Abstract
Temperature-sensitive (ts) mutants have several uses in molecular and cellular biology. First of all, since phenotypic expression of such mutations is conditional, they permit identification of the genetic elements concerned with indispensable enzymes, thereby permitting progress toward the goal of a total definition of the genome of one cell. Careful study of such mutants can sometimes also reveal ancillary cellular roles for indispensable enzymes.
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Neidhardt, F.C. (1968). Structure and Cellular Function of Aminoacyl Ribonucleic Acid Synthetases. In: Wittmann, H.G., Schuster, H. (eds) Molecular Genetics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87534-2_12
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DOI: https://doi.org/10.1007/978-3-642-87534-2_12
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