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Quantum Perturbation Theory and Linear Free Energy Relationships in the Study of Drug Action

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Molecular Orbital Studies in Chemical Pharmacology

Abstract

Considerable emphasis is nowadays being placed on the development of available chemical theories for application in drug resarch. Impetus for these endeavorsis provided by the possibility that these studies couldlead to new approaches for predicting novel molecular structures having a desired biological effect. Until now the approach to the study and design of medicinal agents has centered primarily on the gross chemical structure of natural and synthetic compounds which have an established biological action. Variations of a basic structure are synthesized to arrive at structure-activity relations, and this compilation is used as aguide for the synthes is of other cand idate compounds. This approach, it is estimated [1], leads to only one useful therapeutic agent out of every three to five thousand compounds synthesized.

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Author information

Authors and Affiliations

  1. School of Pharmacy, Tempe University, Philadelphia, Pennsylvania, USA

    Arthur Cammarata

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  1. Arthur Cammarata
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Editor information

Editors and Affiliations

  1. Columbus Laboratories, Battelle Memorial Institute, Columbus, Ohio, USA

    Lemont B. Kier (Associate Fellow in Medicinal Chemistry) (Associate Fellow in Medicinal Chemistry)

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Cammarata, A. (1970). Quantum Perturbation Theory and Linear Free Energy Relationships in the Study of Drug Action. In: Kier, L.B. (eds) Molecular Orbital Studies in Chemical Pharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87536-6_7

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  • DOI: https://doi.org/10.1007/978-3-642-87536-6_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-04972-2

  • Online ISBN: 978-3-642-87536-6

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