Mode de libération des produits de neurosécrétion

  • M. Herlant

Résumé

Le mode de libération du neuro-sécrétat dans les vaisseaux irriguant le lobe postérieur demeure un problème très controversé. La Vasopressine et l’ocytocine sont bien véhiculées par les granulations qui viennent s’accumuler à l’extrémité des fibres neuro-sécrétrices, mais ces hormones qui sont des octopeptides n’existent apparemment pas à l’état libre dans les granulations. Elles sont associées à une molécule protéique beaucoup plus volumineuse (Van Dyke et coll., 1942, Hild et Zetler, 1953; Acher, 1958). Acher a désigné cette association protéique sous le terme de «neurophysine». La neurophysine a été isolée et, actuellement, on lui attribue un poids moléculaire de 25.000 (Ginsburg et Ireland, 1963). Au cours de leur libération, les hormones demeurent apparemment associées à leur substrat protéique (van Dyke et coll., 1955; Heller, 1955; Acher, 1958; Ishii et coll., 1962).

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Bibliographie

  1. Acher, R. : Etat naturel des principes ocytocique et vasopressique de la neuro-hypophyse. 2è Intern. Symposium über Neurosecretion. (Ed. par W. Bargmann, B. Hanström et E. Scharrer), p. 71–78. Berlin-Göttingen-Heidelberg: Springer 1958.Google Scholar
  2. Bargmann, W. : Electronenmikroskopische Untersuchungen an der Neurohypophyse. 2e Intern. Symposium über Neurosekretion. (Ed. par W. Bargmann, B. Hanström et ), p.4–12. Berlin-Göttingen-Heidelberg: Springer 1958.Google Scholar
  3. Bargmann, W. : Neurosecretion. Int. Rev. Cytol. 19, 183–201 (1966).PubMedCrossRefGoogle Scholar
  4. Bargmann, W., u. A. Knoop: Electronenmikroskopische Beobachtungen an der Neurohypophyse. Z. Zellforsch. 46, 242–251 (1957).PubMedCrossRefGoogle Scholar
  5. Bargmann, W., u. A. Knoop: Über die morphologische Beziehungen des neurosekretorischen Zwischenhirnsystems zum Zwischenlappen der Hypophyse (Licht- und elektronenmikroskopische Beobachtungen). Z. Zellforsch. 52, 256–277 (1960).PubMedCrossRefGoogle Scholar
  6. Bern, H. W.: The secretory neuron as a doubly specialized cell, in D. Mazia et A. Tyler: General Physiology of Cell Specialization, pp. 349–366. New York: McGraw-Hill 1963.Google Scholar
  7. Bern, H. W., K. Yagi, and R. S. Nishioka: Structure and function of the caudal neurosecretory system of fishes. Arch. Anat. micr. Morph. exp. 54, 217–238 (1965).PubMedGoogle Scholar
  8. Bodian, D. : Nerve endings, neurosecretory substance and lobular organization of the neurohypophysis. Bull. Johns Hopk. Hosp. 89, 354–376 (1951).Google Scholar
  9. de Robertis, E. : Histophysiologie des synapses et neurosécrétions. Monographie de Physiologie causale. Vol. IV. Paris: Gauthier-Villars 1964.Google Scholar
  10. de Robertis, E., A. Pellegrino de Iraldi, G. Rodriguez, and C. J. Gomez: On the isolation of nerve endings and synaptic vesicles. J. biophys. biochem. Cytol. 9, 229–235 (1961).CrossRefGoogle Scholar
  11. Duncan, D. : An electronmicroscope study of the neurohypophysis of a bird. Anat. Rec. 125, 457–472 (1956).PubMedCrossRefGoogle Scholar
  12. Farquhar, M. G. : Origin and fate of secretory granules in cells of the anterior pituitary gland. Trans. N.Y. Acad. Sci. 23, 346–351 (1961).PubMedCrossRefGoogle Scholar
  13. Follenius, E.: Bases structurales et ultrastructurales des correlations hypothalamo-hypophysaires chez quelques espèces de Poissons téléostéens. Ann. Sci. Natur. Zoologie 12è série. VII. 1–150 (1965).Google Scholar
  14. Follenius, E., et A. Porte: Etude des différents lobes de l’hypophyse de la Perche au microscope électronique. C.R. Soc. Biol. 155, 128–131 (1961).Google Scholar
  15. Fridberg, G., S. Iwasaki, K. Yagi, H. A. Bern, D. M. Wilson, and R. S. Nishioka: Relation of impulse conduction to electrically induced release of neurosecretory material from the urophysis of the teleost fisch, Tilapia mossambica. J. exp. Zool. 161, 137–150 (1966).PubMedCrossRefGoogle Scholar
  16. Fujita, H., and J. F. Hartmann: Electron microscopy of neurohypophysis in normal adrenaline-treated and pilocarpine treated Rabbits. Z. Zeilforsch. 54, 734–763 (1961).CrossRefGoogle Scholar
  17. Gerschenfeld, H. M., J. Tramezzani, and E. de Eobertis: Ultrastructure and function in neurohypophysis of the toad. Endocrinology 66, 741–762 (1960).PubMedCrossRefGoogle Scholar
  18. Ginsburg, M., and M. Ireland: Isolation hormone-binding capacity and subcellular distribution of neurophysin. J. Physiol. (Lond.) 169, 114–115 (1964).Google Scholar
  19. Green, J. D., and V. L. van Breemen: Electron microscopy of the pituitary and observations on neurosecretion. Amer. J. Anat. 97, 177–227 (1955).PubMedCrossRefGoogle Scholar
  20. Hanström, B.: Transportation of colloid from the neurosecretory hypothalamic centres of the brain into the blood vessels of the neural lobe of the hypophysis. K. fysiogr. Sällsk Lund Förh. 22, 18 (1952).Google Scholar
  21. Hartmann, J. F.: Electron microscopy of the neurohypophysis in normal and histamine treated rats. Z. Zeilforsch. 48, 291–308 (1958).CrossRefGoogle Scholar
  22. Heller, H.: Active principles of neurohypophysis. J. Pharm. Pharmacol. 7, 225–247 (1955).PubMedCrossRefGoogle Scholar
  23. Heller, H., and K. Lederis : Characteristics of isolated neurosecretory Vesicles from Mammalian neural Lobes. Pr. 3 Intern. Symposium on Neurosecretion. Memoirs of the Soc. for Endocrinol. (Ed. by H. Heller et R. B. Clark), pp. 35–50. New York: Academic Press 1962.Google Scholar
  24. Hild, W., et G. Zetler: Experimenteller Beweis für die Entstehung der sogenannten Hypophysenhinterlappenwirkstoffe im Hypothalamus. Ark. ges. Physiol. 257, 169–201 (1953).CrossRefGoogle Scholar
  25. Holmes, R. L.: In discussion of E. de Robertis paper. Mem. Soc. Endocrinol. 12, 18 (1962).Google Scholar
  26. Holmes, R. L., J. A. Kiernan : The fine structure of the infundibular process of the hedgehog. Z. Zellforsch. 61, 894–912 (1964).CrossRefGoogle Scholar
  27. Holmes, R. L., and F. G. W. Knowles: “Synaptic vesicles” in the neurohypophysis. Nature (Lond.) 185, 710 (1960).CrossRefGoogle Scholar
  28. Ishii, S., I. Yasumasu, H. Kobayashi, Y. Oota, T. Hirano, and A. Tanaka: Isolation of neurosecretory granules and nerve endings from bovine posterior lobe. Annot. Zool. Jap. 35, 121 (1962).Google Scholar
  29. Kobayashi, H. : Histochemical electron microscopic and pharmacologic studies on the median eminence. Proc. second intern. Congress Endocrinol. Lond. 1964. Excerpta Medica Foundation. Intern. Congress série 83, 570–576.Google Scholar
  30. Kobayashi, H., H. A. Bern, R. S. Nishioka, and Y. Hyodo: The hypothalamo-hypophysial neurosecretory system of the parakeet, Melopsittacus undulatus. Gen. comp. Endocrinol. 1961 I, 545–564.CrossRefGoogle Scholar
  31. Kobayashi, H., and Y. Oota: Functional electron microscopy of the vertebrate neurosecretory storage-release organs. Gunma Symposia Endocrinol. 1964 I, 63–79.Google Scholar
  32. Kobayashi, H., H. Uemura, Y. Oota, and S. Ishii: Cholinergic substances in the caudal neurosecretory storage organ of fish. Science 141, 714–716 (1963).PubMedCrossRefGoogle Scholar
  33. Kobayashi, H., and D. S. Farner: Cholinesterase in the hypothalamo-hypophysial neurosecretory system of the white crowned sparrow, Zonotricha leucophrys gambelii. Z. Zellforsch. 63, 935 (1965).Google Scholar
  34. Kobayashi, H., T. Hirano, and Y. Oota: Electron microscopic and pharmacological studies on the median eminence and pars nervosa. Arch. Anat. microsc. 54, 277–293 (1965).Google Scholar
  35. Kobayashi, H., Y. Oota, H. Uemura, and T. Hirano : Electron microscopic and pharmacological Studies on the Rat median Eminence. Z. Zellforsch. 71, 387–404 (1966).CrossRefGoogle Scholar
  36. Koelle, G. B., et C. Geesey: Localization of acetylcholinesterase in the neurohypophysis and its functional implications. Proc. Soc. exp. Biol. Med. 106, 625–628 (1961).PubMedGoogle Scholar
  37. la Bella, F. S., G. Beaulieu, and R. J. Reiffenstein : Evidence for the existence of separate vasopressin and oxytocin-containing granules in the neurohypophysis. Nature (Lond.) 193, 173–174 (1962).CrossRefGoogle Scholar
  38. Lederis, K. : A preliminary report on the ultrastructure of the human neurohypophysis. J. Endocrinol. 27, 133–135 (1963).PubMedCrossRefGoogle Scholar
  39. Lederis, K. : Relationship between fine structure and function of the vertebrate hypothalamo-neurohypophysial system. Proc. Second intern. Congress, Endocrinol. Londres 1964. Excerpta Medica fundation. Part. I. 563–569.Google Scholar
  40. Lederis, K. : An electron microscopical study of the human neurohypophysis Z. Zellforsch. 65, 847–868 (1965).CrossRefGoogle Scholar
  41. Monroe, B. G., and D. E. Scott: Ultrastructural Changes in the Neural Lobe of the Hypophysis of the Rat during lactation and Suckling. J. Ultrastruct. Res. 14, 497–517 (1966).PubMedCrossRefGoogle Scholar
  42. Oota, Y. : On the synaptic vesicles in the neurosecretory organs of the carp, bullfrog, pigeon and mouse. Annot. Zool. jap. 36, 167–172 (1963).Google Scholar
  43. Oota, Y., and H. Kobayashi: Fine structure of the median eminence and pars nervosa of the Pigeon. Annot. Zool. Jap. 35, 128–138 (1962).Google Scholar
  44. Palade, G. E.: Cell electron Microscopy, in: Anatomy (Eds. Boyd, Johnson and Lever). Baltimore: Williams & Wilkins 1961.Google Scholar
  45. Palay, S. L. : The fine structure of the neurohypophysis, in : Progress in Neurobiology II. Ultrastructure and cellular chemistry of neural tissue. pp. 31–49. (Eds. S. Korey and J. J. Nürnberger). New York 1957.Google Scholar
  46. Palay, S. L.: An electron microscope study of the neurohypophysis in normal, hydrated and dehydrated rats. Anat. Rec. 121, 348 (1955).Google Scholar
  47. Pardoe, A. U., and M. Weatherhall: The intracellular localization of oxytocic and vasopressor substances in the pituitary glands of rats. J. Physiol. 127, 201–212 (1955).PubMedGoogle Scholar
  48. Pasteels, J. J. : Aspects structuraux de la fécondation vus au microscope électronique. Arch. Biol. (Liège) 76, 463–509 (1965).Google Scholar
  49. Picard, D., et A. Stahl: La cellule neurosécrétrice chez les Vertébrés. Bull. Ass. Anat. 130, 1–75 (1966).Google Scholar
  50. Rothballer, A. B. : Changes in the rat neurohypophysis induced with painfull stimuli, with particular reference to neurosecretory material. Anat. Rec. 115, 21–41 (1933).CrossRefGoogle Scholar
  51. Scharrer, E., and R. D. Frandson: The mode of release of neurosecretory material in the posterior pituitary of the dog. Anat. Rec. 118, 350–351 (1954).Google Scholar
  52. Schiebler, Th. H. : Cytochemische und elektronenmikroskopische Untersuchungen an granülaren Fraktionen der Neurohypophyse des Rindes. Z. Zellforsch. 36, 563–576 (1952).PubMedGoogle Scholar
  53. Stutinsky, F., et Y. Guerne: Effets des stimulations électriques hypothalamiques sur la pression artérielle du Rat. CR. Soc. Biol. 159, 1420–1422 (1965).Google Scholar
  54. Uemura, H. : Cholinesterases in the hypothalamo-hyposial neurosecretory system in the bird. Zoosterops palpebrosa japonica. Zool. Mag. (Tokio) 15, 118 (1964).Google Scholar
  55. Uemura, H., H. Kobayashi, and S. Ishii: Cholinergic substance in the neurosecretory storage release organ. Zool. Mag. (Tokio) 72, 204–212 (1963).Google Scholar
  56. van Dyke, H. B., B. Chow, O. R. Greep, and A. Rothen: The isolation of a protein from the pars neutralis of the ox pituitary with constant oxytocic, pressor and diuresis hinibiting activities. J. Pharmacol. exp. Ther. 74, 190–204 (1942).Google Scholar
  57. van Dyke, H. B., K. Adamson, and S. L. Engel: Aspects of the Biochemistry and Physiology of the Neurohypophyseal Hormones. Rec. Progr. Hormone Res. 1955 II, 1–41.Google Scholar
  58. Weinstein, H., A. Malamed, and H. Sachs: Isolation of vasopressin containing granules from the neurohypophysis of the dog. Biochim. biophys. Acta (Amst.) 50, 386–389 (1961).CrossRefGoogle Scholar
  59. Whittaker, V. P.: The isolation and characterization of acetylcholin containing particles from the brain. Biochem. J. 72, 694–706 (1959).PubMedGoogle Scholar
  60. Zeigel, R. F., and A. J. Dalton: Speculations based on the morphology of the Golgi systems in several types of protein-secreting cells. J. Cell. Biol. 15, 45–54 (1962).PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1967

Authors and Affiliations

  • M. Herlant
    • 1
  1. 1.Laboratoire d’Histologie, Laboratoire de Microscopie électroniqueUniversité Libre de BruxellesBelgique

Personalised recommendations