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The Ribosome pp 104-133 | Cite as

Stages of Translation

  • A. S. Spirin
  • L. P. Gavrilova
Part of the Molecular Biology Biochemistry and Biophysics / Molekularbiologie Biochemie und Biophysik book series (MOLECULAR, volume 4)

Abstract

In the complete protein-synthesizing system, i.e., in the presence of all the necessary components enumerated above (Section I), the ribosome performs its function of translation: synthesis of the polypeptide chain of a protein takes place, and the amino acid sequence of the chain synthesized is unambiguously determined by the nucleotide sequence of mRNA. The totality of processes carried out by the ribosome and leading ultimately to the formation of a completed polypeptide chain of a protein, can be divided into three successive stages: 1. initial association of the ribosome with the template and aminoacyl-tRNA and initiation of translation; 2. translation itself, or polymerization of amino acid residues into a polypeptide chain; 3. cessation of polymerization of the amino acid residues and release of the polypeptide chain of the protein from the ribosome, i.e., termination of translation.

Keywords

Polypeptide Chain Peptide Bond Initiation Codon Termination Codon Initial Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1969

Authors and Affiliations

  • A. S. Spirin
    • 1
  • L. P. Gavrilova
    • 1
  1. 1.A. N. Bakh Institute of Biochemistry and Institute of Protein ResearchAcademy of Sciences of the USSRMoscowUSSR

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