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Metallated Hetero-Aromatic Compounds

  • Lambert Brandsma
  • Hermann D. Verkruijsse

Abstract

Thiophenes furans and pyridines are in general the most readily available of the various hetero-aromatic systems and therefore we have carried out a great deal of metallation and derivatization reactions with these compounds. Furan and thiophene are cheap starting compounds and the stability of their easily obtainable 2-lithio derivatives permits reactions with a variety of “electrophilic” reagents. Hetero-aromatics with two or more hetero atoms (e.g. thiazoles, pyrazoles, oxazoles) are less readily available, and some of their metal derivatives have a low thermostability (cyclofragmentations). For these reasons their metallation and functionalization reactions have been studied less extensively [1].

Keywords

Methyl Iodide Liquid Ammonia Dimethyl Disulfide Anhydrous Potassium Carbonate Butyl Bromide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • Lambert Brandsma
    • 1
  • Hermann D. Verkruijsse
    • 1
  1. 1.Organisch Chemisch Laboratorium Vakgroep Organische ChemieRijksuniversiteit UtrechtUtrechtThe Netherlands

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