Abstract
An involved discussion of the soilversus-seed theory of metastases might seem academic if not solely historical today. There are presently available for review many investigations in which varying conditions have been applied experimentally to manipulate the patterns of metastases. Of most general interest has been the manner in which intravascular spread of tumour could be controlled. To quote some examples: local injury, either chemical or physical (Alexander, 1964; Robinson, 1962) general anesthesia (Agostino, 1964) cortisone (Baserga, 1954; Zeidman, 1962) surgical “stress” (Kallenbach, 1962; Buinauskas, 1958) growth hormone (Wood, 1956) reticuloendothelial blockade (Fisher, 1961) proferrin (Fisher, 1962) pancreatic inhibitor (Cagliani, 1962) orotic acid (Chu, 1964) pituitary homogenates (Fisher, 1961) epsilon amnio caproic acid (Cliffton, 1964) and host irradiation (Driessens, 1963) have been observed to increase incidence of metastases; heparin (Agostino, 1962; Gallinotto, 1964) fibrinolysin (Grossi, 1960) chymotrypsin (Cagliani, 1962) neuraminidase (Gasic, 1962) coumadin (Agostino, 1963) surgery (Ketcham, 1961) and x-irradiation of donor (Hoye, 1961) have been observed to reduce incidence of metastases.
This work was supported by Grant # U-1121 from the Health Research Council of the City of New York, and by Grant # CA 07587. National Institutes of Health, U.S. Department of Health, Education and Welfare. A portion of this work was presented in partial fulfillment of the requirements for degree of Master of Arts in the Hunter College of the City University of New York.
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Madden, R.E. (1967). The Tumour Cell and Vascular Bed Size Relationship in Experimental Metastases. In: Denoix, P. (eds) Mechanisms of Invasion in Cancer. UICC Monograph Series, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87458-1_10
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