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Mechanism of Action of Alkylating Agents: Comparisons with other Cytotoxic, Mutagenic and Carcinogenic Agents

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Molekulare Biologie des Malignen Wachstums

Abstract

The general theory of mutagenesis based on Watson-Crick model for DNA structure and replication1,2 appears to be well established. The principal mutagenic mechanisms envisaged are the transition1 and exchange error2 types. Furthermore alkylation of DNA can lead to mutation3, and the induction of transition mutations by such reaction appears to be the best established mechanism for studies with micro-organisms, although it may well not be the sole mechanism4. Knowledge of the reactions of chemical carcinogens with DNA is also increasing (cf. review, ref. 5) and permits some reasonable speculations to be made concerning the possible relevance of such studies to the molecular mechanism of carcinogenesis.

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Authors and Affiliations

  1. Chester Beatty Research Institute, Institute of Cancer Research, Royal Cancer Hospital, London S.W. 3, Great Britain

    P. D. Lawley

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  1. P. D. Lawley
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H. Holzer A. W. Holldorf

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Lawley, P.D. (1966). Mechanism of Action of Alkylating Agents: Comparisons with other Cytotoxic, Mutagenic and Carcinogenic Agents. In: Holzer, H., Holldorf, A.W. (eds) Molekulare Biologie des Malignen Wachstums. Colloquium der Gesellschaft für Physiologische Chemie am 21./23. April 1966 in Mosbach/Baden, vol 17. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87539-7_14

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  • DOI: https://doi.org/10.1007/978-3-642-87539-7_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-03481-0

  • Online ISBN: 978-3-642-87539-7

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