Methods of Detection of Antitumour Immunity
It is well known that a too high challenge dose can overcome immunity so that it is impossible to find any difference between the control and immunized groups. Hence the so-called minimal dose must be determined for each tumour, i. e. the amount of viable tumour cells capable of growing in 100% of the control animals using a standard method of inoculation. This minimal dose shows great variations for different tumours and is influenced not only by the antigenicity of the tumour used, but also by its general biological properties. The degree of immunity achieved for different tumours is therefore best determined not by comparing the absolute number of cells overcoming immunity, but by the number of the minimal doses.
KeywordsTumour Antigen Adoptive Transfer Spontaneous Tumour Rous Sarcoma Virus Polyoma Virus
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