Biochemistry of the adrenocortical hormones

  • Ralph I. Dorfman
Part of the Handbuch der Experimentellen Pharmakologie book series (HEP, volume 14 / 1)

Abstract

The adrenal cortex produces a variety of steroids, some biologically active and others, by present bioassay methods, inactive. These compounds possess from 18 to 27 carbon atoms. Some of these adrenocortical steroids as well as their metabolites are present in the blood and urine, others are represented in these fluids only by their metabolites. During the past 20 years, a wealth of information gathered from isolation studies and from metabolism studies (on biosynthesis and catabolism) has so enriched our knowledge that it is now possible to draw a reasonable balance sheet between steroid production in the adrenal gland and the levels of related steroids in blood and urine. This review will be concerned with (1) the biosynthesis of adrenocortical steroids, (2) factors relating to their metabolism, and (3) the enzymes that regulate the various reactions.

Keywords

Prednisone Prednisolone Physostigmine Dehydro Borneol 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature

  1. Abelson, D., F. Ulrich and C. N. H. Loxo: Proc. Soc. exp. Biol. (N. Y.) 89, 386 (1955).Google Scholar
  2. Alexander, G. J., and E. Schwenk: Arch. Biochetu. 66, 381 (1957).CrossRefGoogle Scholar
  3. Amdur, B. H., H. Rilling and K. Bloch: J. Amer. chem. Soc. 79, 2646 (1957).CrossRefGoogle Scholar
  4. Amelung, D., H. J. Hûbener, L. Roka., G. Meyerheim: Kiln Wschr. 15, 386 (1953).CrossRefGoogle Scholar
  5. Amelung, D., H. J. Hûbener, L. Roka., G. Meyerheim: Hoppe-Seylers Z. physiol. Chem. 294, 36 (1953).CrossRefGoogle Scholar
  6. Anker, H. S., and K. Bloch: J. biol. Chem. 178, 971 (1949).PubMedGoogle Scholar
  7. Anliker, R., O. Rouis., M. Marti: Heiv. chim. Acta 39, 1100 (1956).CrossRefGoogle Scholar
  8. Anliker, R., O. Rouis., L. Ruzicka: Liebigs Ann. Chem. 603, 109 (1957).CrossRefGoogle Scholar
  9. Aprile, M., E. G. Bligh, J. L. Webb and R. D. H. Heard: Rev. canad. Biol. 15, 232 (1956–1957).Google Scholar
  10. Ashmore, J., W. H. Elliott, E. A. Doisy, JR., and E. A. Dorst: J. biol. Chem. 200, 661 (1953).PubMedGoogle Scholar
  11. Axelrod, L. R., and G. Arrayave: J. Amer. chem. Soc. 75, 5729 (1953).CrossRefGoogle Scholar
  12. Ashmore, J., and L. L. Miller: Arch. Biochem. 49, 248 (1954).CrossRefGoogle Scholar
  13. Ashmore, J., and L. L. Miller: Arch. Biochem. 60, 373 (1956).CrossRefGoogle Scholar
  14. Ashmore, J., and L. L. Miller, and F. Herling: J. biol. Chem. 219, 455 (1956).Google Scholar
  15. Ayres, P. J., R. P. Gould, S. A. S. Simpson and J. F. Tait: Biochem. J. 63, 19 (1956).Google Scholar
  16. Ayres, P. J., O. Rechter, N. Saba, S. A. Simpson and J. F. Tait: Biochem. J. 65, 22P (1957a).Google Scholar
  17. Ayres, P. J., O. Garrod, S. A. S. Tait, J. F. Tait, G. Walker and W. H. Pearlman: Ciba Found. Coll. Endocrin. 11, 309 (1957b).Google Scholar
  18. Baggett, B., L. L. Engel, L. Balderas, G. Lansan, K. Savard and R. I. Dorfman: Endocrinology 64, 600 (1959).PubMedCrossRefGoogle Scholar
  19. Barry, M. C., M. L. Eidinoff, K. Dobriner and T. F. Gallagher: Endocrinology 50, 587 (1952).PubMedCrossRefGoogle Scholar
  20. Bartter, F. C.: Recent Progr. Hormone Res. 12, 187 (1956).Google Scholar
  21. Bauld, W. L., and R. D. H. Heard: In: G. Pincus and K. V. Thimann, Eds., The hormones, Vol. I, 620. New York: Academic Press 1948.Google Scholar
  22. Beall, D.: Nature (Lond.) 144, 76 (1939).CrossRefGoogle Scholar
  23. Beall, D.: J. Endocr. 2, 81 (1940).CrossRefGoogle Scholar
  24. Beall, D., and T. ReichsteIn: Nature (Lond.) 142, 479 (1938).CrossRefGoogle Scholar
  25. Beer, C. T., and T. F. Gallagher: J. biol. Chem. 214, 335 (1955).PubMedGoogle Scholar
  26. Benirschke, K., E. Bloch and A. T. Hertig: Endocrinology 58, 598 (1956).PubMedCrossRefGoogle Scholar
  27. Bergstrom, S., and A. Norman: Proc. Soc. exp. Biol. (N. Y.) 83, 71 (1953).Google Scholar
  28. Bergstrom, S., and J. Sjövall: Acta chem. scand. 8, 611 (1954).CrossRefGoogle Scholar
  29. Bergstrom, S., M. Rottenberg., J. Sjövall: Hoppe-Seylers Z. physiol. Chem. 295, 278 (1953).PubMedCrossRefGoogle Scholar
  30. Bergstrom, S., J. Sjövall and J. Voltz: Acta physiol. scand. 30, 22 (1953).PubMedCrossRefGoogle Scholar
  31. Bergstrom, S., K. Pääbo, K. and J. A. Rumpf: Acta chem. scand. 8, 1109 (1954).Google Scholar
  32. Berliner, D. L., and T. F. Dougherty: Fed. Proc. 17, 189 (1958a).Google Scholar
  33. Berliner, D. L., and T. F. Dougherty: Proc. Soc. exp. Biol. (N. Y.) 98, 3 (1958b).Google Scholar
  34. Berliner, D. L., J. E. Jones and H. A. Salhanick: J. biol. Chem. 223, 1043 (1956).PubMedGoogle Scholar
  35. Beyer, K. F., and L. T. Samuels: J. biol. Chem. 219, 69 (1956).PubMedGoogle Scholar
  36. Biggs, M. W., R. M. Lemmon and F. T. Pierce, JR.: Arch. Biochem. 51, 155 (1954).PubMedCrossRefGoogle Scholar
  37. Birke, G., and L. O. PlantIn: Acta med. scand. 146, 184 (1953).PubMedCrossRefGoogle Scholar
  38. Birmingham, M. K., and E. Kurlents: Endocrinology 62, 47 (1958).PubMedCrossRefGoogle Scholar
  39. Birmingham, M. K., F. H. Elliot and P. H. L. Valere: Endocrinology 53, 6867 (1953).CrossRefGoogle Scholar
  40. Blecher, M., and S. GurIn: J. biol. Chem. 209, 953 (1954).PubMedGoogle Scholar
  41. Bleiberg, M. J., and P. S. Larson: J Pharmacol. 121, 421 (1957).Google Scholar
  42. Bligh, E. G., R. D. H. Heard, V. J. O’donnell, J. L. Webb, M. Saffran and E. Schonbaum: Arch. Biochem. 58, 249 (1955).PubMedCrossRefGoogle Scholar
  43. Bloch, E., R. I. Dorfman and G. Pincus: Proc. Soc. exp. Biol. (N. Y.) 85, 106 (1954).Google Scholar
  44. Bloch, E., K. Benirschke and R. I. Dorfman: J. clin. Endocr. 15, 379 (1955).CrossRefGoogle Scholar
  45. Bloch, E., R. I. Dorfman and G. Pincus: Arch. Biochem. 61, 245 (1956a).PubMedCrossRefGoogle Scholar
  46. Bloch, E., R. I. Dorfman and G. Pincus: J. biol. Chem. 224, 737 (1957).PubMedGoogle Scholar
  47. Bloch, E., G. Pincus and R. I. Dorfman: Fed. Proc. 15, 222 (1956b).Google Scholar
  48. Bloch, K.: J. biol. Chem. 155, 255 (1944).Google Scholar
  49. Bloch, K.: J. biol. Chem. 157, 661 (1945).Google Scholar
  50. Bloch, K.: Recent Progr. Hormone Res. 6, 111 (1951).Google Scholar
  51. Bloch, K.: Heiv. chim. Acta 36, 1611 (1953).CrossRefGoogle Scholar
  52. Bloch, K.: Harvey Lect. 48, 68 (1954).Google Scholar
  53. Bloch, K.: Vitam. and Horm. 15, 119 (1957).CrossRefGoogle Scholar
  54. Bloch, K., and D. Rittenberg: J. biol. Chem. 145, 625 (1942).Google Scholar
  55. Bloch, K., and D. Rittenberg: J. biol. Chem. 155, 243 (1944).Google Scholar
  56. Bloch, K., B. N. Berg and D. Rittenberg: J. biol. Chem. 149, 511 (1943).Google Scholar
  57. Bloch, K., B. N. Berg and D. Rittenberg: J. biol. Chem. 162, 441 (1945).Google Scholar
  58. Bloch, K., E. Borer and D. Rittenberg: J. biol. Chem. 162, 441 (1946).PubMedGoogle Scholar
  59. Bloch, K., C. Clark and I. Harary: J. biol. Chem. 211, 687 (1954).PubMedGoogle Scholar
  60. Bloom, B. M., and G. M. Skull: J. Amer. chem. Soc. 77, 5767 (1955).CrossRefGoogle Scholar
  61. M. Hayano, A. Saito, D. Stone and R. I. Dorfman: Fed. Proc. 15, 222 (1956).Google Scholar
  62. Bondy, P. K., and J. R. Altrock: J. clin. Invest. 32, 703 (1953).PubMedCrossRefGoogle Scholar
  63. Bongiovanni, A. M., and W. R. EberleIn: Proc. Soc. exp. Biol. (N. Y.) 89, 281 (1955a).Google Scholar
  64. Bongiovanni, A. M., and W. R. EberleIn: Pediatrics 16, 628 (1955b).PubMedGoogle Scholar
  65. Bongiovanni, A. M., and W. R. Eberlein, M. M. Grumbach, J. J. Van Wyk and G. Clayton: Proc. Soc. exp. Biol. (N. Y.) 87, 282 (1954).Google Scholar
  66. Bonner, J., and B. ArreguIn: Arch. Biochem. 21, 109 (1949).PubMedGoogle Scholar
  67. Borell, U.: Acta endocrin. (Kbh.) 17, 13 (1954).Google Scholar
  68. Borok, E., and D. Rittenberg: J. biol. Chem. 179, 843 (1949).Google Scholar
  69. Borth, R., M. Gesell and H. DE Watteville: Acta endocrin. (Kbh.) 14, 316 (1953).Google Scholar
  70. Bradlow, H. L., and T. F. Gallagher: J. biol. Chem. 229, 505 (1957).PubMedGoogle Scholar
  71. Bradlow, H. L., L. Hellman, B. Zumoff and T. F. Gallagher: Science 124, 1206 (1956).PubMedCrossRefGoogle Scholar
  72. Bradlow, H. L., L. Hellman, B. Zumoff and T. F. Gallagher: Proc. 40th Meeting Endocrine Society, p. 23, (1958).Google Scholar
  73. Brady, R. O., and S. GurIn: J. biol. Chem. 186, 461 (1950).PubMedGoogle Scholar
  74. Brady, R. O., and S. GurIn: J. biol. Chem. 189, 371 (1951).PubMedGoogle Scholar
  75. Briggs, F. N., and W. Toepel: Endocrinology 62, 24 (1958).PubMedCrossRefGoogle Scholar
  76. Brooks, R. V., and W. Klyne: Biochem. J. 62, 21P (1956).Google Scholar
  77. Brooks, R. V., and F. T. G. Prunty: J. Endocr. 15, 385 (1951).CrossRefGoogle Scholar
  78. Brooksbank, B. W. L., and G. A. D. Haslewood: Biochem. J. 44, 111 (1949).Google Scholar
  79. Brown, H., D. C. Willardson, L. T. Samuels and F. H. Tyler: J. clin. Invest. 33, 1524 (1954).PubMedCrossRefGoogle Scholar
  80. Brown, J. B., and G. F. Marrian: J. Endocr. 15, 307 (1957).PubMedCrossRefGoogle Scholar
  81. Brown, J. H. U., J. Griffin and R. B. Smith: Metabolism 4, 542 (1955).PubMedGoogle Scholar
  82. Brownie, A. C., J. K. Grant and D. W. Davidson: Biochem. J. 58, 218 (1954).PubMedGoogle Scholar
  83. Bucher, N. L. R.: J. Amer. chem. Soc. 75, 498 (1953).CrossRefGoogle Scholar
  84. Bucher, N. L. R., and K. Mcgarrahan: J biol. Chem. 222, 1 (1956).PubMedGoogle Scholar
  85. Bulbrook, R. D., and F. C. Greenwood: Brit. med. J. 1957, 662.Google Scholar
  86. Bulbrook, R. D., and F. C. Greenwood, and P. C. Williams: In: Endocrine aspects of breast cancer, p. 181. London: E. and S. Livingstone 1958.Google Scholar
  87. Burstein, S.: Endocrinology 50, 412 (1952).PubMedCrossRefGoogle Scholar
  88. Burstein, S.: J. Amer. chem. Soc. 7S, 1769 (1956).CrossRefGoogle Scholar
  89. Burstein, S., and R. I. Dorfman: J. biol. Chem. 213, 581 (1955).PubMedGoogle Scholar
  90. Burstein, S., and R. I. Dorfman: Unpublished (1958).Google Scholar
  91. Burstein, S., and E. M. Nadel: Fed. Proc. 15, 228 (1956).Google Scholar
  92. Burstein, S., K. Savard and R. I. Dorfman: Endocrinology 52, 448 (1953a).PubMedCrossRefGoogle Scholar
  93. Burstein, S., K. Savard and R. I. Dorfman: Endocrinology 53, 267 (1953b).PubMedCrossRefGoogle Scholar
  94. Burstein, S., R. I. Dorfman and E. M. Nadel: Fed. Proc. 13, 188 (1954a).Google Scholar
  95. Burstein, S., R. I. Dorfman and E. M. Nadel: Arch. Biochem. 53, 307 (1954b).PubMedCrossRefGoogle Scholar
  96. Burstein, S., F. Ungar, M. Gut and R. I. Dorfman: Endocrinology 56, 267 (1955).PubMedCrossRefGoogle Scholar
  97. Burton, R. B., E. H. Keutmann and C. Waterhouse: J. clin. Endocr. 13, 48 (1953).PubMedCrossRefGoogle Scholar
  98. Bush, I. E.: Ciba Found. Coll. Endocrin. 7, 210 (1953a).Google Scholar
  99. Bush, I. E.: J. Endocr. 9, 95 (1953b).PubMedCrossRefGoogle Scholar
  100. Bush, I. E.: Biochem. J. 62, 16P (1956a).Google Scholar
  101. Bush, I. E.: Experientia (Basel) 12, 325 (1956b).CrossRefGoogle Scholar
  102. Bush, I. E.: Biochem. J. 66, 28 (1957).Google Scholar
  103. Bush, I. E., and M. Willoughby: Biochem. J. 67, 689 (1957).PubMedGoogle Scholar
  104. Butenandt, A.: Naturwissenschaften 17, 878 (1929).CrossRefGoogle Scholar
  105. Butenandt, A.: Z. angew. Chem. 44, 905 (1931).CrossRefGoogle Scholar
  106. Butenandt, A.: Z. angew. Chem. 45, 655 (1932).Google Scholar
  107. Butenandt, A.: Dtsch. med. Wschr. 61, 823 (1935).CrossRefGoogle Scholar
  108. Butenandt, A., and., Westphal: Hoppe-Seylers Z. physiol. Chem. 67, 1140 (1934).Google Scholar
  109. Butler, G. C., and G. F. Marrian: J. biol. Chem. 119, 565 (1937).Google Scholar
  110. Callow, N. H.: Biochem. J. 33, 559 (1939).PubMedGoogle Scholar
  111. Callow, N. H., and R. K. Callow: Biochem. J. 33, 931 (1939).PubMedGoogle Scholar
  112. Callow, N. H., and R. K. Callow: Biochem. J. 34, 276 (1940).PubMedGoogle Scholar
  113. Carstensen, H.: Acta chem. scand. 10, 474 (1956).CrossRefGoogle Scholar
  114. Caspi, E.: Transformation products resulting from cortisone and cortisol perfusion through rat livers. Doctoral Thesis, Clark Univ., Worcester, Mass. (1955).Google Scholar
  115. Caspi, E., and J. R. Bergen: Arch. Biochem. 59, 207 (1955).PubMedCrossRefGoogle Scholar
  116. Caspi, E., and J. R. Bergen, and O. Rechter: Arch. Biochem. 52, 478 (1954).PubMedCrossRefGoogle Scholar
  117. Caspi, E., and J. R. Bergen: Arch. Biochem. 61, 299 (1956).PubMedCrossRefGoogle Scholar
  118. Caspi, E., and J. R. Bergen, and M. M. Pechet: Arch. Biochem. 68, 236 (1957).PubMedCrossRefGoogle Scholar
  119. Caspi, E., and J. R. Bergen: J. biol. Chem. 230, 843 (1958).PubMedGoogle Scholar
  120. Caspi, E., G. Rosenfeld and R. I. Dorfman: J. org. Chem. 21, 814 (1956a).CrossRefGoogle Scholar
  121. Caspi, E., M. C. Lindberg, M. Hayano, J. L. Cohen, M. Matsuba, H. Rosenkrant and R. I. Dorfman: Arch. Biochem. 61, 267 (1956b).PubMedCrossRefGoogle Scholar
  122. Caspi, E., F. Ungar and R. I. Dorfman: J. org. Chem. 22, 326 (1957).CrossRefGoogle Scholar
  123. Channon, H. J.: Biochem. J. 20, 400 (1926).PubMedGoogle Scholar
  124. Chart, J. J., H. Sheppard, M. J. Allen, W. L. Bencze and R. Gaunt: Experientia (Basel) 14, 151 (1958).CrossRefGoogle Scholar
  125. Chemama, R.,E. E. Baulieu, O. Crepy and M. F. Jayle: C. R. Soc. Biol. (Paris) 151, 454 (1957).Google Scholar
  126. Chen, P. S., jr., H. P. Schedl, G. Rosenfeld and F. C. Bartter: Proc. Soc. exp. Biol. (N. Y.) 97, 683 (1958).Google Scholar
  127. Chester Jones, I., J. G. Phillips and W. N. Holmes: In: A. Gorbman, Ed., Comparative endocrinology, p. 582. New York: Wiley 1959.Google Scholar
  128. Clark, L. C., JR., C. D. Kochakian and J. Lobotsky: J. biol. Chem. 171, 493 (1947).PubMedGoogle Scholar
  129. Clayton, R. B., and K. Bloch: Fed. Proc. 14, 194 (1955).Google Scholar
  130. Clayton, R. B., and K. Bloch: J. biol. Chem. 218, 305 (1956a).PubMedGoogle Scholar
  131. Clayton, R. B., and K. Bloch: J. biol. Chem. 218, 319 (1956b).PubMedGoogle Scholar
  132. Clayton, R. E., J. E. Hammant and P. Armitage: J. Endocr. 15, 284 (1957).PubMedCrossRefGoogle Scholar
  133. Cook, R. P., A. Kliman and L. F. Fieser: Arch. Biochem. 52, 439 (1954).PubMedCrossRefGoogle Scholar
  134. Cooper, D. Y., J. C. Touchstone and J. M. Roberts: Fed. Proc. 14, 196 (1955).Google Scholar
  135. Cooper, D. Y., M. Kasparow, W. S. Blakemore and O. Rosenthal: Fed. Proc. 17, 205 (1958).Google Scholar
  136. Cooper, D. Y., Cope, C. L., and E. G. Black: Brit. med. J. 1958 1, 1020.CrossRefGoogle Scholar
  137. Cooper, D. Y., Cope, C. L.: Clin. Sci. 17, 147 (1958b).Google Scholar
  138. Cooper, D. Y., and B. Hurlock: Clin. Sci. 13, 69 (1954).Google Scholar
  139. Cooper, D. Y., and C. E. Sewell: Ann. rheum. Dis. 14, 392 (1956).Google Scholar
  140. Cornforth, J. W., and G. Popjak: Biochem. J. 58, 403 (1954).PubMedGoogle Scholar
  141. Cornforth, J. W., and G. Popjak, G. D. Hunter and G. Popjak: Biochem. J. 54, 590, 597 (1953).PubMedGoogle Scholar
  142. Cornforth, J. W., G. Popjak and I. Y. Gore: In: Biochemical problems of lipids, p. 216. London: Butter-worth’s Scientific Publications 1956.Google Scholar
  143. Cornforth, J. W., I. Y. Gore and G. Popjak: Biochem. J. 65, 94 (1957a).PubMedGoogle Scholar
  144. Cornforth, J. W., R. H. Cornforth, G. Popjak and I. Youhotsky-Gore: Biochem. J. 66, 10P (1957b).Google Scholar
  145. Cornforth, J. W., R. H. Cornforth, G. Popjak and I. Youhotsky-Gore: Biochem. J. 69, 146 (1958).PubMedGoogle Scholar
  146. Cox, R. I., and G. F. MARRIAN: Biochem. J. 54, 353 (1953).PubMedGoogle Scholar
  147. Curran, G. L.: J. biol. Chem. 191, 775 (1951).PubMedGoogle Scholar
  148. Curran, G. L., and D. Rittenberg: J. biol. Chem. 190, 17 (1951).PubMedGoogle Scholar
  149. Dauben, W. G., and T. W. Hutton: J. Amer. chem. Soc. 78, 2647 (1956).CrossRefGoogle Scholar
  150. Dauben, W. G., and K. H. Takemura: J. Amer. chem. Soc. 75, 6302 (1953).CrossRefGoogle Scholar
  151. Davidson, A. G., E. G. Dulit and I. D. Frantz, JR.: Fed. Proc. 16, 169 (1957).Google Scholar
  152. Decourcy, D., and J. J. Schneider: Chem. and Ind. 1956, 315.Google Scholar
  153. De Meio, R. H., and C. Lewycka: Endocrinology 56, 489 (1955).CrossRefGoogle Scholar
  154. De Meio, R. H., and C. Lewycka, and M. Wizerkaniuk: Fed. Proc. 15, 241 (1956).Google Scholar
  155. Deulofeu, V., and J. Ferrari: Z physiol. Chem. 226, 192 (1934).CrossRefGoogle Scholar
  156. Diczfalusy, E., and R. Luft: Acta endocr. (Kbh.) 21, 321 (1956).Google Scholar
  157. G. Birke, C. Franksson, J. Hellstrom, S. Hultberg, L. O. Plantin and A. Westman: In: Endocrine aspects of breast cancer, p. 186. London: E. and S. Livingstone, Ltd. 1958.Google Scholar
  158. Dingemanse, E., S. E. Dejongh, S. Kober and E. Laqueur: Dtsch. med. Wschr. 56, 301 (1930).CrossRefGoogle Scholar
  159. Dingemanse, E., E. Laqueur and O. Muhlboch: Nature (Lond.) 141, 927 (1938).CrossRefGoogle Scholar
  160. Dituri, F., F. Cobey, J. V. B. Warms and S. GurIn: Fed. Proc. 14, 203 (1955).Google Scholar
  161. Dituri, F., F. Cobey, J. V. B. Warms and S. GurIn: J. biol. Chem. 221, 181 (1956).PubMedGoogle Scholar
  162. Djerassi, C., L. B. High, J. Fried and E. F. Sabo: J. Amer. chem. Soc. 77, 3673 (1955).CrossRefGoogle Scholar
  163. Dobriner, K.: Steroids in experimental and clinical practice, p. 130. Philadelphia: Blakiston 1951.Google Scholar
  164. Dobriner, K., and S. Lieberman: Ciba Found. Coll. Endocrin. 2, 381 (1952).Google Scholar
  165. Dobriner, K., C. P. Rhoads, S. Lieberman, B. R. HILL and L. F. FIESER: Science 99, 494 (1944).PubMedCrossRefGoogle Scholar
  166. Dobriner, K., E. R. Katzenellenbogen and R. Schneider: Arch. Biochem. 48, 167 (1954).PubMedCrossRefGoogle Scholar
  167. Dobson, R. M., A. H. Goldkamp and R. D. Muir: J. Amer. chem. Soc. 79, 3921 (1937).Google Scholar
  168. Dohan, F. C., J. C. Touchstone and E. M. Richardson: J. clin. Invest. 34, 485 (1955).PubMedCrossRefGoogle Scholar
  169. Doisy, E. A., C. D. Veler and S. A. Thayer: Amer. J. Physiol. 90, 329 (1929).Google Scholar
  170. Doisy, E. A., S. A. Thayer, L. Levin and J. M. Curtis: Proc. Soc. exp. Biol. (N. Y.) 28, 88 (1930).Google Scholar
  171. Doisy, E. A., Done, A. K., R. S. Ely, L. R. Heiselt and V. C. Kelley: Proc. Soc. exp. Biol. (N. Y.) 83, 722 (1953).Google Scholar
  172. Doisy, E. A., Done, A. K., L. J. Olsen and V. C. Kelley: Metabolism 4, 416 (1955).Google Scholar
  173. Dorfman, R. I.: Recent Progr. Hormone Res. 9, 5 (1954a).Google Scholar
  174. Dorfman, R. I.: J. clin. Endocr. 14, 318 (1954b).PubMedCrossRefGoogle Scholar
  175. Dorfman, R. I.: In: G. Pincus and K. V. Thimann, Eds. The hormones, Vol. III, p. 589. New York: Academic Press 1955.Google Scholar
  176. Dorfman, R. I.: Amer. J. Med. 21, 679 (1956).PubMedCrossRefGoogle Scholar
  177. Dorfman, R. I.: Cancer Res. 17, 535 (1957a).PubMedGoogle Scholar
  178. Dorfman, R. I.: Ann. Rev. Biochem. 26, 523 (1957b).PubMedCrossRefGoogle Scholar
  179. Dorfman, R. I., and J. B. Hamilton: J biol. Chem. 133, 753 (1940).Google Scholar
  180. Dorfman, R. I., and F. Ungar: Metabolism of steroid hormones. Minneapolis: Burgess 1953.Google Scholar
  181. Dorfman, R. I., J. W. Cook and J. B. Hamilton: J. biol. Chem. 130, 285 (1939).Google Scholar
  182. Dorfman, R. I., J. Wise and G. Van Wagenen: Endocrinology 36, 347 (1945).CrossRefGoogle Scholar
  183. Dorfman, R. I., J. Wise and R. A. Shipley: Endocrinology 42, 81 (1948).PubMedCrossRefGoogle Scholar
  184. Dorfman, R. I., J. Wise and R. A. Shipley: Endocrinology 46, 127 (1950).PubMedCrossRefGoogle Scholar
  185. Dorfman, R. I., M. Hayano, R. Haynes and K. Savard: Ciba Found. Coll. Endocrin. 7, 191 (1953)Google Scholar
  186. Dougherty, T. F., H. E. Brown and D. L. Berliner: Endocrinology 62, 455 (1958).PubMedCrossRefGoogle Scholar
  187. Douglas, J. F., and C. G. King: J. biol. Chem. 198, 187 (1952).PubMedGoogle Scholar
