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Dose Schedules and Modes of Administration of Chemotherapeutic Agents in Man

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Scientific Basis of Cancer Chemotherapy

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Abstract

Clinical trials with new chemotherapeutic agents must be preceded by extensive pharmacologic study in animals. Freireich [1] reviewing a large number of experimental data showed that there is a close relationship between the LD 10 in small animals and the maximum tolerated dose (MTD) in man, when the values are given on a mg/m2 basis. The ratio of these values is always very close to 1, even when the doses for the different drugs vary with a ratio of 2,000 to 1 (Fig. 1).

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Authors and Affiliations

  1. Department of Medicine and Clinical Investigation-Brussels, Institut Jules Bordet, Belgium

    Y. Kenis

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  1. Y. Kenis
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Editors and Affiliations

  1. Cancérologie Expérimentale à la Faculté de Médecine de Paris, l’Institut de Cancérologie et d’Immunogénétique, France

    Georges Mathé (Professeur, Directeur, Chef) (Professeur, Directeur, Chef)

  2. Service d’Hématologie, l’Institut Gustave Roussy, F-94 Villejuif, France

    Georges Mathé (Professeur, Directeur, Chef) (Professeur, Directeur, Chef)

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© 1969 Springer-Verlag Berlin · Heidelberg

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Kenis, Y. (1969). Dose Schedules and Modes of Administration of Chemotherapeutic Agents in Man. In: Mathé, G. (eds) Scientific Basis of Cancer Chemotherapy. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 21. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-88147-3_5

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  • DOI: https://doi.org/10.1007/978-3-642-88147-3_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-88149-7

  • Online ISBN: 978-3-642-88147-3

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