Abstract
When the inquiring physician encounters a patient with multiple malignant neoplasms of two or more different tissues of origin he will frequently succumb to the urge of speculation. He must wonder if serendipity has offered him in this patient the key to common etiologic influences inciting the two neoplasms, or perhaps to common factors of predisposition shared by the organs or tissues giving rise to these neoplasms. If the patient has received some form of therapy for an initial neoplasm, the physician may well question the possible role the therapeutic procedure might have had in inducing the subsequent neoplasm. Perhaps patients with two distinct types of cancer may show more distinct hereditary patterns than have been demonstrable to date in patients with single cancers. When one is studying a group of patients with multiple primary cancers, the urge to such speculation becomes almost irresistible.
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Reference
Hurt, H. H., and A. C. Broders: Multiple primary malignant neoplasms. J. Lab. clin. Med. 18, 765 (1933).
Bailar, J. C., III: The incidence of independent tumors among uterine cancer patients. Cancer (Philad.) 16, 842 (1963).
Huber, Herbert: Genitalkarzinom und Mammakarzinom als Multiplizitätstumoren. Strahlentherapie 92, 130 (1953).
Mersheimer, W. L., A. Ringel, and H. Eisenberg: Some characteristics of multiple primary cancers. Ann. N. Y. Acad. Sci. 114, 896 (1964).
Pierce, Virginia K., and D. P. Slaughter: The association of breast and pelvic disease. Cancer (Philad.) 1, 468 (1948).
Speert, Harold: Corpus cancer. Clinical, pathological and etiological aspects. Cancer (Philad.) 1, 584 (1948).
Taylor, H. C.: The coincidence of primary breast and uterine cancer. Amer. J. Cancer. 15, 277 (1931).
Benson, W. R.: Carcinoma of the prostate with metastases to breasts and testis: Critical review of the literature and report of a case. Cancer (Philad.) 10, 1235 (1957).
Block, M.A., J. L. Fleming, and J. R. Gish: Lymphangiosarcoma occurring in postmastectomy lymphedema. Henry Ford Hosp. Bull. 4, 63 (1956).
Blom, P. S., A. Querido, and C. H. W. Leeksma: Acute leukaemia following x-ray and radioiodine treatment of thyroid carcinoma. Brit. J. Radiol. 28, 165 (1955).
Boss, J. H., and J. Urka: Stewart-Treves syndrome: Angiosarcoma in postmastectomy lymphedema associated with disseminated vascular lesions. Amer. J. Surg. 101, 248 (1961).
Chu, Florence C. H., and Norman Treves: The value of radiation therapy in postmastectomy lymphangiosarcoma. Amer. J. Roentgen. 89, 64 (1963).
Conte, A. J., and A. J. Rella: Angiosarcoma in lymphedema following mastectomy. N. Y. med. J. 62, 3966 (1962).
Cukier, J.: Lymphangio-sarcomes développés sur gros bras après amputation du sein pour cancer. Ann. Chir. 14, 833 (1960).
De Jager, H.: Secundair lymfangiosarcoom. Ned. T. Geneesk. 107, 1344 (1963).
Delarue, J.: Les résidives-métastases brachiales des cancers due sein (et les prétendus lymphangiosarcomes des bras lymphoedémateux après mammectomie). Mém. Acad. Chir. 88, 98 (1962).
Delarue, J., M. Tubiana et J. Dutreix: Cancer de la thyroïde traité par l’iode radiactif: Terminaison par une leucémie aiguë après une amélioration importante. Bull. Ass. franç. Cancer 40, 263 (1953).
Fricke, R. E.: Two unusual cases of pelvic cancer. J. Amer. Geriat. Soc. 2, 324 (1954).
Giannardi, G. F., G. Pelùe G. Zampi: Il quardo clinoco e le basi istopatologiche della cosidetta sindrome di Stewart e Treves. Arch. De Vecchi Anat. pat. 34, 361 (1960).
Hume, H. A., W. H. Erb, and L. W. Stevens: Lymphangiosarcoma following radical mastectomy. Surg. Gynec. Obstet. 116, 117 (1963).
Jakobsen, A. H. I.: Bilateral mammary carcinoma in the male following stilboestrol therapy. Acta path. microbiol. scand. 31, 61 (1952).
Jelliffe, A.M., and K.M. Jones: Leukaemia after I131 therapy for thyroid cancer. Clin. Radiol. 11, 134 (1960).
Khodadadeh, Manuchehr, Richard Johnson, and G. W. Zeiders: Lymphangiosarcoma arising from postmastectomy lymphedema. J. Amer. med. Ass. 186, 1097 (1963).
Laffargue, P., F. Pinet, and R. Le Go: Syndrome de Stewart et Treves (métastases épithéliomateuses ou angiosarcome dans les gros bras compliquant la mammectomie). Presseméd. 68, 1506 (1960).
Lewallen, C. G., and J. T. Godwin: Acute myelogenous leukemia complicating radioactive iodine therapy of thyroid cancer. Amer. J. Roentgen. 89, 610 (1963).
Martin, E., and R. Vilain: Discussion anatomique sur un ces de syndrome de Stewart-Trèves. Arch. Anat. path. 8, 246 (1960).
Martorell, F.: Linfangiosarcoma postmastectomia. Angiologia. 16, 208 (1964).
McConnell, E. M., and P. Haslam: Angiosarcoma in postmastectomy lymphoedema: A report of 5 cases and a review of the literature. Brit. J. Surg. 46, 322 (1959).
