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An Insulin Degrading Proteinase from Human Erythrocytes and Its Inhibition by Proteinase Inhibitors

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Book cover Proteinase Inhibitors

Part of the book series: Bayer-Symposium ((BAYER-SYMP,volume 5))

Abstract

Hemolytical serum or crude homogenates of red blood cells have long been known to inactivate or degrade insulin [1–4]. When a possible effect of insulin on red cell metabolism was investigated, this very fact occurred to us as a troublesome problem [5]. The half-life of the turnover of the insulin molecule in the human system has been found to be about 12–40 min. The degradation of insulin has been attributed to two different pathways: a) reductive cleavage of the disulfide bridges by means of an enzyme (glutathione-insulin-transhydrogenase) [6–15], and b) proteolytic degradation by an insulin-specific proteinase [16–22].

Supported by the Deutsche Forschungsgemeinschaft.

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Author information

Authors and Affiliations

  1. Lehrstuhl für Organische Chemie und Biochemie, Organisch-Chemisches Laboratorium der Technischen Universität München, 8000, Munich, Fed. Rep. Germany

    H. Tschesche & T. Dietl

  2. Institut für Diabetesforschung, 8000, Munich, Fed. Rep. Germany

    H. J. Kolb & E. Standl

Authors
  1. H. Tschesche
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  2. T. Dietl
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  3. H. J. Kolb
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  4. E. Standl
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Editor information

Editors and Affiliations

  1. Institut für Klinische Chemie und Klinische Biochemie, Universität München, 8000, Munich 2, Fed. Rep. Germany

    Hanz Fritz

  2. Organisch-Chemisches Laboratorium, Technischen Universität München, 8000, Munich 2, Fed. Rep. Germany

    Harald Tschesche

  3. Department of Biology, Brookhaven National Laboratory, Upton, NY, 11973, USA

    Lewis J. Greene

  4. Biochemisches Laboratorium, Bayer AG, 5600, Wuppertal 1, Fed. Rep. Germany

    Ernst Truscheit (Editor-in-Chief) (Editor-in-Chief)

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© 1974 Springer-Verlag

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Tschesche, H., Dietl, T., Kolb, H.J., Standl, E. (1974). An Insulin Degrading Proteinase from Human Erythrocytes and Its Inhibition by Proteinase Inhibitors. In: Fritz, H., Tschesche, H., Greene, L.J., Truscheit, E. (eds) Proteinase Inhibitors. Bayer-Symposium, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87966-1_65

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  • DOI: https://doi.org/10.1007/978-3-642-87966-1_65

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-87968-5

  • Online ISBN: 978-3-642-87966-1

  • eBook Packages: Springer Book Archive

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