Zusammenfassung
Es soll nun die Frage nach der Ausdehnung der empfindlichen Bereiche gestellt werden. In Teil II wurde gezeigt, daß jeder Dosiswirkungsbeziehung eine Mindestzahl S der im Mittel für den Testeffekt zusammenwirkenden Absorptionsereignisse zuzuordnen ist. Man könnte einfach an dieses Ergebnis anschließen und fragen: Wie groß muß ein Bereich im biologischen Objekt wenigstens sein, damit er bei dem beobachteten Mittelwert der Inaktivierungsdosis von S Absorptionsereignissen betroffen wird? Dazu wäre auf die Leasche Methode des assoziierten Volumens zurückzugreifen. Lea benützte diese Methode, um aus exponentiellen Inaktivierungskurven an Enzymen, Viren und in einigen Fällen auch Bakterien die empfindlichen Volumina zu erschließen; er gab für kugelförmige empfindliche Bereiche verschiedener Durchmesser die Dosen an, für die im Mittel ein Absorptionsereignis auftritt. Seine Kurven reichen allerdings nur bis zu Durchmessern des kritischen Bereiches von etwa 0,07 μ; dem entspricht für Röntgenstrahlung eine Dosis von etwa 104 rad. Die Inaktivierungsdosen für in vitro bestrahlte Zellen liegen wesentlich tiefer, und man erhält — wie hier nur erwähnt sei — Mindestdurchmesser von etwa 0,3 μ, wenn man die Leaschen Berechnungen zu größeren Volumina hin erweitert. Dieses Ergebnis weist bereits darauf hin, daß die empfindliche Struktur nicht ein einzelner Bereich von nur makromolekularer Größe ist.
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Kellerer, A.M. (1966). Dosiswirkungsbeziehung und Mikroverteilung der absorbierten Energie. In: Stochastik der Strahlenwirkung. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-88274-6_3
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