Stimulation of Antibody-Forming Cells by Oligonucleotides of Known Composition

  • Werner Braun
  • Masayasu Nakano
  • Lydie Jaraskova
  • Yukiyoshi Yajima
  • Luis Jimenez


The data compiled in this volume illustrate the multiple functions of nucleic acids in antibody formation. Nucleic acid in the form of poly-deoxyribonucleotides supplies the basic information for messenger RNA formation and protein synthesis in cells that participate in antibody synthesis. Nucleic acid in the form of messenger RNA transmits this information to RNA-rich cellular sites of polypeptide synthesis, within cells and possibly even among cells. Furthermore, there is some evidence (Braun and Cohen, 1968) suggesting that RNA itself, or something closely associated with it and present in macrophage-released RNA-antigen complexes, may act as an activator or derepressor for stem-cells of antibody-forming lymphocyte populations. In addition, oligomers of nucleic acids influence the rate with which activated stem-cells of antibody-forming lymphocyte populations increase in numbers during a given period of time. This non-specific effect of oligonucleotides on antibody-forming cells will be the subject of this communication.


Spleen Cell Antibody Formation Deoxynucleoside Triphosphate Antibody Synthesis Normal Immune Response 
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Copyright information

© Springer-Verlag New York Inc. 1968

Authors and Affiliations

  • Werner Braun
    • 1
  • Masayasu Nakano
    • 1
  • Lydie Jaraskova
    • 1
  • Yukiyoshi Yajima
    • 1
  • Luis Jimenez
    • 1
  1. 1.Institute of MicrobiologyRutgers, The State UniversityNew BrunswickUSA

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