Effects of S-Adenosyl-L-Methionine on the Behavior of Mice

  • M. Sansone
Part of the Monographien aus dem Gesamtgebiete der Psychiatrie book series (PSYCHIATRIE, volume 18)


The present work was prompted by recent clinical observations (4), in which antidepressant effects were claimed for S-adenosyl-L-methionine (SAMe). Our work was designed to explore the effects of SAMe on the behavior of experimental animals — namely, on mice treated with the substance either alone or associated with other drugs endowed with actions on the CNS. The animals were then exposed to experimental situations such as are usually implemented for the screening of psychoactive drugs. We chose this experimental design in an attempt to define the behavioral effects of SAMe in comparison with those of the tricyclic antidepressants.


Unconditional Stimulus Avoidance Response Daily Session Avoidance Learning Spontaneous Motor Activity 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • M. Sansone
    • 1
  1. 1.Laboratory of Psychobiology and PsychopharmacologyCNRRomeItaly

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