  188. Dowben, R. M., and J. Rabinowitz: Nature (Lond.) 178, 696 (1956).CrossRefGoogle Scholar
  189. Dulaney, E. L., E. O. Stapley and C. Hlavac: Mycologia 47, 464 (1955).CrossRefGoogle Scholar
  190. Dumm, M. E., H. Gerschberg, E. M. Beck and E. P. Ralli: Proc. Soc. exp. Biol. (N. Y.) 82 659 (1953).Google Scholar
  191. Dutton, G. J., and I. D. E. Storey: Biochem. J. 57, 275 (1954).PubMedGoogle Scholar
  192. Eades, H. C., jr., R. L. Pollack and J. S. King, JR.: Fed. Proc. 13, 201 (1954).Google Scholar
  193. Eberlein, W. R., and A. M. Bongiovanni: J. biol. Chem. 223, 85 (1956).PubMedGoogle Scholar
  194. Eichhorn, J., and O. Rechter: Proc. Soc. exp. Biol. (N. Y.) 95, 311 (1957).Google Scholar
  195. Eichhorn, J., and O. Rechter: Proc. Soc. exp. Biol. (N. Y.) 97, 614 (1958).Google Scholar
  196. Eidinoff, M. L., R. S. Rosenfeld, J. E. Knoll, B. J. Marano and L. Hellman: J clin. Invest. 33, 333 (1954).PubMedCrossRefGoogle Scholar
  197. Entnes, K., J. A. Schellmann, R. Lumry and L. T. Samuels: J. biol. Chem. 206, 411 (1954).Google Scholar
  198. Entnes, K., D. A. Demetriou, Y. C. Mayne and R. S. Jones: Proc. Soc. exp. Biol. (N. Y.) 96, 409 (1957).Google Scholar
  199. Eisenberg, F., and S. GurIn: J. biol. Chem. 195, 317 (1952).PubMedGoogle Scholar
  200. Eisenstein, A. B.: Proc. Soc. exp. Biol. (N. Y.) 83, 27 (1953).Google Scholar
  201. Eisenstein, A. B.: Endocrinology 60, 298 (1957).PubMedCrossRefGoogle Scholar
  202. Eisenstein, A. B., and A. S. Wenneker: Proc. Soc. exp. Biol. (N. Y.) 97, 844 (1958).Google Scholar
  203. Elliott, F. H., and A. V. Schally: Canad. J. Biochem. 33, 174 (1955).PubMedCrossRefGoogle Scholar
  204. Ely, R. S., A. K. Done and V. C. Kelley: Proc. Soc. exp. Biol. (N. Y.) 91, 503 (1956).Google Scholar
  205. Engel, L. A., G. W. Thorn and R. A. Lewis: J. biol. Chem. 137, 205 (1941).Google Scholar
  206. Engel, L. A., W. R. Slaunwhite, JR., P. Carter and I. T. Nathanson: J. biol. Chem. 185, 255 (1950).PubMedGoogle Scholar
  207. Engel, L. A., R. Wilson, W. R. Slaunwhite, JR., P. Carter, P. C. Olmsted and I. T. Nathanson: Ciba Found. Coll. Endocrin. 2, 104 (1952).Google Scholar
  208. Engel, L. A., R. I. Dorfman and A. R. Abarbanel: J. clin. Endocr. 8, 903 (1953).CrossRefGoogle Scholar
  209. Engel, L. A., P. Carter and L. L. Fielding: J. biol. Chem. 213, 99 (1955).PubMedGoogle Scholar
  210. Engel, L. A., B. Baggett and P. Carter: Endocrinology 61, 113 (1957).PubMedCrossRefGoogle Scholar
  211. Eppstein, S. H., P. D. Meister, D. H. Peterson, H. C. Murray, H. M. Leigh Osborne, D. A. Lyttle, L. M. Reineke and A. Weintraub: J. Amer. Chem. Soc. 75, 408 (1953a).CrossRefGoogle Scholar
  212. Eppstein, S. H., D. H. Peterson, H. M. Leigh Osborne, H. C. Murray, A. Weintraub, L. M. Reineke and P. D. Meister: J. Amer. chem. Soc. 75, 421 (1953b).CrossRefGoogle Scholar
  213. Eppstein, S. H., P. D. Meister, D. H. Peterson, H. C. Murray, L. M. Reineke and A. Weintraub: J. Amer. chem. Soc. 76, 3174 (1954).CrossRefGoogle Scholar
  214. Eppstein, S. H., P. D. Meister, H. C. Murray and D. H. Peterson: Microbiological transformations of steroids and their applications to the synthesis of hormones. Vitam. and Horm. 14, 359 (1956).CrossRefGoogle Scholar
  215. Euw, J. v., and T. ReichsteIn: Helv. chim. Acta 24, 879 (1941).CrossRefGoogle Scholar
  216. Euw, J. v., and T. ReichsteIn: Helv. chim. Acta 25, 988 (1942).CrossRefGoogle Scholar
  217. Farrell, G. L., E. W. Rauschkolb, P. C. Royce and H. Hirschmann: PrOC. SOC. exp. Biol. (N. Y.) 87, 587 (1954).Google Scholar
  218. Farrell, G. L., Amer. J. Physiol. 182, 269 (1955).PubMedGoogle Scholar
  219. Farrell, G. L., R. C. Banks and S. Koletsky: Endocrinology 58, 104 (1956).PubMedCrossRefGoogle Scholar
  220. Fazekas, I. G.: J. Endocrin. 15, 440 (1957).CrossRefGoogle Scholar
  221. Fidanza, A., A. De Clcco and L. Eposito: Boll. Soc. ital. Biol. sper. 33, 940 (1957a).Google Scholar
  222. Fidanza, A., G. Carvina and A. DE Clcco: Bull. Soc. ital. Biol. sper. 33, 942 (1957b).Google Scholar
  223. Fieser, L. F.: The chemistry of natural products related to phenanthrene, New York: Reinhold 2nd Ed. 1937.Google Scholar
  224. Finkelstein, M., J. vox Euw and T. ReichsteIn: Rely. chim. Acta 36, 1266 (1953).CrossRefGoogle Scholar
  225. Fish, C. A., M. Hayano and G. Pincus: Arch. Biochem. 42, 480 (1953).PubMedCrossRefGoogle Scholar
  226. Fish, W. R., and R. I. Dorfman: Science 91, 388 (1940a).PubMedCrossRefGoogle Scholar
  227. Fish, W. R., and R. I. Dorfman: J. biol. Chem. 135, 349 (1940b).Google Scholar
  228. Fish, W. R., and R. I. Dorfman: J. biol. Chem. 140, 83 (1941).Google Scholar
  229. Fish, W. R., and R. I. Dorfman: J. biol. Chem. 143, 15 (1942).Google Scholar
  230. Fish, W. R., B. N. Horwitt and R. I. Dorfman: Science 97, 227 (1943).PubMedCrossRefGoogle Scholar
  231. Forbes, T. R., and J. Zander: Recent Progr. Hormone Res. 13, 379 (1956).Google Scholar
  232. Forchielli, E., and R. I. Dorfman: J. biol. Chem. 223, 443 (1956).PubMedGoogle Scholar
  233. Forchielli, E., H. Rosenkrantz and R. I. Dorfman: J. biol. Chem. 215, 713 (1955).PubMedGoogle Scholar
  234. Forchielli, E., K. Brown-Grant and R. I. Dorfman: Steroid 44-hydrogenases of rat liver. Proc. Soc. exp. Biol. (N. Y.) 99, 594 (1958).Google Scholar
  235. Fotherby, K.: Biochem. J. 67, 705 (1957).Google Scholar
  236. Fotherby, K., A. Colas, S. M. Atherden and G. F. Marrian: Biochem. J. 66, 664 (1957).PubMedGoogle Scholar
  237. Franksson, C., C. A. Gemzell and., S. Von Euler: J. clin. Endocr. 14, 608 (1954).PubMedCrossRefGoogle Scholar
  238. Frantz, I. D., JR., and N. L. R. Bucher: J. biol. Chem. 206, 471 (1954).PubMedGoogle Scholar
  239. Fredrickson, D. S., R. E. Peterson and D. Steinberg: Science 127, 704 (1958).PubMedCrossRefGoogle Scholar
  240. Fried, J., and E. F. Sabo: J. Amer. them. Soc. 75, 2273 (1953).CrossRefGoogle Scholar
  241. Fried, J., R. W. Thoma, J. R. Gerke, J. E. Herz, M. N. Donin and D. Perlman: J. Amer. them. Soc. 74, 3962 (1952).CrossRefGoogle Scholar
  242. Fried, J., D. Perlman, J. E. Herz and A. Borman: Recent Progr. Hormone Res. 11, 157 (1955).Google Scholar
  243. Fukushima, D. K., and T. F. Gallagher: J. biol. Chem. 226, 725 (1957a).PubMedGoogle Scholar
  244. Fukushima, D. K., and T. F. Gallagher: J. biol. Chem. 229, 85 (1957b).PubMedGoogle Scholar
  245. Fukushima, D. K., K. Dobriner and T. F. Gallagher: J. biol. Chem. 206, 845 (1954a).PubMedGoogle Scholar
  246. Fukushima, D. K., H. L. Bradlow, K. Dobriner and T. F. Gallagher: J. biol. Chem. 206, 863 (1954b).PubMedGoogle Scholar
  247. Fukushima, D. K., A. D. Kemp, R. Schneider, M. B. Stokem and T. F. Gallagher: J. biol. Chem. 210, 129 (1954c).PubMedGoogle Scholar
  248. Fukushima, D. K., N. S. Leeds, H. L. Bradlow, T. H. Kritchevsky, M. B. Stokem and T. F. Gallagher: J. biol. Chem. 212, 449 (1955).PubMedGoogle Scholar
  249. Fukushima, D. K., C. D. Meyer, E. Ashworth and T. F. Gallagher: Fed. Proc. 15, 257 (1956).Google Scholar
  250. Gallagher, T. F.: Cancer Res. 17, 520 (1957).PubMedGoogle Scholar
  251. Fukushima, D. K., D. K. Fukushima, M. C. Barry and K. Dobriner: Recent Progr. Hormone Res. 6, 131 (1951).Google Scholar
  252. Fukushima, D. K., A. Kappas, H. Spencer and D. Lazlo: Science 124, 487 (1956).Google Scholar
  253. Ganis, F. M., and M. Radakovich: Fed. Proc. 17, 226 (1958).Google Scholar
  254. Ganis, F. M., L. R. Axelrod and L. L. Miller: J. biol. Chem. 218, 841. (1956).PubMedGoogle Scholar
  255. Gardner, L. I., and A. A. Tice: Heiv. paediat. Acta 12, 147 (1957).Google Scholar
  256. Gautschi, F., and K. Bloch: J. Amer. chem. Soc. 79, 684 (1.957).Google Scholar
  257. Gemzell, C. A.: Acta endocr. (Kbh.) 11, 221 (1952).Google Scholar
  258. Geyer, G.: Verh. d. Ges. inn. Med. 62, 476 (1956).Google Scholar
  259. Girond, C. J. P., M. Saffran, A. V. Schally, J. Stachenko and E. H. Yenning: PTOC. SOC exp. Biol. (N. Y.) 92, 855 (1956).Google Scholar
  260. Girond, C. J. P., J. Stachenko and P. Piletta: In: A. F. Muller and C. M. O’conner, Eds., Aldosterone. Boston: Little, Brown 1958.Google Scholar
  261. Glick, J. H., JR.: Endocrinology 60, 368 (1957).PubMedCrossRefGoogle Scholar
  262. Gold, N. I., E. Singleton, D. A. Macfarlane and F. D. Moore: J. clin. Invest. 37, 813 (1958).PubMedCrossRefGoogle Scholar
  263. Goldstein, M., M. Gut and R. I. Dorfman: Biochim. biophys. Acta 38, 190 (1960).PubMedCrossRefGoogle Scholar
  264. Gomez-Maestro, D. V.: Acta ginec. (Mad.) 2, 573 (1951).Google Scholar
  265. Gomez-Mont, F., and D. Berliner: Gac. méd. Méx. 83, 413 (1953).PubMedGoogle Scholar
  266. Gould, R. G.: In: R. P. Cook, Ed., Cholesterol, chemistry, biochemistry and pathology, 209–235. New York: Academic Press 1958.Google Scholar
  267. Gould, R. G., and G. Porjaic: Biochem, J. 66, 51P (1057).Google Scholar
  268. Gray, C. L., and F. Bischoff: Amer. J. Physic)“ 10, 279 (1955).Google Scholar
  269. Gray, C. L., M. A. S. Green, J. J. Holness and J. B. Lunnon: Lancet 1955 11, 1067.CrossRefGoogle Scholar
  270. Gray, C. L., M. A. S. Green, J. J. Holness and J. B. Lunnon: J. Endocr. 14, 146 (1956).PubMedCrossRefGoogle Scholar
  271. Greenwood, F. C., and R. D. Bulbrook: J. Endocr. 13, XX: X III (1956).Google Scholar
  272. De Hachen, D. P.C.: Rev. Soc. argent. Biol. 32, 23 (1956).Google Scholar
  273. Hagopian, M.: An in vitro study of estrogen metabolism. Master of Science Thesis, Clark University, Worcester, Mass. (1955).Google Scholar
  274. Hagopian, M., and L. Levy: Biochim. biophys. Acta. 30, 641 (1958).Google Scholar
  275. Haines, W. J.: Recent Progr. Hormone Res. 7, 255 (1952).Google Scholar
  276. Halkerston, I. D. K., J. Hillman, D. Palmer and A. Rundle: J. Endocr. 13, 433 (1956).PubMedCrossRefGoogle Scholar
  277. Hardy, J. D., and M. D. Turner: Amer. J. Med. 22, 967 (1957).CrossRefGoogle Scholar
  278. Harman, R. E., E. A. Ham, J. Deyoung, N. G. Brink and L. H. Sarett: J. Amer. them. Soc. 76, 5035 (1954).CrossRefGoogle Scholar
  279. Hartmann, M., and F. Locher: Rely. chim. Acta 18, 160 (1935).CrossRefGoogle Scholar
  280. Haussler, E. P.: Holy. chim. Acta 17, 531 (1934).CrossRefGoogle Scholar
  281. Hayano, M., and R. I. Dorfman: Arch. Biochem. 36, 237 (1952).PubMedCrossRefGoogle Scholar
  282. Hayano, M., and R. I. Dorfman: J. biol. Chem. 201, 175 (1953).PubMedGoogle Scholar
  283. Hayano, M., and R. I. Dorfman: Arch. Biochem. 50, 218 (1954).PubMedCrossRefGoogle Scholar
  284. Hayano, M., and R. I. Dorfman: Arch. Biochem. 55, 289 (1955).PubMedCrossRefGoogle Scholar
  285. Hayano, M., M. C. Lindberg, M. Wiener, H. Rosenkrantz and R. I. Dorfman. Endocrinology 55, 326 (1954).PubMedCrossRefGoogle Scholar
  286. Hayano, M., M. C. Lindberg, R. I. Dorfman, J. E. H. Hancock and W. vox E. Doering: Arch. Biochem. 59, 529 (1955).PubMedCrossRefGoogle Scholar
  287. Hayano, M., N. Saba, R. I. Dorfman and O. Hechter: Recent Progr. Hormone Res. 12, 79 (1956a).PubMedGoogle Scholar
  288. Hayano, M., A. Saito, D. Stone and R. I. Dorfman: Biochim. biophys. Acta 21, 380 (1956b).Google Scholar
  289. Hayano, M., M. Gut, R. I. Dorfmian, O. K. Sebek and D. H. Peterson: J. Amer. them. Soc. 80, 2336 (1958).CrossRefGoogle Scholar
  290. Haydar, N. A, J C Laidlaw, W. J. Reddy and G. W. Thorn: J. clin. Endocr. 15, 858 (1955).Google Scholar
  291. Haynes, R. C., JR.: Fed. Proc. 17, 376 (1958).Google Scholar
  292. Haynes, R. C., JR., and L. Berthet: J. biol. Chem. 225, 115 (1957).PubMedGoogle Scholar
  293. Haynes, R. C., JR., K. Savard and R. I. Dorfman: J. clin. Endocr. 12, 972 (1952).Google Scholar
  294. Haynes, R. C., JR., K. Savard and R. I. Dorfman: J. biol. Chem. 207, 925 (1954).PubMedGoogle Scholar
  295. Haynes, R. C., S. Koritz and F. Peron: J. biol. Chem. 234, 1421 (1959).PubMedGoogle Scholar
  296. Heard, R. D. H., and M. M. Hoffman: J. biol. Chem. 138, 651 (1941a).Google Scholar
  297. Heard, R. D. H., and M. M. Hoffman: J. biol. Chem. 141, 329 (1941b).Google Scholar
  298. Heard, R. D. H., and A. F. Mckay: J. biol. Chem. 131, 371 (1939).Google Scholar
  299. Heard, R. D. H., W. S. Bauld and M. M. Hoffman: J. biol. Chem. 141, 709 (1941).Google Scholar
  300. Heard, R. D. H., M. M. Hoffman and G. E. Mack: J. biol. Chem. 155, 607 (1944).Google Scholar
  301. Heard, R. D. H., P. H. Jellinck and V. J. O’donnell: Endocrinology 57, 200 (1955).PubMedCrossRefGoogle Scholar
  302. Heard, R. D. H., E. G. Blich, M. C. Cann, P. H. Jellinck, V. J. O’donnell, B. G. Rao and J. L. Webb: Recent Progr. Hormone Res. 12, 45 (1956).PubMedGoogle Scholar
  303. Hechter, O.: Biogenesis of adrenal cortical hormones. In: E. Ralli, Ed., Trans. 3rd Macy Conference on Adrenal Cortex, 115. 1951.Google Scholar
  304. Hechter, O.: Ciba Found. Coll. Endocr. 7, 161 (1953).Google Scholar
  305. Hechter, O.: In: R. P. Cook, Ed., Cholesterol, chemistry, biochemistry and pathology, 309–347. New York: Academic Press 1958.Google Scholar
  306. Hechter, O., R. P. Jacobsen, R. W. Jeanloz, H. Levy, C. W. Marshall, G. Pincus and V. J. Schenker: J. Amer. them. Soc. 71, 3261 (1949).CrossRefGoogle Scholar
  307. Hechter, O., V. Schenker and G. PINcus: Prog. 118th Meet. Amer. them. Soc., 29C (1950).Google Scholar
  308. Hechter, O., A. Zaffaroni, R. P. Jacobsen, H. Levy, R. W. Jeanloz, V. Schenker and G. Pincus: Recent Progr. Hormone Res. 6, 215 (1951).Google Scholar
  309. Hellman, L., R. S. Rosenfeld and T. F. Gallagher: J. clin. Invest. 33, 142 (1954a).PubMedCrossRefGoogle Scholar
  310. Hellman, L., H. L. Bradlow, J. Adesman, D. K. Fukushima, J. L. Kulp and T. F. Gallagher: J. clin. Invest. 33, 1106 (1954b).PubMedCrossRefGoogle Scholar
  311. Henry, R., M. Therenet and P. Jarrige: Bull. Soc. chim. Biol. 34, 897 (1952).PubMedGoogle Scholar
  312. Hernando, L., J. Crabbé, E. J. Ross, W. J. Reddy, A. E. Renold, D. H. Nelson and G. W. Thorn: Metabolism 6, 518 (1957).PubMedGoogle Scholar
  313. Hertz, R., W. Tullner and M. J. Allen: Proc. Soc. exp. Biol. (N. Y.) 77, 480 (1951).Google Scholar
  314. Hertz, R., W. Tullner, J. A. Shricker, F. G. Dhyse and L. F. Hallman: Recent Progr. Hormone Res. 11, 119 (1955).Google Scholar
  315. Hertz, R., J. A. Pittman and M. M. Graff: J. clin. Endocr. 16, 705 (1956).PubMedCrossRefGoogle Scholar
  316. Herzog, H. L., A. Nobile, S. Tolksdorf, W. Charney, E. B. Hershberg, P. L. Perlman and M. M. Pechet: Science 121, 176 (1955).PubMedCrossRefGoogle Scholar
  317. Hirschmann, H.: J. biol. Chem. 136, 483 (1940).Google Scholar
  318. Hirschmann, H.: J. biol. Chem. 150, 363 (1943).Google Scholar
  319. Hirschmann, H., and F. Hirschmann: J. biol. Chem. 157, 601 (1945).Google Scholar
  320. Hirschmann, H.: J. biol. Chem. 167, 7 (1947).PubMedGoogle Scholar
  321. Hirschmann, H.: Fed. Proc. 8, 206 (1949).Google Scholar
  322. Hirschmann, H., and F. Hirschmann: J. biol. Chem. 187, 137 (1950).PubMedGoogle Scholar
  323. Hirschmann, H., and O. Wintersteiner: J. biol. Chem. 122, 303 (1937/1938).Google Scholar
  324. Hoffman, M. M., V. E. Kazmin and J. S. L. Browne: J. biol. Chem. 147, 259 (1943).Google Scholar
  325. Hoffman, M. N., and M. H. Lott: J. Amer. them. Soc. 73, 878 (1951).CrossRefGoogle Scholar
  326. Holness, N. J., J. B. Lunnon and C. H. Gray: J. Endocr. 14, 138 (1956).PubMedCrossRefGoogle Scholar
  327. Holtz, A. H.: Nature (Lond.) 174, 316 (1954).CrossRefGoogle Scholar
  328. Holzbauer, M.: J. Physiol. (Lond.) 139, 306 (1957).Google Scholar
  329. Holzbauer, M, and M. Vogt: J. Physiol. (Lond.) 138, 460 (1957).Google Scholar
  330. Horwitt, B. N., R. I. Dorfman, R. A. Shipley and W. R. Fish: J. biol. Chem. 155, 213 (1944).Google Scholar
  331. Hubener, H. J.: Recent Progr. Hormone Res. 12, 146 (1956).Google Scholar
  332. Hubener, H. J., D. K. Fukushima and T. F. Gallagher: J. biol. Chem. 220, 499 (1956).PubMedGoogle Scholar
  333. Hudson, P. B., and M. E. Lombardo: J. clin. Endocr. 15, 324 (1955).PubMedCrossRefGoogle Scholar
  334. Huis In’t Veld, L. G., and E. Dingemanse: Acta brew. neerl. Physiol. 16, 9 (1948).Google Scholar
  335. Hume, D. M., and D. H. Nelson: Personal communication (1958).Google Scholar
  336. Ingle, D. J., D. F. Beary and A. Purmalis: Endocrinology 53, 221 (1953).PubMedCrossRefGoogle Scholar
  337. Ishizuka, N., M Maeyama, T. Ide and M. Kawata: Med. J. Osaka Univ. 7, 953 (1957)Google Scholar
  338. Ishizuka, N., M Maeyama, T. Ide and M. Kawata: Chem. Abstr. 52, 2116 (1958).Google Scholar
  339. Isselbacher, K. J.: Recent Progr. Hormone Res. 12, 134 (1956).PubMedGoogle Scholar
  340. Isselbacher, K. J., and J. Axelrod: J. Amer. them. Soc. 77, 1070 (1955).CrossRefGoogle Scholar
  341. Jailer, J. W., J. J. Gold, R. Vande Wiele and S. Lieberman: J. clin. Invest. 34, 1639 (1955).PubMedCrossRefGoogle Scholar
  342. Jayle, M. F., L. G. Huis In’t Veld, E. Baulieu and O. Crepy: Acta endocr. (Kbh.) 21, 115 (1956).Google Scholar
  343. Jeanloz, R. W., H. Levy, R. P. Jacobsen, O. Rechter, V. Schenker and G. Pincus: The chemical transformations of progesterone by adrenal perfusion. Abst. 118th Meeting Amer. them. Soc., Chicago, Ill. p. 29 C (1950).Google Scholar
  344. Jeanloz, R. W.: J. biol. Chem. 203, 453 (1953).PubMedGoogle Scholar
  345. Johnson, B. B., A. H. Liebermann and P. J. Mulrow: J. clin. Invest. 36, 757 (1957).PubMedCrossRefGoogle Scholar
  346. Johnson, D. F., E. Heftmann and J. J. Bunim: Proc. Soc. exp. Biol. (N. Y.) 94, 291 (1957).Google Scholar
  347. Johnson, J. E., jr., A. R. Remmers, G. W. Clayton and R. Gregory: Texas Rep. Biol. Med. 15, 381 (1957).Google Scholar
  348. Johnson, R. H., and W. J. Haines: Science 116, 456 (1952).PubMedCrossRefGoogle Scholar
  349. Johnston, J. D., and K. Bloch: J. Amer. chem. Soc. 79, 1145 (1957).CrossRefGoogle Scholar
  350. De Jongh, S. E., S. Kober and E. Laqueur: Biochem. Z. 240, 247 (1931).Google Scholar
  351. Kahnt, F. W., C. Meystre, R. Neher, E. Vischer and A. WettsteIn: Experientia (Basel) 8, 422 (1952).CrossRefGoogle Scholar
  352. Kahnt, F. W., R. Neher and A. WettsteIn: Rely. shim. Acta 38, 1237 (1955a).Google Scholar
  353. Kahnt, F. W., R. Neher and A. WettsteIn: Experientia (Basel) 11, 446 (1955b).CrossRefGoogle Scholar
  354. Karrer, P.: Organic chemistry. Amsterdam: Elsevier 1938.Google Scholar
  355. Keller, M.: J. clin. Endocr. 16, 1075 (1956).PubMedCrossRefGoogle Scholar
  356. Kemp, A. D., A. Kappas, I. L Salamon, F. Herling and T. F. Gallagher: J. biol. Chem. 210, 123 (1954).PubMedGoogle Scholar
  357. Klein, R., C. Papadatos, J. Furtunato and C. Byers: J. clin. Endocr. 15, 215 (1955a).PubMedCrossRefGoogle Scholar
  358. Klein, R., C. Papadatos, J. Furtunato and C. Byers: J. clin. Endocr. 15, 943 (1955b).PubMedCrossRefGoogle Scholar
  359. Klein, R., J. Fortunato, Z. Laron and C. Papadatos: J. clin. Endocr. 17, 256 (1957).PubMedCrossRefGoogle Scholar
  360. Klopper, A., J. A. Strong and L. R. Cook: J. Endocr. 15, 180 (1957).PubMedCrossRefGoogle Scholar
  361. Knowlton, A. I.: Med. Clin. N. Amer. 1952, 721.Google Scholar
  362. Koch, F. C.: Physiol. Rev. 17, 153 (1937).Google Scholar
  363. Korenchevsky, V., and M. Dennison: J. Path. Bact. 41, 323 (1935).CrossRefGoogle Scholar
  364. Koritz, S. B., and F. G. Peron: J. biol. Chem. 230, 343 (1958).PubMedGoogle Scholar
  365. Koritz, S. B., and F. G. Peron, and R. I. Dorfman: J. biol. Chem. 226, 643 (1957).PubMedGoogle Scholar
  366. Kraychy, S., and T. F. Gallagher: J. Amer. chem. Soc. 79, 754 (1957a).CrossRefGoogle Scholar
  367. Kraychy, S., and T. F. Gallagher: J. biol. Chem. 229, 519 (1957b).PubMedGoogle Scholar
  368. Kritchevsky, D., and I. Gray: Experientia (Basel) 7, 183 (1951).CrossRefGoogle Scholar
  369. Kuizenga, M. H. and G. F. Cartland: Endocrinology 24, 526 (1939).CrossRefGoogle Scholar
  370. Kuizenga, M. H. and G. F. Cartland: Endocrinology 27, 647 (1940).CrossRefGoogle Scholar
  371. Kushinsky, S.: The isolation of products from bovine adrenal perfusion with progesterone and progesterone-4-C’4. Doctoral Thesis, Boston University, Boston, Mass. (1955).Google Scholar
