S-Adenosyl-L-Methionine (SAMe) Blood Levels in Schizophrenia and Depression

  • V. M. Andreoli
  • F. Maffei
  • G. C. Tonon
Part of the Monographien aus dem Gesamtgebiete der Psychiatrie book series (PSYCHIATRIE, volume 18)


S-adenosyl-L-methionine (SAMe) serves as the methyl group donor for several transmethylase enzyme systems, the best known being catechol-O-methyltransferase (COMT), whose intracellular distribution is similar to that of SAMe (3); many other transmethylation reactions, however, are SAMe-dependent (6).


Depression Dopamine Schizophrenia Methionine Indole 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • V. M. Andreoli
    • 1
  • F. Maffei
    • 1
  • G. C. Tonon
    • 2
  1. 1.Neuropsychiatric HospitalsVeronaItaly
  2. 2.Department of PharmacologyUniversity of MilanItaly

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