Abstract
S-adenosyl-L-methionine (SAMe) serves as the methyl group donor for several transmethylase enzyme systems, the best known being catechol-O-methyltransferase (COMT), whose intracellular distribution is similar to that of SAMe (3); many other transmethylation reactions, however, are SAMe-dependent (6).
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References
Andreoli, V.: Anfetamine, loro derivatie comportamento. In: Quaderni die Neuropsicofarmacologia Andreoli, V., Del Mastro, S. (eds.) Societa italiana neuropsico-farmacologia Milano: 1971
Andreoli, V., Danieli, B., Tonon, G.C.: Significato dei derivati metossilati nelle psicosi da anfetamina. Riv. Farm. Ter. 4, 1a (1973)
Andreoli, V.M., Maffei, F., Tonon, G.C.: The subcellular distribution of S-Adenosyl-L-Methionine (SAMe) in the rat brain. This volume, p. 114
Antun, F.T., Burnett, G.B., Cooper, A.J., Daly, R.J., Smythies, J.R., Zealley, A.K.: The effects of L-methionine (without MAOI) in schizophrenics. J. Psychiat. Res. 8, 63, (1971).
Antun, F., Eccleston, D., Smythies, J.R.: Transmethylation processes in schizophrenia. In: Brain Chemistry and Mental Disease, New York: Plenum 1971 pp. 61–71
Axelrod, J.: Methytransferase enzyme in the metabolism of physiologically active compounds and drugs. In: Handbook of Experimental Pharmacology. Eichler, O., Farah, H., Herken, H., Welch, A.D. (eds.) New York: Springer, 1971, Vol. XXVIII/2, p. 610
Baldessarini, R.J.: Factors influencing S-adenosyl-methionine levels in mammalian tissues. In: Amines and Schizophrenia. Himwich, H., Kety, S., Smythies, J. (eds.) Oxford: Pergamon Press, (1966), pp. 198–206
Baldessarini, R.J.: Alterations in tissue levels of S-adenosylmethionine. Biochem. Pharmacol. 15, 741(1966)
Baldessarini, R.J., Kopin, I.J.: S-adenosylmethionine in brain and other tissues. J. Neurochem. 13, 769 (1966)
Colin, C.K., Dünner, D., Axelrod, J.: Reduced c at echol-O-me thy transferase activity in red cells of women with primary affective disorders. Science 170, 1323 (1970)
Deguchi, T., Barchas, J.: Inhibition of transmethylations of biogenic amines by Sadenosylhomocysteine. J. biol. Chem. 246, 3175 (1971)
Fazio, C., Andreoli, V., Agnoli, A., Casacchia, M., Cerbo, R., Pinzello, A.: Therapy of schizophrenia and depressive disorders with S-adenosyl-L-methionine. Intern. Res. Comm. System (IRCS), Clin. Pharmacol. Ther. 2, 1015 (1974)
Friedhoff, A.J.: Biogenic amines and schizophrenia. In: Biological Psychiatry. Mendels, J. (ed.) New York: Wiley, 1973, pp. 113–129
Friedhoff, A.J., Schweitzer, J.W., Miller, J.: The enzymatic formation of 3, 4, di-O-methylated dopamine metabolites by mammalian tissues. Res. Comm. Path. Pharmacol. 3, 293(1972)
Kakimoto, Y., Sano, I., Kanazawa, A., Tsujio, T., Kaneko, Z.: Metabolic effects of methionine in schizophrenic patients pretreated with a monoamine oxidase inhibitor. Nature (Lond.) 216, 1110 (1967)
Kety, S.S.: Current biochemical approaches to schizophrenia. New Engl. J. Med. 276, 325(1967)
Levi, R., Waxmann, S.: Epilepsy, cancer, and Schizophrenia. Lancet II, 11, 1975
Matthysse, S., Baldessarini, R.J.: S-adenosylmethionine and catechol-O-methyl-transferase in schizophrenia. Am. J. Psychiat. 128, 1310 (1972)
Matthysse, S., Lipinski, J., Shin, V.: L-Dopa and S-adenosylmethionine. Clin. chim. Acta 35, 253(1971)
Mendels, J., Stinnett, J.L.: Biogenic amine metabolism, depression and mania. In: Biological Psychiatry. Mendels, J. (ed.) New York: Wiley, 1973, pp. 35–64
Pollin, W., Cardon, P.V., Kety, S.S.: Effects of amino acid feeding in schizophrenic patients treated with iproniazid. Science 133, 104 (1961)
Saavedra, J.M., Axelrod, J.: Psychotomimetic N-methylated tryptamine formation in brain in vivo and in vitro. Science 175, 1365 (1972)
Wurtman, R.J., Rose, CM., Matthysse, S., Stephenson, J., Baldessarini, R.J.: L-Dihydroxyphenylalanine: effect on S-adenosylmethionine in brain. Science 169, 395 (1970)
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Andreoli, V.M., Maffei, F., Tonon, G.C. (1978). S-Adenosyl-L-Methionine (SAMe) Blood Levels in Schizophrenia and Depression. In: Andreoli, V.M., Agnoli, A., Fazio, C. (eds) Transmethylations and the Central Nervous System. Monographien aus dem Gesamtgebiete der Psychiatrie, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-88516-7_16
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DOI: https://doi.org/10.1007/978-3-642-88516-7_16
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