General Discussion Remark: Energetics of Inhibitor Binding

  • D. M. Blow
Conference paper
Part of the Bayer-Symposium book series (BAYER-SYMP, volume 5)

Abstract

It has always seemed to me that the central question about the trypsin inhibitor system is: Why does the inhibitor bind so strongly? I think the answer may be the key to understanding all kinds of biological receptor systems. So I asked that question during the conference and there was a fairly negative response from the audience.

Keywords

Entropy Hydrolysis Ethyl Enthalpy Arginine 

References

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    Baugh, R. J., Trowbridge, C.G.: J. biol. Chem. 247, 7498–7501 (1972).PubMedGoogle Scholar
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    Page, M.J., Jencks, W.P.: Proc. nat. Acad. Sci. (Wash.) 68, 1678–1683 (1971).CrossRefGoogle Scholar
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    Gertler, A., Hofmann, T.: Canad. J. Biochem. 48, 384–386 (1970); THOMPSON, R.C., BLOUT, E.R.: Proc. nat. Acad. Sci. (Wash.) 67, 1734-1740 (1970); ATLAS, D., BERGER, A.: Biochemistry 11, 719-4723 (1972).Google Scholar

Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • D. M. Blow
    • 1
  1. 1.MRC Laboratory of Molecular BiologyCambridgeGreat Britain

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