  372. Lamedica, G., and G. Missale: Arch. E. Maragliano Pat. Clin. 13, 257 (1957)Google Scholar
  373. Lamedica, G., and G. Missale: Chem. Abstr. 51, 13, 226 (1957).Google Scholar
  374. Lamedica, G., L. Correale and R. Bonanni: Arch. Stud. Fisiopat. Ricambio 21, 41 (1957).Google Scholar
  375. Lamedica, G., Langdon, R. G., and K. Bloch: J. Amer. chem. Soc. 74, 1869 (1952).CrossRefGoogle Scholar
  376. Lamedica, G., Langdon, R. G.: J. biol. Chem. 200, 135 (1953a).Google Scholar
  377. Lamedica, G., Langdon, R. G.: J. biol. Chem. 200, 129 (1953b).Google Scholar
  378. Larson, P. S., G. R. Hennigar, J. K. Finnegan, R. B. J. Smith and H. B. Haag: J. Pharmacol. exp. Ther. 115, 408 (1955).PubMedGoogle Scholar
  379. Ledogar, J. A., and H. W. Jones. JR.: Science 112, 536 (1953).CrossRefGoogle Scholar
  380. Levin, L.: J. biol. Chem. 158, 725 (1945).Google Scholar
  381. Levitz, M., J. R. Spitzer and G. H. Twombly: J. biol. Chem. 222, 981 (1956).PubMedGoogle Scholar
  382. Levy, H., and S. Kushinsky: Arch. Biochem. 55, 290 (1955).PubMedCrossRefGoogle Scholar
  383. Levy, H., R. W. Jeanloz, R. P. Jacobsen, O. Hechter, V. Schenker and G.Pincus: Proc. 118th Meeting Amer. chem. Soc. p. 29C (1950).Google Scholar
  384. Levy, H., R. W. Jeanloz, C. W. Marshall, R. P. Jacobsen, O. Rechter, V. Schenker and G. Pincus: J. biol. Chem. 203, 433 (1953).PubMedGoogle Scholar
  385. Levy, H., R. W. Jeanloz, R. P. Jacobsen, O. Hechter, V. Schenker and G. Pincus: J. biol. Chem. 211, 867 (1954).PubMedGoogle Scholar
  386. Levy, L. K., M. Hagopian and C. A. Fish: Private communication (1958).Google Scholar
  387. Liddle, G. W., F. C. Bartter, L. E. Duncan, JR., J. K. Barber and C. Delea: J. clin. Invest. 34, 949 (1955).CrossRefGoogle Scholar
  388. Lieberman, S., and K. Dobriner: J. biol. Chem. 166, 773 (1946).PubMedGoogle Scholar
  389. Lieberman, S., and K. Dobriner: RECENT Progr. Hormone Res. 3, 71 (1948).Google Scholar
  390. Lieberman, S., and K. Dobriner: Proc. Amer. them. Soc. 117th Meeting, p. 19C (1950).Google Scholar
  391. Lieberman, S., and K. Dobriner, B. R. Hill, L. L. Fieser, and C. P. Rhoads: J. biol. Chem. 172, 263 (1948).PubMedGoogle Scholar
  392. Lieberman, S., D. K. Fukushima and K. Dobriner: J. biol. Chem. 182, 299 (1950).Google Scholar
  393. Lieberman, S., B. Praetz, P. Humphries and K. Dobriner: J. biol. Chem. 204, 491 (1953).PubMedGoogle Scholar
  394. Lipschitz, W. L., and E. Bueding: J. biol. Chem. 129, 333 (1939).Google Scholar
  395. Little, B., and E. Rossi: J. clin. Endocr. 61, 109 (1957).Google Scholar
  396. Llaurado, J. G., R. Neher and A. WettsteIn: Clin. chim. Acta 1, 236 (1956).PubMedCrossRefGoogle Scholar
  397. Lore, K. H., and G. F. Marrian: Biochim. biophys. Acta 27, 213 (1958).CrossRefGoogle Scholar
  398. Lombardo, M. E., and P. B. Hudson: J. biol. Chem. 229, 181 (1957).PubMedGoogle Scholar
  399. Lombardo, M. E., E. Rorrman and P. B. Hudson: J. clin. Endocr. 16, 1283 (1956).CrossRefGoogle Scholar
  400. Long, C. N. H.: Recent Progr. Hormone Res. 1, 99 (1947).PubMedGoogle Scholar
  401. Longwell, B. B., A. E. Reif, E. Hansbury and H. S. Baker: Fed. Proc. 14, 246 (1955).Google Scholar
  402. Longwell, B. B., A. E. Reif, E. Hansbury: Fed. Proc. 15, 303 (1956).Google Scholar
  403. Luetscher, J. A., JR.: Recent Progr. Hormone Res. 12, 175 (1956).Google Scholar
  404. Luetscher, J. A., and B. J. Axelrad: Proc. Soc. exp. Biol. (N. Y.) 87, 650 (1954).Google Scholar
  405. Luetscher, J. A., R. Neher and A. WettsteIn: Experientia (Basel) 10, 456 (1954).CrossRefGoogle Scholar
  406. Luetscher, J. A., R. Neher and A. WettsteIn: Experientia (Basel) 12, 22 (1956).CrossRefGoogle Scholar
  407. Lynn, W. S., JR.: Fed. Proc. 15, 305 (1956).Google Scholar
  408. Lynn, W. S., and R. Brown: Biochim. biophys. Acta 21, 403 (1956).Google Scholar
  409. Lynn, W. S., E. Staple and S. GurIn: J. Amer. them. Soc. 76, 4048 (1954).CrossRefGoogle Scholar
  410. Lynn, W. S., E. Staple and S. GurIn: Fed. Proc. 14, 783 (1955).PubMedGoogle Scholar
  411. Lyon, I., R. P. Geyer and L. D. Marshall: J. biol. Chem. 217, 757 (1956).Google Scholar
  412. Mach, R. S., and A. F. Muller: Schweiz. med. Wschr. 87, 406 (1957).PubMedGoogle Scholar
  413. Majnarich, J. J., and R. N. Dillon: Arch. Biochem 49, 247 (1954).PubMedCrossRefGoogle Scholar
  414. Mallassis, D., E. E. Baulieu, S. Weinmann, O. Crepy and M. F. Jayle: C. R. Soc. Biol. (Paris) 151, 447 (1957).Google Scholar
  415. Mancera, O., A. Zaffaroni, B. A. Rubin, F. Sondheimer, G. Rosenkranz and C. Djerassi: J. Amer them. Soc. 74, 3711 (1952).CrossRefGoogle Scholar
  416. Mann, K. M., F. R. Hanson and P. W. O’connell: Fed. Proc. 14, 251 (1955a).Google Scholar
  417. Mann, K. M., F. R. Hanson and P. W. O’connell, H. Anderson, M. P. Brunner and J. N. Karnemaat: Appl. Microbiol. 3, 14 (1955b).PubMedGoogle Scholar
  418. Marcus, P. I., and P. Talalay: J biol. Chem. 218, 661 (1956).PubMedGoogle Scholar
  419. Marker, R. E.: J. Amer. them. Soc. 60, 2442 (1938a).CrossRefGoogle Scholar
  420. Marker, R. E.: J. Amer. chem. Soc. 60, 2931 (1938b).CrossRefGoogle Scholar
  421. Marker, R. E.: J. Amer. chem. Soc. 61, 944 (1939a).CrossRefGoogle Scholar
  422. Marker, R. E.: J. Amer. chem. Soc. 61, 1287 (1939b).CrossRefGoogle Scholar
  423. Marker, R. E., and O. Kamm: J Amer. chem. Soc. 59, 1373 (1937).CrossRefGoogle Scholar
  424. Marker, R. E., and E. J. Lawson: J. Amer. chem. Soc. 60, 2928 (1938).CrossRefGoogle Scholar
  425. Marker, R. E., and E. Rohrmann: J. Amer. chem. Soc. 60, 1565 (1938).CrossRefGoogle Scholar
  426. Marker, R. E., and E. Rohrmann: J. Amer. chem. Soc. 61, 2719 (1939a).CrossRefGoogle Scholar
  427. Marker, R. E., and E. Rohrmann: J. Amer. chem. Soc. 61, 3476 (1939b).CrossRefGoogle Scholar
  428. Marker, R. E., O. Kamm and R. V. Mcgrew: J. Amer. chem. Soc. 59, 616 (1937).CrossRefGoogle Scholar
  429. E. J. Lawson, E. L. Wittle and H. M. Crooks: J. Amer. chem. Soc. 60, 1559 (1938).CrossRefGoogle Scholar
  430. Marks, B. H., M. Alpert and F. A. Kruger: Endocrinology 63, 75 (1958).PubMedCrossRefGoogle Scholar
  431. Marrian, G. F.: Biochem. J. 23, 1090 (1929).PubMedGoogle Scholar
  432. Marrian, G. F.: J. Soc. chem. Ind. (Lond.) 49, 515 (1930).Google Scholar
  433. Marrian, G. F.: Nature (Lond.) 154, 19 (1944).CrossRefGoogle Scholar
  434. Marrian, G. F., and W. S. Bauld: Biochem. J. 59, 136 (1955).PubMedGoogle Scholar
  435. Marrian, G. F., K. H. Lake, E. J. D. Watson and M. Panattoni: Biochem. J. 66, 60 (1957).PubMedGoogle Scholar
  436. Mason, H. L.: J. biol. Chem. 172, 783 (1948).PubMedGoogle Scholar
  437. Mason, H. L., and E. J. Kepler: J. biol. Chem. 160, 255 (1945a).Google Scholar
  438. Mason, H. L., and E. J. Kepler: J. biol. Chem. 161, 235 (1945b).PubMedGoogle Scholar
  439. Mason, H. L., and E. J. Kepler: J. biol. Chem. 167, 73 (1947).PubMedGoogle Scholar
  440. Mason, H. L., and J. J. Schneider: J. biol. Chem. 184, 593 (1950).PubMedGoogle Scholar
  441. Mason, H. L., and H. S. Strickler: J. biol. Chem. 171, 543 (1947).PubMedGoogle Scholar
  442. Mason, H. L., C. S. Meyers and E. C. Kendall: J. biol. Chem. 114, 613 (1936).Google Scholar
  443. Mason, H. L., W. M. Hoehn, B. F. Mckenzie and E. C. Kendall: J. biol. Chem. 120, 719 (1937).Google Scholar
  444. Mason, H. L., and E. C. Kendall: J. biol. Chem. 124, 459 (1938).Google Scholar
  445. Mattox, V. R.: Proc. Mayo Clin. 30, 180 (1955).Google Scholar
  446. Mattox, V. R., and H. L. Mason: J. biol. Chem. 223, 215 (1956).PubMedGoogle Scholar
  447. Mayer, C.: Ann. Endocr. (Paris) 13, 675 (1952).Google Scholar
  448. Mccullagh, E. P., and H. A. Tretbar: J. clin. Endocr. 18, 134 (1958).PubMedCrossRefGoogle Scholar
  449. Mcginty, D. A., G. N. Smith, M. L. Wilson and C. S. Worrel: Science 112, 506 (1950).PubMedCrossRefGoogle Scholar
  450. Meister, P. D., S. H. Eppstein, D. H. Peterson, H. C. Murray, H. M. Leigh, A. Weintraub and L. M. Reineke: Abst. 123rd Meeting Amer. Chem. Soc., Los Angeles, Calif., p. 5C (1953a).Google Scholar
  451. Meister, P. D., D. H. Peterson, H. C. Murray, S. H. Eppstein, L. M. Reineke, A. Weintraub and H. M. Leigh: J. Amer. them. Soc. 75, 55 (1953b).CrossRefGoogle Scholar
  452. Meister, P. D., D. H. Peterson, H. C. Murray, G. B. Spero, S. H. Eppstein, A. Weintraub, L. M. Reineke and H. M. Leigh: J. Amer. them. Soc. 75, 416 (1953c).CrossRefGoogle Scholar
  453. Meister, P. D., L. M. Reineke, R. C. Meeks, H. C. Murray, S. H. Eppstein, H. M. L. Osborn, A. Weintraub and D. H. Peterson: J. Amer. them. Soc. 76, 4050 (1954).CrossRefGoogle Scholar
  454. Meyer, A. S.: Private communication (1952).Google Scholar
  455. Meyer, A. S.: Biochim. biophys. Acta 24, 1435 (1955a).Google Scholar
  456. Meyer, A. S.: Experientia (Basel) 11, 99 (1955b).CrossRefGoogle Scholar
  457. Meyer, A. S., R. W. Jeanloz and G. Pincus: J. biol. Chem. 203, 463 (1953).PubMedGoogle Scholar
  458. Meyer, A. S., O. G. Rodgers and G. PINcus: Acta endocr. (Kbh.) 16, 293 (1954).Google Scholar
  459. Meyer, A. S., M. Hayano, M. C. Lindberg, M. Gut and O. G. Rodgers: Acta endocr. (Kbh.) 18, 148 (1955).Google Scholar
  460. Meystre, C., E. Vischer and A. WettsteIn: Rely. chim. Acta 37, 1548 (1954).CrossRefGoogle Scholar
  461. Meystre, C., E. Vischer and A. WettsteIn: Helv. shim. Acta 38, 381 (1955).CrossRefGoogle Scholar
  462. Miceon, C. J.: J. biol. Chem. 218, 941 (1956).Google Scholar
  463. Miceon, C. J., and J. E. Plager: J. biol. Chem. 209, 767 (1954).Google Scholar
  464. Miceon, C. J., J. Bertrand, P. E. Wall, R. S. Stempfel and H. Prystowsky: Ciba Found. Coll. Endocrin. 11, 338 (1957).Google Scholar
  465. Miller, A. M., and R. I. Dorfman: Endocrinology 42, 174 (1949).CrossRefGoogle Scholar
  466. Miller, A. M., and R. I. Dorfman, and M. Miller: Endocrinology 46, 105 (1950).PubMedCrossRefGoogle Scholar
  467. Miller, A. M., and R. I. Dorfman, and E. H. Sevringhaus: Endocrinology 38, 19 (1946).PubMedCrossRefGoogle Scholar
  468. Miller, A. M., H. Rosenkrantz and R. I. Dorfman: Endocrinology 53, 238 (1953).PubMedCrossRefGoogle Scholar
