Skip to main content
SpringerLink
Log in

Psychedelic Drug Activity: Electronic, Steric and Biochemical Correlates

  • Chapter
Molecular Orbital Studies in Chemical Pharmacology

Abstract

Discerning the interaction of any drug and its receptors is difficult . Before a direct attack on a molecular system that mediates a drug’s action is possible, indirect approaches are important . One of the most fruitful is to corre-late the varying pharmacological potencies of different analogues with varying activities on a test system. As a model of drug-receptor interactions, psychedelic agents present some tempting possibilities as well as almost insuperable difficulties. For instance, d-Lysergicacid diethylamide (d-LSD) is so extra-ordinarily potent, producing effects in man at doses as little as 20 micrograms per 70kg, that one can readily postulate a high degree of affinity for its receptor. Also, there are fairly extensive series of psychedelic drugs which, although apparently differing in structure, produce closely similar effects and seem to be acting on the same receptorsite which raises the question of just what psychotropic effects should be labeled“psychedelic”.

Supported by NIH Grants 1-Ro1-NB-07275 and 1-P01-GM-16492. The author is a recipient of. NIMH Research Career Development Award K3-MH-33128.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Snyder, S. H., Faillace, L., and Hollister, L., Science, 158, 669, (1967).

    Article  PubMed  CAS  Google Scholar 

  2. Snyder, S. H., Faillace, L. A., and Weingartner, H., Amer. J. Psychiat., 125, 357, (1968).

    Google Scholar 

  3. Snyder, S. H., Faillace, L. A., and Weingartner, H., Arch. Gen. Psychiat., 21 , 95, (1969).

    Article  PubMed  CAS  Google Scholar 

  4. Snyder, S. H., Weingartner, H., and Faillace, L. A., in Psychotanimetic Drugs, (ed. by D. H. Efron) , Raven Press, New York, (1969, in press).

    Google Scholar 

  5. Smythies, J. R. and Levy, C. K., J. Mental Sci., 106, 531, (1960).

    CAS  Google Scholar 

  6. Freedman, D. X., Appel, J. B., Hartman, F. R., and Molliver, M. E., J. Tharmacol. Exp. Therap., 143, 309, (1964).

    CAS  Google Scholar 

  7. Smythies, J. R., et al., Nature , 216, 128, (1967).

    Article  PubMed  CAS  Google Scholar 

  8. Appel, J. B. and Freedman, D. X., Life Sci., 4, 2181, (1967).

    Article  Google Scholar 

  9. Uyeno, E. T., Otis, L. S., and Mitoma, C., Comm. Behav. Biol., A1 , 83, (1968).

    Google Scholar 

  10. Shulgin, A. T., Sargent, T., and Naranjo, C., Nature , 221 , 537, (1969).

    Article  PubMed  CAS  Google Scholar 

  11. Uyeno, E. T., J. Pharmacol. Exp. Therap., 159, 216, (1968).

    CAS  Google Scholar 

  12. Ellison, T., Gutziat, L., and Van Loon, E. J., J. Pharmacol, Exp. Therap. 152, 383, (1966).

    CAS  Google Scholar 

  13. Freedman, D. X., Amer. J. Physchiat., 119, 843, (1963).

    CAS  Google Scholar 

  14. Diaz, P., Ngai, S. H., and Costa, E., Pharmacologist, 1, 372, (1967).

    Google Scholar 

  15. Aghajanian, G. K., Foote, W. E., and Sheard, M. H., Science, 161 , 707, (1969).

    Google Scholar 

  16. Hillarp, N. A., Fixe, K., and Dahlstrom, A., Pharmacol. Rev., 18, 727, (1966).

    PubMed  CAS  Google Scholar 

  17. Aghajanian, G. K. and Sheard, M. H., Comm. Behav. Bioi., 1 , 37, (1968).

    Google Scholar 

  18. Cerletti, A., p. 117 in Neuropharmacology , (ed. by P. B. Bradley, et al.), Elsevier, Amsterdam, (1959).

    Google Scholar 

  19. Iversen, L. L., The Uptake and Storage of Noradrenaiine in Sympathetic Nerves, Cambridge University Press, New York, (1967).

