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Sex Cord-Mesenchyme Tumours

Pathologic Classification and its Relation to Prognosis and Treatment
  • Robert E. Scully
Part of the UICC Monograph Series book series (UICC, volume 11)

Abstract

The category “sex cord-mesenchyme tumours” includes all neoplasms composed of cells that are ultimately derived from the sex cords or the mesenchyme of the embryonic gonad (Morris and Scully, 1958). These tumours may contain granulosa cells, stromal-theca cells, Sertoli cells, Leydig cells or the precursors of these elements, alone or in any combination. The term “mesenchymoma” has also been applied to this group of neoplasms (Malkasian et al., 1965), but it has a less acceptable embryologic basis because there is disagreement as to whether the sex cords and their derivatives, the granulosa and Sertoli cells, develop from the mesenchyme or from the “germinal” epithelium. The designation “specialized gonadal stromal tumours” was proposed for neoplasms of the testis that contain combinations of the various cell types mentioned above (Mostofi et al., 1959), and this term was subsequently adopted for the analogous ovarian tumours (Hertig and Gore, 1961; Novak and Long, 1965), but it has the same theoretical disadvantage as “mesenchymoma”. The ideal name awaits a concensus among embryologists on the origins of the gonadal cell types but, whatever term is used, authorities generally agree that the tumours in question fall into four broad categories.

Keywords

Granulosa Cell Sertoli Cell Leydig Cell Theca Cell Granulosa Cell Tumour 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1968

Authors and Affiliations

  • Robert E. Scully
    • 1
    • 2
  1. 1.Massachusetts General HospitalBostonUSA
  2. 2.Harvard Medical SchoolBostonUSA

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