Structure-Activity Relationships of Several Trypsin and Chymotrypsin Inhibitors from Legume Seeds

Conference paper
Part of the Bayer-Symposium book series (BAYER-SYMP, volume 5)


The presence of protein-like trypsin inhibitors in legume seeds is by now a well established fact. Different legume seeds contain one or more inhibitors. Most of them have a molecular weight of about 8000 with a high concentration of cystine (~ 20%) and no free SH groups.


Trypsin Tryptophan Methionine Histidine Leucine 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Birk, Y., Gertler, A., Khalef, S.: Biochem. J. 87, 281–284 (1963).PubMedGoogle Scholar
  2. 2.
    Birk, Y., Gertler, A.: Biochem. Prep. 12, 25–29 (1968).Google Scholar
  3. 3.
    Tur-Sinai, A., Birk, Y., Gertler, A., Rigbi, M.: Biochim. biophys. Acta (Amst.) 263, 666–672 (1972).Google Scholar
  4. 4.
    Finkenstadt, W.R., Laskowski, M, Jr.: J. biol. Chem. 240, PC 962-963 (1965).Google Scholar
  5. 5.
    Birk, Y., Gertler, A., Khalef, S.: Biochim. biophys. Acta 147, 402–404 (1967).PubMedGoogle Scholar
  6. 6.
    Birk, Y., Gertler, A.: In: Fritz, H., Tschesche, H. (Eds.): Proceedings of the International Research Conference on Proteinase Inhibitors, pp. 142–148. Berlin-New York: Walter de Gruyter 1971.Google Scholar
  7. 7.
    Krahn, J., Stevens, F. C.: Biochemistry 9, 2646–2652 (1970).PubMedCrossRefGoogle Scholar
  8. 8.
    Odani, S., Koide, T., Ikenaka, T.: Proc. Japan Acad. 47, 621–624 (1971).Google Scholar
  9. 9.
    Gertler, A., Birk, Y, Bondi, A.: J. Nutr. 91, 358–370 (1967).PubMedGoogle Scholar
  10. 10.
    Konijn, A.M., Birk, Y., Guggenheim, K.: Amer. J. Physiol. 218, 1113–1117 (1970).PubMedGoogle Scholar
  11. 11.
    Konijn, A.M., Birk, Y., Guggenheim, K.: J. Nutr. 100, 361–368 (1970).PubMedGoogle Scholar
  12. 12.
    Butler, P.J.G., Harris, J.I., Hartley, B.S., Leberman, R.: Biochem. J. 112, 679–689 (1968).Google Scholar
  13. 13.
    Madar, Z., Birk, Y., Gertler, A.: Comp. biochem. Physiol. 48B, 251–256 (1974).Google Scholar

Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • Y. Birk
    • 1
  1. 1.Department of Agricultural Biochemistry, Faculty of AgricultureThe Hebrew University of JerusalemRehovotIsrael

Personalised recommendations