    Google Scholar 

  20. Glowinski, J. and Baldessarini, R. J., Pharmacol. Rev., 18, 1201, (1966).

    PubMed  CAS  Google Scholar 

  21. Eisenfeld, A. J., Axelrod, J. , and Krakoff, L. , J. Pharmacol. Exp. Therap. 156, 107, (1967).

    CAS  Google Scholar 

  22. Eisenfeld, A. J., Landsberg, L. , and Axelrod, J., J. Pharmacol. Exp. Therap. 158, 378, (1967).

    CAS  Google Scholar 

  23. Iversen, L. L., British J. Pharmacol., 25, 18, (1965).

    CAS  Google Scholar 

  24. Hendley, E. D. and Snyder, S. H., Federation Proc. 28, 674, (1969).

    Google Scholar 

  25. Schweitzer, J. W. and Friedhoff, A. J., Biochem. Pharmacol., 15, 2097, (1966) .

    Article  PubMed  CAS  Google Scholar 

  26. Sargent, T. W., et al., Biochem. Biophys. Res. Commun., 29, 126, (1967).

    Article  PubMed  CAS  Google Scholar 

  27. Karreman, G., Isenberg, I., and Szent-Gyorgyi, A., Science , 130, 1191, (1959).

    Article  PubMed  CAS  Google Scholar 

  28. Fukui, K., Yonezawa, T., and Nagata, C., J. Chem. Phys., 27, 1247, (1957).

    Article  CAS  Google Scholar 

  29. Axelrod, J., Brady, R. O., Witkop, B., and Evarts, E. V., Ann. N.Y. Acad. Sci., 66, 435, (1957) .

    Article  PubMed  CAS  Google Scholar 

  30. Streitweiser, A., Molecular Orbital Theory for Organic Chemists , Academic Press, New York, (1961).

    Google Scholar 

  31. Snyder, S. H. and Merril, C. R., Proc. Nat. Acad. Sci., U.S., 54, 258, (1965).

    Article  CAS  Google Scholar 

  32. Snyder, S. H. and Merril, C. R., p. 229 in Amine Metabolism in Schizophrenia , (ed. by H. Himwich and Smythies) , Pergamon Press, New York, (1966).

    Google Scholar 

  33. Turner, W. J. and Merles, S., A.M.A. Arch. Neurol. Psychiat., 81 , 121 , (1959).

    CAS  Google Scholar 

  34. Szara, S. and Axelrod, J., Experientia , 15, 216, (1959).

    Article  PubMed  CAS  Google Scholar 

  35. Szara, S. and Hearst, E., Ann. N.Y. Acad. Sci., 96, 134, (1962).

    Article  CAS  Google Scholar 

  36. Kalir, A. and Szara, S. Med. Chem., 6, 716, (1963).

    Article  CAS  Google Scholar 

  37. Rosenberg, D. E., Isbell, H., and Miner, E. J., Psychopharmacologia , 4, 39, (1963).

    Article  PubMed  CAS  Google Scholar 

  38. Snyder, S. H. and Richelson, E., Proc. Nat. Acad. Sci., U.S., 60, 206, (1968).

    Article  CAS  Google Scholar 

  39. Snyder, S. H. and Richelson, E., p. 1199 in Psychotomimetic: A Review of Progress, (ed. by D. H. Efron) , Public Health Service, Washington, D.C., (1968).

    Google Scholar 

  40. Snyder, S. H. and Richelson, E., in Psychotomimetic Drugs, (ed. by D. H. Efron) , Raven Press, New York, (1969, in press).

    Google Scholar 

  41. Szara, S., p. 460 in Psychotropic Drugs, (ed. by S. Garattini and V. Ghetti) , Elsevier, Amsterdam, (1957).

    Google Scholar 

  42. Gessner, P. K., Godse, D. D., Krull, A. H., and McMullan, J. M., Life Sci, 7, 267, (1968).

    Article  PubMed  CAS  Google Scholar 

  43. Shulgin, A. T., Experientia 20, 366, (1964) .

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Pharmacology and Experimental Therapeutics and Psychiatry and the Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Solomon H. Snyder

Authors
  1. Solomon H. Snyder
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Columbus Laboratories, Battelle Memorial Institute, Columbus, Ohio, USA

    Lemont B. Kier (Associate Fellow in Medicinal Chemistry) (Associate Fellow in Medicinal Chemistry)

Rights and permissions

Reprints and permissions

Copyright information

© 1970 Springer Science+Business Media New York

About this chapter

Cite this chapter

Snyder, S.H. (1970). Psychedelic Drug Activity: Electronic, Steric and Biochemical Correlates. In: Kier, L.B. (eds) Molecular Orbital Studies in Chemical Pharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87536-6_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-87536-6_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-04972-2

  • Online ISBN: 978-3-642-87536-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation