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Objektivierung und Quantifizierung von Externa-Wirkungen mittels nicht-invasiver biophysikalischer Meßverfahren

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Neue Entwicklungen in der Dermatologie

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Zusammenfassung

Nicht-invasive biophysikalische Meßverfahren haben in den letzten Jahren einen zunehmenden Einsatz in der physiologischen und pathophysiologischen Erforschung des Hautorgans erfahren. Besondere Bedeutung haben diese Methoden jedoch in der Dermatopharmakologie erlangt, wo sie zur Objektivierung und Quantifizierung therapeutischer Effekte dienen. Auch wenn biophysikalische Meßverfahren vielfach nicht sensitiver sind als der geübte klinische Untersucher, erlaubt ihre quantitative Präzision doch eine Auswertung mit sensitiveren parametrischen statistischen Verfahren, was eine Reduktion der Stichprobengrößen für klinische Versuche erlaubt. In der vorliegenden Übersicht werden die Einsatzmöglichkeiten biophysikalischer Meßverfahren zum Nachweis der Wirkung und Sicherheit von Externa am Beispiel der Glukokortikoide, der Moisturizer und des Tretinoins dargestellt.

Summary

In recent years, non-invasive bioengineering methods have been increasingly applied in the physiological and pathophysiological characterization of human skin in vivo. These methods have been especially useful in dermatopharmacology where they aid the researcher as diagnostic tools to assess drug effects objectively and quantitatively. Even if skin bioengineering methods may not be more sensitive in detecting skin property changes than the experienced clinician, they deliver quantitative data that are necessary to employ sensitive parametric statistical tests resulting in lower sample sizes for clinical studies. The present review outlines the potential of bioengineering methods in dermatopharmacology as illustrated by the assessment of efficacy and safety of topical glucocorticoids, moisturizers and tretinoin.

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  1. Dermatologische Klinik, Universitätsspital Zürich, Schweiz

    P. Elsner

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  1. Erlangen, Deutschland

    O. P. Hornstein

  2. Münster-Hornheide, Deutschland

    M. Hundeiker

  3. Heidelberg, Deutschland

    J. Schönfeld

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© 1993 Springer-Verlag Berlin Heidelberg

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Elsner, P. (1993). Objektivierung und Quantifizierung von Externa-Wirkungen mittels nicht-invasiver biophysikalischer Meßverfahren. In: Hornstein, O.P., Hundeiker, M., Schönfeld, J. (eds) Neue Entwicklungen in der Dermatologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87585-4_10

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  • DOI: https://doi.org/10.1007/978-3-642-87585-4_10

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