Biochemical Aspects of Carcinogenesis with Special Reference to Alkylating Agents and Some Antibiotics

  • E. Boyland
Conference paper
Part of the UICC Monograph Series book series (UICC, volume 7)

Abstract

That many of the methods used in the control of cancer can themselves induce cancer, may appear as a paradox. An early example of an agent producing the two effects is radiation. Soon after their discovery, X-rays were used to treat cancer and within a decade of the discovery it was recognised that X-rays caused cancer in men exposed to the radiation. Other forms of radiation used in the control of cancer and leukaemia have been found to cause cancer. In some cases the biochemical processes involved in carcinogenesis and inhibition of growth are probably similar.

Keywords

Sarcoma Cyclophosphamide Porphyrin Cytosine Guanine 

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References

  1. Berenblum, I.,Ben-ishai, D.,Haran-ghera, N.,Lapidot, A.,Simon, E., andTrainin, N., Skin initiating action and lung carcinogenesis by derivatives of urethane (ethyl carbamate) and related compounds.Biochem. Pharmacol. 2, 168–176 (1959).PubMedCrossRefGoogle Scholar
  2. Boyland, E., andGreen, B., The interaction of polycyclic hydrocarbons and nucleic acids.Brit. J. Cancer16, 507–517 (1962).PubMedCrossRefGoogle Scholar
  3. Boyland, E., andGreen, B., andHorning, E. S., The induction of tumours with nitrogen mustard.Brit. J. Cancer3, 118–123 (1949).PubMedCrossRefGoogle Scholar
  4. Boyland, E., andGreen, B., andNery, R., The metabolism of urethane and related compounds.Biochem. J. 94, 198– 208 (1965).PubMedGoogle Scholar
  5. Brookes, P., andLawley, P. D., Alkylating agents.Brit. med. Bull. 20, 91–95 (1964).PubMedGoogle Scholar
  6. Greenberg, C. H., andTanaku, K. R., Congenital anomalies probably induced by cyclophosphamide. J.Amer. med. Ass. 188, 423– 426 (1964).CrossRefGoogle Scholar
  7. Haddow, A., Influence of certain polycyclic hydrocarbons on the growth of the Jensen rat sarcoma.Nature (Lond.)136, 868–869 (1935).CrossRefGoogle Scholar
  8. Haddow, A., In: Physiopathology of cancer, The chemical and genetic mechanisms of carcinogenesis. II. Biologic alkylating agents, 2nd ed. (ed. F.Homburger), p. 602–685. London: Cas-sell 1953.Google Scholar
  9. Hata, T.,Sano, Y.,Sugawara, R.,Matsumae, A.,Kanamori, K.,Shima, T., andHoshi, T., Mitomycin, a new antibiotic from streptomyces. J.Antibiot. (Tokyo), Ser. A 9, 141–146 (1956).Google Scholar
  10. Hurst, F. W., andPaget, G. E., Protoporphyrin, cirrhosis and hepatomata in the livers of mice given griseofulvin.Brit. J. Derm. 75, 105–112 (1963).CrossRefGoogle Scholar
  11. Iyer, V. N., andSzybalski, U., Mitomycins and porfiromycin: chemical mechanism of activation and cross-linking of DNA.Science145, 55–58 (1964).PubMedCrossRefGoogle Scholar
  12. Kawamata, J.,Nakabayashi, N.,Kawai, A., andUshida, T., Experimental production of sarcoma in mice with actinomycin.Med. J. Osaka8, 753–762 Univ. (1958).Google Scholar
  13. Nettleship, A., andHenshaw, P. S., Induction of pulmonary tumors in mice with ethyl carbamate (urethane).J. nat. Cancer Inst. 4, 309–319 (1943).Google Scholar
  14. Paterson, E., ApThomas, I.,Haddow, A., andWilkinson, J. M., Leukaemia treated with urethane compared with deep X-ray therapy.Lancet1946 I, 677–683.CrossRefGoogle Scholar
  15. Philips, F. S.,Sternberg, S. S.,Cronin, A. P., andVidal, P. M., Cyclophosphamide and urinary bladder toxicity.Cancer Res. 21, 1577–1589 (1961).PubMedGoogle Scholar
  16. Presnov, M. A., andJushkov, S. F., The development of mastopathy and fibroadenoma in the rat mammary gland after intraabdominal sarcolysin injections.Vop. Onkol. 10 (5), 66–72 (1964).Google Scholar
  17. Salaman, M. H., andRoe, F. J. C, Further tests for tumour-initiating activity: N,N-DI(2-chloroethyl)-P-aminophenylbutyric acid (CB 1348) as an initiator of skin tumour formation in the mouse.Brit. J. Cancer10, 363–378 (1956).PubMedCrossRefGoogle Scholar
  18. Shimkin, M., Pulmonary-tumor induction in mice with chemical agents used in the clinical management of lymphomas.Cancer (Philad.)7, 410–413 (1954).CrossRefGoogle Scholar
  19. Thiede, T.,Chievitz, E., andChristensen, B. C., Chlornaphazine as a bladder carcinogen.Acta med. scand. 175, 721–725 (1964).PubMedCrossRefGoogle Scholar
  20. Upton, A. C.,Wolff, F. F., andSniffen, E. P., Leukemogenic effect of myleran on the mouse thymus.Proc. Soc. exp. Biol. (N.Y.)108, 464–467 (1961).Google Scholar
  21. Veselá, H., Induktion von Leukämie mit Phosphoramid bei Mäusen des C 57 B 1Stammes.Neoplasma (Bratisl.)9, 75–80 (1962).Google Scholar
  22. Videbaek, A., Chlornaphazin (Erysan) may induce cancer of the urinary bladder.Acta med. scand. 176, 45–50 (1964).PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1967

Authors and Affiliations

  • E. Boyland
    • 1
  1. 1.Chester Beatty Research InstituteLondonGreat Britain

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