Intrarenal Action of Steroid Hormones on Sodium Transport

  • K. Hierholzer


In the kidneys of adrenaleetomized rats we have analyzed Na+ transport using various mieropuneture techniques.

In the proximal as well as in the distal convolution of surface tubules an impairment of the local Na+ reabsorptive capacity has been observed, using the split oil droplet method.

However, in the proximal convolution fractional reabsorption was found to be normal or even slightly elevated.

Only in the distal convolution the intraluminal Na+ concentration increased both in free flow and in steady state — in the proximal convolution, no such change was observed, indicating that both outward transport and back leakage of NaCl is affected in adrenalectomy.

The impairment of local NaCl transport could be reversed by small doses of d-aldosterone after a typical delay time. The effects could be suppressed by actinomycin D.

Dexamethasone had no apparent mineralocorticoid effect, but Cortison normalized renal Na+ reabsorption in high doses.


Addisons Disease Proximal Convolution Reabsorptive Capacity Distal Convolution Typical Delay Time 
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Intrarenale Wirkung von Steroidhormonen auf den Natriumtransport


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© Springer-Verlag Berlin · Heidelberg 1969

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  • K. Hierholzer

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