  469. Miller, L. L., and L. R. Axelrod: Metabolism 3, 438 (1954)Google Scholar
  470. Mills, G. T., R. Ondarza and E. E. B. Smith: Biochim biophys. Acta 14, 159 (1954).Google Scholar
  471. Moxham, A., and J. D. N. Nabarro: J. clin. Pathol. 9, 351 (1956).PubMedCrossRefGoogle Scholar
  472. Mueller, G. C., and G. Rumney: J. Amer. them. Soc. 79, 1004 (1957).CrossRefGoogle Scholar
  473. Munson, P L, T F Gallagher and F. C. Koch: J. biol. Chem. 152, 67 (1944).Google Scholar
  474. Murray, H. C., and D. H. Peterson: S. Patent 2, 602, 769 July 8 (1952).Google Scholar
  475. Murray, H. C., and D. H. Peterson: S. Patent 2, 649, 400 (1953a).Google Scholar
  476. Murray, H. C., and D. H. Peterson: S. Patent 2, 649, 402 (1953b).Google Scholar
  477. Murray, H. C., and D. H. Peterson: S. Patent 2, 702, 809 (1955a).Google Scholar
  478. Murray, H. C., and D. H. Peterson: S. Patent 2, 703, 326 (1955b).Google Scholar
  479. Murray, H. C., and D. H. Peterson: S. Patent 2, 703, 806 (1955c).Google Scholar
  480. Nadel, E. M., and S. BursteIn: J. nat. Cancer Inst. 17, 213 (1956).PubMedGoogle Scholar
  481. Nadel, E. M., and J. J. Schneider: Endocrinology 51, 5 (1952).PubMedCrossRefGoogle Scholar
  482. Nadel, E. M., S. Burstein and R. I. Dorfman: Arch. Biochem. 61, 144 (1956).PubMedCrossRefGoogle Scholar
  483. Nerer, R., and A. WettsteIn: Helv. chim. Acta 39, 2062 (1956).CrossRefGoogle Scholar
  484. Nelson, A. A., and G. Woodward: Arch. Path. (Chicago) 48, 387 (1949).Google Scholar
  485. Nichols, J., and L. I. Gardner: J. Lab. clin. Med. 37, 229 (1951).PubMedGoogle Scholar
  486. Nichols, J., and G. Hennigar: Endocrinology 61, 226 (1957).PubMedCrossRefGoogle Scholar
  487. Nichols, J., and H. L. Sheehan: Endocrinology 51, 362 (1952).PubMedCrossRefGoogle Scholar
  488. Nichols, J., C. Davis and H. D. Green: Endocrinology 53, 541 (1953).PubMedCrossRefGoogle Scholar
  489. N1colaides, N., O. K. Reess and R. G. Langdon: J. Amer, them. Soc. 77, 1535 (1955)CrossRefGoogle Scholar
  490. Nishikawa, M., and H. Hagiwara: Chem. pharm. Bull. 6, 226 (1958).PubMedCrossRefGoogle Scholar
  491. O’donnell, P. W., K M Mann, E. D. Nielson and F. R. Hansen: Appl. Microbiol. 3, 16 (1955).Google Scholar
  492. Oertel, G. W., and K. Eik-Nee: Fed. Proc. 17, 400 (1958a).Google Scholar
  493. Oertel, G. W., and K. Eik-Nee: Acta endocr. (Kbh.) 28, 293 (1958b).Google Scholar
  494. Okinaka, S., K. Nakao, M. Nishikawa, M. Ikeda and H. Ibayashi: Tôhoku J. exp. Med. 56 153 (1952).PubMedCrossRefGoogle Scholar
  495. Olson, J. A., and K. Bloch: Fed. Proc. 15, 323 (1956).Google Scholar
  496. Oppenauer, R.: Z. physiol. Chem. 270, 97 (1941).CrossRefGoogle Scholar
  497. Paschkis, K. E., A. Cantarow, A. E. Rakoff, L. Hansen and A. A. Walking: Proc. Soc. exp. Biol. (N. Y.) 55, 127 (1954).Google Scholar
  498. Pearlman, W. H.: Endocrinology 30, 270 (1942).CrossRefGoogle Scholar
  499. Pearlman, W. H., and R. H. DE Meio: J. biol. Chem. 179, 1141 (1949).PubMedGoogle Scholar
  500. Pearlman, W. H., and G. Pincus: J. biol. Chem. 144, 569 (1942).Google Scholar
  501. Pearlman, W. H., and G. Pincus, and N. T. Werthessen: J. biol. Chem. 142, 649 (1942).Google Scholar
  502. Pearlman, W. H., A. E. Rakoff, K. E. Paschkis, A. Cantarow and A. A. Walkling: J biol. Chem. 173, 175 (1948).PubMedGoogle Scholar
  503. Pederson, R. L., J. A. Campbell, J. C. Babcock, S. H. Eppstein, H. C. Murray, A. Weintraub, R. C. Meeks, L. M. Meister, L. M. Reineke and D. H. Peterson: J. Amer. them. Soc. 78, 1512 (1956).CrossRefGoogle Scholar
  504. Peruvian, D., E. Titus and J. Fried: J. Amer. chem. Soc. 74, 2126 (1952).Google Scholar
  505. Peruvian, D., E. O’brien, A. P. Bayan and R. B. Greenfield, JR.: J. Bact. 69, 347 (1955).CrossRefGoogle Scholar
  506. Peron, F., and R. I. Dorfman: J. biol. Chem. 223, 877 (1956).PubMedGoogle Scholar
  507. Peron, F., and R. I. Dorfman: Arch. Biochem. 67, 490 (1957).PubMedCrossRefGoogle Scholar
  508. Peron, F., and S. B. Koritz: J. biol. Chem. 223, 256 (1958).Google Scholar
  509. Peterson, D. H.: In: S. A. Waksman, Ed., Perspectives and horizons in microbiology, p. 121. New Brunswick, N. J.: Rutgers Univ. Press 1955.Google Scholar
  510. Peterson, D. H, and H. C. Murray: J. Amer. chem. Soc. 74, 1871 (1952).CrossRefGoogle Scholar
  511. Peterson, D. H, and H. C. Murray, S. H. Eppstein, L. M. Reineke, A. Weintraub, P D Meister and H. M. Leigh: J. Amer. chem. Soc. 74, 5933 (1952).CrossRefGoogle Scholar
  512. Peterson, D. H, S. H. Eppstein, P. D. Meister, B. J. Magerlein, H. C. Murray, H. M. Leigh, A. Weintraub and L. M. Reineke: J. Amer. them. Soc. 75, 412 (1953a).CrossRefGoogle Scholar
  513. Peterson, D. H, A. H. Nathan, P. D. Meister, S. H. Eppstein, H. C. Murray, A. Weintraub, L. M. Reineke and H. M. Leigh: J. Amer. them. Soc. 75, 419 (1953b).CrossRefGoogle Scholar
  514. Peterson, D. H, P. D. Meister, A. Weintraub, L. M. Reineke, S. H. Eppstein, H. C. Murray and H. M. L. OSBORN: J. Amer. them. Soc. 77, 4428 (1955).CrossRefGoogle Scholar
  515. Peterson, R. E., and J. B. Wyngaarden: Ann. N. Y. Acad. Sci. 61, 297 (1955).CrossRefGoogle Scholar
  516. Peterson, R. E., and J. B. Wyngaarden: J. clin. Invest. 35, 552 (1956).PubMedCrossRefGoogle Scholar
  517. Peterson, R. E., R. Hertz and H. A. Lubs: Proc. Soc. exp. Biol. (N. Y.) 94, 421 (1957a).Google Scholar
  518. Peterson, R. E., C. E. Pierce and B. Kliman: Arch. Biochem. 70, 614 (1957b).PubMedCrossRefGoogle Scholar
  519. Peterson, R. E., C. E. Pierce and B. Kliman: Personal communication (1958).Google Scholar
  520. Pfiffner, J. J., and H. B. North: J. biol. Chem. 132, 459 (1940).Google Scholar
  521. Pfiffner, J. J., and H. B. North: J. biol. Chem. 139, 855 (1941).Google Scholar
  522. Picha, G. M., F. J. Saunders and D. M. Green: Science 115, 704 (1952).PubMedCrossRefGoogle Scholar
  523. Pincus, G.: The biosynthesis of adrenal steroids. In: P. Kallos, Ed., Progress in allergy, Vol. IV, 199–226. Basel-New York: Karrer 1954.CrossRefGoogle Scholar
  524. Pincus, G., and E. B. Romanoff: Ciba Found. Coll. Endocrin. 8, 97 (1955).Google Scholar
  525. Plager, J. E., and L. T. Samuels: Fed. Proc. 11, 383 (1952).Google Scholar
  526. Plager, J. E., and L. T. Samuels: J. biol. Chem. 211, 21 (1954).PubMedGoogle Scholar
  527. Plantin, L.-O., and G. Birke: Acta Endocr. 19, 8 (1955).Google Scholar
  528. Plantin, L.-O., E. Diczfalusy and G. Birke: Nature (Lond.) 179, 421 (1957).CrossRefGoogle Scholar
  529. Plate, W. P.: Acta Endocr. 11, 119 (1952).PubMedGoogle Scholar
  530. Popjak, G.: Arch. Biochem. 48, 102 (1954).PubMedCrossRefGoogle Scholar
  531. Popjak, G.: Ann Rev. Biochem. 27, 533 (1958).PubMedCrossRefGoogle Scholar
  532. Popjak, G., G. D. Hunter, and T. H. French: Biochem. J. 54, 238 (1953).PubMedGoogle Scholar
  533. Prelog, V., and J. Führer: Hely. chim Acta 28, 583 (1945).CrossRefGoogle Scholar
  534. Price, T. D., and D. Rittenberg: J. biol. Chem. 185, 449 (1950).PubMedGoogle Scholar
  535. Rabinowitz, J. L.: J. Amer them. Soc. 76, 3037 (1954).CrossRefGoogle Scholar
  536. Rabinowitz, J. L., and S. GurIn: Biochim. biophys. Acta 10, 345 (1953).Google Scholar
  537. Rabinowitz, J. L., and S. GurIn: J. biol. Chem. 208, 307 (1954a).PubMedGoogle Scholar
  538. Rabinowitz, J. L., and S. GurIn: J. Amer. them. Soc. 76, 5168 (1954b).CrossRefGoogle Scholar
  539. Rabinowitz, J. L., F. Dituri, F. Cobey and S. GurIn: Fed. Proc. 14, 760 (1955).PubMedGoogle Scholar
  540. Rao, B. G., and R. D. H. Heard: Arch. Biochem. 66, 504 (1957).PubMedCrossRefGoogle Scholar
  541. Reddy, W. J., N. A. Haydar and J. C. Laidlaw: J. clin. Endocr. 15, 891 (1955).Google Scholar
  542. Reich, E., and A. L. Lehninger: Biochim. biophys. Acta 17, 136 (1955).Google Scholar
  543. Reichstein, T.: Helv. chim. Acta 19, 29 (1936a).CrossRefGoogle Scholar
  544. Reichstein, T.: Helv. chim. Acta 19, 223 (1936b).CrossRefGoogle Scholar
  545. Reichstein, T.: Hely. chim. Acta 19, 1107 (1936c).CrossRefGoogle Scholar
  546. Reichstein, T.: Helv. chim. Acta 20, 953 (1937).CrossRefGoogle Scholar
  547. Reichstein, T., and J. v. Euw: Helv. chim. Acta 21, 1197 (1938).CrossRefGoogle Scholar
  548. Reichstein, T., and J. v. Euw: Rely. chim. Acta 22, 1222 (1939).CrossRefGoogle Scholar
  549. Reichstein, T., and K. Gatzi: Hely. chim. Acta 21, 1185 (1938a).CrossRefGoogle Scholar
  550. Reichstein, T., Hely. chim. Acta 21, 1490 (1938b).CrossRefGoogle Scholar
  551. Renold, A. E., J. Crabbe, L. Hermando-Avendano, D. H. Nelson, E. J. Ross, K. Emerson, JR., and G. W. Thorn: New Engl. J. Med. 256, 16 (1957).Google Scholar
  552. Richardson, E. M., J. C. Touchstone and F. C. Dohan: Fed. Proc. 13, 118 (1954).Google Scholar
  553. Richardson, E. M., J. clin. Invest. 34, 285 (1955).PubMedCrossRefGoogle Scholar
  554. Richardson, E. M., H. Bulaschenko and H. C. Dohan: Fed. Proc. 17, 132 (1958).Google Scholar
  555. Rittenberg, D., and R. Schoenheimer: J. biol. Chem. 121, 235 (1937).Google Scholar
  556. Romanoff, E. B., P. Hudson and G. Pincus: J. clin. Endocr. 13, 1546 (1953).PubMedCrossRefGoogle Scholar
  557. Romanoff, L. P., J. Seelye, R. Rodriguez and G. Pincus: J. clin. Endocr. 17, 434 (1957).PubMedCrossRefGoogle Scholar
  558. Rosemberg, E., G. Rosenfeld, F. Ungar and R. I. Dorfman: Endocrinology 58, 708 (1956).PubMedCrossRefGoogle Scholar
  559. Rosenfeld, G.: Amer. J. Physiol. 182, 57 (1955a).PubMedGoogle Scholar
  560. Rosenfeld, G.: Amer. J. Physiol. 183, 272 (1955b).PubMedGoogle Scholar
  561. Rosenfeld, G., and W. D. Bascom: J. biol. Chem. 222, 565 (1956).PubMedGoogle Scholar
  562. Rosenfeld, G., F. Ungar, R. I. Dorfman and G. Pixcus: Endocrinology 56, 24 (1955).PubMedCrossRefGoogle Scholar
  563. Rosenfeld, G., E. Rosemberg, F. Ungar and R. I. Dorfman: Endocrinology 58, 255 (1956).PubMedCrossRefGoogle Scholar
  564. Rosenfeld, G., Rosenfeld, R. S., L. Hellman, W. J. Considine and T. F. Gallagher: J. biol. Chem. 208, 73 (1954).PubMedGoogle Scholar
