Abstract
Experimental work on the acute, chronic, and fetal toxicity of SAMe was carried out by Stramentinoli and his colleagues (19). The intravenous LD50 in rats is more than 2000 mg/kg, or the equivalent of 140–150 g in a man of 70 kg. In man, on the other hand, clinical trials have revealed a definite action of the substance in the CNS with doses as little as 80/zg/kg; the largest dose so far administered intravenously to humans is 0.5 g daily and has produced no visible side effects.
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Agnoli, A., Andreoli, V.M., Casacchia, M., Maffei, F., Fazio, C. (1978). Results and Possible Developments of the Clinical Use of S-Adenosyl-L-Methionine (SAMe) in Psychiatry. In: Andreoli, V.M., Agnoli, A., Fazio, C. (eds) Transmethylations and the Central Nervous System. Monographien aus dem Gesamtgebiete der Psychiatrie, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-88516-7_18
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