The Various Types of DNA Antibodies in Lupus Sera

  • M. Seligmann
  • R. Arana


The presence of antibodies reacting with deoxyribonucleic acid (DNA) in the sera of some patients with systemic lupus erythematosus (SLE) was demonstrated ten years ago (Seligmann, 1957; Robbins et al., 1957; Ceppellini et al., 1957; Seligmann and Milgrom, 1957). The early studies on these antibodies (Seligmann, 1958; Deicher et al., 1959) were performed with native DNA. Subsequently Barbu et al. (1960) showed that some lupus antibodies also react with DNA previously denatured or degraded by various procedures. Stollar and Levine (1961) and Stollar et al. (1962a) reported that all but one of their DNA-reactive SLE sera reacted exclusively or more effectively with thermally denatured DNA. Most of the experimentally induced antibodies capable of reacting with DNA were shown to react only with denatured DNA. Therefore, in recent years, most reports on DNA antibodies have been devoted to immunological reactions with denatured DNA.


Systemic Lupus Erythematosus Systemic Lupus Erythematosus Patient Precipitin Line Anticomplementary Activity Bovine Serum Albumin Complex 
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© Springer-Verlag New York Inc. 1968

Authors and Affiliations

  • M. Seligmann
    • 1
  • R. Arana
    • 1
  1. 1.Research Institute for Blood Diseases of the University of ParisHôpital Saint-LouisParisFrance

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