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Proteinase Inhibitors pp 677–678Cite as

General Discussion Remark: Energetics of Inhibitor Binding

  • Conference paper

Part of the book series: Bayer-Symposium ((BAYER-SYMP,volume 5))

Abstract

It has always seemed to me that the central question about the trypsin inhibitor system is: Why does the inhibitor bind so strongly? I think the answer may be the key to understanding all kinds of biological receptor systems. So I asked that question during the conference and there was a fairly negative response from the audience.

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References

  1. Baugh, R. J., Trowbridge, C.G.: J. biol. Chem. 247, 7498–7501 (1972).

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  2. Page, M.J., Jencks, W.P.: Proc. nat. Acad. Sci. (Wash.) 68, 1678–1683 (1971).

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  3. Gertler, A., Hofmann, T.: Canad. J. Biochem. 48, 384–386 (1970); THOMPSON, R.C., BLOUT, E.R.: Proc. nat. Acad. Sci. (Wash.) 67, 1734-1740 (1970); ATLAS, D., BERGER, A.: Biochemistry 11, 719-4723 (1972).

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Author information

Authors and Affiliations

  1. MRC Laboratory of Molecular Biology, Cambridge, CB2 2QH, Great Britain

    D. M. Blow

Authors
  1. D. M. Blow
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Editor information

Editors and Affiliations

  1. Institut für Klinische Chemie und Klinische Biochemie, Universität München, 8000, Munich 2, Fed. Rep. Germany

    Hanz Fritz

  2. Organisch-Chemisches Laboratorium, Technischen Universität München, 8000, Munich 2, Fed. Rep. Germany

    Harald Tschesche

  3. Department of Biology, Brookhaven National Laboratory, Upton, NY, 11973, USA

    Lewis J. Greene

  4. Biochemisches Laboratorium, Bayer AG, 5600, Wuppertal 1, Fed. Rep. Germany

    Ernst Truscheit (Editor-in-Chief) (Editor-in-Chief)

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© 1974 Springer-Verlag

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Blow, D.M. (1974). General Discussion Remark: Energetics of Inhibitor Binding. In: Fritz, H., Tschesche, H., Greene, L.J., Truscheit, E. (eds) Proteinase Inhibitors. Bayer-Symposium, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87966-1_72

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  • DOI: https://doi.org/10.1007/978-3-642-87966-1_72

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-87968-5

  • Online ISBN: 978-3-642-87966-1

  • eBook Packages: Springer Book Archive

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