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The Conservation of the Original X and Dosage Compensation in the Face of X-polysomy

  • Susumu Ohno
Part of the Monographs on Endocrinology book series (ENDOCRINOLOGY, volume 1)

Abstract

From the variety of X-polysomic conditions described in man in recent years, one remarkable rule emerged: the number of sex chromatin bodies always equals the number of X-chromosomes present minus one. The dosage compensation mechanism which nullifies the genetic disparity between the male and the female also serves to minimize the detrimental consequences of X-polysomy. But when this rule is viewed against the broad background of knowledge of the whole infraclass Eutheria, it becomes just a small portion of the grand scheme of dosage compensation. In this chapter, it will be shown that the dosage compensation mechanism is universal to all the placental mammals in a qualitative as well as a quantitative sense in that the aim is to preserve only one original X in the functional state in each diploid somatic cell under all the normal and abnormal conditions.

Keywords

Turner Syndrome Placental Mammal Dosage Compensation Tritiated Thymidine Gonadal Dysgenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1966

Authors and Affiliations

  • Susumu Ohno
    • 1
  1. 1.Department of BiologyCity of Hope MedicalDuarteUSA

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