Sex Cord-Mesenchyme Tumours

Pathologic Classification and its Relation to Prognosis and Treatment
  • Robert E. Scully
Part of the UICC Monograph Series book series (UICC, volume 11)


The category “sex cord-mesenchyme tumours” includes all neoplasms composed of cells that are ultimately derived from the sex cords or the mesenchyme of the embryonic gonad (Morris and Scully, 1958). These tumours may contain granulosa cells, stromal-theca cells, Sertoli cells, Leydig cells or the precursors of these elements, alone or in any combination. The term “mesenchymoma” has also been applied to this group of neoplasms (Malkasian et al., 1965), but it has a less acceptable embryologic basis because there is disagreement as to whether the sex cords and their derivatives, the granulosa and Sertoli cells, develop from the mesenchyme or from the “germinal” epithelium. The designation “specialized gonadal stromal tumours” was proposed for neoplasms of the testis that contain combinations of the various cell types mentioned above (Mostofi et al., 1959), and this term was subsequently adopted for the analogous ovarian tumours (Hertig and Gore, 1961; Novak and Long, 1965), but it has the same theoretical disadvantage as “mesenchymoma”. The ideal name awaits a concensus among embryologists on the origins of the gonadal cell types but, whatever term is used, authorities generally agree that the tumours in question fall into four broad categories.


