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Biochemical Regulations

  • Benno Hess

Abstract

In the last 20 years, classical cell physiology has been enlarged and refined by new concepts, the development and investigation of which are due to the expansion of modern technology. This newer knowledge mirrors the impressive impulse given by the technological sciences for research in biochemical systems. Whereas until only recently molecular biology still hesitated to borrow these new ideas, a feedback of newly discovered biological principles upon technological theories can be detected today: interactions, which eliminate the borders of classical sciences. At this symposium I learned that we are concerned with general systems theory, that is, with the theory of molecular organization, control and recognition mechanisms or molecular cybernetics, and for these concepts I shall try to present what is current knowledge in the field of biochemical regulations. First, I shall discuss the static description of biochemical networks, then continue with cellular dynamics in terms of control characteristics, transient states and models, implying that only general principles can be introduced into a field which is so rapidly expanding.

Keywords

Control Characteristic Transient Time Pyridine Nucleotide Glycolytic Rate Cold Spring Harbor Symposium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1).
    Hess, B. Koordination von Atmung und Glykolyse. Dt. Naturforscher und Ärzte, Rottach-Egern 1962. In: Funktionelle und morphologische Organisation der Zelle, hrsg. v. P. Karlson, Berlin—Göttingen—Heidelberg: Springer, 1963, p. 163.Google Scholar
  2. 2).
    Hess, B. Studia Biophysica 1, 1966.Google Scholar
  3. 3).
    Eigen, M. and G. G. Hammes. Advances in Enzymology. 25:1, 1963.Google Scholar
  4. 4).
    Hess, B. and K. Brand. Enzyme and metabolite profiles. In: Control of Energy Metabolism (B. Chance, R. W. Estabrook, and J. R. Williamson, eds.). 111, Academic Press, New York, 1965.Google Scholar
  5. 5).
    Chance, B. Cold Spring Harbor Symposium on Quantitative Biology, 26: 289, 1961.CrossRefGoogle Scholar
  6. 6).
    Umbarger, H. E. Cold Spring Harbor Symposium on Quantitative Biology, 26:301, 1961.CrossRefGoogle Scholar
  7. 7).
    Stadtman, E. R. Advances in Enzymology, 28:41, 1966.Google Scholar
  8. 8).
    Hess, B., R. Haeckel, and K. Brand. Biochem. Biophys. Res. Comm. 24: 824, 1966.PubMedCrossRefGoogle Scholar
  9. 9).
    Monod, J. and F. Jacob. Cold Spring Harbor Symposium on Quantitative Biology, 26:389, 1961.CrossRefGoogle Scholar
  10. 10).
    Monod, J., J. P. Changeux, and F. Jacob. J. Mol. Biol., 6:306, 1963.PubMedCrossRefGoogle Scholar
  11. 11).
    Atkinson, D. E. Annual Review Biochem., 35:85, 1966.CrossRefGoogle Scholar
  12. 12).
    Huennekens, F. M. Biochem. Reactions, Measurements and General Theories. In: Investigations of Rates and Mechanism of Reactions (S. L. Friess, E. S. Lewis, and A. Weissberger, eds.), 1231 Interscience Publishers, Div., John Wiley and Sons, New York-London, VIII Part II 1965.Google Scholar
  13. 13).
    Gerhart, J. C. and A. B. Pardee. J. Biol. Chem., 237:891, 1962.PubMedGoogle Scholar
  14. 14).
    Monod, J., J. Wyman, and J. P. Changeux. J. Mol. Biol. 12:88, 1965.PubMedCrossRefGoogle Scholar
  15. 15).
    Frieden, C. J. Biol Chem., 239:3522, 1964.PubMedGoogle Scholar
  16. 16).
    Atkinson, D. E., J. A. Hathaway, and E. C. Smith. J. Biol. Chem., 240:2682, 1965.PubMedGoogle Scholar
  17. 17).
    Klingenberg, M., H. Goebell and G. Wenske. Biochem. Zeitschrift, 341: 199, 1965.Google Scholar
  18. 18).
