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The Various Types of DNA Antibodies in Lupus Sera

  • M. Seligmann
  • R. Arana

Abstract

The presence of antibodies reacting with deoxyribonucleic acid (DNA) in the sera of some patients with systemic lupus erythematosus (SLE) was demonstrated ten years ago (Seligmann, 1957; Robbins et al., 1957; Ceppellini et al., 1957; Seligmann and Milgrom, 1957). The early studies on these antibodies (Seligmann, 1958; Deicher et al., 1959) were performed with native DNA. Subsequently Barbu et al. (1960) showed that some lupus antibodies also react with DNA previously denatured or degraded by various procedures. Stollar and Levine (1961) and Stollar et al. (1962a) reported that all but one of their DNA-reactive SLE sera reacted exclusively or more effectively with thermally denatured DNA. Most of the experimentally induced antibodies capable of reacting with DNA were shown to react only with denatured DNA. Therefore, in recent years, most reports on DNA antibodies have been devoted to immunological reactions with denatured DNA.

Keywords

Systemic Lupus Erythematosus Systemic Lupus Erythematosus Patient Precipitin Line Anticomplementary Activity Bovine Serum Albumin Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Barbu, E., M. Seligmann, and M. Joly (1960). Réactions entre des acides désoxyribonucléiques diversement dénaturés ou dégradés et les anticorps anti-acide désoxyribonucléique du sérum de malades atteints de lupus érythémateux disséminé. Ann. Inst. Pasteur, 99:695.Google Scholar
  2. Beiser, S. M., and B. F. Erlanger (1966). Antibodies which react with nucleic acids. Cancer Research, 26:2012.PubMedGoogle Scholar
  3. Ceppellini, R., E. Polli, and F. Celada (1957). A DNA reacting factor in serum of a patient with lupus erythematosus diffusus. Proc. Soc. Exp. Biol. Med., 96:572.PubMedGoogle Scholar
  4. Christian, C. L., A. R. Desimone, and J. L. Arbuzzo (1965). Anti-DNA antibodies in hyperimmunized rabbits. J. Exp. Med., 121:309.PubMedCrossRefGoogle Scholar
  5. Deicher, H. R. G., H. R. Holman, and H. G. Kunkel (1959). The precipitin reaction between DNA and a serum factor in systemic lupus erythematosus. J. Exp. Med., 109:97.PubMedCrossRefGoogle Scholar
  6. Levine, L., W. T. Murakami, H. Van Vunakis, and L. Grossmann (1960). Specific antibodies to thermally denatured DNA of phage T4. Proc. Natl. Ac. Sci., 46:1038.CrossRefGoogle Scholar
  7. Mandel, J. D., and A. D. Hershey (1960). A fractionating column for analysis of nucleic acids. Anal. Biochem., 1:66.CrossRefGoogle Scholar
  8. Plescia, O. J., W. Braun, and N. C. Palczuk (1964). Production of antibodies to denatured deoxyribonucleic acid (DNA). Proc. Natl. Ac. Sci., 52:279.CrossRefGoogle Scholar
  9. Plescia, O. J., N. C. Palczuk, W. Braun, and M. E. Cora-Figueroa (1965). Antibodies to DNA and a synthetic polydeoxyribonucleotide produced by oligodeoxyribonucleotides. Science, 148:1102.CrossRefGoogle Scholar
  10. Robbins, W. C., H. R. Holman, H. Deicher, and H. G. Kunkel (1957). Complement fixation with cell nuclei and DNA in lupus erythematosus. Proc. Soc. Exp. Biol. Med. 96:575.PubMedGoogle Scholar
  11. Seligmann, M. (1957). Mise en évidence dans le sérum de malades atteints de lupus érythémateux disséminé d’une réaction de précipitation avec l’acide désoxyribonucléique. C. R. Acad. Sci., 245:243.Google Scholar
  12. Seligmann, M. (1958). Etudes immunologiques sur le lupus érythémateux disséminé. Rev. Fr. Et. Clin. Biol., 3:558.Google Scholar
  13. Seligmann, M. (1963). DNA antibodies. Arthritis and Rheumatism, 6:542.PubMedCrossRefGoogle Scholar
  14. Seligmann, M., and F. Milgrom (1957). Mise en évidence par la fixation du complement de la réaction entre acide désoxyribonucléique et le serum de malades atteints de lupus érythémateux disséminé. C. R. Acad. Sci., 245:1472.Google Scholar
  15. Stollar, D., and L. Levine (1961). Antibodies to denatured DNA in a lupus erythematosus serum. J. Immun., 87:477.PubMedGoogle Scholar
  16. Stollar, D., L. Levine, and J. Marmur (1962a). Antibodies to denatured DNA in lupus erythematosus serum. II. Characterization of antibodies in several sera. Biochem. Biophys. Acta, 61:7.PubMedGoogle Scholar
  17. Stollar, D., L. Levine, H. I. Lehrer, and H. Van Vunakis (1962b). The antigenic determinants of denatured DNA reactive with lupus erythematosus serum. Proc. Natl. Ac. Sci., 48:874.CrossRefGoogle Scholar
  18. Stollar, D., and L. Levine (1963). Antibodies to denatured deoxyribonucleic acid in lupus erythematosus serum. IV. Evidence for purine determinants in DNA. Arch. Biochem. Biophys., 101:417.PubMedCrossRefGoogle Scholar
  19. Stollar, B. D., and A. L. Sandberg (1966). Comparison of antibodies reacting with DNA. I. Systemic lupus erythematosus sera and rabbit antibodies induced by DNA-methylated bovine serum albumin complexes. J. Immun., 96:755.PubMedGoogle Scholar
  20. Tan, E. M., P. H. Schur, R. I. Carr, and H. G. Kunkel (1966). Deoxyribonucleic acid (DNA) and antibodies to DNA in the serum of patients with systemic lupus erythematosus. J. Clin. Invest., 45:1732.PubMedCrossRefGoogle Scholar
  21. Wasserman, E., and L. Levine (1961). Quantitative micro-complement fixation and its use in the study of antigenic structure by specific antigen-antibody inhibition. J. Immun., 87:290.PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1968

Authors and Affiliations

  • M. Seligmann
    • 1
  • R. Arana
    • 1
  1. 1.Research Institute for Blood Diseases of the University of ParisHôpital Saint-LouisParisFrance

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