Carcinomatous and Leukemic Meningitis

  • Brigitte Storch-Hagenlocher
  • Richard Herrmann
  • Martin Schabet
  • Thomas P. Bleck


Because patients with malignancies are now surviving for longer periods, carcinomatous and leukemic meningitis is becoming more common. The most frequent solid malignancies to involve the meninges are those of the breast, lung, gastrointestinal tract, and genitourinary tract, and malignant melanomas (Table 1). In most patients, neoplastic meningitis occurs late in the course of the disease when the cancer is far advanced. Patients with acute lymphocytic and acute myelogenous leukemia and patients with high-grade non-Hodgkin’s lymphoma are also at high risk of meningeal infiltration, which can be reduced by prophylactic intrathecal chemotherapy and radiation of the CNS. Primary brain tumors such as germinoma, ependymoma, and medulloblastoma may also invade the meninges.


Acute Myelogenous Leukemia Leptomeningeal Metastasis Intrathecal Chemotherapy Neoplastic Meningitis Meningeal Carcinomatosis 
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Suggested Reading

  1. Bamborschke S, Huber M (1992) CSF cytology in leukemia and malignant lymphoma involving the CNS. Definite diagnosis by immunocytochemistry. Nervenarzt 63: 218–222PubMedGoogle Scholar
  2. Bleyer WA, Byrne TN (1988) Leptomeningeal cancer in leukemia and solid tumors. Curr Probi Cancer 12: 181–238Google Scholar
  3. Boogerd W et al. (1988) CSF cytology versus immunocytochemistry in meningeal carcinomatosis. J Neurol Neurosurg Psychiatry 51: 142–145PubMedCrossRefGoogle Scholar
  4. Brown MJ et al. (1987) Infectious complications of intraventricular reservoirs in cancer patients. Pediatr Infect Dis J 6: 182–189CrossRefGoogle Scholar
  5. Croghan MK, Booth A, Meyskens FL (1988) A phase I trial of recombinant interferon-alpha and alpha-difluoromethylornithine in metastatic melanoma. J Biol Response Mod 7: 409–415PubMedGoogle Scholar
  6. Gasecki AP, Bashir RM, Foley J (1992) Leptomeningeal carcinomatosis: a report of 3 cases and review of the literature. Eur Neurol 32: 74–78PubMedCrossRefGoogle Scholar
  7. Herrmann R (1991) Behandlung der Meningeosis neoplastica beim Mammacarcinom. In: ZNS-Metastasierung des Mammacarcinoms. Springer, Berlin Heidelberg New York, p 115Google Scholar
  8. Kaplan RS, Wiernik PH (1982) Neurotoxicity of antineoplastic drugs. Semin Oncol 9: 103–130PubMedGoogle Scholar
  9. Krol G, Sze G, Malkin M, Walker R (1988) MR of cranial and spinal meningeal carcinomatosis: comparison with CT and myelography. AJR 151: 583–588PubMedGoogle Scholar
  10. Mackintosh FR, Colby TV, Podolsky WJ, Burke JS, Hoppe RT, Rosenfelt FP, Rosenberg SA, Kaplan HS (1982) Central nervous system involvement in non-Hodgkin’s lymphoma: an analysis of 105 cases. Cancer 49: 586–595PubMedCrossRefGoogle Scholar
  11. Moseley RP et al. (1991) Carcinomatous meningitis: antibody-guided therapy with I-131 HMFG1. J Neurol Neurosurg Psychiatry 54: 260–265PubMedCrossRefGoogle Scholar
  12. Obbens EAMT, Leavens ME, Beal JW, Lee Y (1985) Ommaya reservoir in 387 cancer patients: a 15 year experience. Neurology 35: 1274–1278PubMedCrossRefGoogle Scholar
  13. Schabet M et al. (1986) Diagnosis and treatment of meningeal carcinomatosis in ten patients with breast cancer. Eur Neurol 25: 403–411PubMedCrossRefGoogle Scholar
  14. Schabet M, Bamberg M, Dichgans J (1992) Diagnosis and therapy of leptomeningeal metastasis. Nervenarzt 63: 317–327PubMedGoogle Scholar
  15. Sze G, Soletsky S, Bronen R, Krol G (1989) MR imaging of the cranial meninges with emphasis on contrast enhancement and meningeal carcinomatosis. AJNR 10: 965–975PubMedGoogle Scholar
  16. Theodore HT, Gendelman S (1981) Meningeal carcinomatosis. Arch Neurol 38: 696–699PubMedCrossRefGoogle Scholar
  17. Visser de BWO et al. (1983) Intraventricular methotrexate therapy of leptomeningeal metastasis from breast cancer. Neurology 33: 1565–1572CrossRefGoogle Scholar
  18. Wasserstrom WR, Glass JP, Posner JB (1982) Diagnosis and treatment of leptomeningeal metastasis from solid tumors. Cancer 49: 759–772PubMedCrossRefGoogle Scholar
  19. Weller M, Stevens A, Sommer N, Schabet M, Wiethölter H (1992) Tumor cell dissemination triggers an intrathecal immune response in neoplastic meningitis. Cancer 69: 1475–1480PubMedCrossRefGoogle Scholar
  20. Yuill GM (1980) Leukaemia: neurological involvement. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology, vol 39: Neurological manifestations of systemic diseases, part II. Elsevier/North Holland Biochemical, New York, p 1Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Brigitte Storch-Hagenlocher
  • Richard Herrmann
  • Martin Schabet
  • Thomas P. Bleck

There are no affiliations available

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