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General Discussion Remark: Energetics of Inhibitor Binding

  • D. M. Blow
Part of the Bayer-Symposium book series (BAYER-SYMP, volume 5)

Abstract

It has always seemed to me that the central question about the trypsin inhibitor system is: Why does the inhibitor bind so strongly? I think the answer may be the key to understanding all kinds of biological receptor systems. So I asked that question during the conference and there was a fairly negative response from the audience.

Keywords

Binding Constant Trypsin Inhibitor Soybean Trypsin Inhibitor Tetrahedral Intermediate Amino Acid Interaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Baugh, R. J., Trowbridge, C.G.: J. biol. Chem. 247, 7498–7501 (1972).PubMedGoogle Scholar
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    Page, M.J., Jencks, W.P.: Proc. nat. Acad. Sci. (Wash.) 68, 1678–1683 (1971).CrossRefGoogle Scholar
  3. 3.
    Gertler, A., Hofmann, T.: Canad. J. Biochem. 48, 384–386 (1970); THOMPSON, R.C., BLOUT, E.R.: Proc. nat. Acad. Sci. (Wash.) 67, 1734-1740 (1970); ATLAS, D., BERGER, A.: Biochemistry 11, 719-4723 (1972).Google Scholar

Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • D. M. Blow
    • 1
  1. 1.MRC Laboratory of Molecular BiologyCambridgeGreat Britain

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