S-Adenosyl-L-Methionine (SAMe) Blood Levels in Schizophrenia and Depression

  • V. M. Andreoli
  • F. Maffei
  • G. C. Tonon
Part of the Monographien aus dem Gesamtgebiete der Psychiatrie book series (PSYCHIATRIE, volume 18)


S-adenosyl-L-methionine (SAMe) serves as the methyl group donor for several transmethylase enzyme systems, the best known being catechol-O-methyltransferase (COMT), whose intracellular distribution is similar to that of SAMe (3); many other transmethylation reactions, however, are SAMe-dependent (6).


Biogenic Amine Indole Amine Chronic Schizophrenic High Urinary Excretion Amine Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Andreoli, V.: Anfetamine, loro derivatie comportamento. In: Quaderni die Neuropsicofarmacologia Andreoli, V., Del Mastro, S. (eds.) Societa italiana neuropsico-farmacologia Milano: 1971Google Scholar
  2. 2.
    Andreoli, V., Danieli, B., Tonon, G.C.: Significato dei derivati metossilati nelle psicosi da anfetamina. Riv. Farm. Ter. 4, 1a (1973)Google Scholar
  3. 3.
    Andreoli, V.M., Maffei, F., Tonon, G.C.: The subcellular distribution of S-Adenosyl-L-Methionine (SAMe) in the rat brain. This volume, p. 114Google Scholar
  4. 4.
    Antun, F.T., Burnett, G.B., Cooper, A.J., Daly, R.J., Smythies, J.R., Zealley, A.K.: The effects of L-methionine (without MAOI) in schizophrenics. J. Psychiat. Res. 8, 63, (1971).PubMedCrossRefGoogle Scholar
  5. 5.
    Antun, F., Eccleston, D., Smythies, J.R.: Transmethylation processes in schizophrenia. In: Brain Chemistry and Mental Disease, New York: Plenum 1971 pp. 61–71CrossRefGoogle Scholar
  6. 6.
    Axelrod, J.: Methytransferase enzyme in the metabolism of physiologically active compounds and drugs. In: Handbook of Experimental Pharmacology. Eichler, O., Farah, H., Herken, H., Welch, A.D. (eds.) New York: Springer, 1971, Vol. XXVIII/2, p. 610Google Scholar
  7. 7.
    Baldessarini, R.J.: Factors influencing S-adenosyl-methionine levels in mammalian tissues. In: Amines and Schizophrenia. Himwich, H., Kety, S., Smythies, J. (eds.) Oxford: Pergamon Press, (1966), pp. 198–206Google Scholar
  8. 8.
    Baldessarini, R.J.: Alterations in tissue levels of S-adenosylmethionine. Biochem. Pharmacol. 15, 741(1966)PubMedCrossRefGoogle Scholar
  9. 9.
    Baldessarini, R.J., Kopin, I.J.: S-adenosylmethionine in brain and other tissues. J. Neurochem. 13, 769 (1966)PubMedCrossRefGoogle Scholar
  10. 10.
    Colin, C.K., Dünner, D., Axelrod, J.: Reduced c at echol-O-me thy transferase activity in red cells of women with primary affective disorders. Science 170, 1323 (1970)CrossRefGoogle Scholar
  11. 11.
    Deguchi, T., Barchas, J.: Inhibition of transmethylations of biogenic amines by Sadenosylhomocysteine. J. biol. Chem. 246, 3175 (1971)PubMedGoogle Scholar
  12. 12.
    Fazio, C., Andreoli, V., Agnoli, A., Casacchia, M., Cerbo, R., Pinzello, A.: Therapy of schizophrenia and depressive disorders with S-adenosyl-L-methionine. Intern. Res. Comm. System (IRCS), Clin. Pharmacol. Ther. 2, 1015 (1974)Google Scholar
  13. 13.
    Friedhoff, A.J.: Biogenic amines and schizophrenia. In: Biological Psychiatry. Mendels, J. (ed.) New York: Wiley, 1973, pp. 113–129Google Scholar
  14. 14.
    Friedhoff, A.J., Schweitzer, J.W., Miller, J.: The enzymatic formation of 3, 4, di-O-methylated dopamine metabolites by mammalian tissues. Res. Comm. Path. Pharmacol. 3, 293(1972)Google Scholar
  15. 15.
    Kakimoto, Y., Sano, I., Kanazawa, A., Tsujio, T., Kaneko, Z.: Metabolic effects of methionine in schizophrenic patients pretreated with a monoamine oxidase inhibitor. Nature (Lond.) 216, 1110 (1967)CrossRefGoogle Scholar
  16. 16.
    Kety, S.S.: Current biochemical approaches to schizophrenia. New Engl. J. Med. 276, 325(1967)PubMedCrossRefGoogle Scholar
  17. 17.
    Levi, R., Waxmann, S.: Epilepsy, cancer, and Schizophrenia. Lancet II, 11, 1975CrossRefGoogle Scholar
  18. 18.
    Matthysse, S., Baldessarini, R.J.: S-adenosylmethionine and catechol-O-methyl-transferase in schizophrenia. Am. J. Psychiat. 128, 1310 (1972)PubMedGoogle Scholar
  19. 19.
    Matthysse, S., Lipinski, J., Shin, V.: L-Dopa and S-adenosylmethionine. Clin. chim. Acta 35, 253(1971)PubMedCrossRefGoogle Scholar
  20. 20.
    Mendels, J., Stinnett, J.L.: Biogenic amine metabolism, depression and mania. In: Biological Psychiatry. Mendels, J. (ed.) New York: Wiley, 1973, pp. 35–64Google Scholar
  21. 21.
    Pollin, W., Cardon, P.V., Kety, S.S.: Effects of amino acid feeding in schizophrenic patients treated with iproniazid. Science 133, 104 (1961)PubMedCrossRefGoogle Scholar
  22. 22.
    Saavedra, J.M., Axelrod, J.: Psychotomimetic N-methylated tryptamine formation in brain in vivo and in vitro. Science 175, 1365 (1972)PubMedCrossRefGoogle Scholar
  23. 23.
    Wurtman, R.J., Rose, CM., Matthysse, S., Stephenson, J., Baldessarini, R.J.: L-Dihydroxyphenylalanine: effect on S-adenosylmethionine in brain. Science 169, 395 (1970)PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • V. M. Andreoli
    • 1
  • F. Maffei
    • 1
  • G. C. Tonon
    • 2
  1. 1.Neuropsychiatric HospitalsVeronaItaly
  2. 2.Department of PharmacologyUniversity of MilanItaly

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