The Tumour Cell and Vascular Bed Size Relationship in Experimental Metastases

  • Robert E. Madden
Conference paper
Part of the UICC Monograph Series book series (UICC, volume 6)


An involved discussion of the soilversus-seed theory of metastases might seem academic if not solely historical today. There are presently available for review many investigations in which varying conditions have been applied experimentally to manipulate the patterns of metastases. Of most general interest has been the manner in which intravascular spread of tumour could be controlled. To quote some examples: local injury, either chemical or physical (Alexander, 1964; Robinson, 1962) general anesthesia (Agostino, 1964) cortisone (Baserga, 1954; Zeidman, 1962) surgical “stress” (Kallenbach, 1962; Buinauskas, 1958) growth hormone (Wood, 1956) reticuloendothelial blockade (Fisher, 1961) proferrin (Fisher, 1962) pancreatic inhibitor (Cagliani, 1962) orotic acid (Chu, 1964) pituitary homogenates (Fisher, 1961) epsilon amnio caproic acid (Cliffton, 1964) and host irradiation (Driessens, 1963) have been observed to increase incidence of metastases; heparin (Agostino, 1962; Gallinotto, 1964) fibrinolysin (Grossi, 1960) chymotrypsin (Cagliani, 1962) neuraminidase (Gasic, 1962) coumadin (Agostino, 1963) surgery (Ketcham, 1961) and x-irradiation of donor (Hoye, 1961) have been observed to reduce incidence of metastases.


Circulate Tumor Cell Vascular Channel Experimental Metastasis Orotic Acid Vascular Diameter 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1967

Authors and Affiliations

  • Robert E. Madden
    • 1
  1. 1.Department of SurgeryNew York Medical CollegeNew YorkUSA

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