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The Response of Metanephric Rudiments to Polyoma Virus in Vitro Discussion

  • W. H. Kirsten
  • T. P. Weis
Part of the Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer book series (RECENTCANCER, volume 6)

Abstract

Dr. Dawe’s observations on the response of organ cultures of mouse submandibular rudiments to polyoma virus (PV) can be summarized as follows: (a) the basic unit of the neoplastic response is the epithelio-mesenchymal complex, (b) neoplasms fail to appear from the isolated epithelial or mesenchymal components of the salivary-gland rudiments and (c) acquisition of neoplastic properties by salivary-gland epithelium requires “helper cells” which are provided for by salivary capsular mesenchyme but not by odontogenic mesenchyme. Furthermore, the responsiveness to PV oncogenesis was not maintained by exposure of “chimeric” dental epithelium and salivary-gland mesenchyme.

Keywords

Organ Culture Polyoma Virus Metanephric Mesenchyme Mesenchymal Component Filter Assembly 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag New York Inc. 1966

Authors and Affiliations

  • W. H. Kirsten
    • 1
  • T. P. Weis
    • 1
  1. 1.Department of Pathology, Division of Biological SciencesThe University of ChicagoChicagoUSA

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