Abstract
The term carcinoid was first coined by Oberndorfer (1907) to indicate a lesion which had the histological appearance of a carcinoma without all its malignant attributes. In 1928 Masson showed the tissue of origin to be the argentaffin cells at the base of the crypts of Lieberkuhn. These cells secrete 5-hydroxy-tryptamine into the circulation, which produce diarrhoea as a result of excessive small bowel motility, skin flushing with patchy cyanosis and telangiectases, respiratory stridor and later valvular lesions on the right side of the heart. These features of the carcinoid syndrome were described by Thorson in 1954, yet a very accurate and detailed clinical description of all of them had been given by Sir Maurice Cassidy.
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Cassidy, M. A.: Proc. Roy. Soc. Med. 24, 129 (1930).
Masson, P., and L. Bergen: C. R. Acad. Sci. 176, 1748 (1928).
Oberndorfer, S.: Frankfurt. Z. Path. 1, 426 (1907).
Thorson, A., A. Biorck, G. Bjorkman, and J. Waldenstrom: Amer. Heart J. 47, 795 (1954).
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© 1969 Springer-Verlag Berlin Heidelberg
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Southwood, W.F.W. (1969). Carcinoid Tumours. In: Hoferichter, J. (eds) Progress in Proctology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87959-3_36
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DOI: https://doi.org/10.1007/978-3-642-87959-3_36
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