    Bonnichsen, R. K., B. Chance, and H. Theorell. Acta Chem. Scand., 1:685, 1947.CrossRefGoogle Scholar
  19. 19).
    Chance, B. In: A Ciba Foundation Symposium on the Regulation of Cell Metabolism (Wolstenholme and O’Connor, eds.). 91, J. & A. Churchill Ltd., 1959.Google Scholar
  20. 20).
    Haeckel, R. and B. Hess. Studia Biophysica, 1, 1966.Google Scholar
  21. 21).
    Hess, B., R. Haeckel, A. Boiteux, and K. Wittrock. Unpublished experiments.Google Scholar
  22. 22).
    Chance, B. and G. R. Williams: Advances in Enzymology. 17: 65, 1956.Google Scholar
  23. 23).
    Higgins, J. In: Control of Energy Metabolism (B. Chance, R. W. Estabrook, and J. R. Williamson, eds.). 13, Academic Press, New York, 1965.Google Scholar
  24. 24).
    Pye, K. and B. Chance. Proc. Nat. Acad. Sci. U.S.A. 55:888, 1966CrossRefGoogle Scholar
  25. 25).
    Hess, B., K. Brand, and K. Pye. Biochem. Biophys. Res. Comm., 23:102, 1966.PubMedCrossRefGoogle Scholar
  26. 26).
    Bernhardt, W., K. Panten, and H. Holzer. Biochem. Biophys. Acta, 99: 531, 1965.PubMedGoogle Scholar
  27. 27).
    Chance, B. and B. Hess. Science, 129:700, 1959.PubMedCrossRefGoogle Scholar
  28. 28).
    Chance, B. and B. Hess. J. Biol. Chem., 234:2421, 1959.PubMedGoogle Scholar
  29. 29).
    Hess, B. Dt. Med. Wschr., 88:668, 1963.CrossRefGoogle Scholar
  30. 30).
    Estabrook, R. W., P. K. Maitra, and B. Chance. In: Symposium on the Mechanism of Cellular Regulation in Bacteria (J. Senez, ed.). Marseille, France, July 1963, 491, Centre National de la Recherche Scientifique, Paris, 1965.Google Scholar
  31. 31).
    Hess, B., K. Brand, and G. Gey. Abstracts of papers, presented at the Third Meeting of the Federation of European Biochemical Societies, Warsaw 1966, Continuous glycolytic oscillations in extracts of S. Carlsbergensis.Google Scholar
  32. 32).
    Hess, B. Lecture delivered to the Senate of the Max-Planck Society, Dec. 1965.Google Scholar
  33. 33).
    Hess, B., K. Brand, and Y. Cassuto, Fed. Proc, 24:537, 1965.Google Scholar
  34. 34).
    Frenkel, R. Arch. Biochem. Biophys., 115:112, 1966.PubMedCrossRefGoogle Scholar
  35. 35).
    Chance, B. Enzyme kinetics in the transient state. In: Investigations of Rates and Mechanism of Reactions (S. L. Friess, E. S. Lewis, and A. Weissberger, eds., VIII, Part II, Interscience Publishers, Div., John Wiley and Sons, New York—London, 1963.Google Scholar
  36. 36).
    Gutfreund, H. An Introduction to the Study of Enzymes, Blackwell Scientific Publications, Oxford, 1965.Google Scholar
  37. 37).
    Lotka, A. J. J. Phys. Chem., 14:271, 1910.CrossRefGoogle Scholar
  38. 38).
    Garfinkel, D. and B. Hess. J. Biol. Chem., 239:971, 1964.PubMedGoogle Scholar
  39. 39).
    Betz, A. and B. Chance. Arch. Biochem. Biophys., 109:585, 1965.PubMedCrossRefGoogle Scholar
  40. 40).
    Chance, B., B. Schoener, and S. Elsaessar. J. Biol. Chem., 240:3170, 1965.PubMedGoogle Scholar
  41. 41).
    Graven, S. N., H. A. Lardy, and A. Rutter. Biochemistry, 5:1735, 1966.CrossRefGoogle Scholar
  42. 42).
    Moore, C. L. and B. C. Pressman. Biochem. Biophys. Res. Comm., 15: 562, 1964.CrossRefGoogle Scholar
  43. 43).
    Chance, B. and T. Yoshioka. Arch. Biochem. Biophys., 117:451, 1966.PubMedCrossRefGoogle Scholar
  44. 44).
    Sallis, J. D. and H. De Luca. J. Biol. Chem., 239:4303, 1964.PubMedGoogle Scholar
  45. 45).
    Kirschner, K., M. Eigen, R. Bittman and B. Voigt. Proc. N.A.S., 56:1661, 1966.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1968

Authors and Affiliations

  • Benno Hess
    • 1
  1. 1.Max-Planck-lnstitut für ErnährungsphysiologieDortmundGermany

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