Skip to main content

Aspects of Pharmacokinetics of Opiates

  • Conference paper
Psychic Dependence

Part of the book series: Bayer-Symposium ((BAYER-SYMP,volume 4))

Abstract

When a drug has been absorbed into the blood stream a series of processes take place which are mostly interrelated: dispositions in tissues and organs, excretion, metabolism. Most interesting is the permeation towards the target organ, in the case of narcotic analgesics, towards the brain. This paper will mainly deal with the kinetics of this permeation and other problems shall be treated only in so far as they are helpful to understand this particular process.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Goldstein, A., Aronow, L., Kalman, S. K.: Principles of Drug Action. New York: Harper & Row Publ. 1968.

    Google Scholar 

  • Herz, A., Teschemacher, HJ.: Activities and sites of anti-nociceptive action of morphine-like analgesics and kinetics of distribution following intravenous, intracerebral and intraventricular application. Advanc. Drug. Res. 6, 79–119 (1971).

    CAS  Google Scholar 

  • Hess, R., Herz, A., Friedel, K.: Pharmacokinetics of Fentanyl in rabbits in view of the importance of limiting the effect. J. Pharmacol. exp. Ther. 179, 474–484 (1971).

    CAS  PubMed  Google Scholar 

  • Hess, R., Stiebler, G., Herz, A.: Pharmacokinetics of Fentanyl in man and rabbit. Europ. J. Clin. Pharmacol. 4, 137–141 (1972).

    Article  CAS  Google Scholar 

  • Höllt, V., Teschemacher, HJ.: Hydrophobic interaction effective in binding of morphine-like analgesics to albumine, plasma-proteins and tissue homogenates. Naunyn-Schmiedeberg’s Arch. Pharmacol. Suppl. 274, R. 53 (1972).

    Google Scholar 

  • Hug, C. C.: Transport of narcotic analgesics by choroid plexus and kidney in vitro. Biochem. Pharmacol. 16, 345–359 (1967).

    Article  CAS  PubMed  Google Scholar 

  • Hug, C. C.: Transport in the central nervous system. In: Clouet, D. H. (Ed.): Narcotic Drugs. Biochemical Pharmacology, pp. 122–136. New York-London: Plenum Press 1971.

    Chapter  Google Scholar 

  • Hug, C. C., Oka, T.: Uptake of 3H-dihydromorphine by synaptosomes. Life Sci. Part I 10, 201 (1971).

    Google Scholar 

  • Kupferberg, H. J., Way, E. L.: Pharmacological basis for the increased sensitivity of the newborn rat to morphine J. Pharmacol. exp. Ther. 141, 105–112 (1963).

    CAS  PubMed  Google Scholar 

  • Kutter, E., Herz, A., Teschemacher, HJ., Hess, R.: Structure-activity correlations of morphine-like analgesics based on efficiencies following intravenous and intraventricular application. J. med. Chem. 13, 801–805 (1970).

    Article  CAS  PubMed  Google Scholar 

  • Mirkin, B. L.: Developmental Pharmacology. Ann. Rev. Pharmacol. 10, 255–270 (1970).

    Article  CAS  PubMed  Google Scholar 

  • Misra, A. L.: Disposition and metabolism of drugs of dependence. In: Mule, S. J., Brill., H. (Eds.): Chemical and biological aspects of drug dependence, pp. 219–270. Cleveland: CRP-Press 1972.

    Google Scholar 

  • Misra, A. L., Mitchell, C. L., Woons, L. A.: Persistence of morphine in central nervous system of rats after a single injection and its bearing of tolerance. Nature (Lond.) 232, 48–50 (1971).

    Article  CAS  Google Scholar 

  • Mule, S. J.: Physiological disposition of narcotic agonists and antagonists. In: Clouet, D. H. (Ed.): Narcotic Drugs, Biochemical Pharmacology, Vol. 9, pp. 99–121. New York-London: Plenum Press 1971.

    Chapter  Google Scholar 

  • Scholtan, W.: Die hydrophobe Bindung der Pharmaka an Humanalbumin und Ribonucleinsäure. Arzneimittel-Forsch. 18, 305–317 (1968).

    Google Scholar 

  • Schubert, P., Teschemacher, HJ., Kreutzberg, G. W., Herz, A.: Intracerebral distribution pattern of radioactive morphine and morphine-like drugs after intraventricular and intrathecal injection. Histochemie 22, 277–288 (1970).

    CAS  Google Scholar 

  • Takemori, A. E., Stenwick, M. W.: Studies on the uptake of morphine by the choroid plexus in vitro. J. Pharmacol. exp. Ther. 454, 586–594 (1966).

    Google Scholar 

  • Teschemacher, HJ., Hess, R., Niedner, I., Herz, A.: Characteristics of morphine permeation into the central nervous system after intravenous injection in rabbits. V. Intern. Congress of Pharmacology, San Francisco, p. 232 (1972).

    Google Scholar 

  • Wang, J. H., Takemori, A. E.: Studies of the transport of morphine out of the perfused cerebral ventricles of rabbits. J. Pharmacol. exp. Ther. 181, 46–52 (1972).

    CAS  PubMed  Google Scholar 

  • Way, E. L., Kemp, J. W., Young, J. M., Grasetti, D. R.: The pharmacologic effects of heroine in relationship to its ratio of biotransformation. J. Pharmacol. exp. Ther. 129, 144–154 (1960).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1973 Springer-Verlag

About this paper

Cite this paper

Herz, A. (1973). Aspects of Pharmacokinetics of Opiates. In: Goldberg, L., Hoffmeister, F. (eds) Psychic Dependence. Bayer-Symposium, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87987-6_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-87987-6_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-87989-0

  • Online ISBN: 978-3-642-87987-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics