Mechanism of Action of Alkylating Agents: Comparisons with other Cytotoxic, Mutagenic and Carcinogenic Agents

  • P. D. Lawley
Conference paper
Part of the Colloquium der Gesellschaft für Physiologische Chemie am 21./23. April 1966 in Mosbach/Baden book series (MOSBACH, volume 17)

Abstract

The general theory of mutagenesis based on Watson-Crick model for DNA structure and replication1,2 appears to be well established. The principal mutagenic mechanisms envisaged are the transition1 and exchange error2 types. Furthermore alkylation of DNA can lead to mutation3, and the induction of transition mutations by such reaction appears to be the best established mechanism for studies with micro-organisms, although it may well not be the sole mechanism4. Knowledge of the reactions of chemical carcinogens with DNA is also increasing (cf. review, ref. 5) and permits some reasonable speculations to be made concerning the possible relevance of such studies to the molecular mechanism of carcinogenesis.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1966

Authors and Affiliations

  • P. D. Lawley
    • 1
  1. 1.Chester Beatty Research InstituteInstitute of Cancer Research, Royal Cancer HospitalLondon S.W. 3Great Britain

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