Übersicht — Neue Konzepte Paraneurone anstatt APUD-System? — Überlegungen zur Nomenklatur des diffusen neuroendokrinen Systems (DNES) der Haut

  • W. M. Herbst

Zusammenfassung

Bereits 1975 schlug der Japaner Fujita die Bezeichnung Paraneuron anstelle des mittlerweile überholten Begriffs „APUD-System“ vor. Der Begriff Paraneuron bezeichnet Zellen, die auf ein definiertes Signal (z.B. Neuropeptid) nach Besetzung des jeweiligen Rezeptors sekretorisch aktiv werden und durch charakteristische funktionelle und biochemische Gemeinsamkeiten gekennzeichnet sind. Auch in der Dermatologie und besonders in der Neuroendokrinologie findet dieses neuroparakrine Konzept zunehmend Anwendung bei der Aufklärung der neuronalen Plastizität und Interaktion typischer Paraneurone wie Merkel- und Mastzellen im Rahmen der Erforschung der peripheren Biokommunikation. In der vorliegenden Arbeit wird die Relevanz dieser Nomenklatur für die Haut anhand neuerer morphologischer und biochemischer Daten überprüft.

Summary

In order to improve the nomenclature of the APUD-system, the Japanese Fujita introduced the term paraneuron in 1975. Paraneurons are receptor-secretory cells which produce substances identical or related to neuronal secretions, store them in neurosecretion-like and/or synaptic vesicle-like granules, and release them in response to adequate stimuli. The relevance of this optional classification is considered by critical analysis of potential paraneurons of the skin and adjacent mucosa.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • W. M. Herbst
    • 1
  1. 1.Dermatologische KlinikUniversität Erlangen-NürnbergDeutschland

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