Metallated Hetero-Aromatic Compounds
Thiophenes furans and pyridines are in general the most readily available of the various hetero-aromatic systems and therefore we have carried out a great deal of metallation and derivatization reactions with these compounds. Furan and thiophene are cheap starting compounds and the stability of their easily obtainable 2-lithio derivatives permits reactions with a variety of “electrophilic” reagents. Hetero-aromatics with two or more hetero atoms (e.g. thiazoles, pyrazoles, oxazoles) are less readily available, and some of their metal derivatives have a low thermostability (cyclofragmentations). For these reasons their metallation and functionalization reactions have been studied less extensively .
KeywordsMethyl Iodide Liquid Ammonia Dimethyl Disulfide Anhydrous Potassium Carbonate Butyl Bromide
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