Ogilvy, W. L., R. H. Franklin, and Ian Aird: Angioblastic sarcoma in post-mastectomy lymphoedema. Canad. J. Surg. 2, 195 (1959).
Oota, Kunio, and Tsuneo Baba: A case of postmastectomy lymphangiosarcoma. Gann 47, 748 (1956).
Ozarda, Ahsen, UmiT Ergin, and M. A. Bender: Chronic myelogenous leukemia following I131 therapy for metastatic thyroid carcinoma: Report of a case and some considerations on the etiologic factors. Amer. J. Roentgen. 85, 914 (1961).
Pataro, V. F., and M. W. Acrich: Angiosarcoma postmastectomia: Síndrome de Stewart-Treves. Pren. méd. argent. 51, 802 (1964).
Pochin, E. E.: The Occurrence of Leukaemia Following Radioiodine Therapy. In Pitt-Rivers, Rosalind: Advances in Thyroid Research: Transactions of the Fourth International Goitre Conference, London, July, 1960. New York: Pergamon Press 1961, pp. 392–397.
René, L., M. Bolgert, M. Le Sourd, J. Tabernat et R. Poisson: Un cas de syndrome de Stewart-Treves. Bull. Soc. franç. Derm. Syph. 70, 9 (1963).
Rydell, J. R., W. K. Jennings, and E. T. Smith: Postmastectomy lymphedema. Calif. Med. 89, 390 (1958).
Salm, R.: The nature of the so-called postmastectomy lymphangiosarcoma. J. Path. Bact. 85, 445 (1963).
Scheffey, L. C.: Malignancy subsequent to irradiation of the uterus for benign conditions. Amer. J. Obstet. Gynec. 44, 925 (1942).
Seidlin, S. M., Edward Siegel, S. Melamed, and A. A. Yalow: Occurrence of myeloid leukemia in patients with metastatic thyroid carcinoma following prolonged massive radioiodine therapy. Bull. N. Y. Acad. Med. 31, 410 (1955).
Simon, Norman, Marshall Brucer, and Raymond Hayes: Radiation and leukemia in carcinoma of the cervix. Radiology 74, 905 (1960).
Speert, Harold, and T. C. Peightal: Malignant tumors of the uterine fundus subsequent to irradiation for benign pelvic conditions. Amer. J. Obstet. Gynec. 57, 261 (1949).
Sternby, N. H.: Lympfangiosarkom efter mastektomi. (Abstr.) Nord. med. 61, 291 (1959).
Sternby, N. H., I. Gynning, and K. E. Hogeman: Postmastectomy angiosarcoma. Acta chir. scand. 121, 420 (1961).
Stewart, F. W., and W. Treves: Lymphangiosarcoma in postmastectomy lymphedema: A report of six cases in elephantiasis chirurgica. Cancer (Philad.) 1, 64 (1948).
Taswell, H. F., E. H. Soule, and M. B. Coventry: Lymphangiosarcoma arising in chronic lymphedematous extremities. J. Bone Jt Surg. 44-A, 277 (1962).
Tentschov, G., V. Andreev, R. Raitschev, and B. Kristev: Lymphangiosarkom bei Lymphödem nach Ablatio Mammae (Stewart-Treves-Syndrom). Hautarzt. 12, 399 (1961).
United States Naval Medical School of the National Medical CenterL Color Atlas of Pathology. Philadelphia: J. B. Lippincott Company 1950, vol. 1, p. 243.
Vandaele, R., W. V. Craeynest, E. Haven, and A. Dupont: Lymphangiosarcome sur lymphoedème primitif du bras. Bull. Soc. franç. Derm. Syph. 70, 722 (1963).
Wilson, Roger: Lymphangiosarcoma in the post-mastectomy lymphedematous arm. Canad. J. Surg. 5, 208 (1962).
Ewing, James: Neoplastic diseases, Ed. 2. Philadelphia: W. B. Saunders Company 1922, p. 105.
Tullis, J. L.: Multiple primary malignant lesions. J. Lab. clin. Med. 27, 588 (1942).
Welch, J. W.: Multiple primary malignant lesions. J. Kans. med. Soc. 55, 314 (1954).
Albritton, E. C.: Standard values in blood. Philadelphia: W. B. Saunders Company 1952, p. 26.
Fadhli, H. A., and R. Dominguez: ABO blood groups and multiple cancers. J. Amer. med. Ass. 185, 757 (1963).
Hervey, G. W., L. K. Diamond, and Virginia Watson: Geographic blood group variability in the United States. J. Amer. med. Ass. 145, 80 (1951).
Magath, T. B., and J. Berkson: Unpublished data.
Taswell, H. F.: Unpublished data.
Tsukada, Y., R. H. Moore, I. D. J. Bross, J. W. Pickren, and E. Cohen: Blood groups in patients with multiple cancers. Cancer (Philad.) 17, 1229 (1964).
Abrahamsen, A.M., and Per Wetteland: Kaposis Sarkom og myelogen Leukemi, Nord. Med. 62, 1811 (1959).
Albrecht, P.: Über die Multiplizität primärer maligner Geschwülste. Oncologia (Basel) 5, 12 (1952).
Allen, A. C.: The Skin: A Clinicopathologic Treatise. St. Louis: C. V. Mosby Company 1954, p. 1000.
Angus, H. B., and F. B. Gunz: Chronic granulocytic leukemia and cancer. Blood 22, 88 (1963).
