Abstract
Peroxisomes have essential functions in lipid metabolism. They are involved in the ß-oxidation of a variety of compounds, the synthesis of cholesterol and bile acids, the synthesis of ether lipids, and several other pathways (for review, see [9, 15, 8]). A characteristic of peroxisomes in rodents is their proliferative response and the induction of fatty acid ß-oxidation enzymes upon treatment with several structurally unrelated chemicals, such as hypolipidemic drugs and plasticizers [6,7, 12, 10].
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bradford M (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem 72: 248–254
Brocard C, Es-souni M, Ramirez LC, Latruffe N and Boumot P (1993) Stimulation of peroxisomal palmitoyl-CoA oxidase activity by ciprofibrate in hepatic cell lines: comparative studies in Fao, MH1C1 and HepG2 cells. Bio Cell 77:37–41
Causeret C, Bentejac M, Clemencet MC and Bugaut M (1993) Effects of two peroxisome proliferators (Ciprofibrate and Fenofibrate) on peroxisomal membrane proteins and dihydroxyacetone-phosphate acyl-transferase activity in rat liver. Cell Mol Biol 39:65–80
Deschatrette J, Weiss MC (1974) Characterisation of differentiated and dedifferenciated clones of rat hepatoma. Biochimie 56: 1603–1611
Deschatrette J, Moore EE, Dubois M & Weiss MC (1980) Dedifferenciated variants of a rat hepatoma: reversion analysis. Cell 19: 1043–1051
Hess R, Staubli W, Reiss W (1965) Nature of the hepatomegalic effect produced by ethyl-chlorophenoxy-isobutyrate in the rat. Nature 208: 856–859
Lazarow PB, de Duve C (1976) A fatty acyl-CoA oxidizing system in rat liver peroxisomes; enhancement by Clofibrate, a hypolidemic drug. Proc Natl Acad Sci USA 73: 2043–2046
Mestdagh N, Vamecq J (1992) Mitochondrial and peroxisomal acyl-CoA ß-oxidation in mammalian metabolism. In : Recent Advances in Cellular and Molecular Biology (Wegmann RJ, Wegmann MA, eds) Peteers Press, Leuven — Belgium: 115–160
Osmundsen H, Bremer J, Pedersen JI (1991) Metabolic aspects of peroxisomal ß-oxidation. Biochim Biophys Acta 1085: 141–158
Osumi T, Hashimoto T (1984) The inducible fatty acid oxidation system in mammalian peroxisomes. Trends Biochem Sci 9: 317–319
Osumi T, Yokota S, Hashimoto T (1990) Proliferation of peroxisomes and induction of peroxisomal ß-oxidation enzymes in Rat Hepatoma H4IIEC3 by ciprofibrate. J Biochem 108: 614–621
Reddy JK, Warren JR, Reddy MK, Lalwani ND (1982) Hepatic and renal effects of peroxisome proliferators: biological implications. Ann N Y Acad Sci 386: 81–110
Spydevold O, Bremer J (1989). Induction of peroxisomal ß-oxidation in 7800 C1 Morris hepatoma cells in steady state by fatty acids and fatty acid analogues. Biochim Biophys Acta 1003: 72–79.
Vamecq J (1990) Fluorimetric assay of peroxisomal Oxidases. Anal Biochem 186: 340–349
Van den Bosch H, Schutgens RBH, Wanders JA, Tager JM (1992) Biochemistry of peroxisomes. Ann Rev Biochem 61: 157–97
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Brocard, C., Ramirez, L.C., Bournot, P. (1994). Fao Cell Line as a Model for the Study of the Effect of Peroxisome Proliferators on Cellular Functions. In: Latruffe, N., Bugaut, M. (eds) Peroxisomes. Springer Laboratory. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87807-7_12
Download citation
DOI: https://doi.org/10.1007/978-3-642-87807-7_12
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-87809-1
Online ISBN: 978-3-642-87807-7
eBook Packages: Springer Book Archive