  565. Rosenkrantz, H., and R. I. Dorfman: Proc. 19th Int. physiol. Congress (Montreal), p. 713 (1953).Google Scholar
  566. Rosselet, J.-P., M. Furman, S. Lieberman and J. W. Jailer: Science 120, 788 (1954a).Google Scholar
  567. Rosselet, J.-P., L. Overland, J. W. Jailer and S. Lieberman: Heiv. china. Acta 37, 1933 (1954b).CrossRefGoogle Scholar
  568. Rosselet, J.-P., J. W. Jailer and S. Lieberman: Fed. Proc. 14, 272 (1955).Google Scholar
  569. Rosselet, J.-P., J. W. Jailer and S. Lieberman: J. biol. Chem. 225, 977 (1957).PubMedGoogle Scholar
  570. Roy, A. B.: Biochim. biophys. Acta 15, 300 (1954).Google Scholar
  571. Roy, A. B.: Biochem. J. 62, 41 (1956).PubMedGoogle Scholar
  572. Rubin, B. L.: J. biol. Chem. 227, 917 (1957).PubMedGoogle Scholar
  573. Rubin, B. L., and R. I. Dorfman: Proc. Soc. exp. Biol. (N. Y.) 91, 585 (1956).Google Scholar
  574. Rubin, B. L., and R. I. Dorfman: Endocrinology 61, 601 (1957).PubMedCrossRefGoogle Scholar
  575. Rubin, B. L., and R. I. Dorfman, and M. Miller: Endocrinology 51, 463 (1952).PubMedCrossRefGoogle Scholar
  576. Rudney, H.: Fed. Proc. 13, 286 (1954).Google Scholar
  577. Rudney, H., T. G. Faukas: Fed. Prue. 14, 757 (1955).Google Scholar
  578. Rumney, G.: Fed. Proc. 15, 343 (1956).Google Scholar
  579. Ryan, K. J.: Fed. Proc. 15, 344 (1956).Google Scholar
  580. Ryan, K. J., and L. L. Engel: Endocrinology 52, 277 (1953a).PubMedCrossRefGoogle Scholar
  581. Ryan, K. J., and L. L. Engel: Endocrinology 52, 287 (1953b).PubMedCrossRefGoogle Scholar
  582. Ryan, K. J., and L. L. Engel: J. Amer. them. Soc. 78, 2654 (1956).CrossRefGoogle Scholar
  583. Saba, N., and O. Hechter: Fed. Prot. 14, 775 (1955).Google Scholar
  584. Saba, N., and O. Hechter, and D. Stone: J. Amer. chem. Soc. 76, 3862 (1954).CrossRefGoogle Scholar
  585. Saffran, M., and M. J. Bayliss: Endocrinology 52, 140 (1953).PubMedCrossRefGoogle Scholar
  586. Salamon, I. I., and K. Dobriner: J. clin. Endocr. 12, 967 (1952).Google Scholar
  587. Salhanick, H. A., and D. L. Berliner: J. biol. Chem. 227, 583 (1957).PubMedGoogle Scholar
  588. Salvadori, B., L Cassang: Quad. Clin. octet. ginec. 11, 261 (1956).Google Scholar
  589. Samuels, L. T.: Ciba Found. Coll. Endocrin. 7, 176 (1953).Google Scholar
  590. Samuels, L. T, and M. L. Helmreich: Endocrinology 58, 435 (1956).PubMedCrossRefGoogle Scholar
  591. Samuels, L. T, and M. L. Helmreich, M. B. Lasater and H. Reich: Science 113, 490 (1951).PubMedCrossRefGoogle Scholar
  592. Samuels, L. T, and H. Brown, K. Eix-Nes, F. H. Tyler and O. V. Domingu1:z: Ciba Found. Coll. Endocrin. 11, 221 (1957).Google Scholar
  593. Sandberg, A. A., and W. R. Slaitnwhite, JR.: J. clin. Invest. 35, 1331 (1956).PubMedCrossRefGoogle Scholar
  594. Sandberg, A. A., and W. R. Slaitnwhite, JR.: Proc. Soc. exp. Biol. (N. Y.) 96, 658 (1957).Google Scholar
  595. Sandberg, A. A., D. H. Nelson, E. M. Glenn, F. H. Tyler and L. T. Samuels: J. clin. Endocr. 13, 1445 (1953).PubMedCrossRefGoogle Scholar
  596. Sandberg, A. A., K. Eix-Nes, L. T. Samuels and F. H. Tyler: J. clin. Invest. 33, 1509 (1954).PubMedCrossRefGoogle Scholar
  597. Sandberg, A. A., W. R. Slaunwhite, JR., and H. N. Antoniades: Recent Progr. Hormone Res. 13, 209 (1957).PubMedGoogle Scholar
  598. Sandermann, W., and H. Stockmann: Naturwissenschaften 43, 581 (1956).Google Scholar
  599. Savard, K.: Ciba Found. Coll. Endocrin. 11, 252 (1957).Google Scholar
  600. Savard, K., and R. I. Dorfman: Rev. canad. Biol. 13, 495 (1954).Google Scholar
  601. Savard, K. and S. H. Goldfaden: Fed. Proc. 13, 288 (1954).Google Scholar
  602. Savard, K., A. A. Green and L. A. Lewis: Endocrinology 47, 418 (1950).PubMedCrossRefGoogle Scholar
  603. Savard, K., W. Kolff and A. C. Corcoran: Endocrinology 50, 366 (1952).PubMedCrossRefGoogle Scholar
  604. Savard, K., S. Burstein, H. Rosenkrantz and R. I. Dorfman: J. biol. Chem. 202, 717 (1953).PubMedGoogle Scholar
  605. Savard, K., E. Bagnoli and R. I. Dorfman: Fed. Proc. 13, 289 (1954).Google Scholar
  606. Savard, K., R. I. Dorfman, B. Baggett and L. L. Engel: Fed. Proc. 15, 346 (1956a).Google Scholar
  607. Savard, K., R. I. Dorfman, B. Baggett and L. L. Engel, L. M. L.ster and F. L. Engel: J. clin. Endocr. 16, 970 (1956b).CrossRefGoogle Scholar
  608. Savard, K., R. I. Dorfman, B. Baggett and L. L. Engel: J. clin. Endocr. 16, 1629 (1956c).PubMedCrossRefGoogle Scholar
  609. Savard, K., K. Andrec, B. W. L. Brooksbank, C. Reyneri and R. I. Dorfman: J. biol. Chem. 231, 765 (1958).PubMedGoogle Scholar
  610. Sayers, G., M. A. Sayers, T. Y. Liang and C. N. H. Long: Endocrinology 38, 1 (1946).PubMedCrossRefGoogle Scholar
  611. Schacter, B., and G. F. Marrian: J. biol. Chem. 126, 663 (1938).Google Scholar
  612. Schiller, S., A. M. Miller, R. I. Dorfman, E. H. Sevringhaus and E. P. Mccullough: Endocrinology 27, 262 (1945).Google Scholar
  613. Schneider, J. J.: J. biol. Chem. 194, 337 (1952).PubMedGoogle Scholar
  614. Schneider, J. J.: J. Amer. them. Soc. 75, 2024 (1953).CrossRefGoogle Scholar
  615. Schneider, J. J., and P. M. Horstmann: J. biol. Chem. 191, 327 (1951).PubMedGoogle Scholar
  616. Schneider, J. J. and M. L. Lewbart: J. biol. Chem. 222, 787 (1956).PubMedGoogle Scholar
  617. Schneider, J. J., and H. L. Mason: J. biol. Chem. 172, 771 (1948).PubMedGoogle Scholar
  618. Schneider, J. J., M. Lewbart, P. Levitan and S. Lieberman: J. Amer. them. Soc. 77, 4184 (1955).CrossRefGoogle Scholar
  619. Schneider, J. J., Schönbaum, E., M. K. Birmingham and M. Saffran: Canad. J. Biochem. 34, 527 (1956).CrossRefGoogle Scholar
  620. Schneider, J. J., Schroeder, W., K. D. Voigt, H. Van Der Werth and I. Beckmann: Acta endocr. (Kbh.) 14, 12 (1953).Google Scholar
  621. Schwenk, E., G. J. Alexander, C. A. Fish and T. H. Stoudt: Fed. Proc. 14, 752 (1955a).PubMedGoogle Scholar
  622. Schwenk, E., G. J. Alexander, T. H. Stoudt and C. A. Fish: Arch. Biochem. 55, 274 (1955b).PubMedCrossRefGoogle Scholar
  623. Selye, H., and J. B. Collip: Endocrinology 20, 667 (1936).CrossRefGoogle Scholar
  624. Selye, H., and J. B. Collip and D. L. Thomsox: Proc. Soc. exp. Biol. (N. Y.) 32, 1377 (1935).Google Scholar
  625. Serchi, G.: Chimica (Milan) 8, 9 (1953).Google Scholar
  626. Sheehan, H. L., V. K. Summers and J. Nichols: Lancet 1953 I, 312.CrossRefGoogle Scholar
  627. Short, R. V.: Ciba Found. Coll. Endocrin. 11, 362 (1957).Google Scholar
  628. Shriefers, H., W. Korus and W. Dirscherl: Acta endocr. (Kbh.) 26, 331 (1957).Google Scholar
  629. Shull, G. M., and D. A. Kita: J. Amer. chem. Soc. 77, 763 (1955).CrossRefGoogle Scholar
  630. Shull, G. M., J. L. Sardinas and J. B. Routien: Can. Patent 507, 009 (1954).Google Scholar
  631. Shull, G. M., J. L. Sardinas and J. W. Davisson:., S. Patent 2, 702, 812 (1955).Google Scholar
  632. Silber, R. H.: Clin. Chem. 1, 234 (1955).PubMedGoogle Scholar
  633. Simpson, S. A., J. F. Tait and I. E. Bush: Lancet 1952 11, 226.CrossRefGoogle Scholar
  634. Simpson, S. A., J. F. Tait, A. Wettstein, R. Neher, J. V. Euw, O. Schindler and T. ReichsteIn: Helv. chim. Acta 37, 1163 (1954).CrossRefGoogle Scholar
  635. Siperstein, M. D., and I. L. Chaikoff: Fed. Proc. 14, 767 (1955).PubMedGoogle Scholar
  636. Slauxwhite, W. R., jr., and A. A. Sandberg: Arch. Biochem. 63, 478 (1956).CrossRefGoogle Scholar
  637. Slauxwhite, W. R., jr., and A. A. Sandberg: J. clin. Endocr. 17, 395 (1957).CrossRefGoogle Scholar
  638. Slusher, M. A., and S. Roberts: Endocrinology 61, 98 (1957).PubMedCrossRefGoogle Scholar
  639. Smidt, H., and H. Staudinger: Biochem. Z. 328, 24 (1956).Google Scholar
  640. Smith, E. E. B., and G. T. Mills: Biochim. biophys. Acta 13, 386 (1954).Google Scholar
  641. Smith, E. E. B., A. Munch-Petersen and G. T. Mhls: Nature (Lond.) 172, 1038 (1953).CrossRefGoogle Scholar
  642. Smith, G. V. S., O. W. Smith, M. N. Huffman, D. W. Maccorquodale, S. A. Thayer and E. A. Doisy: J. biol. Chem. 130, 431 (1939).Google Scholar
  643. Suffer, L. J.: Diseases of the endocrine glands, Ed. 2, p. 375. Philadelphia: Lea and Febiger 1956.Google Scholar
  644. Solomon, S., A. L. Lenz, R. Vande WIELE and S Lieberman: Abst. Am. Chem. Soc. 126th Meeting, New York, p. 29C (1954).Google Scholar
  645. Solomon, S., P. Levitan and S. Lieberman: Rev. canad. Biol. 15, 282 (1956–1957).Google Scholar
  646. Sonderhoff, R., and H. Thomas: Liebigs Ann. Chem. 530, 195 (1957).Google Scholar
  647. Southcott, C. M., S. K. Gandossi, A. D. Barker, H. E. Bandy, H. Mcintosh and M. Darrach: Canad. J. Biochem. 34, 146 (1956a).PubMedGoogle Scholar
  648. Southcott, C. M., H. E. Bandy, S. E. Newsom and M. Darrach: Canad. J. Biochem. 34, 913 (1956b).PubMedCrossRefGoogle Scholar
  649. Southcott, C. M., Staple, E., W. S. Lynn, JR., and S. GurIn: J. biol. Chem. 219, 845 (1956).Google Scholar
  650. Steenburg, R. W., R. Lenniham and F. D. Moore: Ann Surg. 143, 180 (1956).PubMedGoogle Scholar
  651. Steiger, M., and T. ReichsteIn: Hely. chim. Acta 21, 546 (1938).CrossRefGoogle Scholar
  652. Steinberg, D., and D. S. Fredrickson: Ann. N. Y. Acad. Sci. 64, 579 (1956).CrossRefGoogle Scholar
  653. Steinberg, D., and D. S. Fredrickson, and J. Avigan: Proe. Soc. exp. Biol. (N. Y.) 97, 784 (1958).Google Scholar
  654. Stimmel, B. F.: Fed. Proc. 17, 317 (1958).Google Scholar
  655. Stitch, S. R., and I. D. Halkerston: Nature (Lond.) 172, 398 (1953).CrossRefGoogle Scholar
  656. Stokes, W. M., W. A. Fish and F. C. Hickey: J. biol. Chem. 220, 415 (1956).PubMedGoogle Scholar
  657. Stone, D., and O. Hechter: Arch. Biochem. 51, 457 (1954).PubMedCrossRefGoogle Scholar
  658. Stokes, W. M., M. Hayano, R. I. Dorfman, O. Hechter, C. R. Robinson and C. Djerassi: J. Amer. chem. Soc. 77, 3926 (1955).CrossRefGoogle Scholar
  659. Storey, I. D. E., and G. J. Dutton: Biochem. J. 59, 279 (1955).PubMedGoogle Scholar
  660. Strong, J. A., J. B. Brown, J. Bruce, M. Douglas, A. J. Klopper and J. A. Loraine: Lancet 1956 11, 955.CrossRefGoogle Scholar
  661. Stroud, S. W.: J. Endocr. 1, 201 (1939).CrossRefGoogle Scholar