Askanazy, M.: Leukämie und Tumoren. Schweiz. med. Wschr. 70, 29 (1940).
Axelrod, A. R., and L. Berman: Multiple squamous cell carcinoma of the skin associated with chronic lymphatic leukemia: Observations on the effect of urethane therapy. Arch. Derm. Syph. (Chic.) 60, 625 (1949).
Bach, W.: Tumorbereitschaft und Leukose. Zbl. Gynäk. 83, 1684 (1961).
Barret, W. D., K. T. Miller, and C. R. Fessenmeyer: Multiple primary cancer: A study of thirty-six patients. Surg. Gynec. Obstet. 89, 767 (1949).
Belloni, L.: Maladie de Kaposi à évolution lymphosarcomateuse (contribution à l’étude des mésenchymopathies hyperplastico-néoplasiques). Ann. Derm. Syph. (Paris) 9, 45 (1949).
Beresford, O. D.: Chronic lymphatic leukaemia associated with malignant disease. Brit. J. Cancer. 6, 339 (1952).
Berk, M., and E. R. Movitt: Leukemia complicated by cancer: Report of a case. Amer. J. clin. Path. 15, 246 (1945).
Bernard, Jean, M. Boiron, A. Manus, C. Jacquillat, and J. Ripault: Epithélioma du col utein, leucémie myéloïde chronique et épithélioma du rein chez la même malade. Presse méd. 72, 2675 1964).
Bichel, J.: Lymphatic leukemia and lymphatic leukemoid states in cancer of stomach. Blood 4, 759 (1949).
Black, C. L., and S. Cummings: Multiple malignancies of major importance occurring in the same individual. New Orleans med. surg. J. 103, 211 (1950).
Blom, P. S., A. Querido, and C. H. W. Leeksma: Acute leukemia following x-ray and radioiodine treatment of thyroid carcinoma. Brit. J. Radiol. 28, 165 (1955).
Bluefarb, S. M.: Kaposi’s Sarcoma: Multiple Idiopathic Hemorrhagic Sarcoma. Springfield, Ill.: Charles C. Thomas, Publisher 1957, p. 126.
Bluefarb, S. M., and J. R. Webster: Kaposi’s sarcoma associated with lymphosarcoma. Arch. intern. Med. 91, 97 (1953).
Bourdial, J., Y. Lallemant, and W. Sarfati: Un cas de leucose survenue chez un malade opéré de laryngectomie totale. Ann. Oto-laryng. (Paris) 76, 983 (1959).
Bousser, J., and G. Mathé: Association du cancer épithélial et de lymphomatose (leucosique ou non). Sem. Hôp. (Paris) 30, 821 (1954).
Brenner, A. J., and B. S. Epstein: Lymphatic leukemia complicated by carcinoma of the stomach. Amer. J. Gastroent. 25, 116 (1956).
Brückner: Lymphatische Leukämie und Portiocarcinom. Arch. Gynäk. 157, 616 (1934).
Brunning, R. D., J. F. Foley, and I.E. Fortuny: Hodgkin’s disease and Kaposi’s sarcoma: Report of a case. Arch. intern. Med. 112, 363 (1963).
Bugher, J. C.: Probability of chance occurrence of multiple malignant neoplasms. Amer. J. Cancer. 21, 809 (1934).
Burg, K.M.: Ein mit Radiothor behandelter Fall von myeloischer Leukämie mit komplizierendem Magenkarzinom. Dtsch. med. Wschr. 1, 881 (1924).
Burke, M.: Multiple primary cancers. Amer. J. Cancer. 27, 316 (1936).
Cahan, W. G., F. S. Butler, W. L. Watson, and J. L. Pool: Multiple cancers: Primary in the lung and other sites. J. thorac. Surg. 20, 335 (1950).
Cattan, R., and J. L. Bonnett: Cancer ano-rectal ictere hémolytique acquis: Stabilisation clinique apparition d’un diabète bronzé puis d’un lymphosarcome. Rev. méd.- chir. Mal. Foie 33, 157 (1958).
Cattan, R., and P. Delavierre: Association d’un cancer gastrique et d’une leucémie lymphoïde, accompagnée d’anomalies des protéines sériques. Arch. Mal. Appar. dig. 47, 1226 (1958).
Chalmers, J. A.: Two cases of dysgerminoma ovarii, one occurring in a malignant teratoma in association with acute myelocytic leukaemia. J. Obstet. Gynaec. Brit. Emp. 57, 437 (1950).
Clay, A., G. Calvet, A. Demaille, and L. Adenis: Hépatome et leucose lymphoide. (Abstr.) Presse méd. 70, 2072 (1962).
Cohen, Hilliard, Sidney Rubin, and Gustav Eisemann: Hodgkin’s disease (familial) associated with multiple malignant neoplasms. Cancer (Philad.) 11, 1247 (1958)
Cole, H. N., and E. S. Crump: Report of two cases of idiopathic hemorrhagic sarcoma (Kaposi), the first complicated with lymphatic leukemia. Arch. Derm. Syph. (Chic.) 1, 283 (1920).
Collins, J. J.: The occurrence of two or more primary malignant lesions. Radiology 32, 462 (1939).
Conejo-Mir: Quoted by Oettle, A. G.: Geographical and racial differences in the frequency of Kaposi’s sarcoma as evidence of environmental or genetic causes. Acta Un. int. Cancr. 18, 330 (1962).
Cornes, J. S.: Multiple primary malignant lymphomas and carcinomas of the intestinal tract in the same patient. J. clin. Path. 13, 483 (1960).
Cornes, J. S., T. G. Jones, and G. B. Fisher: The incidence of carcinoma in patients dying from leukaemia, malignant disorders of plasma cells, and malignant lymphoma. Brit. J. Cancer. 15, 200 (1961).
Cox, F. H., and E. B. Helwig: Kaposi’s sarcoma. Cancer (Philad.) 12, 289 (1959).
Cutler, S. J., and Fred Ederer: Part I. End results in cancer. In: End results and mortality trends in cancer. (National Cancer Institute Monograph 6.) U. S. Department of Health, Education, and Welfare, Public Health Service 1961, p. 5.
Darling, C. E.: Multiple primary malignancies with case illustrations. Grace Hosp. Bull. (Detroit) 26, 55 (1948).
Daron, P., and P. Pizzolato: Acute myelogenous leukemia with giant cell carcinoma of thyroid. Arch. Pat.. 51, 72 (1951).
Deenstra, H., M. C. Verloop, and A. De Minjer: Lymphatische Leucaemie en Kanker. Ned. T. Geneesk. 93, 326 (1949).
Delarue, J., M. Tubiana, and J. Dutreix: Cancer de la thyroïde traité par l’iode radioactif: Terminaison par une leucédie aiguë après une amélioration importante. Bull. Ass. franç. Cancer 40, 263 (1953).
Delcourt, R.: Les tumeurs doubles à tissus histologiquement différents. Bull. Ass. franç. Cancer 31, 128 (1943).
Delcourt, R., and P. Van Vleit: Coexistence d’une leucémie lymphoïde et d’un carcinom. Acta med. scand. 119, 47 (1944).
Desaive, P.: Considérations statistiques et anatomo-cliniques à propos de 207 cas de cancers multiples. Rev. belge Path. 18, 173 (1947).
Desaive, P., J. Firket, M. Chevremont, and A. Dardenne: Contribution à l’étude des cancers multiples non systématisés. Bull. Ass. franç. Cancer 28, 6 (1939).
DeWan, C. H., and A. L. Hunter, Jr.: Multiple primary malignant tumors: A review with a case report. Guthrie Clin. Bull. (Sayre) 16, 71 (1946).
Donelly, W. J. (Ed.): Clinicopathologic conference: Hodgkin’s disease and mucocutaneous lesions. Postgrad. Med. 33, 301 (1963).
Dustin, P., Jr.: Coexistence d’une leucémie lymphoïde et d’un carcinome gastrique. Rev. belge Sci. méd. 13, 199 (1941).
Engelbreth-Holm, J.: Leukaemi og anden malign svulst hos samme patient. Nord. Med. 9, 791 (1941).
Epstein, Ervin: Extracutaneous manifestations of Kaposi’s sarcoma: A systemic lymphoblastoma. Calif. Med. 87, 98 (1957).
Erf, L.: Quoted by Greenstein, R. H., and A. S. Conston: Co-existent Hodgkin’s disease and Kaposi’s sarcoma: Report of a case with unusual clinical features. Amer. J. med. Sci. 218, 384 (1949).
Evans, T. S., M. Y. Swirsky, and H. M. Chernoff: Primary endothelioma of pleura: Report of case in patient with chronic lymphatic leukemia. Ann. intern. Med. 24, 262 (1946).
Evans, T. S., L. Waters, B. Hardin, W. Matossian, E. Goltra, and V. De Luca: Carcinome primitif du foie, apparu chez un sujet atteint de leucémie myéloïde traitée par l’uréthane. Rev. Hémat. 6, 148 (1951).
Even, R., J. Vibert, and M. Oury: Leucémie lymphoïde et cancer du poumon. Paris méd. 139, 141 (1950).
Faber, M., and K. Borum: Leukaemia and a malignant tumour in the same patient. Brit. J. Haemat. 8, 313 (1962).
Fischer, J. W., and D. M. Cohen: Simultaneous occurrence of Kaposi’s sarcoma, leukemia, and diabetes mellitus: Report of a case. Amer. J. clin. Path. 21, 586 (1951).
Fischer, W.: Kombination von Lymphogranulomatose, Tuberkulose und malignem Tumor in Lunge und Lymphknoten. Zbl. allg. Path. path. Anat. 86, 257 (1950).
Fuhs: Multizentrische Basalzellenepitheliome bei lymphatischer Leukämie. Derm. Wschr. 85, 1553 (1927).
Fusi, G.: Considerazioni su di una rara associazione morbosa in un caso di reticolosarcoma ghiandolare irradiato; evoluzione emopatica del processo e coesistenza de un epithelioma laringeo. Radiol. med. (Torino) 41, 594 (1955).
Gallagher, N. G., and R. H. Micks: Multiple primary malignant disease with meningeal carcinomatosis. J. Irish med. Ass. 51, 115 (1962).
Genévrier, Lorrain, and Coirre: Lymphadénome leucémique associé à un épithélioma du poumon. Arch. méd.-chir. Appar. resp. 5, 195 (1930).
Gertler: Lymphatische Leukämie bei gleichzeitigen Haut-Carcinomen. Zbl. Hautu. Geschl.-Kr. 68, 271 (1942).
Graham, J. H., and E. B. Helwig: Bowen’s disease and its relationship to systemic cancer. Arch. Derm. (Chic.) Syph. 80, 133 (1959).
Greenberg, B. B., D. Stats, and M. Goldberg: Simultaneous occurrence of plasma cell multiple myeloma and Hodgkin’s disease. N. Y. med. 50, 305 (1950).
Greenstein, R. H., and A. S. Conston: Co-existent Hodgkin’s disease and Kaposi’s sarcoma: Report of a case with unusual clinical features. Amer. J. med. Sci. 218, (1949).
Grivot, M., L. Leroux, and R. Caussé: Présentation d’un malade chez lequel évoluent simultanément un épithélioma épidermoïde d’une corde vocale et un lymphosarcome de la base de la lange. Presse méd. 1, 437 (1926).
Guichard, A., R. Alex, J.-L. Vauzelle, R. Loire, and J.-F. Didierlaurent: L’association épithélioma leucemie leuco-carcinomes et carcino-leucémies. Lyon méd. 210, 395 (1963).
Gunz, F. W.: Leukaemia in New Zealand and Australia. Path. et Microbiol. (Basel) 27, 697 (1964).
Gunz, F. W., and H. B. Angus: Leukemia and cancer in the same patient. Cancer (Philad.) 18, 145 (1965).
Halpert, Bela, R. P. Foster, and M. J. Musser: Multiple malignant neoplasms in a man aged 89 years: A clinicopathologic conference. Geriatrics 14, 194 (1959).
Harbitz, F.: Über das gleichzeitige Auftreten mehrerer selbständig wachsender (“multipler”) Geschwülste. Beitr. path. Anat. 62, 503 (1916).
Higgins, G. K.: Skin: Kaposi tumor. Brooklyn Hosp. J. 9, 187 (1951).
Hilgert, H.: Über das Zusammentreffen von malignem Neubildungen untereinander und mit Krankheiten nicht sekundärer Art, nebst einigen weiteren statistischen Beiträgen zur Krebsfrage. Z. Krebsforsch. 49, 390 (1939).
Hotz, A.: Zur Differentialdiagnose: Agranulocytose — Leukämie. Z. Kinderheilk. 62, 529 (1941).
Hufnagel, L., and A. Dupont: Sarcomatose idiopathique de Kaposi et leucémie lymphoïde. Bull. Soc. franç. Derm. Syph. 38, 656 (1931).
Hurt, H.H., and A.C. Broders: Multiple primary malignant neoplasms. J. Lab. clin. Med. 18, 765 (1933).
Hyman, G. A., J. E. Ultmann, and C. A. Slanetz: Chronic lymphocytic leukemia or lymphoma and carcinoma of the colon: Correlation with blood type A. J. Amer. med. Ass. 186, 1053 (1963).
Jelliffe,A.M., and K.M. Jones: Leukaemia after I131 therapy for thyroid cancer. Clin. Radiol. 11, 134 (1960).
Joselevich, Miguel, Leon Sucari, and Marcos Kleimans: La asociacon del cancer y la leucemia. Pren. méd. argent. 45, 2154 (1958).
Judson, H.A.: Simultaneous lymphosarcomatosis and carcinoma of the breast in the same individual: Case report. Radiology 29, 578 (1937).
Klatte, E. C., Jack Yardley, E. B. Smith, Robert Rohn, and J. A. Campbell: The pulmonary manifestations and complications of leukemia. Amer. J. Roentgen. 89, 598 (1963).
Kleeman, C. R.: Lymphocytic leukemoid reaction associated with primary carcinoma of breast. Amer. J. Med. 10, 522 (1951).
Krebs, A., and K. Schwarz: Besonders bösartiger, metastasierender Verlauf von Hautkarzinomen bei chronisch-lymphatischer Leukämie. Schweiz, med. Wschr. 93, 15 (1963).
Kreibig, W.: Über multiple Geschwulstbildung im Darmtrakt. Dtsch. Z. Chir. 219, 334 (1929).
Lane, C.G., and A.M. Greenwood: Lymphoblastoma (mycosis fungioides) and hemorrhagic sarcoma of Kaposi in the same person. Arch. Derm. Syph. (Chic.) 27, 643 (1933).
Lannois, M., and C. Regaud: Coexistence de la leucocythémie vraie et d’un cancer epithelial. Arch. Méd. exp. 7, 254 (1895).
Lawrence, J. H., and W. G. Donald, Jr.: The incidence of cancer in chronic leukemia and in polycythemia vera. Amer. J. med. Sci. 237, 488 (1959).
Lechelle, P., S. Vialard, and Rosey: Un cas de leucémie lymphoïde chronique sans Splénomégalie ni adénopathie périphérique, évoluant de pair avec un cancer suppuré du poumon. Bull. Soc. méd. Hôp. (Paris) 62, 168 (1946).
Lewallen, C. G., and J. T. Godwin: Acute myelogenous leukemia complicating radioactive iodine therapy of thyroid cancer: Report of a case. Amer. J. Roentgen. 89, 610 (1963).
Lothe, F., and J. F. Murray: Kaposi’s sarcoma: Autopsy findings in the African. Acta Un. int. Cancr. 18, 429 (1962).
MacDonald, Eleanor J.: Occurrence of multiple primary cancers in a population of 200,000. Acta Un. int. Cancr. 16, 1702 (1960).
Mähr, G., and R. P. Königstein: Leukämie und zweifach primäre Neoplasie. Wien. Z. inn. Med. 43, 353 (1962).
Major, R. H.: Multiple primary malignant tumors: With report of a case of carcinoma and sarcoma in the same individual. Bull. Johns Hopk. Hosp. 29, 223 (1918).
Malkinson, F.D., and Bernard Stone: Kaposi sarcomas, lymphoblastoma and herpes zoster (Abstr.) Arch. Derm. Syph. (Chic.) 72, 79 (1955).
Malmio, Kai: Multiple primary cancer: A clinical-statistical investigation based on 650 cases. Ann. Chir. Gynaec. Fenn. 48 (suppl. 92), 1 (1959).
Marischler, J.: Ein Fall von lymphatischer Leukämie und einem Grawitz’schen Tumor der rechten Niere. Wien. klin. Wschr. 9, 686 (1896).
Mautner, L. S.: Synchronous lymphatic leukaemia, bronchogenic carcinoma and hypernephroma. Canad. med. Ass. J. 63, 66 (1950).
McCarthy, W. D., and G. T. Pack: Malignant blood vessel tumors: A report of 56 cases of angiosarcoma and Kaposi’s sarcoma. Surg. Gynec. Obstet. 91, 465 (1950).
McManus, R. G., and S. C. Sommers: Significance of gastric polyps accompanying cancer. Amer. J. clin. Path. 23, 746 (1953).
Mersheimer, W. L., Abraham Ringel, and Henry Eisenberg: Some characteristics of multiple primary cancers. Ann. N. Y. Acad. Sci. 114, 896 (1964).
Meyer-Laack, H.: Leukamie und Karzinomgenese. Arch. Geschwulstforsch. 3, 18 (1951).
Mills, W. H., R. Dominguez, and J. W. McCall: Simultaneous carcinoma and malignant lymphoma of the larynx: Case report and review of literature. Laryngoscope (St Louis) 57, 491 (1947).
Moertel, C. G., and A. B. Hagedorn: Leukemia or lymphoma and coexistent primary malignant lesions: A review of the literature and a study of 120 cases. Blood 12, 788 (1957).
Moloney, W. C.: Leukemia and exposure to x-ray: A report of 6 cases. Blood 14, 1137 (1959).
Montgomery, H.: Mycosis fungoides, lymphoblastoma of the skin and allied conditions as general diseases. In Christian, H.A.: Oxford Medicine. New York: Oxford Univ. Press 1950, vol. 4, pt. 1. pp. 44(1)—44(20–23).
Morrison, M., F. Feldman, and A. A. Samwick: Carcinoma and leukemia: Report of two cases with combined lesions; review of literature. Ann. intern. Med. 20, 75 (1944).
Mounier-Kuhn, P., J. Gaillard, J.-P. Rebattu, and B. Jakubowicz: Statistique des cancers multiples à la clinique oto-rhino-laryngologique de Lyon de 1950 à 1962. Lyon méd. 212, 1389 (1964).
Nadbath, R. P., and H. G. Bullwinkel: Coexistence of intraocular melanoma and lymphatic leukemia. Arch. Ophthal. 48, 349 (1952).
Ophüls, W.: A Statistical Survey of Three Thousand Autopsies. Stanford University: Stanford Univ. Press 1926, p. 316.
Ortega, P., Jr., I. Y. Li, and M. Shimkin: Metastasis of neoplasms to other neoplasms. Ann. West. Med. & Surg. 5, 601 (1951).
Osborne, E. D., J. W. Jordon, F. C. Hoak, and F. J. Pschierer: Nitrogen mustard therapy in cutaneous blastomatous disease. J. Amer. med. Ass. 135, 1123 (1947).
Osgood, E. E., and A. J. Seaman: Treatment of chronic leukemias. J. Amer. med. Ass. 150, 1372 (1952).
Ovnbøl, Anker, and Knud Terkildsen: Et tilfaelde af sarcom, carcinom og leukose hos samme patient. Nord. Med. 20, 1662 (1943).
Ozarda, A., U. Ergin, and M. A. Bender: Chronic myelogenous leukemia following I-131 therapy for metastatic thyroid carcinoma: Report of a case and some considerations on etiologic factors. Amer. J. Roentgen. 85, 914 (1961).
Pack, G. T., and J. Davis: Concomitant occurrence of Kapcsi’s sarcoma and lymphoblastoma. Arch. Derm. Syph. (Chic.) 69, 604 (1954).
Peller, S.: Metachronous multiple malignancies in 5,876 cancer patients. Amer. J. Hyg. 34, 1 (1941).
Penzold, H.: Leukämie und Carcinom. Dtsch. Arch. klin. Med. 180, 430 (1937).
Petrakis, N. L., H. R. Bierman, K. H. Kelly, L. P. White, and M. B. Shimkin: Effect of 1,4-dimethanesulfonyloxybutane (GT-41 or myleran) upon leukemia. Cancer (Philad.) 7, 383 (1954).
Petri, S.: Quoted by Bichel, J. [13].
Pisciotta, A. V., and J. S. Hirschboeck: Therapeutic considerations in chronic lymphocytic leukemia: Special reference to the natural course of the disease. Arch. intern. Med. 99, 334 (1957).
Pochin, E. E.: The occurrence of leukaemia following radioiodine therapy. In Pitt-Rivers, Rosalind: Advances in thyroid research: Transactions of the Fourth International Goitre Conference, London, July, 1960. New York: Symposium Publications Division, Pergamon Press 1961, pp. 392–397.
Polk, H. C., Jr., J. S. Spratt, Jr., and H. R. Butcher, Jr.: Frequency of multiple primary malignant neoplasms associated with colorectal carcinoma. Amer. J. Surg. 109, 71 (1965).
Postlethwait, R. W., J. E. Adamson, and Deryl Hart: Carcinoma of the colon and rectum. Surg. Gynec. Obstet. 106, 257 (1958).
Potoczek, Stanislaw, Ludmila Hirnlowa, Aleksander Giermański, and Karol Kawecki: Współistnienie przewlikłej białaczki limfatycznej i raka źoladka. Pol. Tyg. lek. 16 (pt. 2), 1408 (1961).
Pulvertaft, R. J. V.: Multiple primary epithelioma in lymphatic leukaemia. Brit. J. Surg. 24, 50 (1936).
Rabinovitch, J., B. Pines, and D. Grayzel: Coexisting lymphosarcoma and ulcer-carcinoma of the stomach. Arch. Surg. 64, 185 (1952).
Rabson, S. M., P. L. Stier, J. C. Baumgartner, and D. Rosenbaum: Metastasis of cancer to cancer. Amer. J. clin. Path. 24, 572 (1954).
Rankin, T. J.: Multiple malignancies: Carcinoma of the colon and multicentric lymphosarcoma with recovery. J. Kans. med. Soc. 63, 99 (1962).
Razis, D. V., H. D. Diamond, and L. F. Craver: Hodgkin’s disease associated with other malignant tumors and certain non-neoplastic diseases. Amer. J. med. Sci. 238, 327 (1959).
Regelson, William, I. D. J. Bross, Juliet Hananian, and Goryun Nigogosyan: Incidence of second primary tumors in children with cancer and leukemia: A seven-year survey of 150 consecutive autopsied cases. Cancer (Philad.) 18, 58 (1965).
Reiss, F., and W. Konheim: Basal squamous cell epithelioma associated with leukemia. Arch. Derm. Syph. (Chic.) 55, 507 (1947).
Reynolds, W. A., R. K. Winkelmann, and E. H. Soule: Kaposi’s sarcoma: A clinicopathologic study with particular reference to its relationship to the reticuloendothelial system. Medicine (Baltimore) 44, 419 (1965).
Roath, S., M. C. Israels, and J. F. Wilkinson: The acute leukemias: A study of 580 patients. Quart. J. Med. 33, 256 (1964).
Roncallo, E., and G. Peluffo: Su di un caso di associazione di carcinoma polmonare primitivo con metastasi ghiandolari e granuloma maligno addominale. Pathologica. 39, 231 (1947).
Rosen, I.: Idiopathic hemorrhagic sarcoma and lymphatic leukemia. Arch. Derm. Syph. (Chic.) 48, 566 (1943).
Rosenberg, S. A., H. D. Diamond, B. Jaslowitz, and L. F. Craver: Lymphosarcoma: A review of 1269 cases. Medicine (Baltimore) 40, 31 (1961).
Rothman, S.: Some clinical aspects of Kaposi’s sarcoma in the European and North American population. Acta Un. int. Cancr. 18, 364 (1962).
Roubier, C.: Quelques observations de cancers primitifs multiples chez le même individu. Lyon med. 189, 69 (1953).
Saar: Quoted by Kreibig, W. [85].
Sachs, W., and M. Gray: Kaposi’s sarcoma and lymphatic leukemia: Report of a case with histologic evidence of the two diseases in the same lesion. Arch. Derm. Syph. (Chic.) 51, 325 (1945).
Saupe, E.: Bestrahlungswirkung bei gleichzeitiger Erkrankung an aleukämischer Lymphadenose und metastasierendem Magenkarzinom. Wien. klin. Wschr. 49, 1104 (1936).
Scheuffler, A.: Carcinobildung auf einem Leukämid. Arch. Derm. Syph. (Berlin) 168, 586 (1933).
Schilling, R. F., and O. O. Meyer: Treatment of chronic granulocytic leukemia with 1,4-dimethanesulfonyloxybutane (myleran). New. Engl. J. Med. 254, 986 (1956).
Schreiner, B. F., and W. H. Wehr: Cancer associated with leukemia. Amer. J. Cancer. 21, 368 (1934).
Scott, R. B.: The place of radiotherapy in the treatment of chronic lymphoid leukaemia. J. Fac. Radiol. (Lond.) 1, 61 (1949).
Scott, R. B. Leukaemia. Lancet 1, 1162 (1957).
Seidlin, S. M., Edward Siegel, A.A. Yalow, and S. Melamed: Acute myeloid leukemia following prolonged iodine-131 therapy for metastatic thyroid carcinoma. Science 123, 800 (1956).
Sforza, M., and M. Perelli-Ercolini: Du casi di tumori maligni doppi. Osped. maggiore 58, 899 (1963).
Shapiro, A. L., and H. Bolker: Triple primary malignancy. Amer. J. Cancer. 40, 441 (1940).
Simon, Norman, Marshall Brucer, and Raymond Hayes: Radiation and leukemia in carcinoma of the cervix. Radiology 74, 905 (1960).
Simpson, C. Lenore, William Regelson, and Franz Lessman: Clinicopathologic conference. N. Y. St. J. Med. 59, 4589 (1959).
Slaughter, D. P.: The multiplicity of origin of malignant tumors. Int. Abstr. Surg. 79, 89 (1944).
Stanley, D. A.: Leukaemia and oestrogen therapy. Brit. med. J. 1, 1460 (1957).
Stich, W., and H. Langhammer: Multiple Karzinome und Leukämie: Gemeinsames Vorkommen von Hautkarzinom, Uteruskarzinom und chronischer myeloischer Leukämie. Münch. med. Wschr. 103, 502 (1961).
Svejda, J.: Quoted by Bichel, J. [13].
Talbott, J. H.: Clinical manifestations of Hodgkin’s disease. N. Y. St. J. Med. 47, 1883 (1947).
Tedeschi, C. G., H. F. Folsom, and T. J. Carnicelli: Visceral Kaposi’s disease. Arch. Path. 43, 335 (1947).
Thalmessinger, V.: Quoted by Major, R. H. [94].
Themel, K. G.: Über das Zusammentreffen von Bronchialkarzinom und Leukämie. Medizinische 1, 186 (1955).
Thiery, M., and S. Ringoir: Leucemie als mogelijke verwikkeling van Stralenbehan-deling van Portiocarcinoom. Belg. T. Geneesk. 17, 524 (1961).
Thijs, A.: Quoted by Oettle, A. G.: Geographical and racial differences in the frequency of Kaposi’s sarcoma as evidence of environmental or genetic causes. Acta Un. int. Cancr. 18, 330 (1962).
Uys, C. J., and M. B. Bennett: Kaposi’s sarcoma: A neoplasm of reticular origin. S. Afr. J. Lab. clin. Med. 5, 39 (1959).
Vander, J. B., and H. A. Johnson: Chronic lymphatic leukemia and multiple myeloma in the same patient. Ann. intern. Med. 53, 1052 (1960).
Varshavskii, A. G.: Association of leukemia with cancer (3 observations). Vop. Onkol. 8, 87 (1962).
Videbaek, A.: Heredity in human leukemia and its relation to cancer: A genetic and clinical study of 209 probands. Copenhagen: Arnold Busck 1947, pp. 83–85.
Vilcek, E.: Koincidencia leukémie S. primárnou multiplicitou rakoviny Kože. Čs. Rentgenol. 18, 54 (1964).
Voll, Artur, and Johannes Tveit: Levkemi hos tidligere Røntgen radium — behandlete Pasienter. Nord. Med. 58, 1114 (1957).
Warren, S., and T. Ehrenreich: Multiple primary malignant tumors and susceptibility to cancer. Cancer Res. 4, 554 (1944).
Warren, S., and O. Gates: Multiple primary malignant tumors: A survey of the literature and a statistical study. Amer. J. Cancer. 16, 1358 (1932).
Warwick, T.: Discussion. Proc. roy. Soc. Med. 24, 206 (1930).
Watson, T. A.: Incidence of multiple cancer. Cancer (Philad.) 6, 365 (1953).
Weiner, J. J., and A. M. Sala: Chronic lymphatic leukemia: Associated with carcinoma. J. Abdom. Surg. 3, 15 (1961).
Wenig, H., and H. Lange: Leukämie und Genitalkarzinom. Zbl. Gynäk. 80, 925 (1958).
Whipham, T.: Splenic leukaemia with carcinoma. Trans. path. Soc. Lond. 29, 313 (1878).
Wiesinger, Herbert, G. W. Phipps, and Du Pont Guerry, III: Bilateral melanoma of the choroid associated with leukemia and meningioma. Arch. Ophthal. 62, 889 (1959).
Willis, R. A.: Pathology of tumours. St. Louis: C.V. Mosby Company 1948, p. 780.
Wolf, Jack: Discussion (idiopathic hemorrhagic sarcoma and lymphatic leukemia). Arch. Derm. Syph. (Chic.) 48, 566 (1943).
Zadek, I.: Radiothorium bei leukämischer Myelose: Grosse Dosierungen. Folia haemat. (Lpz.) 49, 287 (1933).
Caldarola, V. T., R. J. Jackman, C. G. Moertel, and M. B. Dockerty: Carcinoid tumors of the rectum. Amer. J. Surg. 107, 844 (1964).
Foreman, R. C.: Carcinoid tumors: Report of 38 cases. Ann. Surg. 136, 838 (1952).
Moertel, C. G., W. G. Sauer, M. B. Dockerty, and A. H. Baggenstoss: Life history of the carcinoid tumor of the small intestine. Cancer (Philad.) 14, 901 (1961).
Pearson, C. M., and P. J. Fitzgerald: Carcinoid tumors — a re-emphasis of their malignant nature: Review of 140 cases. Cancer (Philad.) 2, 1005 (1949).
Warren, K. W., and E. B. Coyle: Carcinoid tumors of the gastrointestinal tract. Amer. J. Surg. 82, 372 (1951).
Cahan, W. G.: Lung cancer associated with cancer primary in other sites. Amer. J. Surg. 89, 494 (1955).
Cotton, B. H.: Differential diagnosis of primary and metastatic malignancy of the lung. Amer. J. Surg. 54, 173 (1941).
Gore, Ira, and Richard Barr: Metastasis of cancer to cancer. A. M. A. Arch. Path. 66, 293 (1958).
Kelly, C. R., and H. T. Langstron: The treatment of metastatic pulmonary malignancy. J. thorac. Surg. 31, 298 (1956).
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Moertel, C.G. (1966). Multiple Primary Malignant Neoplasms of Different Tissues or Organs. In: Moertel, C.G. (eds) Multiple Primary Malignant Neoplasms. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87565-6_2
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