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Quantum Perturbation Theory and Linear Free Energy Relationships in the Study of Drug Action

  • Arthur Cammarata

Abstract

Considerable emphasis is nowadays being placed on the development of available chemical theories for application in drug resarch. Impetus for these endeavorsis provided by the possibility that these studies couldlead to new approaches for predicting novel molecular structures having a desired biological effect. Until now the approach to the study and design of medicinal agents has centered primarily on the gross chemical structure of natural and synthetic compounds which have an established biological action. Variations of a basic structure are synthesized to arrive at structure-activity relations, and this compilation is used as aguide for the synthes is of other cand idate compounds. This approach, it is estimated [1], leads to only one useful therapeutic agent out of every three to five thousand compounds synthesized.

Keywords

Partition Coefficient Energy Change Inhibition Potency Induce Polarization Linear Free Energy Relationship 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1970

Authors and Affiliations

  • Arthur Cammarata
    • 1
  1. 1.School of PharmacyTempe UniversityPhiladelphiaUSA

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