Skip to main content
SpringerLink
Log in

Operational Research in Cancer Chemotherapy. Chemotherapy in the Strategy of Cancer Treatment

  • Chapter
Scientific Basis of Cancer Chemotherapy

Abstract

If one wishes to examine, in a thoroughly objective manner, the results of chemotherapy on solid tumours, based on valid criteria such as the duration of survival of treated patients compared to untreated patients, one is led to the conclusion that they are collectively very poor.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Amiel, J. L., A. M. Mery et G. Mathe: Les réponses immunitaires chez les patients atteints de choriocarcinome placentaire. Corrélation entre ces réponses et l’évolution de la maladie. Symp. on “Cell bound immunity with special reference to antilymphocyte serum and immunotherapy of cancer”. 1 vol. Liège: Université de Liège, 1967.

    Google Scholar 

  2. Amiel, J. L., M. Sekiguchi, G. Daguet, S. Garattini et V. Palma: Étude de l’effet immunodépresseur des composés chimiques utilisés en chimiothérapie anticancéreuse. J. Europ. Cancer 3, 47 (1967).

    Article  CAS  Google Scholar 

  3. Barnes, D. W. H., C. E. Ford, S. M. Gray, and J. F. Loutit: Spontaneous and induced changes in cell populations in heavily irradiated mice. Prog. Nuclear Energy 2, 1 (1959).

    Google Scholar 

  4. Bergsagel, D. E.: Personal communication.

    Google Scholar 

  5. Brennam, M. J., R. W. Talley, E. L. San Diego, J. H. Burrows, R. M. O’Bryan, V. K. Waitkevicius, and S. Horeglad: Critical analysis of 594 cancer patients treated with 5-fIuorouracil, p. 118. In: Chemotherapy of cancer, 1 vol. Amsterdam: Elsevier 1964.

    Google Scholar 

  6. Broome, J.D.: Evidence that the L-asparaginase of guinea pig serum is responsible for its antilymphoma effects. I. Properties of the L-asparaginase of guinea pig serum in relation to those of the antilymphoma substance. J. exp. Med. 118, 99 (1963).

    Article  PubMed  CAS  Google Scholar 

  7. Bruce, W. R., and B. E. Meeker: Comparison of the sensitivity of normal hemopoietic and transplanted lymphoma colony forming cells to tritiated thymidine. J. nat. Cancer Inst. 34, 849 (1965).

    PubMed  CAS  Google Scholar 

  8. ——— ———, and F. Valeriotte: Comparison of the sensitivity of normal hematopoietic and transplanted lymphoma colony-forming cells to chemotherapeutic agents administered in vivo. J. nat. Cancer Inst. (1968) in press.

    Google Scholar 

  9. Buinauskas, P., G. O. McDonald, and W. H. Cole: Role of operative stress on the resistance of the experimental animal to inoculated cancer cells. Ann. Surg. 184, 642 (1958).

    Article  Google Scholar 

  10. Cachin, Y., J. Richard, R. Gerard-Marchant et C. Vandenbrouk: Chimiosensibilité élective d’un type d’épithélioma particulier des voies aéro-digestives supérieures, la kératose villeuse maligne. Ann. Carc. Cerv. Fac. 1, 81 (1967).

    Google Scholar 

  11. Chirigos, M. A., J. Colsky, S. R. Humphreys, J. P. Glynn, and A. Goldin: Evaluation of surgery and chemotherapy in the treatment of mouse mammary adenocarcinoma 755. Cancer Chemother. Rep. 22, 49 (1962).

    PubMed  CAS  Google Scholar 

  12. Cole, W. H., R. G. Mrazek, S. G. Economou, G. O. McDonald, D. P. Slaughter, and F. W. Strehl: Adjuvant chemotherapy. Cancer 18, 1529 (1965).

    Article  PubMed  CAS  Google Scholar 

  13. Curreri, A. R., F. J. Ansfield, F. A. McIver, H. A. Waisman, and C. Heidelberger: Clinical studies with 5-fluorouracil. Cancer Res. 18, 478 (1958).

    PubMed  CAS  Google Scholar 

  14. Ferrer, F. J., and E. Mihich: Antitumor effects of kethoxal-bis (thiosemicarbazone) and 6-mercaptopurine in neonatally thymectomised mice. Proc. Soc. exp. Biol. Med. 124, 939 (1967).

    PubMed  CAS  Google Scholar 

  15. Frei, E., and E. J. Freireich: Progress and perspectives in the chemotherapy of acute leukaemia, p. 269. In: Advances in chemotherapy, vol. 2. New York: Acad. Press 1965.

    Google Scholar 

  16. Goldacre, R. J., and M. E. Whisson: The biology of large tumours regressing with nitrogen mustard treatment: a study of the mouse plasma cell tumour ADJ-PC-5 and walker carcinosarcoma 256. Brit. J. Cancer 20, 801 (1966).

    Article  PubMed  CAS  Google Scholar 

  17. Griffiths, J. D., and A. J. Salsbory: The circulating cancer cell. Springfield: Acad. Press 1965.

    Google Scholar 

  18. Hertz, R., J. Lewis, and M. B. Lipsett: Five years experience with chemotherapy of metastatic choriocarcinoma and related trophoblastic tumours in women. Amer. J. Obst. Gynec. 82, 631 (1961).

    CAS  Google Scholar 

  19. Holland, J. F.: Intensive high dose treatment of children in complete remission of acute lymphocytic leukemia, p. 163. In: Chemotherapy of Burkitt’s tumor, 1 vol. J. H. Burchenal and D. Burkitt (Ed,). Berlin-Heidelberg-New York: Springer 1967.

    Google Scholar 

  20. Karrer, K., and S. R. Humphreys: Adjuvant chemotherapy given before or after surgery. Proc. Amer. Ass. Cancer Res. 8, 35 (1967).

    Google Scholar 

  21. Kidd, J. G: Regression of transplanted lymphomas induced in vivo by means of normal guinea pig serum. I. Courses of transplanted cancer of various kinds in mice and rats given guinea pig serum, horse serum or rabbit serum. J. exp. Med. 98, 565 (1953).

    Article  PubMed  CAS  Google Scholar 

  22. Klein, G, P. Clifford, E. Klein, and J. Stjernsward: Search for tumour specific immune reactions in Burkitt lymphoma patients by the membrane immunofluorescence reaction. Symp. U.I.C.C. on Burkitt’s tumor, Uganda, 1966. Berlin-Heidelberg-New York: Springer 1967.

    Google Scholar 

  23. Martin, D. S., and R. A. Fugmann: Clinical implications of the interrelationship of tumor size and chemotherapeutic response. Ann. Surg. 151, 97 (1960).

    Article  PubMed  CAS  Google Scholar 

  24. Mathé, G: La dernière cellule. Presse méd. 75, 2591 (1967).

    PubMed  Google Scholar 

  25. ——— L’immunothérapie des cancers. Presse méd. 75, 947 (1967).

    Google Scholar 

  26. ———, J. Dausset, E. Hervet, J. L. Amiel, J. Colombani, and G. Brule: Immunological studies in patients with placental choriocarcinoma. J. nat. Cancer Inst. 33, 193 (1964).

    Google Scholar 

  27. Mathé, G., M. Hayat, L. Schwarzenberg, J. L. Amiel, M. Schneider, A. Cattan, J. R. Schlumberger, and C. Jasmin: Acute lymphoblastic leukaemia treated with a combination of prednisone, vincristine and rubidomycine. Lancet 1967, II, 380.

    Article  Google Scholar 

  28. ———, L. Schwarzenberg, M. Hayat et M. Schneider: Chimiothérapie de la leucémie L 1210: comparaison pour 7 composés, des effets de l’administration continue sur 20 jours, et de l’administration d’une dose unique massive, précoce ou tardive. Rev. Fr. Et. Clin. Biol., 13, 951 (1968).

    Google Scholar 

  29. ——— ——— ——— Dose de cyclophosphamide, action antileucémique et effet immuno-inhibiteur. Rev. Fr. Et. Clin. Biol. 13, 695 (1968).

    Google Scholar 

  30. —, J. L. Amiel, A. Cattan, J. R. Schlumberger et A. Flaisler: Chimiothérapie anticancéreuse intensive; transfusion de moelle osseuse autologue; chambres exemptes de germes pathogènes. Presse méd. 74, 2615, (1966).

    Google Scholar 

  31. ———, O. Schweisguth, G. Brule, J. L. Amiel, A. Cattan, M. Thomas et P. Zamet: Essai de traitement de la maladie de Hodgkin et d’autres affections réticulo-histiocytaires malignes par la vincaleucoblastine. Presse méd. 70, 1349 (1962).

