The Nature of Immunogenic RNA-Antigen Complexes in Immune and Tolerant Mice

  • Herman Friedman


There is currently widespread interest concerning the role of subcellular fractions and nucleic acids in antibody-formation. During the late 1950’s it was reported that nucleoprotein-rich extracts from donor rabbits immunized with bacterial antigens produced specific agglutinins in nonimmune individuals (Sterzl and Hrubesova, 1956; Friedman, 1959). More recent studies concerning molecular aspects of antibody formation have been concerned with the apparent conversion of “normal” nonimmune lymphoid tissues or cells in vitro to specific immunologic competence following treatment with RNA-rich substances extracted from lymphoid cells or macrophages exposed to a specific antigen, either in vitro or in vivo. For example, RNA-rich extracts from rat macrophages exposed to bacteriophage antigen in vitro appear to stimulate specific antibody formation by normal lymph node cultures (Fishman, 1961; Fishman and Adler, 1963). The nature and mode of action of such nucleic acid-rich extracts is under investigation by a number of groups.


Spleen Cell Antibody Formation Recipient Mouse Donor Mouse Spleen Cell Culture 
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© Springer-Verlag New York Inc. 1968

Authors and Affiliations

  • Herman Friedman
    • 1
  1. 1.Departments of MicrobiologyAlbert Einstein Medical Center and Temple University School of MedicinePhiladelphiaUSA

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