Abstract
The catecholamines dopamine, norepinephrine, and epinephrine are metabolized by oxidative deamination and by O-methylation. This latter pathway is catalyzed by the enzyme catechol-O-methyl-transferase (1); it utilizes S-adenosyl-methionine (SAMe) as the methyl donor (Fig. 1), and its products are, for the most part, methylated on the metahydroxyl group. The catecholamines themselves are formed within only a few specific tissues in the body (21). These include a relatively small number of brain neurons, postganglionic sympathetic neurons, adrenomedullary chromaffin cells, and interneurons within sympathetic ganglia. The catechol-amines can be O-methylated within their cells of origin, within synapses, or, after secretion into the blood stream, within the liver, kidneys, and other organs.
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References
Axelrod, J., Tomchick, R.: Enzymatic O-methylation of epinephrine and other catechols. J. biol. Chem. 233, 702 (1958)
Baldessarini, R.J.: Alterations in tissue levels of S-adenosylmethionine. Biochem. Pharmacol. 15, 741(1966)
Bartholini, G., Pletscher, A.: Cerebral accumulation and metabolism of C14-dopa after selective inhibition of peripheral decarboxylase. J. Pharmacol, exp. Ther. 161 14(1968)
Bridgers, W.F.: Serine transhydroxymethylase in developing mouse brain. J. Neurochem. 15, 1325(1968)
Broderich, D.S., Candland, K.L., North, J.A., Mangum, J.H.: The isolation of serine transhydroxymethylase from bovine brain. Arch. Biochem. 148, 196 (1972)
Calne, D.B., Karoum, F., Ruthven C.R.J., Sandler, M.: The metabolism of orally administered L-dopa in Parkinsonism. Brit. J. Pharmacol. 37, 57 (1969)
Chalmers, J.P., Baldessarini, R.J., Wurtman, R.J.: Effects of L-dopa on norepinephrine metabolism in the brain. Proc. nat. Acad. Sei. (Wash) 68, 662 (1971)
Ferrini, R., Glässer, A.: In vitro decarboxylation of new phenylalanine derivatives. Biochem. Pharmacol. 13, 798 (1964)
Finkelstein, J.D., Kyle, W.E., Harris, B.J.: Methionine metabolism in mammals. Regulation of homocysteine methyltransferase in rat tissue. Arch. Biochem. 146, 84(1971)
Langer, B.W.: Organ and intracellular location of the methionine methyl group synthesizing system of the rat. Proc. Soc. exp. Biol. (Ny.) 115, 1088 (1964)
Levitt, M., Nixon, P.F., Pincus, J.H., Bertino, J.R.: Transport characteristics of folates in cerebrospinal fluid; a study utilizing doubly labeled 5-methyltetrahydro-folate and 5-formyltetrahydrofolate. J. clin. Invest. 50, 1301 (1971)
Lytle, L.D., Hurko, O., Romero, J.A., Cottman, K., Leehey, D., Wurtman, R.J.: The effects of 6-hydroxydopamine pretreatment on the accumulation of dopa and dopamine in brain and peripheral organs following L-dopa administration. J. Neural Transm. 33, 63 (1972)
Ordonez, L.A., Wurtman, R.J.: Methylation of exogenous 3, 4-dihydroxyphenylalanine: Effects on methyl group metabolism. Biochem. Pharmacol. 22, 134 (1973a)
Ordonez, L.A., Wurtman, R.J.: Enzymes catalyzing the de novo synthesis of methyl groups in the brain and other tissues of the rat. J. Neurochem. 21, 1447 (1973b)
Ordonez, L.A., Wurtman, R.J.: Folic acid deficiency and methyl group metabolism in rat brain: Effects of L-dopa. Arch. Biochem. 160, 372 (1974)
Ordonez, L.A., Ambrus, M., Boyson, S., Goodman, M.N., Ruderman, N.B., Wurtman, R.J.: Skeletal muscle: Reservoir for exogenously administered L-dopa. J. Pharmacol., exp. Ther. 190, 187 (1974)
Pan, F., Tarver, H.: Comparative studies on methionine, selenomethionine, and their ethyl analogues as substrates for methionine adenosyltransferase from rat liver. Arch. Biochem. 119, 429 (1967)
Romero, J.A., Chalmers, J.P., Cottman, K., Lytle, L.D., Wurtman, R.J.: Regional effects of L-dihydroxyphenylalanine (L-dopa) on norepinephrine metabolism in rat brain. J. Pharmacol, exp. Ther. 180, 277 (1972)
Romero, J.A., Lytle, L.D., Ordonez, L.A., Wurtman, R.J.: Effects of L-dopa administration on the concentrations of dopa, dopamine, and norepinephrine in various rat tissues. J. Pharmacol, exp. Ther. 184, 67 (1973)
Rubin, R.A., Ordonez, L.A., Wurtman, R.J.: Physiological dependence of brain methionine and SAMe concentrations on the serum amino acid pattern. J. Neurochem. 23, 227(1974)
Wurtman, R.J.: Catecholamines. Boston: Little, Brown and Co., 1966
Wurtman, R.J., Chou, C, Rose, C: The fate of Cl4-dihydroxyphenylalanine in the whole mouse. J. Pharmacol, exp. Ther. 174, 351 (1970a)
Wurtman, R.J.: Rose, CM., Matthysse, S., Stephenson, J., Baldessarini R.J.: L-dihydroxyphenylalanine: Effect on S-adenosylmethionine in brain. Science 169, 395 (1970b)
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Wurtman, R.J., Ordonez, L.A. (1978). Effects of Exogenous L-Dopa on the Metabolism of Methionine and S-Adenosylmethionine in the Brain. In: Andreoli, V.M., Agnoli, A., Fazio, C. (eds) Transmethylations and the Central Nervous System. Monographien aus dem Gesamtgebiete der Psychiatrie, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-88516-7_14
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DOI: https://doi.org/10.1007/978-3-642-88516-7_14
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