Proteinase Inhibitors of the Respiratory Tract: Studies on the Structural Relationship between Acid-Stable Inhibitors Present in the Respiratory Tract, Plasma and Urine

  • K. Hochstrasser
  • H. Feuth
  • K. Hochgesand
Part of the Bayer-Symposium book series (BAYER-SYMP, volume 5)


About 10 years ago Laurell and Eriksson described the α1antitrypsin deficiency in man and established an association between homozygous α1 antitrypsin deficiency and obstructive emphysema of the lung [1]. These discoveries have stimulated many investigators to examine the possible role of proteolytic enzymes in the development of emphysema.


Pulmonary Emphysema Urinary Trypsin Inhibitor Antitrypsin Deficiency Plasma Inhibitor Bronchial Mucus 
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  1. 1.
    Laurell, C.B., Eriksson, S.: Scand. J. Lab. Invest. 15, 529–538 (1963).CrossRefGoogle Scholar
  2. 2.
    Goldring, I. P., Park, S.S., Greenberg, L., Ratner, I.M.: In: MITTMAN, CH. (Ed.): Pulmonary Emphysema and Proteolysis, pp. 389–409. New York-London: Academic Press 1972.Google Scholar
  3. 3.
    Gross, P., Pfitzer, E.A., Tolker, E., Babyak, M.A., Kaschak, M.: Arch. environm.Hlth. 11, 50–53 (1966).Google Scholar
  4. 4.
    Wuthrich, B, Schwarzspeck, M.: Schw. med. Wschr. 100, 1908–1914 (1970).Google Scholar
  5. 5.
    Ulmer, W.T., Islam, M.S., Bahran, J.Jr.: Dtsch. med. Wschr. 96, 1759 (1971).PubMedCrossRefGoogle Scholar
  6. 6.
    Hochstrasser, K., Haendle, H., Reichert, R., Werle, E.: Z. physiol. Chem. 352, 954–958 (1971).CrossRefGoogle Scholar
  7. 7.
    Hochstrasser, K., Reichert, R., Werle, E.: Z. physiol. Chem. 353, 221–226 (1972).CrossRefGoogle Scholar
  8. 8.
    Hochstrasser, K., Reichert, R., Schwarz, S., Werle, E.: Z. physiol. Chem. 354, 923–926 (1973).CrossRefGoogle Scholar
  9. 9.
    Hochstrasser, K., Reichert, R., Heimburger, N.: Z. physiol. Chem. 354, 587–588 (1973).Google Scholar
  10. 10.
    Heide, K., Heimburger, N., Haupt, H.: Clin. Chim. Acta 11, 82–85 (1965).CrossRefGoogle Scholar
  11. 11.
    Reichert, R., Hochstrasser, K., Werle, E.: Z. Laryng. Rhinol. 51, 190–193 (1972).Google Scholar
  12. 12.
    Proksch, G.J., Lane, J., Nordschow, C.D.: Clin. Biochem. 6, 200–206 (1973).PubMedCrossRefGoogle Scholar
  13. 13.
    Shulman, N.R.: J. Biol. Chem. 213, 655 (1955).PubMedGoogle Scholar
  14. 14.
    Reichert, R., Hochstrasser, K., Conradi, G.: Pneumonologie 147, 13–20 (1972).PubMedCrossRefGoogle Scholar
  15. 15.
    Laurell, C.B.: Anal. Biochem. 10, 358–361 (1965).PubMedCrossRefGoogle Scholar
  16. 16.
    Hochstrasser, K., Schuster, R., Reichert, R., Heimburger, N.: Z. physiol. Chem. 353, 1120–1124 (1972).CrossRefGoogle Scholar
  17. 17.
    Ohlsson, K.: Scand. J. Clin. Lab. Invest. 28, 5–11 (1971).PubMedCrossRefGoogle Scholar
  18. 18.
    Hochstrasser, K., Hochgesand, K., Rasche, B.: Respiration (1974) in press.Google Scholar

Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • K. Hochstrasser
    • 1
  • H. Feuth
    • 1
  • K. Hochgesand
    • 1
  1. 1.Biochemisches Laboratorium der HNO-KlinikUniversität MünchenMunich 2Fed. Rep. Germany

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