Properties of Human α1-Antitrypsin

  • J. Travis
  • D. Johnson
  • R. Pannell
Part of the Bayer-Symposium book series (BAYER-SYMP, volume 5)


Human blood plasma is known to contain at least six proteinase inhibitors[1]. Two of these proteins, α2-macroglobulin and α1antitrypsin, are normally present in the most significant quantities in plasma and the latter has been found to account for at least 70% of the total inhibitory activity. This protein, which should more accurately be described as an α1-proteinase inhibitor because of its broad inhibition spectrum, has been implicated in several pathological conditions primarily when low levels of the molecule are present in plasma [2].


Sialic Acid Human Blood Plasma Disc Electrophoresis Precipitin Line Broad Inhibition Spectrum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Heimburger, N., Haupt, H., Schwick, H.G.: In: Fritz, H., Tschesche, H. (Eds): Proceedings of the International Research Conference on Proteinase Inhibitors. Berlin-New York: Walter de Gruyter 1971.Google Scholar
  2. 2.
    Sharp, H.L, Bridges, R.A., Krivit, W., Freier, E.F.: J. Lab. clin. Med. 73, 934 (1969).PubMedGoogle Scholar
  3. 3.
    Laurell, C.B., Eriksson, S.: Scand. J. clin. Lab. Invest. 15, 132 (1963).Google Scholar
  4. 4.
    Travis, J., Roberts, R.C: Biochemistry 8, 2884 (1969).PubMedCrossRefGoogle Scholar
  5. 5.
    Travis, J., Pannell, R.: Clin. chim. Acta (in press).Google Scholar
  6. 6.
    Schwert, C. W., Takenaka, Y.: Biochim. biophys. Acta (Amst.) 16, 570 (1955).CrossRefGoogle Scholar
  7. 7.
    Mallory, P., Travis, J.: Biochemistry 12, 2847 (1973).PubMedCrossRefGoogle Scholar
  8. 8.
    Ohlsson, K.: Scand. J. clin. Lab. Invest. 28, 13 (1971).PubMedCrossRefGoogle Scholar
  9. 9.
    Bell, O. F., Carrell, R.W.: Nature (Lond.) 243, 410 (1973).CrossRefGoogle Scholar
  10. 10.
    Heimburger, N., Heide, K., Haupt, H., Schultze, H.F.: Clin. chim. Acta 10, 460 (1964).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • J. Travis
    • 1
  • D. Johnson
    • 1
  • R. Pannell
    • 1
  1. 1.Department of BiochemistryUniversity of GeorgiaAthensUSA

Personalised recommendations