Abstract
Peroxisomes have essential functions in lipid metabolism. They are involved in the ß-oxidation of a variety of compounds, the synthesis of cholesterol and bile acids, the synthesis of ether lipids, and several other pathways (for review, see [9, 15, 8]). A characteristic of peroxisomes in rodents is their proliferative response and the induction of fatty acid ß-oxidation enzymes upon treatment with several structurally unrelated chemicals, such as hypolipidemic drugs and plasticizers [6,7, 12, 10].
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Bradford M (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem 72: 248–254
Brocard C, Es-souni M, Ramirez LC, Latruffe N and Boumot P (1993) Stimulation of peroxisomal palmitoyl-CoA oxidase activity by ciprofibrate in hepatic cell lines: comparative studies in Fao, MH1C1 and HepG2 cells. Bio Cell 77:37–41
Causeret C, Bentejac M, Clemencet MC and Bugaut M (1993) Effects of two peroxisome proliferators (Ciprofibrate and Fenofibrate) on peroxisomal membrane proteins and dihydroxyacetone-phosphate acyl-transferase activity in rat liver. Cell Mol Biol 39:65–80
Deschatrette J, Weiss MC (1974) Characterisation of differentiated and dedifferenciated clones of rat hepatoma. Biochimie 56: 1603–1611
Deschatrette J, Moore EE, Dubois M & Weiss MC (1980) Dedifferenciated variants of a rat hepatoma: reversion analysis. Cell 19: 1043–1051
Hess R, Staubli W, Reiss W (1965) Nature of the hepatomegalic effect produced by ethyl-chlorophenoxy-isobutyrate in the rat. Nature 208: 856–859
Lazarow PB, de Duve C (1976) A fatty acyl-CoA oxidizing system in rat liver peroxisomes; enhancement by Clofibrate, a hypolidemic drug. Proc Natl Acad Sci USA 73: 2043–2046
Mestdagh N, Vamecq J (1992) Mitochondrial and peroxisomal acyl-CoA ß-oxidation in mammalian metabolism. In : Recent Advances in Cellular and Molecular Biology (Wegmann RJ, Wegmann MA, eds) Peteers Press, Leuven — Belgium: 115–160
Osmundsen H, Bremer J, Pedersen JI (1991) Metabolic aspects of peroxisomal ß-oxidation. Biochim Biophys Acta 1085: 141–158
Osumi T, Hashimoto T (1984) The inducible fatty acid oxidation system in mammalian peroxisomes. Trends Biochem Sci 9: 317–319
Osumi T, Yokota S, Hashimoto T (1990) Proliferation of peroxisomes and induction of peroxisomal ß-oxidation enzymes in Rat Hepatoma H4IIEC3 by ciprofibrate. J Biochem 108: 614–621
Reddy JK, Warren JR, Reddy MK, Lalwani ND (1982) Hepatic and renal effects of peroxisome proliferators: biological implications. Ann N Y Acad Sci 386: 81–110
Spydevold O, Bremer J (1989). Induction of peroxisomal ß-oxidation in 7800 C1 Morris hepatoma cells in steady state by fatty acids and fatty acid analogues. Biochim Biophys Acta 1003: 72–79.
Vamecq J (1990) Fluorimetric assay of peroxisomal Oxidases. Anal Biochem 186: 340–349
Van den Bosch H, Schutgens RBH, Wanders JA, Tager JM (1992) Biochemistry of peroxisomes. Ann Rev Biochem 61: 157–97
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© 1994 Springer-Verlag Berlin Heidelberg
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Brocard, C., Ramirez, L.C., Bournot, P. (1994). Fao Cell Line as a Model for the Study of the Effect of Peroxisome Proliferators on Cellular Functions. In: Latruffe, N., Bugaut, M. (eds) Peroxisomes. Springer Laboratory. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87807-7_12
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DOI: https://doi.org/10.1007/978-3-642-87807-7_12
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