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Immunological Membrane Markers of Hodgkin’s Cells

  • Marshall E. Kadin
  • Sondra Gold
  • Eileen M. Garratty
  • Daniel P. Stites
Part of the Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 19)

Summary

Reed-Sternberg and other Hodgkin’s giant cells derived from involved spleens and lymph nodes of patients with Hodgkin’s disease were examined for surface markers of T and B cells and macrophages. Attachment and phagocytosis of untreated (E) or sensitized (EA and EAC) sheep red blood cells and yeast by Reed-Sternberg cells did not occur. IgG frequently detected at the membrane of Reed-Sternberg cells was partially removed by incubation and washing at 37 °C. Fluorescence with a specific anti-T cell serum was not seen on Reed-Sternberg and other Hodgkin’s giant cells. These studies indicate that Reed-Sternberg and other Hodgkin’s giant cells lack most detectable normal human lymphoid cell markers, but do exhibit membrane bound immunoglobulin possibly of exogenous origin.

Keywords

Chronic Lymphocytic Leukemia Latex Particle Mycosis Fungoides Complement Receptor Sheep Erythrocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations used

FCS

Fetal calf serum

BSA-PBS

bovine serum albumin-phosphate buffered saline

CLL

chronic lymphocytic leukemia

SIgG

surface-bound immunoglobulin G

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Copyright information

© J. F. Lehmanns Verlag München 1976

Authors and Affiliations

  • Marshall E. Kadin
    • 1
    • 2
    • 3
  • Sondra Gold
    • 3
  • Eileen M. Garratty
    • 3
  • Daniel P. Stites
    • 1
    • 2
  1. 1.From the Departments of MedicineUniversity of CaliforniaSan FranciscoUSA
  2. 2.Laboratory MedicineUniversity of CaliforniaSan FranciscoUSA
  3. 3.Division of Hematology and the Cancer Research InstituteUniversity of CaliforniaSan FranciscoUSA

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