Granulosa Cell Sertoli Cell Leydig Cell Theca Cell Granulosa Cell Tumour 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Burslem, R. W., Langley, F. A., and Woodcock, A. S., A clinicopathological study of oestrogenic ovarian tumours. Cancer (Philad.) 7, 522–538 (1954).CrossRefGoogle Scholar
  2. Busby, T., and Anderson, G. W., Feminizing mesenchymomas of the ovary. Amer. J. Ob-stet. Gynec. 68, 1391–1420 (1954).Google Scholar
  3. Cohen, M., and Shaw, M. W., Twoxy siblings with gonadal dysgenesis and a female phenotype. New Engl. J. Med. 272, 1083–1088 (1965).PubMedCrossRefGoogle Scholar
  4. Dominguez, C. J., and Greenblatt, R. B., Dysgerminoma of the ovary in a patient with Turner’s syndrome. Amer. J. Obstet. Gynec. 83, 674–677 (1962).PubMedGoogle Scholar
  5. Flick, F. H., and Banfield r., R. S., Malignant theca-cell tumors. Two new case reports and review of the eight published cases. Cancer (Philad.) 9, 731–735 (1956).CrossRefGoogle Scholar
  6. Flor, F. S., Schadt, D. C., and Benz, E. S., Gonadal dysgenesis with male chromatin pattern: testicular feminization syndrome. Clinical and pathological findings in two cases in siblings. J. Amer. med. Ass. 181, 375–379 (1962).CrossRefGoogle Scholar
  7. Foda, M. S., Youssef, A. J., and Shafeek, M. A., Malignant theca cell tumour of the ovary. J. Obstet. Gynaec. Brit. Emp. 68, 982–985 (1961).PubMedCrossRefGoogle Scholar
  8. Frasier, S. D., Bashore, R. A., and Mosier, H. D., Gonadoblastoma associated with pure gonadal dysgenesis in monozygous twins. J. Pediat. 64, 740–745 (1964).PubMedCrossRefGoogle Scholar
  9. Giusti, G., Borghi, A., Bigozzi, U., Negri, L., and Toccafondi, R., Ovarian dysgerminoma with precocious isosexual puberty followed by virilization. Obstet. and Gynec. 20, 755–760 (1962).Google Scholar
  10. Hartz, P. H., Giant cystic arrhenoblastoma of ovary containing entodermal epithelium and carcinoid. Amer. J. Path. 21, 1167–1191 (1945).PubMedGoogle Scholar
  11. Hertig, A. T., and Gore, H., Tumors of the ovary and Fallopian tube, p. 9–176. Armed Forces Instiute of Pathology, Washington 1961.Google Scholar
  12. Hughesdon, P. E., Ovarian lipoid and theca cell tumors; their origins and interrelations. Ob-stet. and Gynec. 21, 245–288 (1966).CrossRefGoogle Scholar
  13. Hughesdon, P. E., and Fraser, I. T., Arrhenoblastoma of ovary. Case report and histological review. Acta obstet. gynec. stand. (Suppl. 4) 32, 1–78 (1953).CrossRefGoogle Scholar
  14. Kortmeier, H. L., Carcinoma of the female genitalia, p. 174–192. Baltimore: Williams & Wilkins Co. 1953.Google Scholar
  15. Malkasian, G. D., Dockerty, M. B., Wilson, R. B., and Faber, J. E., Functioning tumors of the ovary in women under 40. Obstet. and Gynec. 26, 669–675 (1965).Google Scholar
  16. Mathet, P., Les tumeurs masculinisantes de l’ovaire. Paris These 114 p. Paris: Libraire Arnette 1956.Google Scholar
  17. Melicow, M. M., and Uson, A. C., Dysgenetic gonadomas and other gonadal neoplasms in intersexes. Report of 5 cases and review of the literature. Cancer (Philad.) 12, 552–572 (1959).CrossRefGoogle Scholar
  18. Miller, O. J., The sex chromosome anomalies. Amer. J. Obstet. Gynec. 90, 1078–1138 (1964).PubMedGoogle Scholar
  19. Morris, J. McL., and Scully, R. E., Endocrine pathology of the ovary, p. 15–138. St. Louis: C. V. Mosby Co. 1958.Google Scholar
  20. Mostoei, F. K., Theiss, E. A., and Ashley, D. J. B, Tumors of specialized gonadal stroma in human male patients. Androblastoma, Sertoli cell tumor, granulosa-theca cell tumor of the testis, and gonadal Stromal tumor. Cancer (Philad.) 12, 944–957 (1959).CrossRefGoogle Scholar
  21. Novak, E. R., and Long, J. H.,Arrhenoblastoma of the ovary. Amer. J. Obstet. Gynec. 92, 1082–1093 (1965).PubMedGoogle Scholar
  22. O’hern, T. M., and Neubecker, R. D., Arrhenoblastoma. Obstet. and Gynec. 19, 758770 (1962).Google Scholar
  23. Palladino, V. S., Duffy, S. L., and Bures, G. S., Probable true cystic granulosa cell tumor. Report of a case. Obstet and Gynec. 25, 729–733 (1965).Google Scholar
  24. Robinson, A., Priest, R. E., and Bigler, P. C., Male pseudohermaphrodite with XY/XO mosaicism and bilateral gonadoblastomas. Letter to the editor. Lancet 1964 I, 111–112.Google Scholar
  25. Santesson, L., and Marrubini, G., Clinical and pathological survey of ovarian embryonal carcinomas, including so-called “mesonephromas” (SCHILLER), or “mesoblastomas” (TEILuM), treated at the Radiumhemmet. Acta obstet. gynec. stand. 36, 399–419 (1957).CrossRefGoogle Scholar
  26. Scully, R. E., Gonadoblastoma. A gonadal tumor related to the dysgerminoma (semi-noma) and capable of sex-hormone production. Cancer (Philad.) 6, 455–463 (1953).CrossRefGoogle Scholar
  27. Scully, R. E.: An unusual ovarian tumor containing Leydig cells, but associated with endometrial hyperplasia, in a postmenopausal woman. J. clin. Endocr. 13, 1254–1263 (1953).PubMedCrossRefGoogle Scholar
  28. Scully, R. E.: Stromal luteoma of the ovary. A distinctive type of lipoidcell tumor. Cancer (Philad.) 17, 769–778 (1964).CrossRefGoogle Scholar
  29. Scully, R. E.: Unpublished observations 1966.Google Scholar
  30. Siebenmann, R. B., Pseudohermaphroditismus masculinus mit Gonadoblastom-line besondere Intersexform. Path. et Microbiol. (Basel) 24, 233–238 (1961).Google Scholar
  31. Sher, J., and Marsh, M., MUltilOCUlar cystic granulosa cell tumor. Report of a case. Amer. J. clip. Path. 40, 72–77 (1963).Google Scholar
  32. Sjöstedt, S., and Wahlen, T., Prognosis of granulosa cell tumours. Acta obstet. gynec. stand. 40, 1–26 (Suppl. 6 ) (1961).Google Scholar
  33. Sternberg, W. H., and Barclay, D. L., Luteoma of pregnancy. Amer. J. Obstet. Gynec. 95, 165–184 (1966).PubMedGoogle Scholar
  34. Strumpf, I. J., Gonadoblastoma in a patient with gonadal dysgenesis. Amer. J. Obstet. Gynec. 92, 992–995 (1965).PubMedGoogle Scholar
  35. Taylor, H. B., In: Pathology annual, vol. 1, ed. by S. C. Sommers, p. 127–147. New York: Appleton-Century-Crofts 1966.Google Scholar
  36. Teilum, G., Classification of testicular and ovarian androblastoma and Sertoli cell tumors. A survey of comparative studies with consideration of histogenesis, endocrinology, and embryological theories. Cancer (Philad.) 11, 769–782 (1958).CrossRefGoogle Scholar
  37. Teter, J., An usual gonadal tumour (gonadoblastoma) in a male pseudo-hermaphrodite with testicular dysgenesis. J. Obstet. Gynaec. Brit. Emp. 67, 238–242 (1960).PubMedCrossRefGoogle Scholar
  38. Teter, J., Philip, J., Wecçevicz, G., and Potocki, J., A masculinizing mixed germ cell tumour (Gonocytoma III). Acta endocr. (Kbh.) 46, 1–11 (1964).Google Scholar
  39. Teter, J., Philip, J., and Weçevicz, G., “Mixed” gonadal dysgenesis with gonadoblastoma in situ. Amer. J. Obstet. Gynec. 90, 929–935 1964 ).PubMedGoogle Scholar
  40. Usizima, H., Ovarian dysgerminoma associated with masculinization. Report of a case. Cancer (Philad.) 9, 736–739 (1956).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1968

Authors and Affiliations

  • Robert E. Scully
    • 1
    • 2
  1. 1.Massachusetts General HospitalBostonUSA
  2. 2.Harvard Medical SchoolBostonUSA

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