Advertisement

Organometallic Reagents, Solvents and Laboratory Equipment

  • Lambert Brandsma
  • Hermann D. Verkruijsse

Abstract

Most pK values of sp2-hydrogen atoms in the various types of organic compounds lie in the range of 30–40 [8]. With the exception of some heterocyclic compounds (e.g. 1,3-thiazole, 1-methylimidazole, polyfluorobenzenes, dimethylformamide and its sulfur analogue) the kinetic acidity of sp2-hydrogens in organic compounds is much lower than that of the ethynyl sp-hydrogen in terminal acetylenes. As a result of the available basic reagents, alkyllithiums are most frequently used for deprotonation. The same holds if the organometallic intermediate is to be generated via halogen-lithium exchange from a bromo or iodo derivative [8, 10].

Keywords

Reaction Flask Liquid Ammonia Ferric Nitrate Organometallic Reagent Basic Reagent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • Lambert Brandsma
    • 1
  • Hermann D. Verkruijsse
    • 1
  1. 1.Organisch Chemisch Laboratorium Vakgroep Organische ChemieRijksuniversiteit UtrechtUtrechtThe Netherlands

Personalised recommendations