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Zelluläre Adhäsionsmoleküle und ihre Bedeutung für die Dermatologie. Eine Zwischenbilanz

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Neue Entwicklungen in der Dermatologie

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Zusammenfassung

Zelluläre Adhäsionsmoleküle (CAMs) und ihre Zell/Zell- und Zell/Matrix-Interaktionen sind ein wesentliches Thema der biologischen Forschung der letzten Jahre. Mittlerweile sind von vier verschiedenen Familien zumindest teilweise Funktion und Bedeutung bekanntgeworden.

Hierbei war die Haut in ihrer Funktion als Schutz- und hochsensibles Immunorgan natürlich von großem Interesse. Der gegenwärtige Wissensstand zeigt vor allem die umfassende Relevanz von Adhäsion für immunologische Reaktionen an der Haut. Dabei scheint die Erkenntnis, daß eine ganze Reihe von primär unabhängigen Interaktionen die Extravasation und Immigration von Leukozyten moduliert, wesentlich. Weitere wichtige Resultate zeigen die Rolle der Adhäsionsmoleküle für das biologische Verhalten maligner Tumore, vor allem des Melanoms. Noch relativ gering ist aber bisher das Wissen um die Beteiligung von CAMs bei Embryogenese, Wachstum und Differenzierung.

Ziel der vorliegenden Arbeit soll es sein, den Stand des Wissens über die CAMs mit Blickpunkt auf die Haut darzustellen. Bei den schnellen Fortschritten in diesem Sektor kann aber ein solches Review naturgemäß nur eine Zwischenbilanz darstellen.

Summary

Realization of cellular adhesion molecules (CAMs) and their cell/cell and cell/extracellular matrix interactions represent a major effort of the biological research during the past years. So far, four different adhesion families and, in part, their functions have been described. The skin as a protection and highly sensible immune organ was of considerable interest for this work. The present knowledge underlines the fundamental significance of cellular adhesion for the immunological reactions in the skin. Thereby, the finding that a couple of primary independent adhesion mechanisms can modulate leukocyte immigration into the skin is of considerable interest.

Other important results have been reported about the role of CAMs in the biological behaviour of malignant tumors like melanoma. Less has been achieved for the knowledge about the influence of CAMs in embryogenesis, tissue organization, growth and differentiation.

The aim of this paper is to review the state of the art especially according to the skin. But due to the rapid progress in this field, such a review can only represent an intermediate balance.

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  1. Dermatologische Universitätsklinik Erlangen, Deutschland

    P. von den Driesch

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    O. P. Hornstein

  2. Münster-Hornheide, Deutschland

    M. Hundeiker

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    J. Schönfeld

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von den Driesch, P. (1993). Zelluläre Adhäsionsmoleküle und ihre Bedeutung für die Dermatologie. Eine Zwischenbilanz. In: Hornstein, O.P., Hundeiker, M., Schönfeld, J. (eds) Neue Entwicklungen in der Dermatologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87585-4_3

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