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NMR Relaxation and Water Contents in Normal Tissues and Cancer Cells

  • G. N. Ling
  • M. Tucker
Part of the NMR Basic Principles and Progress book series (NMR, volume 19)

Abstract

Different nuclear magnetic resonance (NMR) relaxation times for water protons in six normal rat tissues and three malignant tumors were reported by Damadian in 1971 [1]. He regarded the lower relaxation times in normal tissues (T1 and T2) as consistent with Ling’s theory of cell water [2–5], in which the bulk of cell water exists in a state of polarized multilayers. Damadian interpreted the slower relaxation times seen in cancer tissues as indicating a loosening up of the water structure of normal cells. (This had been suggested by Szent-Györgyi from a consideration of the difference in the patterns of metabolism between cancer cells and normal tissues [6].) At the time, investigators concurred with Damadian’s interpretation of the reason for the lengthening of relaxation times of the water protons in cancer cells [7–10]. However, alternative interpretations soon emerged.

Keywords

Nuclear Magnetic Resonance Water Proton Total Water Content Ascites Cell Nuclear Magnetic Resonance Relaxation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Damadian, R.: Science 171; 1151 (1971)PubMedCrossRefGoogle Scholar
  2. 2.
    Ling, GN.: Ann. NY. Acad. Sci. 725;401 (1965)Google Scholar
  3. 3.
    Ling, GN.: Hydration of macromolecules, in Structure and transport processes in water and aqueous solutions A. Home, (ed.) Wiley-Interscience, N.Y. 1972, pp. 201–213Google Scholar
  4. 4.
    Ling, GN., et al.: Physiol. Chem. Phys. 12, 3 (1980)Google Scholar
  5. 5.
    Ling, GN, et al.: Physiol. Chem. Phys. 10, 87 (1978)PubMedGoogle Scholar
  6. 6.
    Szent-Györgyi, A.: Bioenergetics. Academic Press, N.Y. 1957Google Scholar
  7. 7.
    Hazlewood, C. F., et al.: Proc. Nat. Acad. Sci. 50, 1478 (1972)CrossRefGoogle Scholar
  8. 8.
    Hollis, D. P., Saryan, L. A., Morris, H. P.: Johns Hopkins Med. J. 131, 441 (1972)PubMedGoogle Scholar
  9. 9.
    Saryan, A., Hollis, D. P., Economou, J. S.: J. Natl. Cancer Inst. 52, 599 (1974)PubMedGoogle Scholar
  10. 10.
    Frey, H. E., et al.: J. Natl. Cancer Inst. 49, 903 (1972)PubMedGoogle Scholar
  11. 11.
    Cooke, R., Wein, R.: Ann. N.Y. Acad. Sci. 204, 197 (1973)PubMedCrossRefGoogle Scholar
  12. 12.
    Outhred, R. K., George, E. P.: Biophys. J. 13, 97 (1973)PubMedCrossRefGoogle Scholar
  13. 13.
    Belton, P. S., Jackson, R. R., Packer, K. J.: Biochem. Biophys. Acta. 286, 16 (1972)PubMedCrossRefGoogle Scholar
  14. 14.
    Kiricuta, Jr., I. C., Demco, D., Simplaceanu, V.: Arch. Geschwulstforsch. 42, 226 (1973)PubMedGoogle Scholar
  15. 15.
    Hollis, D. P., et al.: Cancer Res. 33, 2156 (1973)PubMedGoogle Scholar
  16. 16.
    Inch, W. R., et al.: J. Natl. Cancer Inst. 52, 353 (1974)PubMedGoogle Scholar
  17. 17.
    Fung, B. M., McCaughy, T. W.: Biochem. Biophys. Acta 343, 663 (1974)PubMedCrossRefGoogle Scholar
  18. 18.
    Fung, B. M., Durham, D. L., Wassil, D. A.: Biochim. Biophys. Acta 399, 191 (1975)PubMedCrossRefGoogle Scholar
  19. 19.
    Block, R. E., Maxwell, G. P.: J. Magn. Res. 14, 329 (1974)CrossRefGoogle Scholar
  20. 20.
    Foster, K. R., Resing, H. A., Garroway, A. N.: Science 194, 324 (1976)PubMedCrossRefGoogle Scholar
  21. 21.
    Ranade, S. S., et al.: Physiol. Chem. Phys. 8, 131 (1976)PubMedGoogle Scholar
  22. 22.
    Cottam, G. L., Vasek, A., Lusted, D.: Res. Comm. Chem. Path. Pharm. 4, 495 (1972)Google Scholar
  23. 23.
    Cope, F. W.: Biophys. J. 9, 303 (1969)PubMedCrossRefGoogle Scholar
  24. 24.
    Block, R. E., et al: J. Natl. Cancer Inst. 58, 151 (1977)PubMedGoogle Scholar
  25. 25.
    Kagimoto, P., et al.: J. Natl. Cancer Inst. 59, 335 (1977)Google Scholar
  26. 26.
    Beall, P. T., Cailleau, R. M., Hazlewood, C. F.: Physiol. Chem. Phys. 8, 281 (1976)PubMedGoogle Scholar
  27. 27.
    Beall, P. T., Hazlewood, D. F., Rao, P. N.: Science 192, 904 (1976)PubMedCrossRefGoogle Scholar
  28. 28.
    Beall, P. T., et al.: Distinction of normal, preneoplastic and neoplastic mouse mammary primary cell ultures by water NMR relaxation times. J. Natl. Cancer Inst. 64, 335 (1980)PubMedGoogle Scholar
  29. 29.
    Lewa, C. J., Baczkowski, A.: Acta Physica Polonica.450, 865 (1976)Google Scholar
  30. 30.
    Kasturi, S. R., Ranade, S., Shah, S.: Proc. Indian Acad. Sci. 84, 60 (1976)Google Scholar
  31. 31.
    Eggleston, J. C., Saryan, L. A., Hollis, D. P.: Cancer Res. 35, 1326 (1978)Google Scholar
  32. 32.
    Kodama, M., et al.: Br. J. Cancer 37, 233 (1978)CrossRefGoogle Scholar
  33. 33.
    Inch, W. R., et al.: J. Natl. Cancer Inst. 53, 689 (1974)PubMedGoogle Scholar
  34. 34.
    Weisman, I. D., et al.: Science 178, 1288 (1972)PubMedCrossRefGoogle Scholar
  35. 35.
    Weisman, I. D., et al.: J. R. Natl. Bur. Stand. 80A, 439 (1976)Google Scholar
  36. 36.
    Raaphorst, G. P., Kruuv, J., Pintar, M. M.: Biophys. J. 15, 391 (1975)PubMedCrossRefGoogle Scholar
  37. 37.
    Hogeboom, G. H., Schneider, W. C., Palade, G. H.: J. Biol. Chem. 172, 619 (1948)PubMedGoogle Scholar
  38. 38.
    Damadian, R., Zaner, H., Hor, D., Physiol. Chem. Phys. 5, 381 (1973)PubMedGoogle Scholar
  39. 39.
    Hollis, D. P., et al.: J. Natl. Cancer Inst. 54, 1469 (1975)PubMedGoogle Scholar
  40. 40.
    Morris, H. P., Wagner, B.: Induction and transplantation of rat hepatomas with different growth rate (including “minimal deviation” hepatomas), in Methods in Cancer Research, Vol 4, Academic Press, N.Y. 1968, p. 125–152Google Scholar
  41. 41.
    Potter, VR.: Cancer Res. 21, 1331 (1961)PubMedGoogle Scholar
  42. 42.
    Hauschka, T. S.: Ann. N.Y. Acad. Sci. 63, 637 (1956)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • G. N. Ling
    • 1
  • M. Tucker
    • 1
  1. 1.Department of Molecular BiologyPennsylvania HospitalPhiladelphiaUSA

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