Abstract
Thiophenes furans and pyridines are in general the most readily available of the various hetero-aromatic systems and therefore we have carried out a great deal of metallation and derivatization reactions with these compounds. Furan and thiophene are cheap starting compounds and the stability of their easily obtainable 2-lithio derivatives permits reactions with a variety of “electrophilic” reagents. Hetero-aromatics with two or more hetero atoms (e.g. thiazoles, pyrazoles, oxazoles) are less readily available, and some of their metal derivatives have a low thermostability (cyclofragmentations). For these reasons their metallation and functionalization reactions have been studied less extensively [1].
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© 1987 Springer-Verlag Berlin Heidelberg
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Brandsma, L., Verkruijsse, H.D. (1987). Metallated Hetero-Aromatic Compounds. In: Preparative Polar Organometallic Chemistry. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87921-0_6
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DOI: https://doi.org/10.1007/978-3-642-87921-0_6
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-16916-1
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