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Stages of Translation

  • Chapter
The Ribosome

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Abstract

In the complete protein-synthesizing system, i.e., in the presence of all the necessary components enumerated above (Section I), the ribosome performs its function of translation: synthesis of the polypeptide chain of a protein takes place, and the amino acid sequence of the chain synthesized is unambiguously determined by the nucleotide sequence of mRNA. The totality of processes carried out by the ribosome and leading ultimately to the formation of a completed polypeptide chain of a protein, can be divided into three successive stages: 1. initial association of the ribosome with the template and aminoacyl-tRNA and initiation of translation; 2. translation itself, or polymerization of amino acid residues into a polypeptide chain; 3. cessation of polymerization of the amino acid residues and release of the polypeptide chain of the protein from the ribosome, i.e., termination of translation.

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  1. A. N. Bakh Institute of Biochemistry and Institute of Protein Research, Academy of Sciences of the USSR, Moscow, USSR

    Professor Dr. A. S. Spirin & Dr. L. P. Gavrilova

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Spirin, A.S., Gavrilova, L.P. (1969). Stages of Translation. In: The Ribosome. Molecular Biology Biochemistry and Biophysics / Molekularbiologie Biochemie und Biophysik, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-88446-7_8

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