  662. Sutherland, E. S., and G. F. Marrian: Biochem. J. 41, 193 (1947).Google Scholar
  663. Sweat, M. L., R. A. Aldrich, C. H. DE Bruin, W. L. Fowlks, L. R. Heiselt and H. S. Mason: Fed. Proc. 15, 367 (1956).Google Scholar
  664. Talalay, P.: Physiol. Rev. 37, 362 (1957).PubMedGoogle Scholar
  665. Talalay, P., and P. I. Marcus: Nature (Load.) 173, 1189 (1954).CrossRefGoogle Scholar
  666. Talalay, P., and P. I. Marcus: J. biol. Chem. 218, 675 (1956).PubMedGoogle Scholar
  667. Talalay, P., M. M. Dobson, and D. F. Tapley: Nature (Lond.) 170, 620 (1952).CrossRefGoogle Scholar
  668. Taliaferro, I., and L. Leone: New Engl. J. Med. 257, 855 (1957).PubMedCrossRefGoogle Scholar
  669. Taliaferro, I., F. Cobey and L. Leone: Proc. Soc. exp. Biol. (N. Y.) 92, 742 (1956).Google Scholar
  670. Tamm, J., I. Beckmann and K. D. Voight: Acta endocr. (Kbh.) 27, 403 (1958).Google Scholar
  671. Tavormina, P. A., and M. H. Gibbs: J. Amer. chem. Soc. 78, 6210 (1956).CrossRefGoogle Scholar
  672. Tavormina, P. A., and M. H. Gibbs, and J. W. Huff: J. Amer. chem. Soc. 78, 4498 (1956).CrossRefGoogle Scholar
  673. Taylor, W.: Biochem. J. 66, 58P (1957).Google Scholar
  674. Tchen, T. T., and K. Bloch: J. biol. Chem. 226, 921 (1957a).PubMedGoogle Scholar
  675. Tchen, T. T., and K. Bloch: J. biol. Chem. 226, 931 (1957b).PubMedGoogle Scholar
  676. Thoma, R. W., and J. Fried: U S Patent 2,801,251 July 30 (1957).Google Scholar
  677. Thorn, G. W., A. E. Renold, A. Goldfien, D. H. Nelson, W. J. Reddy and R. Hertz: New Engl. J. Med. 254, 547 (1956).PubMedCrossRefGoogle Scholar
  678. Tomxins, G. M.: J. biol. Chem. 218, 437 (1956a).Google Scholar
  679. Tomxins, G. M.: Recent Progr. Hormone Res. 12, 125 (1956b).Google Scholar
  680. Tomxins, G. M.: Abst. Amer. them. Soc. 130th Meeting, p. 57C (1956c)Google Scholar
  681. Tomxins, G. M.: Abst. Amer. them. Soc. 131st Meeting, p. 4C (1957).Google Scholar
  682. Tomxins, G. M., and K. J. Isselbacher: J. Amer. them. Soc. 76, 3100 (1954).CrossRefGoogle Scholar
  683. Tomxins, G. M., H. H. Sheppard and I. L. Chaikoff: J. biol. Chem. 203, 701 (1953).Google Scholar
  684. Tomxins, G. M., P. J. Michael and J. F. Curran: Biochim. biophys. Acta 23, 655 (1957).Google Scholar
  685. Tomxins, G. M., J. F. Curran and P. J. Michael: Fed. Proc. 17, 323 (1958).Google Scholar
  686. Touchstone, J. C., L. Glazer, D. Y. Cooper and J. M. Roberts: J. clin. Endocr. 15, 382 (1955).PubMedCrossRefGoogle Scholar
  687. Touchstone, J. C., H. Bulaschenro, E. M. Richardson and F. C. Dohan: J. clin. Endocr. 17, 250 (1957).PubMedCrossRefGoogle Scholar
  688. Touchstone, J. C., Travis, R. H., and G. L. Farrell: Fed. Proc. 17, 324 (1958).Google Scholar
  689. Troop, R. C.: Fed. Proc. 17, 415 (1958).Google Scholar
  690. Troop, R. C.: Influence of gonadal hormones on the metabolism of cortisone. Endocrinology 64, 671 (1959).Google Scholar
  691. Troop, R. C., Tullner, W. W., M. M. Graff and R. Hertz: Endocrinology 58, 802 (1956).CrossRefGoogle Scholar
  692. Troop, R. C., Tyler, F. H., C. D. Schmidt, K. Eix-Nes, H. Brown and L. T. Samuels: J. clin. Invest. 33, 1517 (1954).CrossRefGoogle Scholar
  693. Udaev, N. A., and K. V. Druzhinia: Probl. Endocr. Horm. Ther. (U.S.S.R.) 4, 21 (1958).Google Scholar
  694. Ulicm, S., and S. Lieberman: J. Amer. them. Soc. 79, 6567 (1957).CrossRefGoogle Scholar
  695. Ungar, F., and B. R. Bloom: Biochim. biophys. Acta 24, 431 (1957).Google Scholar
  696. Ungar, F., and R. I. Dorfman: Science 115, 115 (1952).PubMedCrossRefGoogle Scholar
  697. Ungar, F., and R. I. Dorfman: J. biol. Chem. 205, 125 (1953).PubMedGoogle Scholar
  698. Ungar, F., and R. I. Dorfman: J. Amer. them. Soc. 76, 1197 (1954).CrossRefGoogle Scholar
  699. Ungar, F., and R. I. Dorfman: J. clin. Endocr 16, 920 (1956).Google Scholar
  700. Ungar, F., J. W. Davis, H. Rosenkrantz and R. I. Dorfman: J. biol. Chem. 207, 375 (1954a).PubMedGoogle Scholar
  701. Ungar, F., A. M. Miller and R. I. Dorfman: J. biol. Chem. 206, 597 (1954b).PubMedGoogle Scholar
  702. Ungar, F., M. Gut and R. I. Dorfman: J. biol. Chem. 224, 191 (1957).PubMedGoogle Scholar
  703. Ungar, F., E. B. Romanoff, R. I. Dorfman and G. Pincus: Unpublished (1958).Google Scholar
  704. Yenning, E. H.: Recent Progr. Hormone Res. 12, 185 (1956).Google Scholar
  705. Yenning, E. H., and J. S. L. Browne: Proc. Soc. exp. Biol. (N. Y.) 34, 792 (1936).Google Scholar
  706. Yenning, E. H., and J. S. L. Browne: Endocrinology 21, 711 (1937).CrossRefGoogle Scholar
  707. Yenning, E. H., M. M. Hoffman and J. S. L. Browne: J. biol. Chem. 146, 369 (1942).Google Scholar
  708. Yenning, E. H., C. J. P. Glroud, I. Dyrenfurth and J. C. Bell: Canad. J. Bioehem. 33, 605 (1955).Google Scholar
  709. Vermeulen, A.: Acta endocr. (Kbh.) 23, 113 (1956a).Google Scholar
  710. Yenning, E. H.: J. clin. Endocr 16, 163 (1956b).CrossRefGoogle Scholar
  711. Yenning, E. H.: Acta endocr. (Kbh.) 22, 115 (1956c).Google Scholar
  712. Yenning, E. H.: Lancet 273, 79 (1957).Google Scholar
  713. Yenning, E. H., and E. Caspi: J. biol. Chem. 233, 54 (1958).Google Scholar
  714. Visoher, E., J. Scmidlin and A. WettsteIn: Rely. chim. Acta 37, 321 (1954).CrossRefGoogle Scholar
  715. Vliers, M., L. Demey, C. Heusghem and H. Van Cauwenberge: C. R. Soc. Biol. (Paris) 149, 2271 (1955).Google Scholar
  716. Vogt, M.: J. Physiol. 103, 317 (1944).PubMedGoogle Scholar
  717. Vogt, M.: J. Physiol. 130, 601 (1955).PubMedGoogle Scholar
  718. Vogt, M.: Ciba Found. Coll. Endocrin. 11, 193 (1957).Google Scholar
  719. Voigt, K. D., and W. Schroeder: Naturwissenschaften 40, 485 (1953).CrossRefGoogle Scholar
  720. Voigt, K. D., and W. Schroeder: Nature (Lond.) 176, 599 (1955).CrossRefGoogle Scholar
  721. Voigt, K. D., and W. Schroeder: Acta endocr. (Kbh.) 21, 343 (1956).Google Scholar
  722. Voigt, K. D., and W. Schroeder: I. Beckmann and H. Van Der Werth: Acta endocr. (Kbh.) 14, 1 (1953).Google Scholar
  723. Voigt, K. D., Wallace, E. Z., H. I. Wilverberg, A. C. Carter and L. S. Hersch: Proc. Soc. exp. Biol. (N. Y.) 95, 805 (1957).Google Scholar
  724. Wallach, S., H. Brown, E. Englert and K. Erx-Nes: J. clin. Endocr. 17, 945 (1957).PubMedCrossRefGoogle Scholar
  725. Watson, E. J. D., and G. F. Marrian: Biochem. J. 61, 24 (1955).Google Scholar
  726. Watson, E. J. D., and G. F. Marrian: Biochem. J. 63, 64 (1956).PubMedGoogle Scholar
  727. Weichselbaum, T. E., and H. W. Margraf: J. clin. Endocr. 15, 970 (1955).PubMedCrossRefGoogle Scholar
  728. Weinmann, S., E. E. Baulieu, A. Alfsen, B. Lisboa and M. F. Jayle: C. R. Soc. Biol. 151, 454 (1957a).Google Scholar
  729. Weinmann, S., F. F. Demoisson, E. E. Baulieu and M. F. Jayle: C. R. Soc. Biol. 151, 518 (1957b).Google Scholar
  730. Weinmann, S., Werbin, H., and G. V. Leroy: J. Amer. them. Soc. 76, 5260 (1954).CrossRefGoogle Scholar
  731. Weinmann, S., Werbin, H.: Fed. Proc. 14, 303 (1955).Google Scholar
  732. Werbin, H., J. Plotz, G. V. Leroy and E. Davis: Fed. Proc. 16, 346 (1957a).Google Scholar
  733. Werbin, H., D. M. Bercenstal, R. G. Gould and G. V. Leroy: J. clin. Endocr. 17, 337 (1957b).PubMedCrossRefGoogle Scholar
  734. Werbin, H., I. L. Chaikoff and E. Jones: Fed. Proc. 17, 333 (1958).Google Scholar
  735. West, C. D., B. Damast and O. H. Pearson: J clin. Invest. 37, 341 (1958).PubMedCrossRefGoogle Scholar
  736. Westphal, U.: Hoppe-Seylers Z. physiol. Chem. 273, 13 (1942).Google Scholar
  737. Wettstein, A.: Experientia (Basel) 10, 397 (1954).CrossRefGoogle Scholar
  738. Wettstein, A.: Experientia (Basel) 11, 465 (1955).CrossRefGoogle Scholar
  739. Wettstein, A., and G. Anner: Experientia (Basel) 10, 397 (1954).CrossRefGoogle Scholar
  740. Wettstein, A., H. Neuer and J. G. Llaurado: Proc. Univ. Otago med. Sch. 34, 7 (1956).Google Scholar
  741. Wiest, W. G.: Fed. Proc. 17, 335 (1958).Google Scholar
  742. Winters, R. W., R. B. Schultz and W. A. Krehl: Endocrinology 50, 377 (1952a).PubMedCrossRefGoogle Scholar
  743. Winters, R. W., R. B. Schultz and W. A. Krehl: Endocrinology 50, 388 (1952b).PubMedCrossRefGoogle Scholar
  744. Wintersteiner, O., and J. J. Pfiffner: J. biol. Chem. 111, 599 (1935).Google Scholar
  745. Wintersteiner, O., and J. J. Pfiffner: J. biol. Chem. 116, 291 (1936).Google Scholar
  746. Wintersteiner, O., E. Schwenk and B. Whitman: Proc. Soc. exp. Biol. (N. Y.) 32, 1087 (1935).Google Scholar
  747. Woodward, R., and K. BLOCH: J. Amer. chem. Soc. 75, 2023 (1953).CrossRefGoogle Scholar
  748. Wuersch, J., R. L. Huang and K. Bloch: J. biol. Chem. 195, 439 (1952).PubMedGoogle Scholar
  749. Yates, F. E., A. L. Herbst and J. Urquhart: Sex difference in rate of ring A reduction of 44–3-keto-steroids in vitro by rat liver. Endocrinology 63, 887–902 (1958).PubMedCrossRefGoogle Scholar
  750. Zabin, I., and W. F. Barker: J. biol. Chem. 205, 633 (1953).PubMedGoogle Scholar
  751. Zabin, I., and K. Bloch: J. biol. Chem. 185, 117 (1950a).PubMedGoogle Scholar
  752. Zabin, I., and K. Bloch: J. biol. Chem. 185, 131 (1950b).PubMedGoogle Scholar
  753. Zabin, I., and K. Bloch: J. biol. Chem. 192, 261 (1951a).PubMedGoogle Scholar
  754. Zabin, I., and K. Bloch: J. biol. Chem. 192, 267 (1951b).PubMedGoogle Scholar
  755. Zaffaroni, A., and R. B. Burton: Arch. Biochem. 42, 1 (1953).PubMedCrossRefGoogle Scholar
  756. Zaffaroni, A., O. Hechter and G. Pincus: J. Amer. chem. Soc. 73, 1390 (1951).CrossRefGoogle Scholar
  757. C. C. Campillo, F. Cardoba and G. Rosenkranz: Experientia (Basel) 11, 219 (1955).Google Scholar
  758. Zander, J., and H. Summer: Klin Wschr. 32, 529 (1954).PubMedCrossRefGoogle Scholar
  759. Zimmerman, N. B., H. S. Bloch, W. L. Williams, C. R. Hitchcock and B. Hoelscher: Cancer (N.Y.) 9, 940 (1956).CrossRefGoogle Scholar
  760. Zondek, B., and S. Burstein: Endocrinology 50, 419 (1952).PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1962

Authors and Affiliations

  • Ralph I. Dorfman

There are no affiliations available

Personalised recommendations