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Isolation and Fragmentation of α1-Antitrypsin

  • Conference paper
Proteinase Inhibitors

Part of the book series: Bayer-Symposium ((BAYER-SYMP,volume 5))

Abstract

Knowledge of the biologic function of the major protease inhibitor of plasma α1-antitrypsin is still only fragmentary. There is reason to believe that the inhibition of trypsin and plasmin as proposed earlier are test tube phenomena and that its biologic function of α1-antitrypsin is concerned rather with other proteases such as of the granulocytes. The chemical nature of the remarkable physicochemical heterogeneity of α1-antitrypsin is not properly understood, nor is the structural background of its well-known genetic variation of α1-antitrypsin.

Supported by grants from the Swedish Medical Research Council (Project No B72-13X-581-O8A).

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Author information

Authors and Affiliations

  1. Department of Clinical Chemistry, University of Lund, Malmö General Hospital, Malmö, Sweden

    J.-O. Jeppsson & C.-B. Laurell

Authors
  1. J.-O. Jeppsson
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  2. C.-B. Laurell
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Editor information

Editors and Affiliations

  1. Institut für Klinische Chemie und Klinische Biochemie, Universität München, 8000, Munich 2, Fed. Rep. Germany

    Hanz Fritz

  2. Organisch-Chemisches Laboratorium, Technischen Universität München, 8000, Munich 2, Fed. Rep. Germany

    Harald Tschesche

  3. Department of Biology, Brookhaven National Laboratory, Upton, NY, 11973, USA

    Lewis J. Greene

  4. Biochemisches Laboratorium, Bayer AG, 5600, Wuppertal 1, Fed. Rep. Germany

    Ernst Truscheit (Editor-in-Chief) (Editor-in-Chief)

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© 1974 Springer-Verlag

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Jeppsson, JO., Laurell, CB. (1974). Isolation and Fragmentation of α1-Antitrypsin. In: Fritz, H., Tschesche, H., Greene, L.J., Truscheit, E. (eds) Proteinase Inhibitors. Bayer-Symposium, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87966-1_7

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  • DOI: https://doi.org/10.1007/978-3-642-87966-1_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-87968-5

  • Online ISBN: 978-3-642-87966-1

  • eBook Packages: Springer Book Archive

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