain and mycobacteria in water-in-oil emulsion. J. Immunol. 57, 179 (1947).Google Scholar
  191. Freund, J., G. E. Thompson and M. M. Lipton: Aspermatogenesis, anaphylaxis and cutaneous sensitization induced in the guinea pig by homologous testicular extract. J. exp. Med. 101, 591 (1955).Google Scholar
  192. Freund, J., and C. E. Whitney: The distribution of antibodies in the serum and organs of rabbits. II. The effect of perfusion upon the antibody content of serum and organs. J. Immunol. 15, 369 (1928).Google Scholar
  193. Frick, O. L., C. Stiffel, and G. Biozzi: Studies on the effect of complement on anaphylaxis in the mouse. J. Immunol. 88, 595 (1962).PubMedGoogle Scholar
  194. Friedberger, E., u. O. Hartoch: Über das Verhalten des Complements bei der aktiven und passiven Anaphylaxie. Z. Immun.-Forsch. 3, 581 (1909).Google Scholar
  195. Friou, G. J.: Identification of the nuclear component of the interaction of lupus erythematosus globulin and nuclei. J. Immunol. 80, 476 (1958a).PubMedGoogle Scholar
  196. Friou, G. J.: Improved method for measuring lupus globulin nucleoprotein interaction. Proc. Soc. exp. Biol. (N.Y.) 97, 738 (1958b).Google Scholar
  197. Fudenberg, H. H., and H. G. Kunkel: Specificity of the reaction between rheumatoid factors and gamma globulin. J. exp. Med. 114, 257 (1961).PubMedGoogle Scholar
  198. Furth, J.: Antigenic character of heated protein. J. Immunol. 10, 777 (1925).Google Scholar
  199. Furth, J., and E. A. Kabat: Association of the Wassermann antigen with heavy material present in tissue. Science 94, 46 (1941).PubMedGoogle Scholar
  200. Gajdusek, D. C: An “autoimmune” reaction against human tissue antigens in certain acute and chronic diseases. I. Serological investigations. Arch, inter. Med. 101, 9 (1958).Google Scholar
  201. Gangarosa, E. J., J. T. Inglefield, C. G. A. Thomas and H. R. Morgan: Studies on hypersensitivity of human tissues in vitro. I. Tuberculin hypersensitivity. J. exp. Med. 102, 425 (1955).PubMedGoogle Scholar
  202. Garvey, J. S., and D. H. Campbell: The relation of circulating antibody concentration to localization of labeled (S35) antigen. J. Immunol. 72, 131 (1954).PubMedGoogle Scholar
  203. Garvey, J. S., and D. H. Campbell: The retention of S35 labelled bovine serum albumin in normal and immunized rabbit liver tissue. J. exp. Med. 105, 361 (1957).PubMedGoogle Scholar
  204. Gay, F. P., and Associates: Agents of disease and host resistance. Chapt. 16 and 22. Springfield, 111.: Ch. C. Thomas 1935.Google Scholar
  205. Gell, P. G. H., and B. Benacerraf: Delayed hypersensitivity to simple protein antigens. In: Advances in immunology (Taliaferro and Humphrey). New York and London: Academic Press 1961).Google Scholar
  206. Gell, P. G. H., C. R. Harington and R. P. Rivers: The antigenic function of simple chemical compounds; production of precipitins in rabbits. Brit. J. exp. Path. 27, 267 (1946).PubMedGoogle Scholar
  207. Gell, P. G. H., and A.M. Silverstein: Delayed hypersensitivity to hapten-protein conjugates. I. The effect of carrier protein and site of attachments to hapten. J. exp. Med. 115, 1037 (1962).PubMedGoogle Scholar
  208. Gellhorn, A., and E. Hirschberg, ed.: Basic problems in neoplastic disease. New York: Columbia Univ. Press 1962.Google Scholar
  209. Gengou, O.: Sur les sensibilisatrices des serums actifs contre les substances albuminoldes. Ann. Inst. Pasteur 16, 734 (1902).Google Scholar
  210. Gengozian, N., T. Makinodan and I. C. Shekarchi: Transplantation of antibody forming cells in lethally irradiated mice. J. Immunol. 86, 113 (1961).PubMedGoogle Scholar
  211. Germuth, F. G.: A comparative histologic and immunologic study in rabbits of induced hypersensitivity of the serum sickness type. J. exp. Med. 97, 257 (1953).PubMedGoogle Scholar
  212. Germuth, F. G., and G. E. Mc Kinnon: Studies in the biological properties of antigen-antibody complexes. I. Anaphylactic shock induced by soluble antigen-antibody complexes in unsensitized normal guinea pigs. Bull. Johns Hopk. Hosp. 101, 13 (1957).Google Scholar
  213. Germuth, F. G., A. E. Maumenee, L. B. Senterfit and A.D. Pollack: Immunohistologic studies on antigen-antibody reactions in the avascular cornea. I. Reactions in rabbits actively sensitized to foreign protein. J. exp. Med. 115, 919 (1962).PubMedGoogle Scholar
  214. Germuth, F. G., J. Oyama and B. Ottinger: The mechanism of action of 17-hydroxy-ll-de-hydrocorticosterone (compound E) and of the adrenocorticotropic hormone in experimental hypersensitivity in rabbits. J. exp. Med. 94, 139 (1951).PubMedGoogle Scholar
  215. Germuth, F. G., M. G. Pace and J. C. Tippett: Comparative histologic and immunologic studies in rabbits of induced hyper-sensitivity of the serum sickness type. II. The effect of sensitization to homologous and cross-reactive antigens on the rate of antigen elimination and the development of allergic lesions. J. exp. Med. 101, 135 (1955).PubMedGoogle Scholar
  216. Germuth, F. G., and A. D. Pollack: The production of lesions of serum sickness in normal animals (rabbits) by the passive transfer of antibody in the presence of antigen. Bull. Johns Hopk. Hosp. 102, 245 (1958).Google Scholar
  217. Gershon, M. D., and L. L. Ross: Studies on the relationship of 5-hydroxytryptamine and the entero-chromaffin cell to anaphylactic shock in mice. J. exp. Med. 115, 367 (1962).PubMedGoogle Scholar
  218. Gitlin, D., L. Harrison, W. H. Batchelor and C. A. Janeway: Experimental hypersensitivity in the rabbit. Disappearance rates of native and labelled heterologous proteins from the serum after intravenous injection. J. Immunol. 66, 451 (1951).PubMedGoogle Scholar
  219. Glenny, A. T.: Active immunization with toxin. In: A system of bacteriology, vol. 6. London: H. M. Stationery Office 1931.Google Scholar
  220. Goldberg, R. J.: A theory of antibody-antigen reactions. I. Theory for reactions of multivalent antigen with bivalent and univalent antibody. J. Amer. chem. Soc. 74, 5718 (1952).Google Scholar
  221. Goldberg, R. J., and D. H. Campbell: The light-scattering properties of an antigen-antibody reaction. J. Immunol. 66, 79 (1951).PubMedGoogle Scholar
  222. Good, R. A.: A gammaglobu-linemia-an experimental study. II. Abstracts of combined meeting of pediatric societies, p. 68. Quebec 1955.Google Scholar
  223. Good, R. A., and L. Thomas: Studies on the generalized Shwartzman reaction. IV. Prevention of the local and generalized Shwartzman reactions with heparin. J. exp. Med. 97, 871 (1953).PubMedGoogle Scholar
  224. Good, R. A., and R. L. Varco: Successful homograft of skin in a child with agammaglobulinemia. J. Amer. Med. Ass. 159, 713 (1955a).Google Scholar
  225. Good, R. A., and R. L. Varco: A clinical and experimental study of agammaglobulinemia. J. Lancet 75, 245 (1955b).PubMedGoogle Scholar
  226. Goodfriend, L., and A. H. Sehon: Antibodies to estrone-protein conjugates. Canad. J. Biochem. 39, 941 (1961).PubMedGoogle Scholar
  227. Goodner, K., and F. L. Horsfall Jr.: Properties of the type specific proteins of antipneumococcus sera. J. exp. Med. 66, 413, 425, 437 (1937).Google Scholar
  228. Gordon, J.: The prevention of delayed hypersensitivity to homologous serum and transplantation antigens in guinea pigs. Immunology 5, 153 (1962).PubMedGoogle Scholar
  229. Gorer, P. A.: The antigenic structure of tumors. Advanc. Immunol. 1, 345 (1961).Google Scholar
  230. Grabar, P.: Mise en evidence par hemagglutination passive, de reactions de divers serums normaux avec quelques substances macromoleculaires naturelles ou synthetiques. VI. Int. Congr. of Microbiology, Rome, vol. 1, p. 475, Sept. 6.-12. 1953.Google Scholar
  231. Grabar, P.: Reactions de divers serums normaux avec des substances macromoleculaires naturelles ou synthetiques. Ann. Inst. Pasteur 88, 11 (1955).Google Scholar
  232. Grabar, P.: Use of immunoelectrophoretic analysis in the study of specific precipitation (Heidelberger and Plescia). New Brunswick, N.Y. Rutgers Univ.Press 1961.Google Scholar
  233. Grabar, P., and P. Miescher (eds.): Immunopathology. First Int’l. Symposium. Basel: Benno Schwabe & Co. 1959.Google Scholar
  234. Grabar, P., and P. Miescher (eds.): Mechanism of cell and tissue damage produced by immune reactions. New York: Grune & Stratton 1962.Google Scholar
  235. Grabar, P., et C.A. Williams Jr.: Methode immunoelectrophoretique d’analyse de melanges de substances antigeniques. Biochim. biophys. Acta (Amst.) 17, 67 (1955).Google Scholar
  236. Graham, J. B., and R. M. Graham: Antibodies elicited by cancer in patients. Cancer (Philad.) 8, 409 (1955).Google Scholar
  237. Grove, E. F.: Studies in anaphylaxis in the rabbit. 1. A study of the factors concerned in the establishment of maximal hypersensitiveness in rabbits to egg white and horse serum. J. Immunol. 23, 101 (1932).Google Scholar
  238. Grubb, R.: Agglutination of erythrocytes coated with “incomplete” anti-Rh by certain rheumatoid arthritic Handbuch d. allg. Pathologie, Bd. vii/2 20 sera and some other sera. Acta path, microbiol. scand. 39, 195 (1956).Google Scholar
  239. Grubb, R.: Vox Sang. (Basel) 2, 305 (1957).Google Scholar
  240. Gunn, W. C.: The variation in the amount of complement in the blood in some acute infectious diseases and its relation to the clinical features. J. Path. Bact. 19, 155 (1914).Google Scholar
  241. Halbert, S. P., D. Locatcher-Khorazo, L. Swick, R. Witmer, B. Seegal and P. Fitzgerald: Homologous immunological studies of ocular lens. II. Biological aspects. J. exp. Med. 105, 453 (1957).PubMedGoogle Scholar
  242. Halpern, B. N.: Les antihistaminiques de synthese: Essais de chimiotherapie des etats allergiques. Arch. int. Pharmacodyn. 68, 339 (1942).Google Scholar
  243. Halpern, B. N., P. Liacopoulos, M. Liacopoulos-Briot, R. Binaghi and F. van Neer: Patterns of in vitro sensitization of isolated smooth muscle tissues with precipitating antibody. Immunology 2, 351 (1959).PubMedGoogle Scholar
  244. Hanger Jr., F. M.: Effect of intravenous bacterial filtrates on skin tests and local infections. Proc. Soc. exp. Biol. (N.Y.) 25, 775 (1928).Google Scholar
  245. Hanks, J. H.: The mechanism of tuberculin hypersensitivity. J. Immunol. 28, 105 (1935).Google Scholar
  246. Harber, L. C, S. A. Rosenthal and R. L. Baer: Actively acquired tolerance to dinitrochlorobenzene. J. Immunol. 38, 66 (1962).Google Scholar
  247. Harris, T. N., and S. Harris: The genesis of antibodies. Amer. J. Med. 20, 114 (1956).PubMedGoogle Scholar
  248. Haurowitz, F.: The immunological response. Ann. Rev. Microbiol. 7, 389 (1953).Google Scholar
  249. Haurowitz, F., and C. F. Crampton: The fate in rabbits of intravenously injected iodoovalbumin. J. Immunol. 68, 73 (1952).PubMedGoogle Scholar
  250. Hauschka, T. S.: Immunologic aspects of cancer. A review. Cancer Res. 12, 615 (1952).PubMedGoogle Scholar
  251. Havens jr., W. P.: Liver disease and antibody formation. Int. Arch. Allergy 14, 75 (1959).PubMedGoogle Scholar
  252. Hawn, C. V. Z., and C. A. Janeway: Histological and serological sequences in experimental hypersensitivity. J. exp. Med. 85, 571 (1947).PubMedGoogle Scholar
  253. Haxthausen, H.: The pathogenesis of allergic eczema elucidated by transplantation experiments on identical twins. Acta derm.-venereol. (Stockh.) 23, 438 (1943).Google Scholar
  254. Haxthausen, H.: Studies on the role of the lymphocytes as “transmitter” of the hypersensitiveness in allergic eczema. Acta derm.-venereol. (Stockh.) 27, 275 (1947).Google Scholar
  255. Heidelberger, M.: The molecular composition of specific immune precipitates from rabbit sera. J. Amer. chem. Soc. 60, 242 (1938).Google Scholar
  256. Heidelberger, M.: Quantitative absolute methods in the study of antigen-antibody reactions. Bact. Rev. 3, 49 (1939).PubMedGoogle Scholar
  257. Heidelberger, M.: 5. Immuno-chemistry of antigens and antibodies. In R. A. Cooke, Allergy in theory and practice. Philadelphia and London: W. B. Saunders Company 1947.Google Scholar
  258. Heidelberger, M.: Chemical constitution and immunological specificity. Ann. Rev. Biochem. 25, 641 (1956a).PubMedGoogle Scholar
  259. Heidelberger, M.: Lectures in immunochemistry. New York: Academic Press 1956b.Google Scholar
  260. Heidelberger, M., and J. Adams: The immunological specificity of Type II pneumococcus and its separation into partial specificities. J.exp.Med. 103, 189 (1956).PubMedGoogle Scholar
  261. Heidelberger, M., A.C. Aisenberg and W. Z. Hassid: Glycogen, an immunologically specific polysaccharide. J. exp. Med. 99, 343 (1954).PubMedGoogle Scholar
  262. Heidelberger, M., and O. T. Avery: The soluble specific substance of pneumococcus. J. exp. Med. 38, 73 (1923).PubMedGoogle Scholar
  263. Heidelberger, M., and E. A. Kabat: Chemical studies on bacterial agglutination. III. A reaction mechanism and a quantitative theory. J. exp. Med. 65, 885 (1937).PubMedGoogle Scholar
  264. Heidelberger, M., E. A. Kabat and M. Mayer: A further study of the cross reaction between the specific polysaccharides of types III and VIII pneumococci in horse antisera. J. exp. Med. 75, 35 (1942).PubMedGoogle Scholar
  265. Heidelberger, M., E. A. Kabat and D. L. Shrivastava: A quantitative study of the cross reaction of types III and VIII pneumococci in horse and rabbit antisera. J. exp. Med. 65, 487 (1937).PubMedGoogle Scholar
  266. Heidelberger, M., and F. E. Kendall: Studies on the precipitin reaction. Precipitating haptens; species differences in antibodies. J. exp. Med. 57, 373 (1933).PubMedGoogle Scholar
  267. Heidelberger, M., and F. E. Kendall: A quantitative theory of the precipitin reaction. III. The reaction between crystalline egg albumin and its homologous antibody. J. exp. Med. 62, 697 (1935).PubMedGoogle Scholar
  268. Heidelberger, M., C. M. Mac Leod, H. Markowitz and A. S. Roe: Improved methods for the preparation of the specific polysaccharides of pneumococcus. J. exp. Med. 91, 341 (1950).PubMedGoogle Scholar
  269. Heidelberger, M., and M. Mayer: Quantitative chemical studies on complement or alexin. IV. Addition of human complement to specific precipitates. J. exp. Med. 75, 285 (1942).PubMedGoogle Scholar
  270. Heidelberger, M., and O. J. Plescia: Immunochemical approaches to problems in microbiology. New Brunswick, N. J.: Rutgers Univ. Press 1961.Google Scholar
  271. Heidelberger, M., and P. A. Rebers: Cross reactions of polyglucoses in antipneumococcal sera VI. Precipitation of Type VIII and Type III antisera by beta glucans. J. Amer. chem. Soc. 80, 116 (1958).Google Scholar
  272. Hershey, A. D.: A descriptive theory of specific precipitation. J. Immunol. 42, 455, 485, 515 (1941); 48, 381 (1944).Google Scholar
  273. Heymann, W., J. L. P. Hunter and D. B. Hackel: Experimental autoimmune nephrosis in rats. III. J. Immunol. 88, 135 (1962).PubMedGoogle Scholar
  274. Hill, J. H., and L. Martin: A review of experimental studies of non-specific inhibition of anaphylactic shock. Medicine (Baltimore) 11, 141 (1932).Google Scholar
  275. Hochwald, G. M., G. J. Thorbecke, and R. Asofsky: Site of formation of immune globulins and of a component of C3. I. A new method for the demonstration of the synthesis of individual serum proteins by tissues in vitro. J. exp. Med. 114, 459 (1961).PubMedGoogle Scholar
  276. Holiday, E.: Breakdown products of antigen. Proc. roy. Soc. B 127, 40 (1939).Google Scholar
  277. Holman, H. R., and H. G. Kunkel: Affinity between the LE serum factor and cell nuclei and nucleoprotein. Science 126, 162 (1957).PubMedGoogle Scholar
  278. Holub, M.: Morphology of antibody production by different cell systems in diffusion chambers. Folia microbiol. 5, 347 (1960).Google Scholar
  279. Holub, M., and L. Jaroskova: Mechanisms of antibody formation. Prague: Czechoslovak Academy of Sciences 1960.Google Scholar
  280. Holub, M., and L. Jaroskova: Also New York and London: Academic Press 1960.Google Scholar
  281. Holtjb, M., and I. Rika: Morphological changes in lymphocytes cultivated in diffusion chambers during the primary antibody response to a protein antigen. Mechanisms of antibody formation (ed. by M. Holub and L. Jaroskova). New York and London: Academic Press 1960.Google Scholar
  282. Hooker, S.B.: Human hypersensitiveness to different proteins of horse serum. J. Immunol. 8, 469 (1923).Google Scholar
  283. Hooker, S. B., and W. C. Boyd: The existence of antigenic determinants of diverse specificity in a single protein. II. In two natural proteins; crystalline duck egg albumin and crystalline hen egg albumin. J. Immunol. 26, 469 (1934).Google Scholar
  284. Hooker, S. B., and W. C. Boyd: III. Further notes on crystalline hen-and duck-ovalbumins. J. Immunol. 30, 41 (1936).Google Scholar
  285. Hume, D. M., J. P. Merrill, B. F. Miller and G. W. Thorn: Experiences with renal Homotransplantation in the human: Report of nine cases. J. clin. Invest. 34, 327 (1955).PubMedGoogle Scholar
  286. Humphrey, J. H., and R. Jaques: The release of histamine and 5-hydroxytryptamine (serotonin) from platelets by antigen-antibody reaction (in vitro). J. Physiol. (Lond.) 128, 9 (1955).Google Scholar
  287. Humphrey, J. H., and I. Mota: The mechanism of anaphylaxis. Observations on the failure of antibodies from certain species to sensitize guinea pigs in direct and reversed passive anaphylaxis. Immunology 2, 19 (1959).PubMedGoogle Scholar
  288. Humphrey, J. H., and I. Mota: The mechanism of anaphylaxis: specificity of antigen-induced mast cell damage in anaphylaxis in the guinea pig. Immunology 2, 31 (1959).PubMedGoogle Scholar
  289. Imagawa, D. T., J. T. Syverton and J. J. Bittner: The cytotoxicity of serum for mouse mammary cancer cells. Cancer Res. 14, 8 (1954).PubMedGoogle Scholar
  290. Ishizaka, K., T. Ishizaka and D. H. Campbell: The biological activity of soluble antigen-antibody complexes. II. Physical properties of soluble complexes having skin-irritating activity. J. exp. Med. 109, 127 (1959).PubMedGoogle Scholar
  291. Jackson, C.: A quantitative study of serum precipitin in anaphylaxis in the rabbit. J. Immunol. 28, 225 (1935).Google Scholar
  292. Jacobs, J. L.: Immediate generalized skin reactions in hypersensitive guinea pigs. Proc. Soc. exp. Biol. (N.Y.) 40, 641 (1940).Google Scholar
  293. Jacobs, J. L., T. S. Golden, and J. J. Kelley: Immediate reactions to anhydrides of wheal- and erythema-type. Proc. Soc. exp. Biol. (N.Y.) 43, 74 (1940).Google Scholar
  294. Jadassohn, W., H. Fierz u. A. Margot: Anaphylaktisierung durch eine chemisch bekannte Substanz. Helv. chim. Acta 21, 293 (1938).Google Scholar
  295. Jankovic, B. D., B. Waksman, and B. G. Arnason: Role of the thymus in immune reactions in rats. I. J. exp. Med. 116, 159 (1962).Google Scholar
  296. Janeway, C. A., L. Apt, and D. Gitlin: Agammaglobulinemia. Trans. Ass. Amer. Phycns 66, 200 (1952).Google Scholar
  297. Jenner, E.: An inquiry into the causes and effects of the variolae vaccinae. London: S. Low 1798.Google Scholar
  298. Jeter, W. S., M. M. Tremaine and P. M. Seebohm: Passive transfer of delayed hyper-sensitivity to 2,4. Dinitrochlorobenzene in guinea pigs with leukocytic extracts. Proc. Soc. exp. Biol. (N. Y.) 86, 251 (1954).Google Scholar
  299. Johnson, A. G., S. Gaines and M. Landy: Studies on the 0 antigen of Salmonella typhosa. V. Enhancement of antibody response to protein antigens by the purified lipopolysaccharide. J. exp. Med. 103, 225 (1956).PubMedGoogle Scholar
  300. Jones, L., and M. S. Fleischer: The relation of serum protein fractions to serum sickness in rabbits. J. Immunol. 26, 455 (1934).Google Scholar
  301. Kabat, E. A.: Immunochemistry of the proteins. J. Immunol. 47, 513 (1943).Google Scholar
  302. Kabat, E. A.: Quantitative immunochemical aspects of some allergic reactions. Amer. J. Med. 3, 535 (1947).PubMedGoogle Scholar
  303. Kabat, E. A. A. M. Pappenheimer Jr. : The nature and significance of the antibody response. New York: Columbia University Press 1953.Google Scholar
  304. Kabat, E. A.: Some configurational requirements and dimensions of the combining site on an antibody to a naturally occurring antigen. J. Amer. chem. Soc. 76, 3709 (1954).Google Scholar
  305. Kabat, E. A.: Second International Congress on Allergology, Rio de Janiero, Brazil, Nov. 6–12, 1955.Google Scholar
  306. Kabat, E. A.: Blood group substances, Their chemistry and immunochemistry. New York: Academic Press 1956a.Google Scholar
  307. Kabat, E. A.: Heterogeneity in extent of the combining regions of human antidextrans. J. Immunol. 77, 377 (1956).PubMedGoogle Scholar
  308. Kabat, E. A.: Discussion, 2nd Tissue Transplantation Conference. Ann. N. Y. Acad. Sci. 64, 924 (1957).Google Scholar
  309. Kabat, E. A.: Kabat and Meyer’s Experimental immunochemistry. Springfield, 111.: Ch. C. Thomas 1961.Google Scholar
  310. Kabat, E. A., and B. Benacerraf: A quantitative study of passive anaphylaxis in the guinea pig. IV. Passive sensitization with non-precipitable or “univalent” rabbit antiovalbumin. J. Immunol. 62, 97 (1949).PubMedGoogle Scholar
  311. Kabat, E. A., and D. Berg: Dextran an antigen in man. J. Immunol. 70, 514 (1953).PubMedGoogle Scholar
  312. Kabat, E. A., and M. H. Boldt: A quantitative study of passive anaphylaxis in the guinea pig. J. Immunol. 48, 181 (1944).Google Scholar
  313. Kabat, E. A., G. S. Coffin and D. J. Smith: A quantitative study of passive anaphylaxis in the guinea pig. III. J. Immunol. 56, 377 (1947).PubMedGoogle Scholar
  314. Kabat, E. A., and M. Heidelberger: A quantitative theory of the precipitin reaction. V. The reaction between crystalline horse serum albumin and antibody formed in the rabbit. J. exp. Med. 66, 229 (1937).PubMedGoogle Scholar
  315. Kabat, E. A., and H. Landow: A quantitative study of passive anaphylaxis in the guinea pig. J. Immunol. 44, 69 (1942).Google Scholar
  316. Kabat, E. A., A. Wolf, and A. E. Bezer: The rapid production of acute disseminated encephalomyelitis in rhesus monkeys by injection of heterologous and homologous brain tissue with adjuvants. J. exp. Med. 85, 117 (1947).PubMedGoogle Scholar
  317. Kahn, R. L.: Studies on sensitization. III. Skin sensitivity in the absence of serum precipitins. Proc. Soc. exp. Biol. (N. Y.) 30, 608 (1933).Google Scholar
  318. Kallos, P. (editor): Progress in allergy. In: Fortschritte der Allergielehre, Bd. I-IV, 1939–1955. Basel u. New York: S. Karger.Google Scholar
  319. Kallös, P., and L. Kallös-Deffner: Die experimentellen Grundlagen der Erkennung und Behandlung der allergischen Krankheiten. Ergebn. Hyg. Bakt. 19, 178 (1937).Google Scholar
  320. Kaplan, M. H., and M. Meyeserian: Immunologic studies of heart tissue. V. Antigens related to heart tissue revealed by cross-reaction of rabbit antisera to heterologous heart. J. Immunol. 88, 450 (1962).PubMedGoogle Scholar
  321. Karelitz, S.: Studies on the specific mechanism of serum sickness. II. Prevention and modification of serum sickness with human serum sickness convalescent serum (s. s. c. s.). J. Immunol. 44, 285 (1942).Google Scholar
  322. Karelitz, S., and A. Glorig: Studies on the specific mechanism of serum sickness. III. Passive sensitization with antibody contained in serum sickness convalescent serum. J. Immunol. 47, 121 (1943).Google Scholar
  323. Karelitz, S., and S. S. Stempien: Studies on the specific mechanism of serum sickness. I. Passive serum sickness. J. Immunol. 44, 271 (1942).Google Scholar
  324. Karush, F.: Disulfide pairing and the biosynthesis of antibody. In: Heidelberger and Plescia, p. 368, Immunochemical approaches to problems in microbiology. New Brunswick, N.J.: Rutgers University Press 1961.Google Scholar
  325. Karush, F., and R. Marks: The preparation and properties of purified anti-hapten antibody. J. Immunol. 78, 296 (1957).PubMedGoogle Scholar
  326. Kass, E. H., and M. Finland: Adrenocortical hormones in infection and immunity. Ann. Rev. Microbiol. 7, 361 (1953).Google Scholar
  327. Katz, G., and S. Cohen: Experimental evidence of histamine in the blood of ragweed-sensitive individuals. J. Amer. med. Ass. 117, 1782 (1941).Google Scholar
  328. Kellet, C. E., and J. G. Thomson: Complementary activity of blood serum in nephritis. J. Path. Bact. 48, 519 (1939).Google Scholar
  329. Kellner, A., and E. F. Hedal: Experimental erythroblastosis fetalis in rabbits. I. Characterization of a pair of allelic blood group factors and their specific immune isoantibodies. J. exp. Med. 97, 33 (1953).PubMedGoogle Scholar
  330. Kendall, F. E.: The quantitative relationship between antigen and antibody in the precipitin reaction. Ann. N. Y. Acad. Sci. 43, 85 (1942).Google Scholar
  331. Kidd, J. G., and W. F. Friedewald: Natural antibody that reacts in vitro with sedimentable constituent of normal tissue cells. J. exp. Med. 76, 543 (1942).PubMedGoogle Scholar
  332. Klinge, F.: Die EiweißüberempfincUichkeit (Gewebsanaphylaxie) der Gelenke. Beitr. path. Anat. 83, 185 (1929).Google Scholar
  333. Klinge, F.: Der Rheumatismus. München: J. F. Bergmann 1933.Google Scholar
  334. Klopstock, A., and G. E. Selter: Über chemospezifische Antigene. IV. Mitt. Anaphylaxiereaktionen mit chemospezifischen Antigenen. Z. Immun.-Forsch. 63, 463 (1929).Google Scholar
  335. Knepper, R.: Über die Lokalisierung der experimentellen allergischen Hyperergie. Virchows Arch. path. Anat. 296, 364 (1935/36).Google Scholar
  336. Koch, R.: Weitere Mittheilung über das Tuberkulin. Dtsch. med. Wschr. 1891, 1189.Google Scholar
  337. Kojis, F. G.: Serum sickness and anaphylaxis. Analysis of cases of 6,211 patients treated with horse serum for various infections. Amer. J. Dis. Child. 64, 93, 313 (1942).Google Scholar
  338. Korngold, L., G. L. Stahly, M. C. Dodd and W. G. Myers: The comparative retention of antigen in the skin of immune and normal rabbits as determined with egg albumin labelled with radioactive iodine. J. Immunol. 70, 345 (1953).PubMedGoogle Scholar
  339. Kuhns, W. J.: Immunochemical studies of antitoxin. VI. Further investigations on the identity and specificity of non-precipitating skin sensitizing antitoxin. J. exp. Med. 101, 109 (1955).PubMedGoogle Scholar
  340. Kuhns, W. J.: Types and distribution of antibodies. Amer. J. Med. 20, 251 (1956).PubMedGoogle Scholar
  341. Kuhns, W. J., and A. M. Pappenheimer Jr.: Immunochemical studies of antitoxin produced in normal and allergic individuals hyperimmunized with diphtheria toxoid. I., II. J. exp. Med. 95, 363, 375 (1952).PubMedGoogle Scholar
  342. Kulka, A. M.: Studies on antibody-antigen mixtures. I. Effect on normal living excised tissue. J. Immunol. 43, 273 (1942).Google Scholar
  343. Kulka, A. M.: II. The effect on normal living excised tissue and its dependence on the presence of free antibody in the mixture. J. Immunol. 46, 235 (1943).Google Scholar
  344. Lachmann, P. J., H. J. Muller-Eberhard, H. G. Kunkel and F. Paronetto: The localization of in vivo bound complement in tissue sections. J. exp. Med. 115, 63 (1962).PubMedGoogle Scholar
  345. Lancefield, R. L.: Specific relationship of cell composition to biological activity of hemolytic streptococci. Harvey Lect. 36, 251 (1940/41).Google Scholar
  346. Landsteiner, K.: Über Agglutinationserscheinungen normalen menschlichen Blutes. Wien. klin. Wschr. 1901, 1132.Google Scholar
  347. Landsteiner, K.: Experiments on anaphylaxis to azoproteins. J. exp. Med. 39, 631 (1924).PubMedGoogle Scholar
  348. Landsteiner, K.: Serological reactivity of hydrolytic products from silk. J. exp. Med. 75, 269 (1942).PubMedGoogle Scholar
  349. Landsteiner, K.: The specificity of serological reactions. Revised edition. Cambridge, Mass.: Harvard University Press 1946.Google Scholar
  350. Landsteiner, K., and M. W. Chase: Observations on serological reactions with albumose preparation. II. Proc. Soc. exp. Biol. (N. Y.) 30, 1413 (1933).Google Scholar
  351. Landsteiner, K., and M. W. Chase: Experiments on transfer of cutaneous sensitivity to simple compounds. Proc. Soc. exp. Biol. (N. Y.) 49, 688 (1942).Google Scholar
  352. Landsteiner, K., and J. Jacobs: Studies on the sensitization of animals with simple chemical compounds. III. Anaphylaxis induced by arsphenamine. J. exp. Med. 64, 717 (1936).PubMedGoogle Scholar
  353. Landsteiner, K., and H. Lampl: Über die Abhängigkeit der serologischen Spezifizität von der chemischen Struktur. (Darstellung von Antigenen mit bekannter chemischer Konstitution der spezifischen Gruppen.) XII. Mitt. über Antigene. Biochem. Z. 86, 343 (1918).Google Scholar
  354. Landsteiner, K., and J. van der Scheer: Observations on serological reactions with albumose preparations. Proc. Soc. exp. Biol. (N. Y.) 28, 983 (1931).Google Scholar
  355. Lange, K., F. Craig, J. Oberman, L. Slobody, G. Ogur and F. Locasto: Changes in serum complement during the course and treatment of glomerulonephritis. Arch, intern. Med. 88, 433 (1951).Google Scholar
  356. Lange, K., M. Gold, D. Weiner and V. Simon: Autoantibodies in human glomerulonephritis. J. clin. Invest. 28, 50 (1949).Google Scholar
  357. Lapresle, C.: Etude de la degradation de la serumalbumine humaine par un extrait de rate de lapin. II. Mise en evidence de trois groupements specifiques differents dans le motif antigenique de 1’albumine humaine et de trois anticorps corres-pondants dans le serum de lapin antialbumine humaine. Ann. Inst. Pasteur. 89, 654 (1955).Google Scholar
  358. Lawrence, H. S.: The cellular transfer of cutaneous hypersensitivity to tuberculin in man. Proc. Soc. exp. Biol. (N. Y.) 71, 516 (1949).Google Scholar
  359. Lawrence, H. S.: The cellular transfer in humans of delayed cutaneous reactivity to hemolytic streptococci. J. Immunol. 68, 159 (1952).PubMedGoogle Scholar
  360. Lawrence, H. S.: The transfer in humans of delayed skin sensitivity to streptococcal M substance and to tuberculin with disrupted leucocytes. J. clin. Invest. 34, 219 (1955).PubMedGoogle Scholar
  361. Lawrence, H. S.: The delayed type of allergic inflammatory response. Amer. J. Med. 20, 428 (1956).PubMedGoogle Scholar
  362. Lawrence, H. S.: ed.: Cellular and Humoral aspects of the hypersensitive states. New York: Hoeber 1959.Google Scholar
  363. Lawrence, H. S.: Delayed sensitivity and homograft sensitivity. Ann. Rev. Med. 11, 207 (1960).PubMedGoogle Scholar
  364. Ledingham, J. C. G.: The experimental production of purpura in animals by the introduction of anti-blood-platlet sera. A preliminary communication. Lancet 1914, 1673.Google Scholar
  365. Lepow, I. H., O. D. Ratnoff, and L. R. Levy: Studies on the activation of a proesterase associated with partially purified first component of human complement. J. exp. Med. 107, 451 (1958).PubMedGoogle Scholar
  366. Leskowitz, S., and Z. Ovary: The relation between molecular weight of antigen and ability to elicit passive cutaneous anaphylaxis. Immunology 5, 1 (1962).PubMedGoogle Scholar
  367. Letzterer, E.: Morphische Manifestationen allergisch-hypererischer Vorgänge im Verlaufe von Infektionskrankheiten. Acta allerg. (Kbh.) Suppl. 3, 79 (1953).Google Scholar
  368. Letzterer, E.: Die allergisch-hyperergische Entzündung. Dieses Handbuch, Bd. VII, Teil 1. 1956.Google Scholar
  369. Levine, B. B.: Studies on the mechanism of formation of the penicillin antigen. J. exp. Med. 112, 1131 (1960).PubMedGoogle Scholar
  370. Levine, B. B., and Z. Ovary: Studies on the mechanism of the formation of the penicillin antigen. III. The N-(d-alpha-benzyl penicilloyl groups as an antigenic determinant responsible for hypersensitivity to penicillin. J. exp. Med. 114, 875 (1961).PubMedGoogle Scholar
  371. Levine, L.: Inhibition of immune hemolysis by diisopropyl-fluorophosphate. Biochim. biophys. Acta (Amst.) 18, 283 (1955).Google Scholar
  372. Levine, L., W. T. Murakami, H. van Vunakis, and L. Grossman: Specific antibodies to thermally denatured desoxyribonucleic acid of phage T 4. Proc. nat. Acad. Sci. (Wash.) 46, 1038 (1960).Google Scholar
  373. Levine, P., E. M. Katzin and L. Burnham: Isoimmunization in pregnancy. Its possible bearing on etiology of erythroblastosis foetalis. J. Amer. med. Ass. 116, 825 (1941).Google Scholar
  374. Liacopoulos, P., M. Liacopoulos-Briot, B.N. Halpern, and R. Binaghi: Correlation entre la quantite d’antigene et l’intensite de la reaction anaphylactique au cours de la desensibilisation passive in vitro. C.R.Soc. Biol. (Paris) 154, 272 (1960).Google Scholar
  375. Lidd, D., and R. S. Farr: Interaction between I131 labelled ragweed pollen and antibodies. J. Allergy 33, 45 (1962).PubMedGoogle Scholar
  376. Ling, N. R.: The coupling of protein antigens to erythrocytes with difluorodinitrobenzene. Immunology 4, 49 (1961).PubMedGoogle Scholar
  377. Lippard, V. W., and W. M. Schmidt: Human passive transfer antibody. I. Titration by neutralization. Amer. J. Dis. Child. 54, 288 (1937).Google Scholar
  378. Litt, M.: Studies in experimental eosinophilia III. J. Immunol. 67, 522 (1961).Google Scholar
  379. Longcope, W. T.: The production of experimental nephritis by repeated proteid intoxication. J. exp. Med. 18, 678 (1913).PubMedGoogle Scholar
  380. Longcope, W. T.: Serum sickness and analogous reactions from certain drugs, particularly the sulfonamides. Medicine (Baltimore) 22, 251 (1943).Google Scholar
  381. Longcope, W. T., and F. M. Rackemann: The relation of circulating antibodies to serum disease. J. exp. Med. 27, 341 (1918).PubMedGoogle Scholar
  382. Loveless, M. H.: Immunological studies of pollonosis. I. The presence of two antibodies related to the same pollen-antigen in the serum of treated hay fever patients. J. Immunol. 38, 25 (1940).Google Scholar
  383. Lowell, F. C, and E. M. Follensby: Detection of antibody capable of removing skin reactivity in pollen extract. In: Shaffer, Lo Grippo and Chase, p. 85. 1959.Google Scholar
  384. Lucie, H.: Uveal tissue sensitization in rabbits by synergic action of staphylotoxin. Proc. Soc. exp. Biol. (N.Y.) 40, 273 (1939).Google Scholar
  385. Lurie, M. B.: Studies on the mechanism of immunity in tuberculosis. The fate of tubercle bacilli ingested by mononuclear phagocytes derived from normal and immunized animals. J. exp. Med. 75, 247 (1942).PubMedGoogle Scholar
  386. Mackay, I. R., and D. C. Gajdusek: An “autoimmune” reaction against human tissue antigens in certain acute and chronic diseases. II. Clinical correlations. Arch, intern. Med. 101, 30 (1958).Google Scholar
  387. Malkiel, S., and B. J. Hargis: Anaphylactic shock in the pertussis vaccinated mouse. Proc. Soc. exp. Biol. (N.Y.) 80, 122 (1952).Google Scholar
  388. Marrack, J. R.: The chemistry of antigens and antibodies. H. M. Stationery office, 1938.Google Scholar
  389. Marrack, J. R.: The structure of antigen-antibody aggregates and complement fixation. Ann. Rev. Microbiol. 9, 369 (1955).Google Scholar
  390. Masugi, M.: Über das Wesen der spezifischen Veränderungen der Niere und der Leber durch das Nephrotoxin bzw. das Hepatotoxin. Beitr. path. Anat. 91, 82 (1933).Google Scholar
  391. Masugi, M.: Über die experimentelle Glomerulonephritis durch das spezifische Antinierenserum. Beitr. path. Anat. 92, 429 (1934/35).Google Scholar
  392. Mathews, K. P., and H. J. Spear: A comparative study of the hemagglutinating and skin sensitizing activities of ragweed sensitive human sera. J. Immunol. 87, 274 (1961).PubMedGoogle Scholar
  393. Maurer, P. H.: II. Antigenicity of gelatin in rabbits and other species. J. exp. Med. 100, 515 (1954 a).PubMedGoogle Scholar
  394. Maurer, P. H.: The cross reactions between albumins of different species and gamma globulins of different species. J. Immunol. 72, 119 (1954b).PubMedGoogle Scholar
  395. Maurer, P. H.: Antigenicity of gelatin. III. The effect of physical and enzymatic treatment of gelatin on the subsequent precipitin reaction. J. exp. Med. 107, 125 (1958).PubMedGoogle Scholar
  396. Maurer, P. H.: Some applications of radioactive isotopes to immunochemical studies. In: Heidelberger and Plescia, p. 49. New Brunswich, N. J. Rutgers Univ. Press 1961.Google Scholar
  397. Maurer, P. H.: Antigenicity of polypeptides (poly-alpha-amino acids) II. J. Immunol. 88, 330 (1962).PubMedGoogle Scholar
  398. Maurer, P. H., and R.M. Thorpe: The effect of heat on the immunochemical and biologic properties of rabbit antisera. J. Immunol. 84, 318 (1960).Google Scholar
  399. Maurer, P.H., and W. Weigle: The effect of complement of various species on soluble antigen and antibody com-plexes. Bact. Proc. 1955, 65.Google Scholar
  400. Mayer, M.M.: Immunochemistry. Ann. Rev. Biochem. 20, 415 (1951).PubMedGoogle Scholar
  401. Mayer, M. M., A. G. Osler, O. G. Bier and M. Heidelberger: The activating effect of magnesium and other cations on the hemolytic function of complement. J. exp. Med. 84, 535 (1946).PubMedGoogle Scholar
  402. Mayer, M. M., A. G. Osler, O. G. Bier and M. Heidelberger: Quantitative studies of complement fixation. I. A method. J. Immunol. 59, 195 (1948).PubMedGoogle Scholar
  403. Mc Carty, M.: The immune response in rheumatic fever. In L. Thomas, Rheumatic fever, a symposium. Minneapolis: University Minnesota Press 1952.Google Scholar
  404. Mc Cluskey, R. T., and B. Benacerraf: Localization of colloidal substances in vascular endothelium. A mechanism of tissue damage. II. Experimental serum sickness with acute glomerulonephritis induced passively in mice by antigen-antibody complexes in antigen excess. Amer. J. Path. 35, 275 (1959).PubMedGoogle Scholar
  405. Mc Cluskey, R. T., F. Miller, and B. Benacerraf: Sensitization to denatured autologous gamma globulin. J. exp. Med. 115, 253 (1962).PubMedGoogle Scholar
  406. Mc Duffie, F. C, and E. A. Kabat: A comparative study of methods used for analysis of specific precipitates in quantitative immunochemistry. J. Immunol. 77, 193 (1956).PubMedGoogle Scholar
  407. Mc Kenna, J. M., and K. M. Stevens: The early phase of the antibody response. J. Immunol. 78, 311 (1957).PubMedGoogle Scholar
  408. Mc Master, P. D., In A. M. Pappenheimer Jr., The nature and significance of the antibody response. New York: Columbia University Press 1953.Google Scholar
  409. Mc Master, P. D., and H. Kruse: The persistence in mice of certain foreign proteins and azoprotein tracer-antigens derived from them. J. exp. Med. 94, 323 (1951).PubMedGoogle Scholar
  410. Mc Master, P. D., H. Kruse, E. Sturm and J. L. Edwards: The persistence of bovine y-globulin injected as an antigen into rabbits. A comparison with its previously studied persistence in mice. J. exp. Med. 100, 341 (1954).PubMedGoogle Scholar
  411. Medawar, P. B.: Homografts and agammaglobulinemia. Transplantat. Bull. 2, 86 (1955).Google Scholar
  412. Medawar, P. B.: The immunology of transplantation. Harvey Lect. 52 (1956/57).Google Scholar
  413. Mehlman, J., and B. C. Seegal: Passive sensitization of the guinea pig with rabbit and horse anti-pneumococcus type I serums. J. Immunol. 26, 1 (1934).Google Scholar
  414. Mellors, R. C, and W. J. Brzosko: Studies in molecular pathology. I. Localization and pathogenic role of heterologous immune complexes. J. exp. Med. 115, 891 (1962).PubMedGoogle Scholar
  415. Menken, V.: Studies on inflammation. IV. Fixation of foreign protein at site of inflammation. J. exp. Med. 52, 201 (1930).Google Scholar
  416. Metaxas, M. N., and M. Metaxas-Buehler: Studies on the cellular transfer of tuberculin sensitivity in the guinea pig. J. Immunol. 75, 333 (1955).PubMedGoogle Scholar
  417. Meyer, K., J. W. Palmer, R. Thompson and D. Khorozo: On the mechanism of lysozyme action. J. biol. Chem. 113, 479 (1936).Google Scholar
  418. Meyer, K., R. Thompson, J. W. Palmer and D. Khorazo: The purification and properties of lysozymes. J. biol. Chem. 113, 303 (1936).Google Scholar
  419. Middleton Jr., E.: In vitro passive transfer of atopic hypersensitivity. Proc. Soc. exp. Biol. (N.Y.) 104, 245 (1960).Google Scholar
  420. Miescher, P., N. S. Cooper and B. Benacerraf: Experimental production of antinuclear antibodies. J. Immunol. 85, 27 (1960).PubMedGoogle Scholar
  421. Miescher, P., and M. Fauconnet: L’absorption du factor LE par desnoyaux cellulaires isoles. Experientia (Basel) 10;252 (1954).Google Scholar
  422. Miller, J.F.A.P.: Immunological function of the thymus. Lancet 1961 II, 748.Google Scholar
  423. Mohos, S. C, and J. G. Kidd: Effects of various immune rabbit serums on the cells of several transplanted mouse lymphomas in vitro and in vivo. J. exp. Med. 105, 233 (1957).PubMedGoogle Scholar
  424. Mongar, J. L., and H. O. Schild: Inhibition by gamma globulin of passive sensitization in vitro. J.Physiol. (Lond.) 145, 46P (1958).Google Scholar
  425. Mongar, J. L., and H. O. Schild: A study of the mechanism of passive sensitization. J.Physiol. (Lond.) 150, 546 (1960).Google Scholar
  426. Morgan, I. M.: Allergic encephalomyelitis in monkeys in response to injection of normal monkey nervous tissue. J. exp. Med. 85, 131 (1947).PubMedGoogle Scholar
  427. Morgan, W. T. J.: The estimation of small amounts of a bacterial polysaccharide by the induction of anaphylaxis. Brit. J. exp. Path. 13, 342 (1932).Google Scholar
  428. Morgan, W. T. J.: Studies in immuno-chemistry. I. The preparation and properties of a specific polysaccharide from B. dysenteriae (shiga). Biochem. J. 30, 909 (1936).PubMedGoogle Scholar
  429. Morrison, L. R.: Disseminated encephalomyelitis experimentally produced by use of homologous antigen. Arch. Neurol. Psychiat. (Chicago) 58, 391 (1947).Google Scholar
  430. Mountain, I. M.: Cytopathogenic effect of antiserum to human malignant epithelial cells (strain He La) on He La cell culture. J. Immunol. 75, 478 (1955).PubMedGoogle Scholar
  431. Mueller, A. P., H. R. Wolfe, R. K. Meyer and R. L. Aspinall: Further studies on the role of the bursa of Fabri-cius in antibody production. J. Immunol. 88, 354 (1962).PubMedGoogle Scholar
  432. Mueller-Eberhard, H. J.: Two proteins of human serum related to the complement system. Ann. N.Y. Acad. Sci. 94, 4 (1961).Google Scholar
  433. Munoz, J., and E. L. Becker: Antigen-antibody reaction in agar. 1. Complexity of antigen-antibody systems as demonstrated by a serum agar technic. J. Immunol. 65, 47 (1950).PubMedGoogle Scholar
  434. Nachtsheim, H.: Eine erbliche fetale Erythroblastose beim Tier und ihre Beziehungen zu den Gruppenfaktoren des Blutes. Klin. Wschr. 1947, 590.Google Scholar
  435. Najarian, J. S., and F. D. Feldman: Passive transfer of tuberculin sensitivity by tritiated thymidine-labeled lymphoid cells. J. exp. Med. 114, 779 (1961).PubMedGoogle Scholar
  436. Nelson Jr., R. A., and D. S. Nelson: On the mechanism of immune adherence. II. Antibody to mixed aggregation of sensitized antigens in the presence of complement: Immune adherence with ammal platlets. Yale J. Biol. Med. 31, 201 (1959).PubMedGoogle Scholar
  437. Neu, H. C, H. G. Randall, and A. G. Osler: Studies on the mechanism of hypersensitivity phenomena. V. Antigen-antibody interaction in the guinea-pig small intestine. Immunology 4, 401 (1961).PubMedGoogle Scholar
  438. Nicolle, M.: Contribution a l’etude du “phenomene d’Arthus”. Ann. Inst. Pasteur 21, 128 (1907).Google Scholar
  439. Nielsen, C. B., and G. A. Feigen: Studies on the kinetics of histamine release from normal and sensitized tissues. J. Immunol. 88, 377 (1962).PubMedGoogle Scholar
  440. Nisonoff, A., and D. Pressman: Heterogeneity of antibody sites in their relative combining affinities for structurally related haptenes. J. Immunol. 81, 126 (1958).PubMedGoogle Scholar
  441. Noah, J. W., and A. Brand: Release of histamine in the blood of ragweed-sensitive individuals. J. Allergy 25, 210 (1954).PubMedGoogle Scholar
  442. Nossal, G. J. V., and O. Malkela: Kinetic studies on the incidence of cells appearing to form two antibodies. J. Immunol. 88, 604 (1962).PubMedGoogle Scholar
  443. Obermayer, F., u. E. F. Pick: Über die chemischen Grundlagen der Arteigenschaften der Eiweißkörper. Wien.klin. Wschr. 1906, 327.Google Scholar
  444. Oda, M., and T.T. Puck: The interaction of mammalian cells with antibodies. J.exp.Med. 113, 599 (1961).PubMedGoogle Scholar
  445. Opie, E.L.: The relation of antigen to antibody (precipitin) in vitro. J. Immunol. 8, 19 (1923 a).Google Scholar
  446. Opie, E.L.: The relation of antigen to antibody (precipitin) in the circulating blood. J.Immunol. 8, 55 (1923b).Google Scholar
  447. Opie, E.L.: Inflammatory reaction of the immune animal to antigen (Arthus phenomenon) and its relation to antibodies. J. Immunol. 9, 231 (1924 a).Google Scholar
  448. Opie, E.L.: Desensitization to local action of antigen (Arthus phenomenon). J. Immunol. 9, 247 (1924b).Google Scholar
  449. Opie, E.L.: Acute inflammation caused by antibody in an animal previously treated with antigen. The relation of antigen to antibody in the Arthus phenomenon. J. Immunol. 9, 255 (1924c).Google Scholar
  450. Opie, E.L.: Pathogenesis of the specific inflammatory reaction of immunized animals (Arthus phenomenon). The relation of local “sensitization” to immunity. J. Immunol. 9, 259 (1924d).Google Scholar
  451. Opie, E.L.: The fate of antigen (protein) in an animal immunized against it. J. exper. Med. 39, 659 (1924e).Google Scholar
  452. Opie, E.L.: The significance of allergy in disease. Medicine (Baltimore) 15, 489 (1936).Google Scholar
  453. Oreskes, I., and J. M. Singer: The mechanism of particulate carrier reactions. I. Adsorption of human gamma globulin to polystryene latex particles. J. Immunol. 86, 338 (1961).PubMedGoogle Scholar
  454. Osborn, T. W. B.: Complement or alexin. London: Oxford University Press 1937.Google Scholar
  455. Osler, A. G.: Functions of the complement system. In: Taliaferro and Humphrey. New York and London: Academic Press 1961.Google Scholar
  456. Osler, A. G., M.M. Hawrisiak, Z. Ovary, M. Siqueira and O. G. Bier: Studies on the mechanism of hypersensitivity phenomena. II. The participation of complement in passive cutaneous anaphylaxis of the albino rat. J.exp.Med. 106, 811 (1957).PubMedGoogle Scholar
  457. Osler, A. G., and M. Heidelberger: Quantitative studies of complement fixation. III. Homologous and cross-reactions in pneumococcal Type III and Type VIII systems. J. Immunol. 60, 317 (1948a).PubMedGoogle Scholar
  458. Osler, A. G., and M. Heidelberger: IV. Homologous and cross-reactions in chicken-and duck-egg-albumin systems. J. Immunol. 60, 327 (1948 b).PubMedGoogle Scholar
  459. Osler, A. G., and E. A. Knipp: Estimation of the Wassermann antibody in absolute weight units. J. Immunol. 78, 19 (1957).PubMedGoogle Scholar
  460. Osler, A. G., M. M. Mayer and M. Heidelberger: Quantitative studies of complement fixation. II. Fixation of complement in the reaction between Type III pneumococcus specific polysaccharide and homologous antibody. J. Immunol. 60, 205 (1948).PubMedGoogle Scholar
  461. Osler, A. G., H. G. Randall, B. M. Hill, and Z. Ovary: Studies on the mechanism of hypersensitivity phenomena. III. The participation of complement in the formation of anaphyla-toxin. J. exp. Med. 110, 39 (1959).Google Scholar
  462. Osler, A. G., H. G. Randall, B. M. Hill, and Z. Ovary: Some relationships between complement, passive cutaneous anaphylaxis and anaphylatoxin. In: Shaffer, Lo Grippo and Chase, p. 281. 1959.Google Scholar
  463. Otto, R.: Das Theobald Smithsche Phänomen der Serumüberempfindlichkeit. In R. v. Lenthold, Gedenkschrift (Herausgeb. Otto Schjerning), Bd. 1, S. 153. Berlin: August Hirschwald 1906.Google Scholar
  464. Ouchterlony, O.: In vitro method for testing the toxin-producing capacity of diphtheria bacteria. Acta path, microbiol. scand. 25, 186 (1948).Google Scholar
  465. Ouchterlony, O.: Diffusionin-gel methods for immunological analysis. Progr. Allergy 5, 1 (1958).Google Scholar
  466. Ouchterlony, O.: Interpretation of comparative immune precipitation patterns obtained by diffusion-in-gel techniques. In: Heidelberger and Plescia, p. 5. 1961.Google Scholar
  467. Oudin, J.: L’analyse immunochimique qualitative; methode par diffusion des antigenes au sein de 1’immunserum precipitant gelose. Ann. Inst. Pasteur. 75, 30 (1948).Google Scholar
  468. Ovary, Z.: Recherches sur Fanaphylaxie passive cutanee locale du cobaye. Influence de la procaine et de Fadrenaline en infiltrations locales dans Fanaphylaxie passive cutanee locale du cobaye. Rev. Immunol. (Paris) 14, 375 (1950).Google Scholar
  469. Ovary, Z.: Le temps latent au cours de Fanaphylaxie passive cutanee locale du cobaye. Acta allerg. (Kbh.) 4, 324 (1951a).Google Scholar
  470. Ovary, Z.: A new method for the quantitative determination of anaphylactic antibody in sera of guinea-pigs and rabbits. First Int. Congr. of Allergists, Zürich, Sept. 23.-29., 1951b. Basel: S. Karger.Google Scholar
  471. Ovary, Z.: Quantitative studies in passive cutaneous anaphylaxis of the guinea pig. Int. Arch. Allergy 3, 162, Suppl. (1952a).PubMedGoogle Scholar
  472. Ovary, Z.: Cutaneous anaphylaxis in the albino rat. Int. Arch. Allergy 3, 293, Suppl. (1952b).PubMedGoogle Scholar
  473. Ovary, Z.: Quantitative aspects of passive cutaneous anaphylaxis. VI. Congr. Int. di Microbiologia, Roma, 1953.Google Scholar
  474. Ovary, Z.: Immediate reactions on skin of experimental animals provoked by antibody-antigen interaction. Progr. Allergy 5, 459 (1958).Google Scholar
  475. Ovary, Z.: Reverse passive cutaneous anaphylaxis in the guinea pig with horse, sheep, or hen antibodies. Immunology 3, 19 (1960).PubMedGoogle Scholar
  476. Ovary, Z., and O. G. Bier: Quantitative study of Arthus reaction and of cutaneous anaphylaxis induced passively in the rat. Proc. Soc. exp. Biol. (N. Y.) 81, 584 (1952).Google Scholar
  477. Ovary, Z., and O. G. Bier: Quantitative studies on passive cutaneous anaphylaxis in the guinea pig and its relationship to the Arthus phenomenon. J. Immunol. 71, 6 (1953).PubMedGoogle Scholar
  478. Ovary, Z., and G. Biozzi: Passive sensitization of the skin of the guinea pig with human antibody. Int. Arch. Allergy 5, 241 (1954).PubMedGoogle Scholar
  479. Ovary, Z., G. Biozzi et G. Mene: L’action du 2786 RP (neoantergan) sur Fanaphylaxie passive cutanee locale du cobaye lors du transport passif. Experentia (Basel) 7, 151 (1951).Google Scholar
  480. Ovary, Z., et M. Briot: Nouvelle methode de dosage de Fanticorps anaphylactique et son rapport avec Fazote de Fanticorps. Ann. Inst. Pasteur 81, 670 (1951).Google Scholar
  481. Ovary, Z., and F. Karush: Antibody hapten interactions studied by passive cutaneous anaphylaxis in the guinea pig. J. Immunol. 84, 409 (1960).PubMedGoogle Scholar
  482. Ovary, Z., and F. Karush: Studies on the immunologic mechanism of anaphylaxis. II. Sensitizing and combining capacity in vivo of fractions separated from papain digests of antihapten antibody. J. Immunol. 86, 146 (1961).PubMedGoogle Scholar
  483. Pappenheimer Jr., A. M.: The nature and significance of the antibody response. New York: Columbia University Press 1953.Google Scholar
  484. Pappenheimer Jr., A. M.: Use of diphtheria toxin and toxoid in the study of immediate and delayed hypersensitivity in man. J. Immunol. 75, 259 (1955).PubMedGoogle Scholar
  485. Pappenheimer Jr., A. M., and H. S. Lawrence: See Lawrence 1949.Google Scholar
  486. Parfentjev, I. A., and M. A. Goodline: Histamine shock in mice sensitized with hemophilus pertussis vaccine. J. Pharmacol, exp. Ther. 92, 411 (1948).Google Scholar
  487. Parker, C. W., M. Kern and H. N. Eisen: Poly-functional dinitrophenyl haptens as reagents for elicitation of immediate type allergic skin responses. J. exp. Med. 115, 789 (1962).PubMedGoogle Scholar
  488. Parker, C. W., J. Shapiro, M. Kern and H. N. Eisen: Hypersensitivity to penicillenic acid derivatives in human beings with penicillin allergy. J. exp. Med. 115, 821 (1962).PubMedGoogle Scholar
  489. Paulino, L., D. H. Campbell and D. Pressman: The nature of the forces between antigen and antibody and of the precipitation reaction. Physiol. Rev. 23, 203 (1943).Google Scholar
  490. Pauling, L., D. Pressman and collaborators: Serological properties of simple substances. I-X. J. Amer. chem. Soc. 64, 2994, 3003, 3010, 3015 (1942); 65, 728 (1943); 66, 330, 784, 1371 (1944); 67, 1003, 1219 (1945).Google Scholar
  491. Pearce, R. M.: Concerning the specificity of the somatogenic cytotoxins. J. med. Res. 12, 1 (1904).PubMedGoogle Scholar
  492. Pearson, CM., B. H. Waksman and J. T. Sharp: Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvants. J. exp. Med. 113, 485 (1961).PubMedGoogle Scholar
  493. Philips, F. S., F. H. Hopkins and M. L. H. Freeman: Effect of tris (beta-chloroethyl) amine on antibody-production in goats. J.Immunol. 55, 289 (1947).PubMedGoogle Scholar
  494. Phillips, J.H., W. Braun and O. Plescia: Antigenicity of a bacterial DNA. Nature (Lond.) 181, 573 (1958).Google Scholar
  495. Pillemer, L., L. Blum, I. H. Lepow, L. Würz and E. W. Todd: The properdin system and immunity. III. The zymosan assay of properdin. J. exp. Med. 103, 1 (1956).PubMedGoogle Scholar
  496. Pirquet, C. v.: Allergie. Münch, med. Wschr. 1906, 1457.Google Scholar
  497. Pirquet, C. v.: Klinische Studien über Vakzination und Vakzinale Allergie. Leipzig: Franz Deuticke 1907.Google Scholar
  498. Pirquet, C. v., u. B. Schick: Zur Theorie der Inkubationszeit. Wien. klin. Wschr. 1903, 758, 1244.Google Scholar
  499. Pirquet, C. v., u. B. Schick: Die Serumkrankheit. Leipzig u. Wien: Franz Deuticke 1905.Google Scholar
  500. Pittman, M., and F. G. Germuth: Some quantitative aspects of passive anaphylaxis in pertussis-vaccinated mice. Proc. Soc. exp. Biol. (N.Y.) 87, 425 (1954).Google Scholar
  501. Pope, C. G., M. F. Stevens, E. A. Caspary and E. L. Fenton: Some new observations on diphtheria toxin and antitoxin. Brit. J. exp. Path. 32, 246 (1951).PubMedGoogle Scholar
  502. Porter, R. R.: The hydrolysis of rabbit gamma globulin and antibodies with crystalline papain. Biochem. J. 73, 119 (1959).PubMedGoogle Scholar
  503. Porter, R. R.: In: Basic problems in neoplastic diseases, ed. by A. Gelhorn and E. Hirschberg. New York City: Columbia Univ. Press 1962.Google Scholar
  504. Portier, P., et C. Richet: De Faction anaphylactique de certains venins. C.R. Soc. Biol. (Paris) 54, 170 (1902).Google Scholar
  505. Portnoy, J., and W. B. Sherman: Complement fixation studies in ragweed allergy. II. Determination of antibody in human sera to ragweed antigen by means of a complement fixation inhibition test; the relationship of antibody so determined to the passive transfer for blocking antibody. J. Allergy 25, 229 (1954).PubMedGoogle Scholar
  506. Prausnitz, C, u. H. Küstner: Studien über die Überempfindlichkeit. Zbl. Bakt., I.Abt. Orig. 86, 160 (1921).Google Scholar
  507. Preer Jr., J. R.: A quantitative study of a technique of double diffusion in agar. J. Immunol. 77, 55 (1956).Google Scholar
  508. Pressman, D.: Zone of localization of antibodies; use of radioactive sulfur 35 as label for anti-kidney serum. J. Immunol. 65, 559 (1950).PubMedGoogle Scholar
  509. Pressman, D., A. L. Grossberg, L. H. Pence and L. Pauling: The reactions of antiserum homologous to the p-azo-phenyl-trimethylammonium group. J. Amer. chem. Soc. 68, 250 (1946).Google Scholar
  510. Pressman, D., A. B. Pardee and L. Pauling: The reactions of antisera homologous to various azophenylarsenic acid groups and the p-azophenylmythylarsinic acid group with some heterologous haptens. J. Amer. chem. Soc. 67, 1602 (1945).Google Scholar
  511. Pressman, D., and L. A. Sternberger: The nature of the combining sites of antibodies. The specific protection of the combining site by hapten during iodination. J. Immunol. 66, 609 (1951).PubMedGoogle Scholar
  512. Pressman, D., Y. Yagi and R. Hiramoto: Review of use of radioactive label. Int. Arch. Allergy 12, 127 (1958).Google Scholar
  513. Pruzansky, J. J., and S. M. Feinberg: The conversion of precipitating to nonprecipitating antibody in immune sera of the guinea pig. J. Immunol. 88, 256 (1962).PubMedGoogle Scholar
  514. Race, R. R., and R. Sanger: Blood groups in man, 3. edit. London: Blackwell 1958.Google Scholar
  515. Raffel, S.: Immunity, hypersensitivity, serology. New York: Appleton-Century, Crofts 1953.Google Scholar
  516. Raffel, S.: Delayed hypersensitivities. Progr. Allergy 4, 173 (1954).Google Scholar
  517. Raffel, S., and S. M. Newell: The “delayed hypersensitivity” induced by antigen-antibody complexes. J. exp. Med. 108, 823 (1958).PubMedGoogle Scholar
  518. Ragan, C, R. Lattes, J. W. Blunt Jr., G. de Vaillancourt, R. A. Jesser and W. Epstein: The effect of cortisone upon repair process in dense and loose connective tissue. In G. Shwartzman, The effect of ACTH and cortisone upon infection and resistance. New York: Columbia University Press 1953.Google Scholar
  519. Rammelkamp Jr., C. H.: Microbiologic considerations in glomerulonephritis. Harvey Lect. 1955/56.Google Scholar
  520. Rammelkamp Jr., C. H.: J. chron. Dis. 1, 28 (1957).Google Scholar
  521. Ramon, G.: L’immunite et l’influence des “substances adjuvantes et stimulantes” injectees en melange avec l’antigene; introduction a une etude d’ensemble. Rev. Immunol. (Paris) 3, 193 (1937).Google Scholar
  522. Ramon, G.: Essais sur l’immunite antitoxique, les facteurs adjuvants et leur intervention dans la resistance non specifique a l’intoxication et dans l’augmentation de l’immunite specifique. Rev. Immunol. (Paris) 4, 5 (1938).Google Scholar
  523. Ramsdell, S. G.: The transfer of the skin-reacting antibody in human serum to guinea pig skin. J. Immunol. 19, 411 (1930).Google Scholar
  524. Ratner, B.: Allergy, anaphylaxis and immunotherapy. Baltimore: Williams & Wilkins Company 1943.Google Scholar
  525. Reader, R.: Serum complement in acute nephritis. Brit. J. exp. Path. 29, 255 (1948).PubMedGoogle Scholar
  526. Relyveld, E. H., P. Grabar, M. Raynaud et C. M. J. R. Williams: Etude par la methode immunoelectrophoretique de la toxine diphterique purifiee. Ann. Inst. Pasteur 90, 688 (1956).Google Scholar
  527. Rich, A.R.: Hypersensitivity in disease, with especial reference to periarteritis nodosa, rheumatic fever, disseminated lupus erythematosus and rheumatoid arthritis. Harvey Lect. 42, 106 (1947).Google Scholar
  528. Rich, A.R.: The pathogenesis of tuberculosis. Springfield, 111.: Ch. C. Thomas 1951.Google Scholar
  529. Rich, A. R., and M. R. Lewis: The nature of allergy in tuberculosis as revealed by tissue culture studies. Bull. Johns Hopk. Hosp. 50, 115 (1932).Google Scholar
  530. Richet, Ch.: Die Anaphylaxie. Leipzig: Akademische Verlagsgesellschaft 1920.Google Scholar
  531. Roessle, R.: Die morphologischen Äquivalente der Allergic Acta rheum. (Amst.) 8, 64 (1936).Google Scholar
  532. Roizman, B., and P. R. Roane Jr.: Studies on the determinant antigens of viable cells. J. Immunol. 87, 714 (1961).PubMedGoogle Scholar
  533. Rose, N. R., S. Shulman and E. Witebsky: Studies on organ specificity. XIII. Immunological analysis of thyroglobulin and thyralbumin. J. Immunol. 88, 229 (1962).PubMedGoogle Scholar
  534. Rose, N. R., and E. Witebsky: Studies on organ specificity. Changes in the thyroid glands of rabbits following active immunization with rabbit thyroid extracts. J. Immunol. 76, 417 (1956).PubMedGoogle Scholar
  535. Rosenau, M. J., and J. F. Anderson: The specific nature of anaphylaxis. J. infect. Dis. 4, 552 (1907).Google Scholar
  536. Rosenberg, L. T., M. H. Chandler and E. E. Fischel: Passive cutaneous anaphylaxis with antigen-antibody complexes and additional antigen. Proc. Soc. exp. Biol. (N.Y.) 98, 451 (1958).Google Scholar
  537. Rosenberg, L. T., M. H. Chandler and E. E. Fischel: Biologic reactivity of the antigen and antibody in specific precipitate. Proc. Soc. exp. Biol. (N.Y.) 100, 649 (1959a).Google Scholar
  538. Rosenberg, L. T., M. H. Chandler and E. E. Fischel: Quantitative studies of repeated cutaneous anaphylaxis at sites sensitized with a single injection of antibody. J. Immunol. 83, 264 (1959b).PubMedGoogle Scholar
  539. Rosenberg, L. T., M. H. Chandler, A. S. Gordon and E. E. Fischel: Antibody production demonstrated by passive transfer of cells and dye localization. Fed. Proc. 16, 431 (1957).Google Scholar
  540. Ross, A., and I. H. Lepow: Studies on immune cellular injury. I. Cytotoxic effects of antibody and complement. J. exp. Med. 112, 1085 (1960).PubMedGoogle Scholar
  541. Rothbard, S., and R. F. Watson: Antigenicity of rat collagen. Demonstration of antibody to rat collagen in the renal glomeruli of rats by fluorescence microscopy. J. exp. Med. 113, 1041 (1961).PubMedGoogle Scholar
  542. Rothberg, R., and D. W. Talmage: Circulating antibody and anaphylaxis in mice. J. Immunol. 86, 302 (1961).PubMedGoogle Scholar
  543. Roulet, F.: Über die granulom-artige allergische Entzündung. Verh. dtsch. path. Ges. 26, 189 (1931).Google Scholar
  544. Roulet, F.: Die infektiösen „spezifischen“ Granulome. Dieses Handbuch, Bd. VII, Teil 1, S. 325. 1956.Google Scholar
  545. Rutstein, D.D., and W.H.Walker: Complement ectivity in pneumonia. J. clin. Invest. 21, 347 (1942).PubMedGoogle Scholar
  546. Sabin, F. R.: Cellular reactions to tuberculo-proteins compared with reactions to tuber-culo-lipids. J. exp. Med. 68, 837 (1938 a).PubMedGoogle Scholar
  547. Sabin, F. R.: Cellular reactions to a dye-protein with a concept of the mechanism of antibody formation. J. exp. Med. 70, 67 (1939).PubMedGoogle Scholar
  548. Sabin, F. R., and A. L. Joyner: Cellular reactions to defatted tubercle bacilli and their products. J. exp. Med. 68, 853 (1938b).PubMedGoogle Scholar
  549. Salvin, S. B., and R. F. Smith: Delayed hypersensitivity in the development of circulating antibody. The effect of x-irradiation. J. exp. Med. 109, 325 (1959).PubMedGoogle Scholar
  550. Sanarelli, G.: De la pathogenie du cholera. Le cholera experimental. Ann. Inst. Pasteur 38, 11 (1924).Google Scholar
  551. Schmidt, H.: Fortschritte der Serologic Darmstadt: Dr. Dietrich Stein-kopff 1950–1952, 704 S.Google Scholar
  552. Schmidt, W. M., and V. W. Lippard: Human passive transfer antibody. II. Neutralization of antigen. Amer. J. Dis. Child. 54, 777 (1937).Google Scholar
  553. Schultz, W. H.: Physiological studies in anaphylaxis. I. The reaction of smooth muscle of the guinea pig sensitized with horse serum. J. Pharmacol, exp. Ther. 1, 549 (1910).Google Scholar
  554. Schwab, L., F. C. Moll, T. Hall, H. Breen, M. Kirk, C. van Z. Hawn and C. A. Janeway: Experimental hypersensitivity in the rabbit. Effect on inhibition of antibody formation by x-radia-tion and nitrogen mustards on the histologic and serologic sequences, and on the behavior of serum complement following single large injections of foreign proteins. J. exp. Med. 91, 505 (1950).PubMedGoogle Scholar
  555. Schwartz, R., J. Stack, and W. Dameshek: Effect of 6-mercaptopurine on antibody production. Proc. Soc. exp. Biol. (N.Y.) 99, 164 (1958).Google Scholar
  556. Schwentker, F. F., and T. M. Rivers: The antibody response of rabbits to injections of emulsions and extracts of homologous brain. J. exp. Med. 60, 559 (1934).PubMedGoogle Scholar
  557. Seegal, B. C: Anaphylaxis. In: Gay and Associates. Agents of disease and host resistance. Springfield, 111.: Ch. C. Thomas 1935.Google Scholar
  558. Seegal, B. C: Allergy of infection: relation to immunity. Ann. N.Y. Acad. Sci. 56, 758 (1949).Google Scholar
  559. Seegal, B. C: Antigen-antibody reactions. Amer. J. Med. 13, 355 (1952).Google Scholar
  560. Seegal, B. C, and M. Bevans: Experimental glomerulonephritis. J. chron. Dis. 1, 153 (1957).Google Scholar
  561. Seegal, B. C, and D. Seegal: Local organ hypersensitiveness. VI. An indirect method for its production in the rabbit eye. J. Immunol. 25, 221 (1933b).Google Scholar
  562. Seegal, B. C, and D. Seegal: VII. Demonstration of agglutinins in tissues of the rabbit eye following immunization with Eb. typhi vaccine. Proc. Soc. exp. Biol. (N.Y.) 31, 437 (1934).Google Scholar
  563. Seegal, B. C, D. Seegal and D. Khorazo: Local organ hypersensitiveness. V. The fate of antigen and the appearance of antibodies during the development of hypersensitiveness in the rabbit eye. J. Immunol. 25, 207 (1933).Google Scholar
  564. Seegal, D., M. Heidelberger and E. L. Jost: The formation of precipitin for the group A specific carbohydrate of streptococcus hemolyticus in rabbits injected intravenously and subcutaneously. J. Immunol. 27, 211 (1934).Google Scholar
  565. Seegal, D., and B. C. Seegal: Local organ hypersensitiveness. I. Experimental production in the rabbit eye. Proc. Soc. exp. Biol. (N.Y.) 27, 390 (1930a).Google Scholar
  566. Seegal, D., and B. C. Seegal: II. Repeated response in the rabbit eye. Proc. Soc. exp. Biol. (N.Y.) 27, 393 (1930b).Google Scholar
  567. Seegal, D., and B. C. Seegal: III. Further observations on its experimental production in the rabbit eye. J. exp. Med. 54, 249 (1931 a).PubMedGoogle Scholar
  568. Seegal, D., and B. C. Seegal: IV. Inflammation produced in the actively sensitized rabbit eye by the introduction of homologous antigen into the gastrointestinal tract. J.exp.Med. 54, 265 (1931b).PubMedGoogle Scholar
  569. Seegal, D., and B. C. Seegal: Allergy. In: Gay and Associates, Agents of disease and host resistance. Springfield, 111.: Ch. C. Thomas 1935.Google Scholar
  570. Seegal, D., B. C. Seegal and E. L. Jost: The Arthus phenomenon. Local anaphylactic inflammation in rabbit pericardium heart and aorta. J. exp. Med. 55, 155 (1932).PubMedGoogle Scholar
  571. Sehon, A. H.: The detection and nature of non-precipitating antibodies in allergic sera. In: Shaffer, Lo Grippo and Chase. Boston: Little, Brown & Co. 1959.Google Scholar
  572. Seligmann, M.: Mise en evidence dans le serum de malades atteints de lupus erythemateux dissemine d’une substance determinant une reaction de precipitation avec l’acide desoxyribonucleique. C.R. Acad. Sci. (Paris) 245, 243 (1957).Google Scholar
  573. Shaffer, J. H., G. A. Lo Grippo, and M. W. Chase: Mechanisms of hypersensitivity. Boston: Little, Brown & Co. 1959.Google Scholar
  574. Sherman, W. B., and J. Portnoy: Detection of human blocking antibody to ragweed by inhibition of a complement-fixation test. In: Shaffer, Lo Grippo and Chase. Boston: Little, Brown & Co. 1959.Google Scholar
  575. Shulman, S., N. R. Rose and E. Witebsky: Studies on organ specificity. Ultra-centrifugal and electrophoretic examinations of thyroid extracts. J. Immunol. 75, 291 (1955).PubMedGoogle Scholar
  576. Shwartzman, G.: The phenomenon of local tissue reactivity. New York: Paul Hoeber 1938.Google Scholar
  577. Simonsen, M.: Graft-versus-host reactions, their history and applicability as tools of research. Progress in allergy. Basel: Karger 1961.Google Scholar
  578. Sinclair, I. J. B.: The role of complement in the immune reactions of Paramecium aurelia and Tetrahymena pyriformis. Immunology 1, 291 (1958).PubMedGoogle Scholar
  579. Singer, J. M., and C. M. Plötz: The latex fixation test. Application to the serologic diagnosis of rheumatoid arthritis. Amer. J. Med. 21, 888 (1956).PubMedGoogle Scholar
  580. Singer, S. J.: Preparation of an electron-dense antibody conjugate. Nature (Lond.) 183, 1523 (1959).Google Scholar
  581. Smith, W., and J. H. Humphrey: The effect of sodium salicylate upon hypersensitivity reactions. Brit. J. exp. Path. 30, 560 (1949).Google Scholar
  582. Snell, G. D.: The homograft reaction. Ann. Rev. Microbiol. 11, 439 (1957).Google Scholar
  583. Snell, G. D., H. J. Winn, and A. A. Kandutsch: A quantitative study of cellular immunity. J. Immunol. 87, 1 (1961).Google Scholar
  584. Stavitsky, A. B.: Micromethods for the study of proteins and antibodies. II. Specific applications of haemagglutination and haemagglutination inhibition reactions with tannic acid and protein treated red blood cells. J. Immunol. 72, 368 (1954).PubMedGoogle Scholar
  585. Steblay, R. W.: Localization in human kidney of antibodies formed in sheep against human placenta. J. Immunol. 88, 434 (1962).PubMedGoogle Scholar
  586. Steblay, R. W., and M. H. Lepper: Some immunologic properties of human and dog glomerular basement membranes. J. Immunol. 87, 627, 636 (1961).PubMedGoogle Scholar
  587. Sterzl, J.: Effect of some metabolic inhibitors on antibody formation. Nature (Lond.) 189, 1022 (1961).Google Scholar
  588. Stoerk, H. C, H. N. Eisen and H. M. John: Impairment of antibody response in pyridoxine-deficient rats. J.exp.Med. 85, 365 (1947).PubMedGoogle Scholar
  589. Swift, H. F.: The etiology of rheumatic fever. Ann. intern. Med. 31, 715 (1949).PubMedGoogle Scholar
  590. Taliaferro, W. H., and J. H. Humphrey: Advances in immunology I. New York and London: Academic Press 1961.Google Scholar
  591. Taliaferro, W. H., and L. G. Taliaffero: Effect of X-rays on immunity: A review. J. Immunol. 66, 181 (1951).PubMedGoogle Scholar
  592. Talmadge, D.W., and J. R. Cann: The chemistry of immunity in health and disease. Springfield, 111.: Ch. C. Thomas 1961.Google Scholar
  593. Talmadge, D.W., F.J. Dixon, S. C. Bukantz and G. J. Dammin: Antigen elimination from the blood as an early manifestation of the immune response. J. Immunol. 67, 243 (1951).Google Scholar
  594. Teorell, T.: Quantitative aspects of antigen-antibody reactions. I. A theory and its corollaries. J. Hyg. (Lond.) 44, 227 (1946).Google Scholar
  595. Tokuda, S., and R. S. Weiser: Studies on the role of serotonin and mast cells in anaphylaxis of the mouse produced with soluble antigen-antibody complexes. J. Immunol. 86, 292 (1961).PubMedGoogle Scholar
  596. Tomcsik, J.: Immuno-polysaccharides. Ann. Rev, Biochem. 22, 351 (1953).Google Scholar
  597. Townsend, E., W. T. Murakami, and H. van Vunakis: The antigenic determinant groups of bacteriophage DNA. Fed. Proc. 20, 438 (1961).Google Scholar
  598. Trapani, I. L., J. S. Garvey and D. H. Campbell: Stimulating action of soluble antigen-antibody complexes on normal guinea-pig muscle. Science 127, 700 (1958).PubMedGoogle Scholar
  599. Treffers, H. P.: Some contributions of immunology to the study proteins. Ad vane. Protein Chem. 1, 69–119 (1944).Google Scholar
  600. Treffers, H. P., R. J. Dubos, Bacterial and mycotic infections of man. Philadelphia: J. B. Lippincott Company 1952.Google Scholar
  601. Treffers, H. P., M. Heidelberger and J. Freund: Antiproteins in horse sera. IV. Antibodies to rabbit serum globulin and their interaction with antigen. J. exp. Med. 86, 95 (1947).PubMedGoogle Scholar
  602. Tuft, L., and S. G. Ramsdell: The antibody response in the human being after injection with normal horse serum. J. exp. Med. 50, 431 (1929a).PubMedGoogle Scholar
  603. Tuft, L., and S. G. Ramsdell: Antibody studies in serum sickness. I. With special reference to the Prausnitz-Kustner reaction. J. Immunol. 16, 411 (1929b).Google Scholar
  604. Tuft, L., and S. G. Ramsdell: II. Study of sera secured by serial bleeding from persons treated with immune Serum. J. Immunol. 17, 539 (1929c).Google Scholar
  605. Turk, J. L.: The relationship between complement and antibodies of different animals in the immune-adherence phenomenon. Immunology 2, 127 (1959).PubMedGoogle Scholar
  606. Uhr, J. W., S. B. Salvin and A.M. Pappenheimer Jr.: Delayed hypersensitivity. II. Induction of hypersensitivity in guinea pigs by means of antigen-antibody complexes. J. exp. Med. 105, 11 (1957).PubMedGoogle Scholar
  607. Undenfriend, S., and T. P. Waalkes: On the role of serotonin in anaphylaxis. In: Shaffer, Lo Grippo and Chase, p. 219. Boston: Little, Brown & Co. 1959.Google Scholar
  608. Ungar, G., and E. Damgaard: Tissue reactions to anaphylactic and anaphylactoid stimuli; proteolysis and release of histamine and heparin. J. exp. Med. 101, 1 (1955).PubMedGoogle Scholar
  609. van Arsdel, P. P., and E. Middleton Jr.: The effect of hyposensitization on the in vitro histamine release by specific antigen. J. Allergy 32, 348 (1961).Google Scholar
  610. van Arsdel, P., S. Wack, E. Middleton, W. B. Sherman and H. Buchwald: A quantitative study on the in vitro release of histamine from leukocytes of atopic persons. J. Allergy 29, 429 (1958).Google Scholar
  611. van den Ende, M.: Some observations on reversed anaphylaxis. J. Hyg. (Lond.) 39, 471 (1939).Google Scholar
  612. van der Scheer, J., E. Bohnel, F. H. Clarke and R. W. G. Wyckoff: An electrophoretic examination of several antipneumococci rabbit sera. J. Immunol. 44, 165 (1942).Google Scholar
  613. Vaughan, J. H., and E. A. Kabat: Studies on the antibodies in rabbit antisera responsible sensitization of human skin. I. The role of impurities in crystalline egg albumin in stimulating the production of skin-sensitizing antibody. J. exp. Med. 97, 821 (1953).PubMedGoogle Scholar
  614. Vaughan, J. H., and E. A. Kabat: Studies on the antibodies in rabbit antisera responsible for sensitization of human skin. II. Characteristics of antisera to egg white and to conalbumin. J. Allergy 25, 387 (1954a).PubMedGoogle Scholar
  615. Vaughan, J. H., and E. A. Kabat: An unidentified antibody in anti-egg albumin sera revealed by the agar diffusion technic: methods for its immunochemical analysis. J.Immunol. 73, 205 (1954b).PubMedGoogle Scholar
  616. Veil, W. H., u. B. Buchholz: Der Komplementschwund im Blut. Klin. Wschr. 11, 2019 (1932).Google Scholar
  617. Waksman, B. H.: Auto-immunization and the lesions of auto-immunity. Medicine (Baltimore) 41, 93 (1962).Google Scholar
  618. Waksman, B. H., and S. J. Bullington: A quantitative study of the passive Arthus reaction in the rabbit eye. J. Immunol. 76, 411 (1956).Google Scholar
  619. Wallace, L. L., A.G. Osler and M.M. Mayer: Quantitative studies of complement-fication. V. Estimation of complement-fixing potency of immune sera and its relation to antibody-nitrogen content. J. Immunol. 65, 661 (1950).PubMedGoogle Scholar
  620. Walzer, M., and I. Glazer: Passive transfer of atopic hypersensitiveness in man by means of leucocythes. Proc. Soc. exp. Biol. (N. Y.) 74, 872 (1950).Google Scholar
  621. Watson, D. W., and W. J. Cromartie: Tissue factors in streptococcal infections. In L. Thomas, Rheumatic fever. A symposium. Minneapolis: Univ. of Minnesota Press 1952.Google Scholar
  622. Weck, A. L., and H. N. Eisen: Some immunochemical properties of penicillinic acid. An antigenic determinant derived from penicillin. J. exp. Med. 112, 1227 (1960).Google Scholar
  623. Weigle, W. O.: Fate and biological action of antigen-antibody complexes. In: Taliaferro and Humphrey, p. 283. New York and London: Academic Press 1961.Google Scholar
  624. Weigle, W. O., and F. J. Dixon: The elimination of heterologous serum proteins and associated antibody responses in guinea pigs and rats. J. Immunol. 79, 24 (1957).PubMedGoogle Scholar
  625. Weigle, W. O., and P.H. Maurer: Behaviour of complement in antigen-antibody complement precipitates. J. Immunol. 79, 319 (1957).PubMedGoogle Scholar
  626. Weil, A. J.: The Wassermann antigen and related “alcohol-soluble” antigens. Bact. Rev. 5, 293 (1941).PubMedGoogle Scholar
  627. Weil, A. J., O. Kotsevalov and E. Wilson: The antigens of human seminal plasma. Proc. Soc. exp. Biol. (N.Y.) (in press).Google Scholar
  628. Weil, A. J., and L. Reddin Jr.: Dermal supersensitivity, heat-labile and heat-stabile antibody against ragweed in cattle. J. Immunol. 47, 345 (1943).Google Scholar
  629. Weil, A. J., and H. E. Rogers: Allergic reactivity to simple aliphatic acids in man. J. invest. Derm 17, 227 (1951). (unpublished).PubMedGoogle Scholar
  630. Weil, R.: The nature of anaphylaxis and the relations between anaphylaxis and immunity. J. med. Res. 27, 497 (1912).Google Scholar
  631. Weil, R.: Studies in anaphylaxis. J. med. Res. 28, 243 (1913).PubMedGoogle Scholar
  632. Weiss, D. W.: Inhibition of tuberculin skin hypersensitivity in guinea pigs by injection of tuberculin and intact tubercle bacilli during foetal life. J. exp. Med. 108, 83 (1958).PubMedGoogle Scholar
  633. Wells, H. G.: The chemical aspects of immunity, 2. edit. New York: Chemical Catalog Co. 1929.Google Scholar
  634. Wertheim, A. R., J. D. Lyttle, E. N. Loeb, D. P. Earle Jr., B. C. Seegal and D. Seegal: The association of type specific hemolytic streptococci with acute glomerulonephritis at the Presbyterian and Babies Hospitals, N.Y., N.Y. in the years 1936–1942. J. chlin. Invest. 32, 359 (1953).Google Scholar
  635. Westwater, J. O.: Antibody formation in a tuberculous lesion at the site of inoculation. J. exp. Med. 71, 455 (1940).PubMedGoogle Scholar
  636. Wetter, L. R., M. Cohn and H. Deutsch: Immunological studies of egg white proteins. V. The cross-reactions of egg white proteins of various species. J. Immunol. 70, 507 (1953).PubMedGoogle Scholar
  637. White, R. G., A. H. Coons and J. M. Connolly: Studies on antibody production. III. The alum granuloma. J. exp. Med. 102, 73 (1955a).PubMedGoogle Scholar
  638. White, R. G., A. H. Coons and J. M. Connolly: IV. The role of a wax fraction of mycobacterium tuberculosis in adjuvant emulsions on the production of antibody to egg albumin. J.exp.Med. 102, 83 (1955b).PubMedGoogle Scholar
  639. Wiener, A. S.: Blood groups and transfusion, 3. edit. Springfield, 111.: Ch. C. Thomas 1943.Google Scholar
  640. Wiener, A. S., E.B. Gordon and C. Gallop: Studies on autoantibodies in human sera. J. Immunol. 71, 58 (1953).PubMedGoogle Scholar
  641. Williams Jr., C. A., and P. Grabar: Immunoelectrophoretic studies on serum proteins. I. The antigens of human serum. J. Immunol. 74, 158 (1955).PubMedGoogle Scholar
  642. Wilson, G. S., and A. A. Miles: Topley and Wilson’s principles of bacteriology and immunity, 4. edit. Baltimore: Williams & Wilkins Company 1956.Google Scholar
  643. Wilson, G. W., and J. Oliver: Experiments on the production of specific antisera for infections of unknown cause. III. Nephrotoxins: Their specificity as demonstrates by the method of selective absorption. J. exp. Med. 32, 183 (1920).PubMedGoogle Scholar
  644. Wilson, L.: Sperm agglutinins in human semen and blood. Pr. c. Soc. exp. Biol. (N.Y.) 85, 652 (1954).Google Scholar
  645. Witebsky, E., and F. Milgrom: Immunological studies on adrenal glands. II. Immunization with adrenals of the same species. Immunology 5, 67 (1962).PubMedGoogle Scholar
  646. Witebsky, E., and N. R. Rose: Studies on organ specificity. Production of rabbit thyroid antibodies in the rabbit. J. Immunol. 76, 408 (1956).PubMedGoogle Scholar
  647. Witebsky, E., N. R. Rose, and S. Shulman: Studies on organ specificity. The serological specificity of thyroid extract. J. Immunol. 75, 269 (1955).PubMedGoogle Scholar
  648. Woodworth, H. C.: Studies with immune-adherence. I. Titration of human complement with a rice-starch system. Immunology 5, 181 (1962).PubMedGoogle Scholar
  649. Zimmerman, H. J., J.R. Walsh and P. Heller: Production of nucleophagocytosis by rabbit antileukocytic serum. Blood 8, 651 (1953).PubMedGoogle Scholar
  650. Zinsser, H.: On the significance of bacterial allergy in infectious diseases. Bull. N.Y. Acad. Med. 4, 351 (1928).PubMedGoogle Scholar
  651. Zinsser, H., J. F. Enders and L. D. Fothergill: Immunity. Principles and applications in medicine and public health. New York: Macmillan 1939.Google Scholar
  652. Zweifach, B.W., A. L. Nagler, and W. Troll: Some effects of proteolytic inhibitors on tissue injury and systemic anaphylaxis. J. exp. Med. 113, 437 (1961).PubMedGoogle Scholar

Copyright information

© Springer-Verlag, Berlin · Heidelberg 1967

Authors and Affiliations

  • Edward E. Fischel
    • 1
  1. 1.Department of MedicineThe Bronx Lebanon Hospital CenterNew York 56USA

Personalised recommendations