Abstract
On basis of our experimental observations we would like to suggest some points of view concerning the mode of action of dibromomannitol and dibromodulcitol which represent a new type of the myelotropic alkylating agents. We found that in vivo they are more stable than other biological alkylating agents. Half of the compound decomposes in four to six hours, and organic bromine compounds were found as the main metabolites. Therefore, it is difficult to explain their cytostatic effects merely by their alkylating action.
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Literatur
Helge, H., D. Neubert, R. Bass und N. Brock: Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 253, 44 (1966).
Neubert, D.: Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 253, 152 (1966).
Neubert, D., and H. Helge: 2. FEBS-Meeting, Wien e 84 (1965). 3. FEBS-Meeting, Warschau G 27 (1966).
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© 1966 Springer-Verlag Berlin · Heidelberg
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Horváth, I.P., Institóris, L. (1966). Some New Points of View Concerning the Mode of Action of Biological Alkylating Agents. In: Holzer, H., Holldorf, A.W. (eds) Molekulare Biologie des Malignen Wachstums. Colloquium der Gesellschaft für Physiologische Chemie am 21./23. April 1966 in Mosbach/Baden, vol 17. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87539-7_18
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DOI: https://doi.org/10.1007/978-3-642-87539-7_18
Publisher Name: Springer, Berlin, Heidelberg
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