Abstract
The application of nuclear magnetic resonance (NMR) spectroscopy to the structure analysis of flavonoids is now well established. Many flavonoid aglycones, in particular isoflavones and highly methylated flavones and flavonols, are sufficiently soluble in the commonly used solvent, deuteriochloroform (CDC13) for direct NMR analysis. However, most naturally occurring flavonoids, including all of the flavonoid glycosides, have low solubility in CDC13; therefore, prior to 1964 most workers were limited to the NMR analysis of the more soluble methyl, ethyl and acetyl derivatives (see for example reference [1]). However, the signals observed for the substituent groups in these derivatives often obscure signals of other protons in the flavonoid.
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References
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Mabry, T.J., Markham, K.R., Thomas, M.B. (1970). The Determination and Interpretation of NMR Spectra of Flavonoids. In: The Systematic Identification of Flavonoids. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-88458-0_8
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DOI: https://doi.org/10.1007/978-3-642-88458-0_8
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