Summary
Reed-Sternberg and other Hodgkin’s giant cells derived from involved spleens and lymph nodes of patients with Hodgkin’s disease were examined for surface markers of T and B cells and macrophages. Attachment and phagocytosis of untreated (E) or sensitized (EA and EAC) sheep red blood cells and yeast by Reed-Sternberg cells did not occur. IgG frequently detected at the membrane of Reed-Sternberg cells was partially removed by incubation and washing at 37 °C. Fluorescence with a specific anti-T cell serum was not seen on Reed-Sternberg and other Hodgkin’s giant cells. These studies indicate that Reed-Sternberg and other Hodgkin’s giant cells lack most detectable normal human lymphoid cell markers, but do exhibit membrane bound immunoglobulin possibly of exogenous origin.
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Abbreviations
- FCS:
-
Fetal calf serum
- BSA-PBS:
-
bovine serum albumin-phosphate buffered saline
- CLL:
-
chronic lymphocytic leukemia
- SIgG:
-
surface-bound immunoglobulin G
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© 1976 J. F. Lehmanns Verlag München
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Kadin, M.E., Gold, S., Garratty, E.M., Stites, D.P. (1976). Immunological Membrane Markers of Hodgkin’s Cells. In: Neth, R., Gallo, R.C., Mannweiler, K., Moloney, W.C. (eds) Modern Trends in Human Leukemia II. Hämatologie und Bluttransfusion, vol 19. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87524-3_24
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DOI: https://doi.org/10.1007/978-3-642-87524-3_24
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