    Google Scholar 

  32. —, C. Brezin, J. L. Amiel, L. Schwarzenberg, M. Schneider, A. Cattan, C. Jasmin et R. Smadja: Essai de traitement par la leurocristine de la leucémie aigue lymphoblastique et du lymphoblastosarcome. Presse méd. 71, 529 (1963).

    Google Scholar 

  33. ——— et al: Extrême chimiosensibilité de certaines tumeurs solides, contrastant avec la faible chimiosensibiHté habituelle. 1969, to be published.

    Google Scholar 

  34. Mihich, F.: Chimiothérapie anti-tumorale. Considérations sur le rôle potentiel de l’immunité. Path. Biol. 15, 209 (1967).

    CAS  Google Scholar 

  35. Moore, G. E., and C. A. Ross: Chemotherapy as an adjuvant to surgery. Ann. Rev. Med. 14, 141 (1963).

    Article  CAS  Google Scholar 

  36. Oliviero, V. L, et C. G. Zubrod: Clinical pharmacology of the effective antitumor drugs. Ann. Rev. Pharmacol. 5, 335 (1965).

    Article  Google Scholar 

  37. Salsbury, A. J.: Erasmus demonstration. Roy. Coll. Surg. England. 1966 (not published).

    Google Scholar 

  38. Schaudig, H.: Experiences with cytostatic treatment of cancer patients in surgery. Med. Welt 17, 2406 (1966).

    Google Scholar 

  39. Schneider, M.: Les défenses immunitaires des cancéreux. In preparation.

    Google Scholar 

  40. Schwarzenberg, L., G. Mathé, M. Hayat, F. de Vassal, J. L. Amiel, A. Cattan, M. Schneider, J. R. Schlumberger, C. Rosenfeld et C. Jasmin: Une nouvelle combinaison de méthotrexate-acide folinique pour le traitement des cancers (leucémies aigues et tumeurs solides). Presse Med. 77, 385 (1969).

    PubMed  CAS  Google Scholar 

  41. Skipper, H. E., F. M. Schabel, and W. S. Wilcox: Experimental evaluation of potential anticancer agents. XIII. On the criteria and kinetics associated with “curability” of experimental leukaemia. Cancer Chemoth. Rep. 35, 3 (1964).

    Google Scholar 

  42. Experimental evaluation of potential anticancer agents. XIV. Further study of certain basic concepts underlying chemotherapy of leukaemia. Cancer Chemoth. Rep. 45, 5 (1965).

    Google Scholar 

  43. ——— ——— ——— Experimental evaluation of potential anticancer agents. XXI. Schedulling of arabinosylcytosine to take advantage of its S-phase specificity against leukaemia cells. Cancer Chemoth. Rep. 51, 125 (1967).

    Google Scholar 

  44. Stevens, J. E., and D. A. Willougby: Phytohemagglutinin and cell mediated hyper-sensibility reactions in rat. Nature 215, 967 (1963).

    Article  Google Scholar 

  45. Veterans Administration Cooperative Surgical Adjuvant Study Group: Use of Thio-TEPA as an adjuvant to the surgical management of carcinoma of the stomach. Cancer 18, 291 (1965).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut de Cancérologie et d’Immunogénétique, Hôpital Paul-Brousse, 14 Av. Paul-Vaillant-Couturier, 94 Villejuif, France

    G. Mathé

  2. Service d’Hématologie de l’Institut Gustave Roussy, 16 bis. Avenue Paul-Vaillant-Couturier, 94 Villejuif, France

    G. Mathé

Authors
  1. G. Mathé
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Cancérologie Expérimentale à la Faculté de Médecine de Paris, l’Institut de Cancérologie et d’Immunogénétique, France

    Georges Mathé (Professeur, Directeur, Chef) (Professeur, Directeur, Chef)

  2. Service d’Hématologie, l’Institut Gustave Roussy, F-94 Villejuif, France

    Georges Mathé (Professeur, Directeur, Chef) (Professeur, Directeur, Chef)

Rights and permissions

Reprints and permissions

Copyright information

© 1969 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Mathé, G. (1969). Operational Research in Cancer Chemotherapy. Chemotherapy in the Strategy of Cancer Treatment. In: Mathé, G. (eds) Scientific Basis of Cancer Chemotherapy. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 21. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-88147-3_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-88147-3_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-88149-7

  • Online ISBN: 978-3-642-88147-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation