Because patients with malignancies are now surviving for longer periods, carcinomatous and leukemic meningitis is becoming more common. The most frequent solid malignancies to involve the meninges are those of the breast, lung, gastrointestinal tract, and genitourinary tract, and malignant melanomas (Table 1). In most patients, neoplastic meningitis occurs late in the course of the disease when the cancer is far advanced. Patients with acute lymphocytic and acute myelogenous leukemia and patients with high-grade non-Hodgkin’s lymphoma are also at high risk of meningeal infiltration, which can be reduced by prophylactic intrathecal chemotherapy and radiation of the CNS. Primary brain tumors such as germinoma, ependymoma, and medulloblastoma may also invade the meninges.
KeywordsAcute Myelogenous Leukemia Leptomeningeal Metastasis Intrathecal Chemotherapy Neoplastic Meningitis Meningeal Carcinomatosis
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- Bleyer WA, Byrne TN (1988) Leptomeningeal cancer in leukemia and solid tumors. Curr Probi Cancer 12: 181–238Google Scholar
- Herrmann R (1991) Behandlung der Meningeosis neoplastica beim Mammacarcinom. In: ZNS-Metastasierung des Mammacarcinoms. Springer, Berlin Heidelberg New York, p 115Google Scholar
- Yuill GM (1980) Leukaemia: neurological involvement. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology, vol 39: Neurological manifestations of systemic diseases, part II. Elsevier/North Holland Biochemical, New York, p 1Google Scholar