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Reactive Site Cleavage, Thermodynamic Control Resynthesis, and Properties of Chemically Derivatized Trypsin-Kallikrein-Inhibitors

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Book cover Proteinase Inhibitors

Part of the book series: Bayer-Symposium ((BAYER-SYMP,volume 5))

Abstract

The basic trypsin-kallikrein inhibitor (Kunitz) of bovine organs was the first inhibitor to be purified [1], elucidated in its covalent structure [2–9] and in its atomic structure [10, 11]. The kinetics of complex association upon inhibition of trypsin[12] and of chymotrypsin [12–14] have been investigated. Because of its broad specificity this inhibitor has found wide use in therapeutical applications [15].

Supported by the Deutsche Forschungsgemeinschaft, Bonn-Bad Godesberg, and the Fonds der Chemischen Industrie, Frankfurt.

Part of the Ph. D.-thesis, H. Jering, Technische Universität München 1973.

The animal experiments were performed in the Institute für Klinische Chemie und Klinische Biochemie, Universität München.

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Authors and Affiliations

  1. Lehrstuhl für Organische Chemie und Biochemie, Organisch-Chemisches Laboratorium der Technischen Universität München, 8000, Munich 2, Arcisstraße 21, Fed. Rep. Germany

    H. Tschesche, H. Jering, G. Schorp & T. Dietl

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  1. H. Tschesche
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  2. H. Jering
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  3. G. Schorp
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  4. T. Dietl
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Editor information

Editors and Affiliations

  1. Institut für Klinische Chemie und Klinische Biochemie, Universität München, 8000, Munich 2, Fed. Rep. Germany

    Hanz Fritz

  2. Organisch-Chemisches Laboratorium, Technischen Universität München, 8000, Munich 2, Fed. Rep. Germany

    Harald Tschesche

  3. Department of Biology, Brookhaven National Laboratory, Upton, NY, 11973, USA

    Lewis J. Greene

  4. Biochemisches Laboratorium, Bayer AG, 5600, Wuppertal 1, Fed. Rep. Germany

    Ernst Truscheit (Editor-in-Chief) (Editor-in-Chief)

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Tschesche, H., Jering, H., Schorp, G., Dietl, T. (1974). Reactive Site Cleavage, Thermodynamic Control Resynthesis, and Properties of Chemically Derivatized Trypsin-Kallikrein-Inhibitors. In: Fritz, H., Tschesche, H., Greene, L.J., Truscheit, E. (eds) Proteinase Inhibitors. Bayer-Symposium, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87966-1_42

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  • DOI: https://doi.org/10.1007/978-3-642-87966-1_42

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