Target Cells for Transformation with Avian Leukosis Viruses
Leukemia is a widespread disorder of the hemopoietic system of vertebrates which has been particularly well analyzed in chickens, mice and recently also in cats (for review see 1). It seems now safe to assume that the majority of the different ypes of leukemias found in animals are caused by infection with or activation of C-type leukemia viruses (1). In fact, it has been known since 1908 that leukemia can be induced by a filterable agent, i.e., a virus (2). With the availability of modern biochemical technology and quantitative biological assays, leukosis-sarcoma viruses have since then been thoroughly analyzed in their structure, mechanism of replication and genetics (1). Little is known, however, about the mechanism of virus-induced leukemogenesis.
KeywordsAcute Myeloid Leukemia Chronic Myeloid Leukemia Bone Marrow Cell Pluripotent Stem Cell Hemopoietic Cell
Unable to display preview. Download preview PDF.
- 1.Tooze, J. (Ed.), The Molecular Biology of Tumour Viruses. Cold Spring Harbor Laboratory, 1973.Google Scholar
- 2.Ellermann, V., and Bang, O., Centr. Bakteriol. Parasitenk., Abt. I, Orig. 46: 595, 1908.Google Scholar
- 4.Baluda, M. A., Moscovici, C., and Goetz, I. E., J. Nat. Cancer Inst. Monograph 17: 449 (1964).Google Scholar
- 8.Graf, T., Z. Naturforsch. 30c 847, 1975.Google Scholar
- 10.Friend, C., Scher, W., Holland, J. G., and Sato, T., Proc. Nat. Acad. Sci. U.S. 68: 378, 1971.Google Scholar
- 12.Metcalf, D., and Moore, M. A. S., Haemopoietic cells. North Holland Publishing Co., Amsterdam, London, 1971.Google Scholar
- 13.Moscovici, C., and Moscovici, M. G., In: Methods in Cell Physiology Vol. 7. D. M. Prescott (Ed.) (Academic Press, New York and London) pp. 313–328, 1973.Google Scholar
- 19.Purchase, H. G., and Burmester, B. R. In: Diseases of Poultry, Hofstad, M. S. et al. (Eds.) Sixth edition (The Iowa State University Press) pp. 502–571, 1972.Google Scholar